Quantitative CT lung volumetry and densitometry in pediatric pectus excavatum

The purpose of this study was to evaluate the quantitative computed tomography (CT) volumetry and densitometry and in pediatric patients with pectus excavatum (PE). We measured pectus index (PI) and separated inspiratory and expiratory lung volumes and densities. We obtained the total lung volume (T...

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Bibliographic Details
Published in:PloS one 2024-07, Vol.19 (7), p.e0299589
Main Authors: Song, Yeong Ran, Im, Soo Ah
Format: Article
Language:English
Subjects:
Adolescent
Age
Biology and Life Sciences
Case-Control Studies
Child
Children
Computed tomography
CT imaging
Densitometry
Densitometry - methods
Density
Diagnostic imaging
Disease
Evaluation
Female
Funnel Chest - diagnostic imaging
Funnel Chest - physiopathology
Health aspects
Heart surgery
Humans
Lung - diagnostic imaging
Lung - physiopathology
Lung Volume Measurements - methods
Lungs
Male
Medical imaging
Medical research
Medicine and Health Sciences
Medicine, Experimental
Parenchyma
Patients
Pediatrics
Research and Analysis Methods
Tomography, X-Ray Computed - methods
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Summary:The purpose of this study was to evaluate the quantitative computed tomography (CT) volumetry and densitometry and in pediatric patients with pectus excavatum (PE). We measured pectus index (PI) and separated inspiratory and expiratory lung volumes and densities. We obtained the total lung volume (TLV) and mean lung density (MLD) during inspiration and expiration, and the ratio of end expiratory to inspiratory volume (E/I volume) and MLD (E/I density) were calculated. The difference between inspiratory and end expiratory volume (I-E volume) and MLD (I-E density) were also calculated. A total of 199 patients, including 164 PE patients and 35 controls, were included in this study. The result shows that the PE group had lower inspiratory TLV (mean, 2670.76±1364.22 ml) than the control group (3219.57±1313.87 ml; p = 0.027). In the PE group, the inspiratory (-787.21±52.27 HU vs. -804.94±63.3 HU) and expiratory MLD (-704.51±55.41 HU vs. -675.83±64.62 HU) were significantly lower than the indices obtained from the control group (p = 0.006). In addition, significantly lower values of TLV and MLD difference and higher value of TLV and MLD ratio were found in the PE group (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0299589