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Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery
1 This study was undertaken to characterize pharmacologically the prostanoid receptor subtypes mediating constriction and relaxation of human isolated uterine artery. 2 U‐46619 was a potent constrictor agonist on human uterine artery (EC50 [95% CL] = 3.5 [1.8‐6.7] μM). Prostaglandin E2 (PGE2α), PGF2...
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| Published in: | British journal of pharmacology 1995-09, Vol.116 (1), p.1692-1696 |
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| creator | Baxter, G.S. Clayton, J.K. Coleman, R.A. Marshall, K. Sangha, R. Senior, J. |
| description | 1
This study was undertaken to characterize pharmacologically the prostanoid receptor subtypes mediating constriction and relaxation of human isolated uterine artery.
2
U‐46619 was a potent constrictor agonist on human uterine artery (EC50 [95% CL] = 3.5 [1.8‐6.7] μM). Prostaglandin E2 (PGE2α), PGF2, PGD2 and PGI2 only weakly constricted the uterine artery, being at least 100 times less potent than U‐46619. The PGE2 and PGI2 constrictor effects may be modified by the potent dilator effects of these compounds. A number of agonists which show selectivity for FP‐, DP‐ and EP‐receptors including ICI 81008, BW 245C, sulprostone, rioprostil and butaprost, failed to cause any constriction at concentrations up to 30 μM.
3
Constrictor responses induced by all agonists tested were reduced or abolished by the TP‐receptor blocking drugs, GR 32191 and EP 092. pA2 estimates for both antagonists versus U‐46619 were 8.50, values which are consistent with their affinities at TP‐receptors.
4
In preparations pre‐constricted with phenylephrine (1 μM) both PGI2 and PGE2 were potent relaxant agonists. The selective IP‐receptor agonists, cicaprost and iloprost, also dilated human uterine artery and were approximately 10 fold more potent than PGI2. The EP2‐receptor agonists, butaprost and rioprostil and the selective DP‐agonist, BW 245C, were at least 100 fold weaker than PGI2 and PGE2 suggesting that neither DP‐ nor EP2 receptors were involved.
5
We conclude that TP‐receptors mediate constriction, whereas IP‐ and possibly EP4‐receptors mediate relaxation of human uterine artery. |
| doi_str_mv | 10.1111/j.1476-5381.1995.tb16393.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1908906</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77629826</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5733-570b048e34e75ac42f6489f7a08e8afb535df29fb81b06a461c1132ab5b4f4b03</originalsourceid><addsrcrecordid>eNqVkV-L1DAUxYMo67j6EYQi4ltr0jR_6oOsO6grLOiDPofbTLKToZOMSaoz--ltd0rRR_OSC-d3Tw45CL0iuCLjeburSCN4yagkFWlbVuWOcNrS6vgIrRbpMVphjEVJiJRP0bOUdhiPomAX6EIy3tS0XaG03kIEnU1095Bd8EWwRd6a4hBDyuCD2xTRaHPIIaZibzZupPxdoYNPOTr9sAJ-gno4Lg7bYQ--cCn0kM2mGCZ_bwqI43B6jp5Y6JN5Md-X6Menj9_XN-Xt189f1h9uS80EpSUTuMONNLQxgoFuassb2VoBWBoJtmOUbWzd2k6SDnNoONGE0Bo61jW26TC9RO_PvoehG5Nr43OEXh2i20M8qQBO_at4t1V34ZciLZYt5qPBm9kghp-DSVntXdKm78GbMCQlBK9bWU_guzOox19L0djlEYLVVJnaqakXNfWipsrUXJk6jssv_465rM4djfrrWYekobcRvHZpwSjnGFMxYldn7Lfrzek_AqjrbzcPI_0DHma4Rw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77629826</pqid></control><display><type>article</type><title>Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery</title><source>PubMed (Medline)</source><source>Wiley Journals</source><creator>Baxter, G.S. ; Clayton, J.K. ; Coleman, R.A. ; Marshall, K. ; Sangha, R. ; Senior, J.</creator><creatorcontrib>Baxter, G.S. ; Clayton, J.K. ; Coleman, R.A. ; Marshall, K. ; Sangha, R. ; Senior, J.</creatorcontrib><description>1
This study was undertaken to characterize pharmacologically the prostanoid receptor subtypes mediating constriction and relaxation of human isolated uterine artery.
2
U‐46619 was a potent constrictor agonist on human uterine artery (EC50 [95% CL] = 3.5 [1.8‐6.7] μM). Prostaglandin E2 (PGE2α), PGF2, PGD2 and PGI2 only weakly constricted the uterine artery, being at least 100 times less potent than U‐46619. The PGE2 and PGI2 constrictor effects may be modified by the potent dilator effects of these compounds. A number of agonists which show selectivity for FP‐, DP‐ and EP‐receptors including ICI 81008, BW 245C, sulprostone, rioprostil and butaprost, failed to cause any constriction at concentrations up to 30 μM.
3
Constrictor responses induced by all agonists tested were reduced or abolished by the TP‐receptor blocking drugs, GR 32191 and EP 092. pA2 estimates for both antagonists versus U‐46619 were 8.50, values which are consistent with their affinities at TP‐receptors.
4
In preparations pre‐constricted with phenylephrine (1 μM) both PGI2 and PGE2 were potent relaxant agonists. The selective IP‐receptor agonists, cicaprost and iloprost, also dilated human uterine artery and were approximately 10 fold more potent than PGI2. The EP2‐receptor agonists, butaprost and rioprostil and the selective DP‐agonist, BW 245C, were at least 100 fold weaker than PGI2 and PGE2 suggesting that neither DP‐ nor EP2 receptors were involved.
5
We conclude that TP‐receptors mediate constriction, whereas IP‐ and possibly EP4‐receptors mediate relaxation of human uterine artery.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1995.tb16393.x</identifier><identifier>PMID: 8564239</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid ; Arteries - ultrastructure ; Biological and medical sciences ; Biphenyl Compounds - pharmacology ; Blood vessels and receptors ; Epoprostenol - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Heptanoic Acids - pharmacology ; human uterine artery ; Humans ; In Vitro Techniques ; IP‐receptors and relaxation ; Muscle Contraction - physiology ; Muscle Relaxation - physiology ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - physiology ; Muscle, Smooth, Vascular - ultrastructure ; Prostaglandin Antagonists - pharmacology ; Prostaglandin Endoperoxides, Synthetic - pharmacology ; Prostanoid receptors ; Receptors, Prostaglandin - agonists ; Receptors, Prostaglandin - classification ; Receptors, Prostaglandin - physiology ; Thromboxane A2 - analogs & derivatives ; Thromboxane A2 - pharmacology ; TP‐receptors and constriction ; Uterus - blood supply ; Vasoconstrictor Agents - pharmacology ; Vertebrates: cardiovascular system</subject><ispartof>British journal of pharmacology, 1995-09, Vol.116 (1), p.1692-1696</ispartof><rights>1995 British Pharmacological Society</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5733-570b048e34e75ac42f6489f7a08e8afb535df29fb81b06a461c1132ab5b4f4b03</citedby><cites>FETCH-LOGICAL-c5733-570b048e34e75ac42f6489f7a08e8afb535df29fb81b06a461c1132ab5b4f4b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908906/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908906/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,1424,27957,27958,45609,45610,53827,53829</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3660037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8564239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baxter, G.S.</creatorcontrib><creatorcontrib>Clayton, J.K.</creatorcontrib><creatorcontrib>Coleman, R.A.</creatorcontrib><creatorcontrib>Marshall, K.</creatorcontrib><creatorcontrib>Sangha, R.</creatorcontrib><creatorcontrib>Senior, J.</creatorcontrib><title>Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
This study was undertaken to characterize pharmacologically the prostanoid receptor subtypes mediating constriction and relaxation of human isolated uterine artery.
2
U‐46619 was a potent constrictor agonist on human uterine artery (EC50 [95% CL] = 3.5 [1.8‐6.7] μM). Prostaglandin E2 (PGE2α), PGF2, PGD2 and PGI2 only weakly constricted the uterine artery, being at least 100 times less potent than U‐46619. The PGE2 and PGI2 constrictor effects may be modified by the potent dilator effects of these compounds. A number of agonists which show selectivity for FP‐, DP‐ and EP‐receptors including ICI 81008, BW 245C, sulprostone, rioprostil and butaprost, failed to cause any constriction at concentrations up to 30 μM.
3
Constrictor responses induced by all agonists tested were reduced or abolished by the TP‐receptor blocking drugs, GR 32191 and EP 092. pA2 estimates for both antagonists versus U‐46619 were 8.50, values which are consistent with their affinities at TP‐receptors.
4
In preparations pre‐constricted with phenylephrine (1 μM) both PGI2 and PGE2 were potent relaxant agonists. The selective IP‐receptor agonists, cicaprost and iloprost, also dilated human uterine artery and were approximately 10 fold more potent than PGI2. The EP2‐receptor agonists, butaprost and rioprostil and the selective DP‐agonist, BW 245C, were at least 100 fold weaker than PGI2 and PGE2 suggesting that neither DP‐ nor EP2 receptors were involved.
5
We conclude that TP‐receptors mediate constriction, whereas IP‐ and possibly EP4‐receptors mediate relaxation of human uterine artery.</description><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid</subject><subject>Arteries - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Biphenyl Compounds - pharmacology</subject><subject>Blood vessels and receptors</subject><subject>Epoprostenol - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heptanoic Acids - pharmacology</subject><subject>human uterine artery</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>IP‐receptors and relaxation</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle Relaxation - physiology</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>Muscle, Smooth, Vascular - ultrastructure</subject><subject>Prostaglandin Antagonists - pharmacology</subject><subject>Prostaglandin Endoperoxides, Synthetic - pharmacology</subject><subject>Prostanoid receptors</subject><subject>Receptors, Prostaglandin - agonists</subject><subject>Receptors, Prostaglandin - classification</subject><subject>Receptors, Prostaglandin - physiology</subject><subject>Thromboxane A2 - analogs & derivatives</subject><subject>Thromboxane A2 - pharmacology</subject><subject>TP‐receptors and constriction</subject><subject>Uterus - blood supply</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqVkV-L1DAUxYMo67j6EYQi4ltr0jR_6oOsO6grLOiDPofbTLKToZOMSaoz--ltd0rRR_OSC-d3Tw45CL0iuCLjeburSCN4yagkFWlbVuWOcNrS6vgIrRbpMVphjEVJiJRP0bOUdhiPomAX6EIy3tS0XaG03kIEnU1095Bd8EWwRd6a4hBDyuCD2xTRaHPIIaZibzZupPxdoYNPOTr9sAJ-gno4Lg7bYQ--cCn0kM2mGCZ_bwqI43B6jp5Y6JN5Md-X6Menj9_XN-Xt189f1h9uS80EpSUTuMONNLQxgoFuassb2VoBWBoJtmOUbWzd2k6SDnNoONGE0Bo61jW26TC9RO_PvoehG5Nr43OEXh2i20M8qQBO_at4t1V34ZciLZYt5qPBm9kghp-DSVntXdKm78GbMCQlBK9bWU_guzOox19L0djlEYLVVJnaqakXNfWipsrUXJk6jssv_465rM4djfrrWYekobcRvHZpwSjnGFMxYldn7Lfrzek_AqjrbzcPI_0DHma4Rw</recordid><startdate>199509</startdate><enddate>199509</enddate><creator>Baxter, G.S.</creator><creator>Clayton, J.K.</creator><creator>Coleman, R.A.</creator><creator>Marshall, K.</creator><creator>Sangha, R.</creator><creator>Senior, J.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199509</creationdate><title>Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery</title><author>Baxter, G.S. ; Clayton, J.K. ; Coleman, R.A. ; Marshall, K. ; Sangha, R. ; Senior, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5733-570b048e34e75ac42f6489f7a08e8afb535df29fb81b06a461c1132ab5b4f4b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid</topic><topic>Arteries - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Biphenyl Compounds - pharmacology</topic><topic>Blood vessels and receptors</topic><topic>Epoprostenol - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heptanoic Acids - pharmacology</topic><topic>human uterine artery</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>IP‐receptors and relaxation</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle Relaxation - physiology</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>Muscle, Smooth, Vascular - ultrastructure</topic><topic>Prostaglandin Antagonists - pharmacology</topic><topic>Prostaglandin Endoperoxides, Synthetic - pharmacology</topic><topic>Prostanoid receptors</topic><topic>Receptors, Prostaglandin - agonists</topic><topic>Receptors, Prostaglandin - classification</topic><topic>Receptors, Prostaglandin - physiology</topic><topic>Thromboxane A2 - analogs & derivatives</topic><topic>Thromboxane A2 - pharmacology</topic><topic>TP‐receptors and constriction</topic><topic>Uterus - blood supply</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baxter, G.S.</creatorcontrib><creatorcontrib>Clayton, J.K.</creatorcontrib><creatorcontrib>Coleman, R.A.</creatorcontrib><creatorcontrib>Marshall, K.</creatorcontrib><creatorcontrib>Sangha, R.</creatorcontrib><creatorcontrib>Senior, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baxter, G.S.</au><au>Clayton, J.K.</au><au>Coleman, R.A.</au><au>Marshall, K.</au><au>Sangha, R.</au><au>Senior, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1995-09</date><risdate>1995</risdate><volume>116</volume><issue>1</issue><spage>1692</spage><epage>1696</epage><pages>1692-1696</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>1
This study was undertaken to characterize pharmacologically the prostanoid receptor subtypes mediating constriction and relaxation of human isolated uterine artery.
2
U‐46619 was a potent constrictor agonist on human uterine artery (EC50 [95% CL] = 3.5 [1.8‐6.7] μM). Prostaglandin E2 (PGE2α), PGF2, PGD2 and PGI2 only weakly constricted the uterine artery, being at least 100 times less potent than U‐46619. The PGE2 and PGI2 constrictor effects may be modified by the potent dilator effects of these compounds. A number of agonists which show selectivity for FP‐, DP‐ and EP‐receptors including ICI 81008, BW 245C, sulprostone, rioprostil and butaprost, failed to cause any constriction at concentrations up to 30 μM.
3
Constrictor responses induced by all agonists tested were reduced or abolished by the TP‐receptor blocking drugs, GR 32191 and EP 092. pA2 estimates for both antagonists versus U‐46619 were 8.50, values which are consistent with their affinities at TP‐receptors.
4
In preparations pre‐constricted with phenylephrine (1 μM) both PGI2 and PGE2 were potent relaxant agonists. The selective IP‐receptor agonists, cicaprost and iloprost, also dilated human uterine artery and were approximately 10 fold more potent than PGI2. The EP2‐receptor agonists, butaprost and rioprostil and the selective DP‐agonist, BW 245C, were at least 100 fold weaker than PGI2 and PGE2 suggesting that neither DP‐ nor EP2 receptors were involved.
5
We conclude that TP‐receptors mediate constriction, whereas IP‐ and possibly EP4‐receptors mediate relaxation of human uterine artery.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8564239</pmid><doi>10.1111/j.1476-5381.1995.tb16393.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 1995-09, Vol.116 (1), p.1692-1696 |
| issn | 0007-1188 1476-5381 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1908906 |
| source | PubMed (Medline); Wiley Journals |
| subjects | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Arteries - ultrastructure Biological and medical sciences Biphenyl Compounds - pharmacology Blood vessels and receptors Epoprostenol - pharmacology Female Fundamental and applied biological sciences. Psychology Heptanoic Acids - pharmacology human uterine artery Humans In Vitro Techniques IP‐receptors and relaxation Muscle Contraction - physiology Muscle Relaxation - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Muscle, Smooth, Vascular - ultrastructure Prostaglandin Antagonists - pharmacology Prostaglandin Endoperoxides, Synthetic - pharmacology Prostanoid receptors Receptors, Prostaglandin - agonists Receptors, Prostaglandin - classification Receptors, Prostaglandin - physiology Thromboxane A2 - analogs & derivatives Thromboxane A2 - pharmacology TP‐receptors and constriction Uterus - blood supply Vasoconstrictor Agents - pharmacology Vertebrates: cardiovascular system |
| title | Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery |
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