EEG findings in dementia with Lewy bodies and Alzheimer’s disease

OBJECTIVES To evaluate the role of the EEG in the diagnosis of dementia with Lewy bodies (DLB). METHODS Standard EEG recordings from 14 patients with DLB confirmed at postmortem were examined and were compared with the records from 11 patients with Alzheimer’s disease confirmed at postmortem RESULTS...

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Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1999-03, Vol.66 (3), p.401-403
Main Authors: Briel, R C G, McKeith, I G, Barker, W A, Hewitt, Y, Perry, R H, Ince, P G, Fairbairn, A F
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - physiopathology
Alzheimer's disease
Asymmetry
Biological and medical sciences
Consciousness
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dementia - pathology
Dementia - physiopathology
Electroencephalography
Female
Hallucinations
Humans
Lewy Bodies - pathology
Lewy body
Male
Medical sciences
Middle Aged
Neurology
Neuropathology
Short Report
Temporal Lobe - pathology
Temporal Lobe - physiopathology
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container_issue 3
container_start_page 401
container_title Journal of neurology, neurosurgery and psychiatry
container_volume 66
creator Briel, R C G
McKeith, I G
Barker, W A
Hewitt, Y
Perry, R H
Ince, P G
Fairbairn, A F
description OBJECTIVES To evaluate the role of the EEG in the diagnosis of dementia with Lewy bodies (DLB). METHODS Standard EEG recordings from 14 patients with DLB confirmed at postmortem were examined and were compared with the records from 11 patients with Alzheimer’s disease confirmed at postmortem RESULTS Seventeen of the total of 19 records from the patients with DLB were abnormal. Thirteen showed loss of alpha activity as the dominant rhythm and half had slow wave transient activity in the temporal lobe areas. This slow wave transient activity correlated with a clinical history of loss of consciousness. The patients with Alzheimer’s disease were less likely to show transient slow waves and tended to have less marked slowing of dominant rhythm. CONCLUSIONS The greater slowing of the EEG in DLB than in Alzheimer’s disease may be related to a greater loss of choline acetyltransferase found in DLB. Temporal slow wave transients may be a useful diagnostic feature in DLB and may help to explain the transient disturbance of consciousness which is characteristic of the disorder.
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METHODS Standard EEG recordings from 14 patients with DLB confirmed at postmortem were examined and were compared with the records from 11 patients with Alzheimer’s disease confirmed at postmortem RESULTS Seventeen of the total of 19 records from the patients with DLB were abnormal. Thirteen showed loss of alpha activity as the dominant rhythm and half had slow wave transient activity in the temporal lobe areas. This slow wave transient activity correlated with a clinical history of loss of consciousness. The patients with Alzheimer’s disease were less likely to show transient slow waves and tended to have less marked slowing of dominant rhythm. CONCLUSIONS The greater slowing of the EEG in DLB than in Alzheimer’s disease may be related to a greater loss of choline acetyltransferase found in DLB. Temporal slow wave transients may be a useful diagnostic feature in DLB and may help to explain the transient disturbance of consciousness which is characteristic of the disorder.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.66.3.401</identifier><identifier>PMID: 10084544</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Asymmetry ; Biological and medical sciences ; Consciousness ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; Dementia - pathology ; Dementia - physiopathology ; Electroencephalography ; Female ; Hallucinations ; Humans ; Lewy Bodies - pathology ; Lewy body ; Male ; Medical sciences ; Middle Aged ; Neurology ; Neuropathology ; Short Report ; Temporal Lobe - pathology ; Temporal Lobe - physiopathology</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1999-03, Vol.66 (3), p.401-403</ispartof><rights>Journal of Neurology, Neurosurgery, and Psychiatry</rights><rights>1999 INIST-CNRS</rights><rights>Copyright: 1999 Journal of Neurology, Neurosurgery, and Psychiatry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b511t-8a96abc46663424e4b55a9d25f6955935e25073345d0bd1f4b56a4e810c691fb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736269/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1736269/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1685996$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10084544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Briel, R C G</creatorcontrib><creatorcontrib>McKeith, I G</creatorcontrib><creatorcontrib>Barker, W A</creatorcontrib><creatorcontrib>Hewitt, Y</creatorcontrib><creatorcontrib>Perry, R H</creatorcontrib><creatorcontrib>Ince, P G</creatorcontrib><creatorcontrib>Fairbairn, A F</creatorcontrib><title>EEG findings in dementia with Lewy bodies and Alzheimer’s disease</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>OBJECTIVES To evaluate the role of the EEG in the diagnosis of dementia with Lewy bodies (DLB). METHODS Standard EEG recordings from 14 patients with DLB confirmed at postmortem were examined and were compared with the records from 11 patients with Alzheimer’s disease confirmed at postmortem RESULTS Seventeen of the total of 19 records from the patients with DLB were abnormal. Thirteen showed loss of alpha activity as the dominant rhythm and half had slow wave transient activity in the temporal lobe areas. This slow wave transient activity correlated with a clinical history of loss of consciousness. The patients with Alzheimer’s disease were less likely to show transient slow waves and tended to have less marked slowing of dominant rhythm. CONCLUSIONS The greater slowing of the EEG in DLB than in Alzheimer’s disease may be related to a greater loss of choline acetyltransferase found in DLB. 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Telephone 0044 191 256 3018; fax 0044 191 273 1156.</notes><notes>PMID:10084544</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>OBJECTIVES To evaluate the role of the EEG in the diagnosis of dementia with Lewy bodies (DLB). METHODS Standard EEG recordings from 14 patients with DLB confirmed at postmortem were examined and were compared with the records from 11 patients with Alzheimer’s disease confirmed at postmortem RESULTS Seventeen of the total of 19 records from the patients with DLB were abnormal. Thirteen showed loss of alpha activity as the dominant rhythm and half had slow wave transient activity in the temporal lobe areas. This slow wave transient activity correlated with a clinical history of loss of consciousness. The patients with Alzheimer’s disease were less likely to show transient slow waves and tended to have less marked slowing of dominant rhythm. CONCLUSIONS The greater slowing of the EEG in DLB than in Alzheimer’s disease may be related to a greater loss of choline acetyltransferase found in DLB. Temporal slow wave transients may be a useful diagnostic feature in DLB and may help to explain the transient disturbance of consciousness which is characteristic of the disorder.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>10084544</pmid><doi>10.1136/jnnp.66.3.401</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
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ispartof Journal of neurology, neurosurgery and psychiatry, 1999-03, Vol.66 (3), p.401-403
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subjects Aged
Aged, 80 and over
Alzheimer Disease - physiopathology
Alzheimer's disease
Asymmetry
Biological and medical sciences
Consciousness
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dementia - pathology
Dementia - physiopathology
Electroencephalography
Female
Hallucinations
Humans
Lewy Bodies - pathology
Lewy body
Male
Medical sciences
Middle Aged
Neurology
Neuropathology
Short Report
Temporal Lobe - pathology
Temporal Lobe - physiopathology
title EEG findings in dementia with Lewy bodies and Alzheimer’s disease
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