Clusters of resilience and vulnerability: executive functioning, coping and mental distress in patients with diffuse low-grade glioma

Purpose Diffuse low-grade gliomas (dLGG) often have a frontal location, which may negatively affect patients’ executive functions (EF). Being diagnosed with dLGG and having to undergo intensive treatment can be emotionally stressful. The ability to cope with this stress in an adaptive, active and fl...

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Bibliographic Details
Published in:Journal of neuro-oncology 2024-08, Vol.169 (1), p.95-104
Main Authors: Gelmers, Floor, Timmerman, Marieke E., Siebenga, Femke F., van der Weide, Hiska L., Rakers, Sandra E., Kramer, Miranda C. A., van der Hoorn, Anouk, Enting, Roelien H., Bosma, Ingeborg, Groen, Rob J. M., Jeltema, Hanne-Rinck, Wagemakers, Michiel, Spikman, Jacoba M., Buunk, Anne M.
Format: Article
Language:English
Subjects:
Brain injury
Coping
Executive function
Glioma
Medicine
Medicine & Public Health
Neurology
Oncology
Social interactions
Tumors
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Summary:Purpose Diffuse low-grade gliomas (dLGG) often have a frontal location, which may negatively affect patients’ executive functions (EF). Being diagnosed with dLGG and having to undergo intensive treatment can be emotionally stressful. The ability to cope with this stress in an adaptive, active and flexible way may be hampered by impaired EF. Consequently, patients may suffer from increased mental distress. The aim of the present study was to explore profiles of EF, coping and mental distress and identify characteristics of each profile. Methods 151 patients with dLGG were included. Latent profile analysis (LPA) was used to explore profiles. Additional demographical, tumor and radiological characteristics were included. Results Four clusters were found: 1) overall good functioning (25% of patients); 2) poor executive functioning, good psychosocial functioning (32%); 3) good executive functioning, poor psychosocial functioning (18%) and; 4) overall poor functioning (25%). Characteristics of the different clusters were lower educational level and more (micro)vascular brain damage (cluster 2), a younger age (cluster 3), and a larger tumor volume (cluster 4). EF was not a distinctive factor for coping, nor was it for mental distress. Maladaptive coping, however, did distinguish clusters with higher mental distress (cluster 3 and 4) from clusters with lower levels of mental distress (cluster 1 and 2). Conclusion Four distinctive clusters with different levels of functioning and characteristics were identified. EF impairments did not hinder the use of active coping strategies. Moreover, maladaptive coping, but not EF impairment, was related to increased mental distress in patients with dLGG.
ISSN:0167-594X
1573-7373
1573-7373
DOI:10.1007/s11060-024-04704-4