Capsaicin inhalation in man and the effects of sodium cromoglycate

1 The inhalation of capsaicin for 1 min, delivered as an aerosol by nebulising solutions of capsaicin at concentrations of 2–65 μmol l−1, caused dose‐dependent coughing in normal volunteers and subjects with mild asthma. Capsaicin did not cause a feeling of breathlessness, and had no effect on force...

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Bibliographic Details
Published in:British journal of pharmacology 1984-01, Vol.81 (1), p.113-117
Main Authors: Collier, J.G., Fuller, R.W.
Format: Article
Language:English
Subjects:
Aerosols
Anesthesia, Local
Biological and medical sciences
Capsaicin - administration & dosage
Capsaicin - antagonists & inhibitors
Capsaicin - pharmacology
Cough - chemically induced
Cough - physiopathology
Cromolyn Sodium - administration & dosage
Cromolyn Sodium - pharmacology
Forced Expiratory Volume
Heart Rate - drug effects
Histamine and antagonists. Allergy
Humans
Medical sciences
Pharmacology. Drug treatments
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Summary:1 The inhalation of capsaicin for 1 min, delivered as an aerosol by nebulising solutions of capsaicin at concentrations of 2–65 μmol l−1, caused dose‐dependent coughing in normal volunteers and subjects with mild asthma. Capsaicin did not cause a feeling of breathlessness, and had no effect on forced expiratory volume in 1 s (FEV1) measured at the 1st, 5th and 9th min after the challenge was completed. 2 Coughing started within seconds of applying the face mask, continued throughout the minute of capsaicin inhalation, and stopped within seconds of the mask being removed. In any one subject the number of coughs was reproducible when repeated on the same day or after an interval of several days. 3 Experiments using local anaesthesia applied to the buccal mucosa or larynx indicated that the cough was caused by the stimulation of capsaicin‐sensitive nerve terminals situated in the larynx. 4 Cough response was not altered by the prior inhalation of sodium cromoglycate.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1984.tb10750.x