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Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms
Phenol-saline tumour extracts, active in the immunotherapy of bovine ocular squamous cell carcinoma (BOSCC), were used to immunize mice. The immunized mice became resistant to the depression of delayed type hypersensitivity (DTH) reactions by products of BOSCC cells or cultured mouse or rat tumour c...
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| Published in: | Clinical and experimental immunology 1985-07, Vol.61 (1), p.109-117 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 117 |
| container_issue | 1 |
| container_start_page | 109 |
| container_title | Clinical and experimental immunology |
| container_volume | 61 |
| creator | NELSON, M NELSON, D. S SPRADBROW, P. B KUCHROO, V. K JENNINGS, P. A CIANCIOLO, G. J SNYDERMAN, R |
| description | Phenol-saline tumour extracts, active in the immunotherapy of bovine ocular squamous cell carcinoma (BOSCC), were used to immunize mice. The immunized mice became resistant to the depression of delayed type hypersensitivity (DTH) reactions by products of BOSCC cells or cultured mouse or rat tumour cells. They also showed partial resistance to the growth of an unrelated tumour. Monoclonal antibodies to a type C retrovirus protein, p15E, also induced resistance to the depression of DTH by products of BOSCC and mouse tumours. It is suggested that successful immunotherapy of BOSCC is associated with the induction of resistance to anti-inflammatory or immunosuppressive tumour cell products, allowing the operation of host defences, and that these products share antigenic determinants with a retrovirus protein. |
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It is suggested that successful immunotherapy of BOSCC is associated with the induction of resistance to anti-inflammatory or immunosuppressive tumour cell products, allowing the operation of host defences, and that these products share antigenic determinants with a retrovirus protein.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 4042416</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Antibodies, Neoplasm - immunology ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - therapy ; Cattle ; Eye Neoplasms - therapy ; Hypersensitivity, Delayed - immunology ; Immunization ; Immunotherapy ; Mice ; Mice, Inbred Strains ; Rats ; Retroviridae - immunology ; Sarcoma, Experimental - immunology ; Sarcoma, Experimental - therapy ; Tissue Extracts - immunology ; Viral Proteins - immunology</subject><ispartof>Clinical and experimental immunology, 1985-07, Vol.61 (1), p.109-117</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577247/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577247/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,53827,53829</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8413648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4042416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NELSON, M</creatorcontrib><creatorcontrib>NELSON, D. S</creatorcontrib><creatorcontrib>SPRADBROW, P. B</creatorcontrib><creatorcontrib>KUCHROO, V. K</creatorcontrib><creatorcontrib>JENNINGS, P. A</creatorcontrib><creatorcontrib>CIANCIOLO, G. J</creatorcontrib><creatorcontrib>SNYDERMAN, R</creatorcontrib><title>Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>Phenol-saline tumour extracts, active in the immunotherapy of bovine ocular squamous cell carcinoma (BOSCC), were used to immunize mice. The immunized mice became resistant to the depression of delayed type hypersensitivity (DTH) reactions by products of BOSCC cells or cultured mouse or rat tumour cells. They also showed partial resistance to the growth of an unrelated tumour. Monoclonal antibodies to a type C retrovirus protein, p15E, also induced resistance to the depression of DTH by products of BOSCC and mouse tumours. It is suggested that successful immunotherapy of BOSCC is associated with the induction of resistance to anti-inflammatory or immunosuppressive tumour cell products, allowing the operation of host defences, and that these products share antigenic determinants with a retrovirus protein.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Neoplasm - immunology</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Cattle</subject><subject>Eye Neoplasms - therapy</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immunization</subject><subject>Immunotherapy</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Rats</subject><subject>Retroviridae - immunology</subject><subject>Sarcoma, Experimental - immunology</subject><subject>Sarcoma, Experimental - therapy</subject><subject>Tissue Extracts - immunology</subject><subject>Viral Proteins - immunology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNqFUU1LxDAULKKs6-pPEHIQb4UkTdPGgyDiFwge1HN5zYcbSZqaNML-e6suoicvbxhmmDePt1MsScXrklImdoslxliUgmC2Xxyk9DpTzjldFAuGGWWEL4vwmKXUKZns0JR9yBFZ7_MQprWOMG7O0BhSsr3TKIZ5BINgmGwflNUJTeGLlXYwDryHKcQNMiBnTGiMQWWpFeo3aNBhdJB8Oiz2DLikj7a4Kp6vr54ub8v7h5u7y4v7cqwomcqKCqygUsCIajTlxPC-6gWnhNGWQ9sSVhNRK2akbgDjtlY9boygrWgZF7RaFeffuWPuvVZSD1ME143ReoibLoDt_iqDXXcv4b0jddNQ1swBp9uAGN6yTlPnbZLaOZhvyalreNXUNSP_Gj8bM4rr2Xj8u9JPl-0vZv1kq0OS4EyEQdr0Y2vnXZy11QcjypX1</recordid><startdate>19850701</startdate><enddate>19850701</enddate><creator>NELSON, M</creator><creator>NELSON, D. 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J ; SNYDERMAN, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p321t-3290da3da41d7e261f6b3b96214286a88145195d4fce7a0085db07f9289846923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibodies, Neoplasm - immunology</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Cattle</topic><topic>Eye Neoplasms - therapy</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immunization</topic><topic>Immunotherapy</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Rats</topic><topic>Retroviridae - immunology</topic><topic>Sarcoma, Experimental - immunology</topic><topic>Sarcoma, Experimental - therapy</topic><topic>Tissue Extracts - immunology</topic><topic>Viral Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NELSON, M</creatorcontrib><creatorcontrib>NELSON, D. S</creatorcontrib><creatorcontrib>SPRADBROW, P. B</creatorcontrib><creatorcontrib>KUCHROO, V. K</creatorcontrib><creatorcontrib>JENNINGS, P. A</creatorcontrib><creatorcontrib>CIANCIOLO, G. J</creatorcontrib><creatorcontrib>SNYDERMAN, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NELSON, M</au><au>NELSON, D. S</au><au>SPRADBROW, P. B</au><au>KUCHROO, V. K</au><au>JENNINGS, P. A</au><au>CIANCIOLO, G. J</au><au>SNYDERMAN, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1985-07-01</date><risdate>1985</risdate><volume>61</volume><issue>1</issue><spage>109</spage><epage>117</epage><pages>109-117</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Phenol-saline tumour extracts, active in the immunotherapy of bovine ocular squamous cell carcinoma (BOSCC), were used to immunize mice. The immunized mice became resistant to the depression of delayed type hypersensitivity (DTH) reactions by products of BOSCC cells or cultured mouse or rat tumour cells. They also showed partial resistance to the growth of an unrelated tumour. Monoclonal antibodies to a type C retrovirus protein, p15E, also induced resistance to the depression of DTH by products of BOSCC and mouse tumours. It is suggested that successful immunotherapy of BOSCC is associated with the induction of resistance to anti-inflammatory or immunosuppressive tumour cell products, allowing the operation of host defences, and that these products share antigenic determinants with a retrovirus protein.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>4042416</pmid><tpages>9</tpages></addata></record> |
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| ispartof | Clinical and experimental immunology, 1985-07, Vol.61 (1), p.109-117 |
| issn | 0009-9104 1365-2249 |
| language | eng |
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| source | PubMed Central |
| subjects | Animals Antibodies, Monoclonal - immunology Antibodies, Neoplasm - immunology Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - therapy Cattle Eye Neoplasms - therapy Hypersensitivity, Delayed - immunology Immunization Immunotherapy Mice Mice, Inbred Strains Rats Retroviridae - immunology Sarcoma, Experimental - immunology Sarcoma, Experimental - therapy Tissue Extracts - immunology Viral Proteins - immunology |
| title | Successful tumour immunotherapy: possible role of antibodies to anti-inflammatory factors produced by neoplasms |
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