Selenoprotein P, peroxiredoxin-5, renalase, and total antioxidant status in patients with suspected obstructive sleep apnea

Purpose The aim of this study was to investigate the relationship between selenoprotein P, peroxiredoxin-5, renalase, total antioxidant status (TAS), mean blood pressure (mBP), and apnea-hypopnea index (AHI). Methods The study group consisted of 112 patients hospitalized to verify the diagnosis of o...

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Published in:Sleep & breathing 2024-03, Vol.28 (1), p.211-219
Main Authors: Czerwińska, Karolina, Januszewska, Lidia, Markiewicz-Górka, Iwona, Jaremków, Aleksandra, Martynowicz, Helena, Pawlas, Krystyna, Mazur, Grzegorz, Poręba, Rafał, Gać, Paweł
Format: Article
Language:English
Subjects:
Adolescent
Antihypertensives
Antioxidants
Apnea
Blood pressure
Dentistry
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Mental disorders
Monoamine Oxidase
Neurology
Otorhinolaryngology
Pediatrics
Peroxiredoxin
Peroxiredoxins
Pneumology/Respiratory System
Regression analysis
Selenoprotein P
Sleep apnea
Sleep Apnea, Obstructive
Sleep Breathing Physiology and Disorders • Original
Sleep Breathing Physiology and Disorders • Original Article
Sleep disorders
Statistical analysis
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Summary:Purpose The aim of this study was to investigate the relationship between selenoprotein P, peroxiredoxin-5, renalase, total antioxidant status (TAS), mean blood pressure (mBP), and apnea-hypopnea index (AHI). Methods The study group consisted of 112 patients hospitalized to verify the diagnosis of obstructive sleep apnea (OSA). The inclusion criteria were consent to participate in the study and age ≥ 18 years. Patients with active proliferative disease, severe systemic diseases, or mental diseases were excluded from the study. Each patient underwent full polysomnography and had blood pressure measured. Blood samples were collected and laboratory test was performed. Results Among 112 patients enrolled, there was a statistically significant negative linear correlation between blood pressure values (sBP, dBP, mBP) and selenoprotein P, renalase, and TAS levels. Similarly, there was a negative linear correlation between AHI and selenoprotein P, renalase, and TAS levels, but none between AHI and peroxiredoxin-5. Based on the obtained regression models, higher selenoprotein P, peroxiredoxin-5, and renalase levels were independently associated with higher TAS. Lower mBP values were independently associated with the use of antihypertensive drugs, higher TAS, and younger age. Male gender, higher BMI, and higher mBP were independently associated with higher AHI. Conclusions Higher concentrations of selenoprotein P, peroxiredoxin-5, and renalase were associated with higher TAS, which confirms their antioxidant properties. There was an indirect connection between tested antioxidants and blood pressure values.
ISSN:1520-9512
1522-1709
DOI:10.1007/s11325-023-02880-7