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Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer
Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation a...
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| Published in: | Cancer Immunology, Immunotherapy Immunotherapy, 2015-02, Vol.64 (2), p.181-190 |
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| container_title | Cancer Immunology, Immunotherapy |
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| creator | Cui, Guanglin Qi, Haili Gundersen, Mona D. Yang, Hang Christiansen, Ingrid Sørbye, Sveinung W. Goll, Rasmus Florholmen, Jon |
| description | Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation and cancer. The aim of this study was to evaluate the dynamics of the IL-33/ST2 axis during the sequence of progression from normal colorectum to adenoma to carcinoma and to investigate the association of IL-33 and ST2 expression with clinicopathological parameters and prognosis. The results demonstrated that the levels of IL-33 and ST2 in adenomas (
n
= 50), determined by real-time PCR, were significantly higher than those of normal controls (
n
= 30); the levels of both IL-33/ST mRNA in CRCs (
n
= 50) were higher than in normal controls but lower than in adenomas. Further analysis revealed that the expression level of ST2 in CRCs was associated with tumor/node/metastasis (TNM) stage. The log-rank test showed that neither the IL-33 nor the ST2 expression level was correlated with overall survival in patients with CRC. The increased expression of IL-33/ST2 in adenomas and CRC tissues was confirmed by immunohistochemistry and was observed in both the tumor stromal cells and adenomatous/cancerous cells. Notably, increased densities of IL-33-positive and ST2-positive microvessels were found in the stroma of adenomas and CRCs. In conclusion, increased expression of the IL-33/ST2 axis along the colorectal adenoma–carcinoma sequence might be involved in the neoplastic transformation via the participation of this axis in the regulation of angiogenesis. |
| doi_str_mv | 10.1007/s00262-014-1624-x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11028541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1660402717</sourcerecordid><originalsourceid>FETCH-LOGICAL-c593t-9d6b0ab28487d9447f90fe36650ba7e2ffa4799afd50636459ba498d032ccb813</originalsourceid><addsrcrecordid>eNqNkk9v1DAQxS0EokvhA3BBkbhwCZ2xnTg-IVT-VVqJA-VsOY6z65LYi52U9tvjkLYUJCROtvx-npk3eoQ8R3iNAOIkAdCaloC8xJry8uoB2SBn-aWp8CHZAONQCgB-RJ6kdJEvFKR8TI5oxShHKTbEv7v2enQmFaEvpr0tzrYlYydfzmnh7fQjxG-F87-EQwy7aFNywS_sfh61L0wYQrRm0kOhO-vDqIspFOkQou6cuS8b7Y2NT8mjXg_JPrs5j8nXD-_PTz-V288fz07fbktTSTaVsqtb0C1teCM6ybnoJfSW1XUFrRaW9r3mQkrddxXUrOaVbDWXTQeMGtM2yI7Jm7XuYW5H2xnrp6gHdYhu1PFaBe3Un4p3e7ULlwoRaFPxpcKLtYKJLk3OK589qbx2JpSgKDLw6qZFDN9nmyY1umTsMGhvw5wU1jVwoOK_0IpyjgKqjL78C70Ic_R5VwuFDBEbmim8HS6kFG1_5wxhmVGoNRoqR0Mt0VBXvw2txu9-3GYhA3QFUpb8zsZ7rf9Z9SeRjsLM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1651311182</pqid></control><display><type>article</type><title>Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer</title><source>NORA - Norwegian Open Research Archives</source><source>PubMed</source><source>Springer Link</source><creator>Cui, Guanglin ; Qi, Haili ; Gundersen, Mona D. ; Yang, Hang ; Christiansen, Ingrid ; Sørbye, Sveinung W. ; Goll, Rasmus ; Florholmen, Jon</creator><creatorcontrib>Cui, Guanglin ; Qi, Haili ; Gundersen, Mona D. ; Yang, Hang ; Christiansen, Ingrid ; Sørbye, Sveinung W. ; Goll, Rasmus ; Florholmen, Jon</creatorcontrib><description>Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation and cancer. The aim of this study was to evaluate the dynamics of the IL-33/ST2 axis during the sequence of progression from normal colorectum to adenoma to carcinoma and to investigate the association of IL-33 and ST2 expression with clinicopathological parameters and prognosis. The results demonstrated that the levels of IL-33 and ST2 in adenomas (
n
= 50), determined by real-time PCR, were significantly higher than those of normal controls (
n
= 30); the levels of both IL-33/ST mRNA in CRCs (
n
= 50) were higher than in normal controls but lower than in adenomas. Further analysis revealed that the expression level of ST2 in CRCs was associated with tumor/node/metastasis (TNM) stage. The log-rank test showed that neither the IL-33 nor the ST2 expression level was correlated with overall survival in patients with CRC. The increased expression of IL-33/ST2 in adenomas and CRC tissues was confirmed by immunohistochemistry and was observed in both the tumor stromal cells and adenomatous/cancerous cells. Notably, increased densities of IL-33-positive and ST2-positive microvessels were found in the stroma of adenomas and CRCs. In conclusion, increased expression of the IL-33/ST2 axis along the colorectal adenoma–carcinoma sequence might be involved in the neoplastic transformation via the participation of this axis in the regulation of angiogenesis.</description><identifier>ISSN: 0340-7004</identifier><identifier>EISSN: 1432-0851</identifier><identifier>DOI: 10.1007/s00262-014-1624-x</identifier><identifier>PMID: 25324197</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenoma - metabolism ; Adenoma - mortality ; Adenoma - pathology ; Adenoma - surgery ; Adenoma-carcinoma transition ; Adult ; Aged ; Aged, 80 and over ; Basale medisinske, odontologiske og veterinærmedisinske fag: 710 ; Basic medical, dental and veterinary science disciplines: 710 ; Biopsy ; Cancer Research ; Clinical medical disciplines: 750 ; Colorectal cancer ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Cytokines ; Disease Progression ; Gastroenterology ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Immunology ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33 ; Interleukins - genetics ; Interleukins - metabolism ; Investigations ; Klinisk medisinske fag: 750 ; Medical disciplines: 700 ; Medical immunology: 716 ; Medical prognosis ; Medicine ; Medicine & Public Health ; Medisinsk immunologi: 716 ; Medisinske Fag: 700 ; Metastasis ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Neovascularization, Pathologic - genetics ; Neovascularization, Pathologic - metabolism ; Oncology ; Oncology: 762 ; Onkologi: 762 ; Original ; Original Article ; Pathogenesis ; Phenotype ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Signal Transduction ; ST2 ; Stromal Cells - metabolism ; Stromal Cells - pathology ; Transcription, Genetic ; Tumor Microenvironment - genetics ; Tumors ; VDP</subject><ispartof>Cancer Immunology, Immunotherapy, 2015-02, Vol.64 (2), p.181-190</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-9d6b0ab28487d9447f90fe36650ba7e2ffa4799afd50636459ba498d032ccb813</citedby><cites>FETCH-LOGICAL-c593t-9d6b0ab28487d9447f90fe36650ba7e2ffa4799afd50636459ba498d032ccb813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11028541/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11028541/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,26600,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25324197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Guanglin</creatorcontrib><creatorcontrib>Qi, Haili</creatorcontrib><creatorcontrib>Gundersen, Mona D.</creatorcontrib><creatorcontrib>Yang, Hang</creatorcontrib><creatorcontrib>Christiansen, Ingrid</creatorcontrib><creatorcontrib>Sørbye, Sveinung W.</creatorcontrib><creatorcontrib>Goll, Rasmus</creatorcontrib><creatorcontrib>Florholmen, Jon</creatorcontrib><title>Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer</title><title>Cancer Immunology, Immunotherapy</title><addtitle>Cancer Immunol Immunother</addtitle><addtitle>Cancer Immunol Immunother</addtitle><description>Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation and cancer. The aim of this study was to evaluate the dynamics of the IL-33/ST2 axis during the sequence of progression from normal colorectum to adenoma to carcinoma and to investigate the association of IL-33 and ST2 expression with clinicopathological parameters and prognosis. The results demonstrated that the levels of IL-33 and ST2 in adenomas (
n
= 50), determined by real-time PCR, were significantly higher than those of normal controls (
n
= 30); the levels of both IL-33/ST mRNA in CRCs (
n
= 50) were higher than in normal controls but lower than in adenomas. Further analysis revealed that the expression level of ST2 in CRCs was associated with tumor/node/metastasis (TNM) stage. The log-rank test showed that neither the IL-33 nor the ST2 expression level was correlated with overall survival in patients with CRC. The increased expression of IL-33/ST2 in adenomas and CRC tissues was confirmed by immunohistochemistry and was observed in both the tumor stromal cells and adenomatous/cancerous cells. Notably, increased densities of IL-33-positive and ST2-positive microvessels were found in the stroma of adenomas and CRCs. In conclusion, increased expression of the IL-33/ST2 axis along the colorectal adenoma–carcinoma sequence might be involved in the neoplastic transformation via the participation of this axis in the regulation of angiogenesis.</description><subject>Adenoma - metabolism</subject><subject>Adenoma - mortality</subject><subject>Adenoma - pathology</subject><subject>Adenoma - surgery</subject><subject>Adenoma-carcinoma transition</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Basale medisinske, odontologiske og veterinærmedisinske fag: 710</subject><subject>Basic medical, dental and veterinary science disciplines: 710</subject><subject>Biopsy</subject><subject>Cancer Research</subject><subject>Clinical medical disciplines: 750</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Cytokines</subject><subject>Disease Progression</subject><subject>Gastroenterology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunology</subject><subject>Interleukin-1 Receptor-Like 1 Protein</subject><subject>Interleukin-33</subject><subject>Interleukins - genetics</subject><subject>Interleukins - metabolism</subject><subject>Investigations</subject><subject>Klinisk medisinske fag: 750</subject><subject>Medical disciplines: 700</subject><subject>Medical immunology: 716</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medisinsk immunologi: 716</subject><subject>Medisinske Fag: 700</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Oncology</subject><subject>Oncology: 762</subject><subject>Onkologi: 762</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathogenesis</subject><subject>Phenotype</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Signal Transduction</subject><subject>ST2</subject><subject>Stromal Cells - metabolism</subject><subject>Stromal Cells - pathology</subject><subject>Transcription, Genetic</subject><subject>Tumor Microenvironment - genetics</subject><subject>Tumors</subject><subject>VDP</subject><issn>0340-7004</issn><issn>1432-0851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNqNkk9v1DAQxS0EokvhA3BBkbhwCZ2xnTg-IVT-VVqJA-VsOY6z65LYi52U9tvjkLYUJCROtvx-npk3eoQ8R3iNAOIkAdCaloC8xJry8uoB2SBn-aWp8CHZAONQCgB-RJ6kdJEvFKR8TI5oxShHKTbEv7v2enQmFaEvpr0tzrYlYydfzmnh7fQjxG-F87-EQwy7aFNywS_sfh61L0wYQrRm0kOhO-vDqIspFOkQou6cuS8b7Y2NT8mjXg_JPrs5j8nXD-_PTz-V288fz07fbktTSTaVsqtb0C1teCM6ybnoJfSW1XUFrRaW9r3mQkrddxXUrOaVbDWXTQeMGtM2yI7Jm7XuYW5H2xnrp6gHdYhu1PFaBe3Un4p3e7ULlwoRaFPxpcKLtYKJLk3OK589qbx2JpSgKDLw6qZFDN9nmyY1umTsMGhvw5wU1jVwoOK_0IpyjgKqjL78C70Ic_R5VwuFDBEbmim8HS6kFG1_5wxhmVGoNRoqR0Mt0VBXvw2txu9-3GYhA3QFUpb8zsZ7rf9Z9SeRjsLM</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Cui, Guanglin</creator><creator>Qi, Haili</creator><creator>Gundersen, Mona D.</creator><creator>Yang, Hang</creator><creator>Christiansen, Ingrid</creator><creator>Sørbye, Sveinung W.</creator><creator>Goll, Rasmus</creator><creator>Florholmen, Jon</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>3HK</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer</title><author>Cui, Guanglin ; Qi, Haili ; Gundersen, Mona D. ; Yang, Hang ; Christiansen, Ingrid ; Sørbye, Sveinung W. ; Goll, Rasmus ; Florholmen, Jon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-9d6b0ab28487d9447f90fe36650ba7e2ffa4799afd50636459ba498d032ccb813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenoma - metabolism</topic><topic>Adenoma - mortality</topic><topic>Adenoma - pathology</topic><topic>Adenoma - surgery</topic><topic>Adenoma-carcinoma transition</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Basale medisinske, odontologiske og veterinærmedisinske fag: 710</topic><topic>Basic medical, dental and veterinary science disciplines: 710</topic><topic>Biopsy</topic><topic>Cancer Research</topic><topic>Clinical medical disciplines: 750</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Cytokines</topic><topic>Disease Progression</topic><topic>Gastroenterology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunology</topic><topic>Interleukin-1 Receptor-Like 1 Protein</topic><topic>Interleukin-33</topic><topic>Interleukins - genetics</topic><topic>Interleukins - metabolism</topic><topic>Investigations</topic><topic>Klinisk medisinske fag: 750</topic><topic>Medical disciplines: 700</topic><topic>Medical immunology: 716</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medisinsk immunologi: 716</topic><topic>Medisinske Fag: 700</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Oncology</topic><topic>Oncology: 762</topic><topic>Onkologi: 762</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathogenesis</topic><topic>Phenotype</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Signal Transduction</topic><topic>ST2</topic><topic>Stromal Cells - metabolism</topic><topic>Stromal Cells - pathology</topic><topic>Transcription, Genetic</topic><topic>Tumor Microenvironment - genetics</topic><topic>Tumors</topic><topic>VDP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Guanglin</creatorcontrib><creatorcontrib>Qi, Haili</creatorcontrib><creatorcontrib>Gundersen, Mona D.</creatorcontrib><creatorcontrib>Yang, Hang</creatorcontrib><creatorcontrib>Christiansen, Ingrid</creatorcontrib><creatorcontrib>Sørbye, Sveinung W.</creatorcontrib><creatorcontrib>Goll, Rasmus</creatorcontrib><creatorcontrib>Florholmen, Jon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer Immunology, Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Guanglin</au><au>Qi, Haili</au><au>Gundersen, Mona D.</au><au>Yang, Hang</au><au>Christiansen, Ingrid</au><au>Sørbye, Sveinung W.</au><au>Goll, Rasmus</au><au>Florholmen, Jon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer</atitle><jtitle>Cancer Immunology, Immunotherapy</jtitle><stitle>Cancer Immunol Immunother</stitle><addtitle>Cancer Immunol Immunother</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>64</volume><issue>2</issue><spage>181</spage><epage>190</epage><pages>181-190</pages><issn>0340-7004</issn><eissn>1432-0851</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Most sporadic colorectal cancers (CRCs) develop from preformed adenomas. Cytokines are involved in the transition from adenoma to CRC. Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family and involved in the development of chronic inflammation and cancer. The aim of this study was to evaluate the dynamics of the IL-33/ST2 axis during the sequence of progression from normal colorectum to adenoma to carcinoma and to investigate the association of IL-33 and ST2 expression with clinicopathological parameters and prognosis. The results demonstrated that the levels of IL-33 and ST2 in adenomas (
n
= 50), determined by real-time PCR, were significantly higher than those of normal controls (
n
= 30); the levels of both IL-33/ST mRNA in CRCs (
n
= 50) were higher than in normal controls but lower than in adenomas. Further analysis revealed that the expression level of ST2 in CRCs was associated with tumor/node/metastasis (TNM) stage. The log-rank test showed that neither the IL-33 nor the ST2 expression level was correlated with overall survival in patients with CRC. The increased expression of IL-33/ST2 in adenomas and CRC tissues was confirmed by immunohistochemistry and was observed in both the tumor stromal cells and adenomatous/cancerous cells. Notably, increased densities of IL-33-positive and ST2-positive microvessels were found in the stroma of adenomas and CRCs. In conclusion, increased expression of the IL-33/ST2 axis along the colorectal adenoma–carcinoma sequence might be involved in the neoplastic transformation via the participation of this axis in the regulation of angiogenesis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25324197</pmid><doi>10.1007/s00262-014-1624-x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0340-7004 |
| ispartof | Cancer Immunology, Immunotherapy, 2015-02, Vol.64 (2), p.181-190 |
| issn | 0340-7004 1432-0851 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11028541 |
| source | NORA - Norwegian Open Research Archives; PubMed; Springer Link |
| subjects | Adenoma - metabolism Adenoma - mortality Adenoma - pathology Adenoma - surgery Adenoma-carcinoma transition Adult Aged Aged, 80 and over Basale medisinske, odontologiske og veterinærmedisinske fag: 710 Basic medical, dental and veterinary science disciplines: 710 Biopsy Cancer Research Clinical medical disciplines: 750 Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Cytokines Disease Progression Gastroenterology Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Immunology Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Interleukins - genetics Interleukins - metabolism Investigations Klinisk medisinske fag: 750 Medical disciplines: 700 Medical immunology: 716 Medical prognosis Medicine Medicine & Public Health Medisinsk immunologi: 716 Medisinske Fag: 700 Metastasis Middle Aged Neoplasm Grading Neoplasm Staging Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Oncology Oncology: 762 Onkologi: 762 Original Original Article Pathogenesis Phenotype Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction ST2 Stromal Cells - metabolism Stromal Cells - pathology Transcription, Genetic Tumor Microenvironment - genetics Tumors VDP |
| title | Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T23%3A17%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dynamics%20of%20the%20IL-33/ST2%20network%20in%20the%20progression%20of%20human%20colorectal%20adenoma%20to%20sporadic%20colorectal%20cancer&rft.jtitle=Cancer%20Immunology,%20Immunotherapy&rft.au=Cui,%20Guanglin&rft.date=2015-02-01&rft.volume=64&rft.issue=2&rft.spage=181&rft.epage=190&rft.pages=181-190&rft.issn=0340-7004&rft.eissn=1432-0851&rft_id=info:doi/10.1007/s00262-014-1624-x&rft_dat=%3Cproquest_pubme%3E1660402717%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c593t-9d6b0ab28487d9447f90fe36650ba7e2ffa4799afd50636459ba498d032ccb813%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1651311182&rft_id=info:pmid/25324197&rfr_iscdi=true |