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The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy
The vasopressin 1b receptor (Avpr1b) is one of two principal receptors mediating the behavioral effects of vasopressin (Avp) in the brain. Avpr1b has recently been shown to strongly influence social forms of aggression in mice and hamsters. This receptor appears to play a role in social recognition...
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| Published in: | Neuroscience 2006-12, Vol.143 (4), p.1031-1039 |
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| creator | Young, W.S. Li, J. Wersinger, S.R. Palkovits, M. |
| description | The vasopressin 1b receptor (Avpr1b) is one of two principal receptors mediating the behavioral effects of vasopressin (Avp) in the brain. Avpr1b has recently been shown to strongly influence social forms of aggression in mice and hamsters. This receptor appears to play a role in social recognition and motivation as well as in regulating the hypothalamic–pituitary–adrenal axis. Most of these studies have been performed in knockout mice, a species in which the localization of the Avpr1b has not been described, thus precluding correlations with the behaviors. We performed
in situ hybridization histochemistry (ISHH) with specific probes and found especially prominent expression within the CA2 pyramidal neurons of the hippocampus, with much lower expression in the hypothalamic paraventricular nucleus and amygdala. Reverse transcriptase–polymerase chain reaction (RT-PCR) confirmed expression in those as well other areas in which the ISHH was not sensitive enough to detect labeled cells (e.g. piriform cortex, septum, caudate-putamen and lower brainstem areas). Mouse Avpr1b transcript levels were not altered in the CA2 field by restraint stress or adrenalectomy. Finally, ISHH and RT-PCR showed expression of the
Avpr1b gene in the rat and human hippocampi as well. We suggest that the CA2 field may form or retrieve associations (memories) between olfactory cues and social encounters. |
| doi_str_mv | 10.1016/j.neuroscience.2006.08.040 |
| format | article |
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in situ hybridization histochemistry (ISHH) with specific probes and found especially prominent expression within the CA2 pyramidal neurons of the hippocampus, with much lower expression in the hypothalamic paraventricular nucleus and amygdala. Reverse transcriptase–polymerase chain reaction (RT-PCR) confirmed expression in those as well other areas in which the ISHH was not sensitive enough to detect labeled cells (e.g. piriform cortex, septum, caudate-putamen and lower brainstem areas). Mouse Avpr1b transcript levels were not altered in the CA2 field by restraint stress or adrenalectomy. Finally, ISHH and RT-PCR showed expression of the
Avpr1b gene in the rat and human hippocampi as well. We suggest that the CA2 field may form or retrieve associations (memories) between olfactory cues and social encounters.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2006.08.040</identifier><identifier>PMID: 17027167</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adrenal Cortex - metabolism ; Adrenal Cortex Hormones - metabolism ; Adrenalectomy ; Adult ; aggression ; Animals ; Biological and medical sciences ; Brain - metabolism ; Brain - physiopathology ; corpora amylacea ; Disease Models, Animal ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - genetics ; Hippocampus - anatomy & histology ; Hippocampus - metabolism ; Hippocampus - physiopathology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Middle Aged ; paraventricular nucleus ; Pituitary Gland - metabolism ; Pituitary Gland - physiopathology ; Rats ; Receptors, Vasopressin - genetics ; Restraint, Physical ; RNA, Messenger - metabolism ; social memory ; Species Specificity ; Stress, Psychological - genetics ; Stress, Psychological - metabolism ; Stress, Psychological - physiopathology ; Vasopressins - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2006-12, Vol.143 (4), p.1031-1039</ispartof><rights>2006 IBRO</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-e12e694c65cd7b8232dbdad2cbdc0dc2d7af19dae8cbcfc6bc4a580970cb652c3</citedby><cites>FETCH-LOGICAL-c546t-e12e694c65cd7b8232dbdad2cbdc0dc2d7af19dae8cbcfc6bc4a580970cb652c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18346112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17027167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Young, W.S.</creatorcontrib><creatorcontrib>Li, J.</creatorcontrib><creatorcontrib>Wersinger, S.R.</creatorcontrib><creatorcontrib>Palkovits, M.</creatorcontrib><title>The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>The vasopressin 1b receptor (Avpr1b) is one of two principal receptors mediating the behavioral effects of vasopressin (Avp) in the brain. Avpr1b has recently been shown to strongly influence social forms of aggression in mice and hamsters. This receptor appears to play a role in social recognition and motivation as well as in regulating the hypothalamic–pituitary–adrenal axis. Most of these studies have been performed in knockout mice, a species in which the localization of the Avpr1b has not been described, thus precluding correlations with the behaviors. We performed
in situ hybridization histochemistry (ISHH) with specific probes and found especially prominent expression within the CA2 pyramidal neurons of the hippocampus, with much lower expression in the hypothalamic paraventricular nucleus and amygdala. Reverse transcriptase–polymerase chain reaction (RT-PCR) confirmed expression in those as well other areas in which the ISHH was not sensitive enough to detect labeled cells (e.g. piriform cortex, septum, caudate-putamen and lower brainstem areas). Mouse Avpr1b transcript levels were not altered in the CA2 field by restraint stress or adrenalectomy. Finally, ISHH and RT-PCR showed expression of the
Avpr1b gene in the rat and human hippocampi as well. We suggest that the CA2 field may form or retrieve associations (memories) between olfactory cues and social encounters.</description><subject>Adrenal Cortex - metabolism</subject><subject>Adrenal Cortex Hormones - metabolism</subject><subject>Adrenalectomy</subject><subject>Adult</subject><subject>aggression</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>corpora amylacea</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - genetics</subject><subject>Hippocampus - anatomy & histology</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Middle Aged</subject><subject>paraventricular nucleus</subject><subject>Pituitary Gland - metabolism</subject><subject>Pituitary Gland - physiopathology</subject><subject>Rats</subject><subject>Receptors, Vasopressin - genetics</subject><subject>Restraint, Physical</subject><subject>RNA, Messenger - metabolism</subject><subject>social memory</subject><subject>Species Specificity</subject><subject>Stress, Psychological - genetics</subject><subject>Stress, Psychological - metabolism</subject><subject>Stress, Psychological - physiopathology</subject><subject>Vasopressins - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqNkk2P0zAQhi0EYkvhLyALCW4ttuPYCQekVfmUVuKynC1nPKGukjjYSVe98dNx1YhdTuDLHOZ55-s1Ia8423LG1dvDdsA5hgQeB8CtYExtWbVlkj0iK17pYqNLKR-TFSuY2shSiCvyLKUDy6-UxVNyxTUTmiu9Ir9u90iPNoUxYkp-oLyhEQHHKUTqEx1j6P2Aw0Rzbsrs3o9jANuPtqM2oqW7a0Hv9hiR-umsmAfbtggTOtqccq00ReuzPsfcgeay1kUcbJeZ0J-ekyet7RK-WOKafP_08Xb3ZXPz7fPX3fXNBkqppg1ygaqWoEpwuqlEIVzjrBPQOGAOhNO25bWzWEEDLagGpC0rVmsGjSoFFGvy_lJ3nJseHeSVou3MGH1v48kE683fmcHvzY9wNFzLqs5nW5M3S4EYfs55LdP7BNh1dsAwJ6MqwRmT5T9BXmteK64z-O4CQjYzRWz_TMOZOTttDuah0-bstGGVyU5n8cuH-9xLF2sz8HoBbALbtdEO4NM9VxVScS4y9-HCYb7-0WM0Szvn80eYjAv-f-b5Ded70yg</recordid><startdate>20061228</startdate><enddate>20061228</enddate><creator>Young, W.S.</creator><creator>Li, J.</creator><creator>Wersinger, S.R.</creator><creator>Palkovits, M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20061228</creationdate><title>The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy</title><author>Young, W.S. ; Li, J. ; Wersinger, S.R. ; Palkovits, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-e12e694c65cd7b8232dbdad2cbdc0dc2d7af19dae8cbcfc6bc4a580970cb652c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adrenal Cortex - metabolism</topic><topic>Adrenal Cortex Hormones - metabolism</topic><topic>Adrenalectomy</topic><topic>Adult</topic><topic>aggression</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>corpora amylacea</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation - genetics</topic><topic>Hippocampus - anatomy & histology</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Middle Aged</topic><topic>paraventricular nucleus</topic><topic>Pituitary Gland - metabolism</topic><topic>Pituitary Gland - physiopathology</topic><topic>Rats</topic><topic>Receptors, Vasopressin - genetics</topic><topic>Restraint, Physical</topic><topic>RNA, Messenger - metabolism</topic><topic>social memory</topic><topic>Species Specificity</topic><topic>Stress, Psychological - genetics</topic><topic>Stress, Psychological - metabolism</topic><topic>Stress, Psychological - physiopathology</topic><topic>Vasopressins - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Young, W.S.</creatorcontrib><creatorcontrib>Li, J.</creatorcontrib><creatorcontrib>Wersinger, S.R.</creatorcontrib><creatorcontrib>Palkovits, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Young, W.S.</au><au>Li, J.</au><au>Wersinger, S.R.</au><au>Palkovits, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2006-12-28</date><risdate>2006</risdate><volume>143</volume><issue>4</issue><spage>1031</spage><epage>1039</epage><pages>1031-1039</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Current address: Department of Psychology, The University at Buffalo, SUNY, Buffalo, NY 14260</notes><notes>Current address: Graduate program in Molecular, Cell, Genetics and Development, Yale University, New Haven, CT, 06511</notes><notes>Laboratory of Neuromorphology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary, 1094</notes><abstract>The vasopressin 1b receptor (Avpr1b) is one of two principal receptors mediating the behavioral effects of vasopressin (Avp) in the brain. Avpr1b has recently been shown to strongly influence social forms of aggression in mice and hamsters. This receptor appears to play a role in social recognition and motivation as well as in regulating the hypothalamic–pituitary–adrenal axis. Most of these studies have been performed in knockout mice, a species in which the localization of the Avpr1b has not been described, thus precluding correlations with the behaviors. We performed
in situ hybridization histochemistry (ISHH) with specific probes and found especially prominent expression within the CA2 pyramidal neurons of the hippocampus, with much lower expression in the hypothalamic paraventricular nucleus and amygdala. Reverse transcriptase–polymerase chain reaction (RT-PCR) confirmed expression in those as well other areas in which the ISHH was not sensitive enough to detect labeled cells (e.g. piriform cortex, septum, caudate-putamen and lower brainstem areas). Mouse Avpr1b transcript levels were not altered in the CA2 field by restraint stress or adrenalectomy. Finally, ISHH and RT-PCR showed expression of the
Avpr1b gene in the rat and human hippocampi as well. We suggest that the CA2 field may form or retrieve associations (memories) between olfactory cues and social encounters.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17027167</pmid><doi>10.1016/j.neuroscience.2006.08.040</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuroscience, 2006-12, Vol.143 (4), p.1031-1039 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Adrenal Cortex - metabolism Adrenal Cortex Hormones - metabolism Adrenalectomy Adult aggression Animals Biological and medical sciences Brain - metabolism Brain - physiopathology corpora amylacea Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics Hippocampus - anatomy & histology Hippocampus - metabolism Hippocampus - physiopathology Humans Male Mice Mice, Inbred C57BL Mice, Knockout Middle Aged paraventricular nucleus Pituitary Gland - metabolism Pituitary Gland - physiopathology Rats Receptors, Vasopressin - genetics Restraint, Physical RNA, Messenger - metabolism social memory Species Specificity Stress, Psychological - genetics Stress, Psychological - metabolism Stress, Psychological - physiopathology Vasopressins - metabolism Vertebrates: nervous system and sense organs |
| title | The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy |
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