Loading…
Fewer driver synapses in higher order than in first order thalamic relays
Abstract We used electron microscopy to determine the relative numbers of the three synaptic terminal types, RL (round vesicle, large terminal), RS (round vesicles, small terminal), and F (flattened vesicles), found in several representative thalamic nuclei in cats chosen as representative examples...
Saved in:
| Published in: | Neuroscience 2007-04, Vol.146 (1), p.463-470 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c601t-f4283ad653db1fa8e34aafdc439df18199d9342a828703d0520acbf669bfd34a3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c601t-f4283ad653db1fa8e34aafdc439df18199d9342a828703d0520acbf669bfd34a3 |
| container_end_page | 470 |
| container_issue | 1 |
| container_start_page | 463 |
| container_title | Neuroscience |
| container_volume | 146 |
| creator | Van Horn, S.C Sherman, S.M |
| description | Abstract We used electron microscopy to determine the relative numbers of the three synaptic terminal types, RL (round vesicle, large terminal), RS (round vesicles, small terminal), and F (flattened vesicles), found in several representative thalamic nuclei in cats chosen as representative examples of first and higher order thalamic nuclei, where the first order nuclei relay subcortical information mainly to primary sensory cortex, and the higher order nuclei largely relay information from one cortical area to another. The nuclei sampled were the first order ventral posterior nucleus (somatosensory) and the ventral portion of the medial geniculate nucleus (auditory), and the higher order posterior nucleus (somatosensory) and the medial portion of the medial geniculate nucleus (auditory). We found that the relative percentage of synapses from RL terminals varied significantly among these nuclei, these values being higher for first order nuclei (12.6% for the ventral posterior nucleus and 8.2% for the ventral portion of the medial geniculate nucleus) than for the higher order nuclei (5.4% for the posterior nucleus, and 3.5% for the medial portion of the medial geniculate nucleus). This is consistent with a similar analysis of first and higher order nuclei for the visual system (the lateral geniculate nucleus and pulvinar, respectively). Since synapses from RL terminals represent the main information to be relayed, whereas synapses from F and RS terminals are modulatory in function, we conclude that there is relatively more modulation of the thalamic relay in the cortico-thalamo-cortical higher order pathway than in first order relays. |
| doi_str_mv | 10.1016/j.neuroscience.2007.01.026 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1941769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0306452207000577</els_id><sourcerecordid>19708714</sourcerecordid><originalsourceid>FETCH-LOGICAL-c601t-f4283ad653db1fa8e34aafdc439df18199d9342a828703d0520acbf669bfd34a3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhi0EotvCX0ArJLgljD8SJxwqVaWFSpU4AGfLa4-7XrLOYieL9t_jaCO2cAHL8kjjZz7sdwh5TaGkQOt3mzLgGPtkPAaDJQOQJdASWP2ELGgjeSErIZ6SBXCoC1ExdkbOU9pAXpXgz8kZlZwBa6sFubvFnxiXNvp9NukQ9C5hWvqwXPuHdXb10eZzWOswOZ2PaTj5Or31Zhmx04f0gjxzukv4crYX5NvtzdfrT8X9549311f3hamBDoUTrOHa1hW3K-p0g1xo7awRvLWONrRtbcsF0w1rJHALFQNtVq6u25WzmeUX5PKYdzeutmgNhiHqTu2i3-p4UL326s-b4Nfqod8r2goq6zYneDsniP2PEdOgtj4Z7DodsB-TkpC_jOf9L5C2EhpJRQbfH0GTVUkR3e9uKKhJMrVRjyVTk2QKqMqS5eBXj99zCp01ysCbGdDJ6M5FHYxPJ66RVd0AZO7DkcP8-3uPUc3lrI9oBmV7_3_9XP6VxnQ--Fz5Ox4wbfoxhqyvoioxBerLNGTTjIGcxktK_guU4NII</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19708714</pqid></control><display><type>article</type><title>Fewer driver synapses in higher order than in first order thalamic relays</title><source>ScienceDirect Freedom Collection</source><creator>Van Horn, S.C ; Sherman, S.M</creator><creatorcontrib>Van Horn, S.C ; Sherman, S.M</creatorcontrib><description>Abstract We used electron microscopy to determine the relative numbers of the three synaptic terminal types, RL (round vesicle, large terminal), RS (round vesicles, small terminal), and F (flattened vesicles), found in several representative thalamic nuclei in cats chosen as representative examples of first and higher order thalamic nuclei, where the first order nuclei relay subcortical information mainly to primary sensory cortex, and the higher order nuclei largely relay information from one cortical area to another. The nuclei sampled were the first order ventral posterior nucleus (somatosensory) and the ventral portion of the medial geniculate nucleus (auditory), and the higher order posterior nucleus (somatosensory) and the medial portion of the medial geniculate nucleus (auditory). We found that the relative percentage of synapses from RL terminals varied significantly among these nuclei, these values being higher for first order nuclei (12.6% for the ventral posterior nucleus and 8.2% for the ventral portion of the medial geniculate nucleus) than for the higher order nuclei (5.4% for the posterior nucleus, and 3.5% for the medial portion of the medial geniculate nucleus). This is consistent with a similar analysis of first and higher order nuclei for the visual system (the lateral geniculate nucleus and pulvinar, respectively). Since synapses from RL terminals represent the main information to be relayed, whereas synapses from F and RS terminals are modulatory in function, we conclude that there is relatively more modulation of the thalamic relay in the cortico-thalamo-cortical higher order pathway than in first order relays.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2007.01.026</identifier><identifier>PMID: 17320295</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cats ; corticocortical communication ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - metabolism ; medial geniculate nucleus ; Microscopy, Electron, Transmission - methods ; Microscopy, Immunoelectron - methods ; Neural Pathways - anatomy & histology ; Neurology ; neuromodulators ; Neurons - metabolism ; Neurons - ultrastructure ; posterior nucleus ; Synapses - physiology ; Synapses - ultrastructure ; Thalamus - cytology ; ventral posterior nucleus ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2007-04, Vol.146 (1), p.463-470</ispartof><rights>IBRO</rights><rights>2007 IBRO</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-f4283ad653db1fa8e34aafdc439df18199d9342a828703d0520acbf669bfd34a3</citedby><cites>FETCH-LOGICAL-c601t-f4283ad653db1fa8e34aafdc439df18199d9342a828703d0520acbf669bfd34a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18756800$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17320295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Horn, S.C</creatorcontrib><creatorcontrib>Sherman, S.M</creatorcontrib><title>Fewer driver synapses in higher order than in first order thalamic relays</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract We used electron microscopy to determine the relative numbers of the three synaptic terminal types, RL (round vesicle, large terminal), RS (round vesicles, small terminal), and F (flattened vesicles), found in several representative thalamic nuclei in cats chosen as representative examples of first and higher order thalamic nuclei, where the first order nuclei relay subcortical information mainly to primary sensory cortex, and the higher order nuclei largely relay information from one cortical area to another. The nuclei sampled were the first order ventral posterior nucleus (somatosensory) and the ventral portion of the medial geniculate nucleus (auditory), and the higher order posterior nucleus (somatosensory) and the medial portion of the medial geniculate nucleus (auditory). We found that the relative percentage of synapses from RL terminals varied significantly among these nuclei, these values being higher for first order nuclei (12.6% for the ventral posterior nucleus and 8.2% for the ventral portion of the medial geniculate nucleus) than for the higher order nuclei (5.4% for the posterior nucleus, and 3.5% for the medial portion of the medial geniculate nucleus). This is consistent with a similar analysis of first and higher order nuclei for the visual system (the lateral geniculate nucleus and pulvinar, respectively). Since synapses from RL terminals represent the main information to be relayed, whereas synapses from F and RS terminals are modulatory in function, we conclude that there is relatively more modulation of the thalamic relay in the cortico-thalamo-cortical higher order pathway than in first order relays.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>corticocortical communication</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>medial geniculate nucleus</subject><subject>Microscopy, Electron, Transmission - methods</subject><subject>Microscopy, Immunoelectron - methods</subject><subject>Neural Pathways - anatomy & histology</subject><subject>Neurology</subject><subject>neuromodulators</subject><subject>Neurons - metabolism</subject><subject>Neurons - ultrastructure</subject><subject>posterior nucleus</subject><subject>Synapses - physiology</subject><subject>Synapses - ultrastructure</subject><subject>Thalamus - cytology</subject><subject>ventral posterior nucleus</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkk1v1DAQhi0EotvCX0ArJLgljD8SJxwqVaWFSpU4AGfLa4-7XrLOYieL9t_jaCO2cAHL8kjjZz7sdwh5TaGkQOt3mzLgGPtkPAaDJQOQJdASWP2ELGgjeSErIZ6SBXCoC1ExdkbOU9pAXpXgz8kZlZwBa6sFubvFnxiXNvp9NukQ9C5hWvqwXPuHdXb10eZzWOswOZ2PaTj5Or31Zhmx04f0gjxzukv4crYX5NvtzdfrT8X9549311f3hamBDoUTrOHa1hW3K-p0g1xo7awRvLWONrRtbcsF0w1rJHALFQNtVq6u25WzmeUX5PKYdzeutmgNhiHqTu2i3-p4UL326s-b4Nfqod8r2goq6zYneDsniP2PEdOgtj4Z7DodsB-TkpC_jOf9L5C2EhpJRQbfH0GTVUkR3e9uKKhJMrVRjyVTk2QKqMqS5eBXj99zCp01ysCbGdDJ6M5FHYxPJ66RVd0AZO7DkcP8-3uPUc3lrI9oBmV7_3_9XP6VxnQ--Fz5Ox4wbfoxhqyvoioxBerLNGTTjIGcxktK_guU4NII</recordid><startdate>20070425</startdate><enddate>20070425</enddate><creator>Van Horn, S.C</creator><creator>Sherman, S.M</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20070425</creationdate><title>Fewer driver synapses in higher order than in first order thalamic relays</title><author>Van Horn, S.C ; Sherman, S.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-f4283ad653db1fa8e34aafdc439df18199d9342a828703d0520acbf669bfd34a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>corticocortical communication</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>medial geniculate nucleus</topic><topic>Microscopy, Electron, Transmission - methods</topic><topic>Microscopy, Immunoelectron - methods</topic><topic>Neural Pathways - anatomy & histology</topic><topic>Neurology</topic><topic>neuromodulators</topic><topic>Neurons - metabolism</topic><topic>Neurons - ultrastructure</topic><topic>posterior nucleus</topic><topic>Synapses - physiology</topic><topic>Synapses - ultrastructure</topic><topic>Thalamus - cytology</topic><topic>ventral posterior nucleus</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Horn, S.C</creatorcontrib><creatorcontrib>Sherman, S.M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Horn, S.C</au><au>Sherman, S.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fewer driver synapses in higher order than in first order thalamic relays</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2007-04-25</date><risdate>2007</risdate><volume>146</volume><issue>1</issue><spage>463</spage><epage>470</epage><pages>463-470</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Section Editor: M Herkenham</notes><abstract>Abstract We used electron microscopy to determine the relative numbers of the three synaptic terminal types, RL (round vesicle, large terminal), RS (round vesicles, small terminal), and F (flattened vesicles), found in several representative thalamic nuclei in cats chosen as representative examples of first and higher order thalamic nuclei, where the first order nuclei relay subcortical information mainly to primary sensory cortex, and the higher order nuclei largely relay information from one cortical area to another. The nuclei sampled were the first order ventral posterior nucleus (somatosensory) and the ventral portion of the medial geniculate nucleus (auditory), and the higher order posterior nucleus (somatosensory) and the medial portion of the medial geniculate nucleus (auditory). We found that the relative percentage of synapses from RL terminals varied significantly among these nuclei, these values being higher for first order nuclei (12.6% for the ventral posterior nucleus and 8.2% for the ventral portion of the medial geniculate nucleus) than for the higher order nuclei (5.4% for the posterior nucleus, and 3.5% for the medial portion of the medial geniculate nucleus). This is consistent with a similar analysis of first and higher order nuclei for the visual system (the lateral geniculate nucleus and pulvinar, respectively). Since synapses from RL terminals represent the main information to be relayed, whereas synapses from F and RS terminals are modulatory in function, we conclude that there is relatively more modulation of the thalamic relay in the cortico-thalamo-cortical higher order pathway than in first order relays.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17320295</pmid><doi>10.1016/j.neuroscience.2007.01.026</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2007-04, Vol.146 (1), p.463-470 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1941769 |
| source | ScienceDirect Freedom Collection |
| subjects | Animals Biological and medical sciences Cats corticocortical communication Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism medial geniculate nucleus Microscopy, Electron, Transmission - methods Microscopy, Immunoelectron - methods Neural Pathways - anatomy & histology Neurology neuromodulators Neurons - metabolism Neurons - ultrastructure posterior nucleus Synapses - physiology Synapses - ultrastructure Thalamus - cytology ventral posterior nucleus Vertebrates: nervous system and sense organs |
| title | Fewer driver synapses in higher order than in first order thalamic relays |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T21%3A30%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fewer%20driver%20synapses%20in%20higher%20order%20than%20in%20first%20order%20thalamic%20relays&rft.jtitle=Neuroscience&rft.au=Van%20Horn,%20S.C&rft.date=2007-04-25&rft.volume=146&rft.issue=1&rft.spage=463&rft.epage=470&rft.pages=463-470&rft.issn=0306-4522&rft.eissn=1873-7544&rft.coden=NRSCDN&rft_id=info:doi/10.1016/j.neuroscience.2007.01.026&rft_dat=%3Cproquest_pubme%3E19708714%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c601t-f4283ad653db1fa8e34aafdc439df18199d9342a828703d0520acbf669bfd34a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=19708714&rft_id=info:pmid/17320295&rfr_iscdi=true |