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In vitro and in vivo studies of Syzygium cumini -loaded electrospun PLGA/PMMA/collagen nanofibers for accelerating topical wound healing
This work aims to develop plant extract-loaded electrospun nanofiber as an effective wound dressing scaffolds for topical wound healing. Electrospun nanofibers were fabricated from leaf extract (SCLE), poly(lactic- -glycolic acid) (PLGA), poly(methyl methacrylate) (PMMA), collagen and glycine. Elect...
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Published in: | RSC advances 2024-01, Vol.14 (1), p.101-117 |
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Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | This work aims to develop plant extract-loaded electrospun nanofiber as an effective wound dressing scaffolds for topical wound healing. Electrospun nanofibers were fabricated from
leaf extract (SCLE), poly(lactic-
-glycolic acid) (PLGA), poly(methyl methacrylate) (PMMA), collagen and glycine. Electrospinning conditions were optimized to allow the formation of nanosized and uniform fibers that display smooth surface. Morphology and swelling behavior of the formed nanofibers were studied. In addition, the antibacterial activity of the nanofibers against multidrug-resistant and human pathogens was assessed by agar-well diffusion. Results showed that nanofibers containing
extract at concentrations of 0.5 and 1% w/v exhibited greater antibacterial activity against the tested Gram-positive (
,
,
,
and
) and Gram-negative (
,
and
) pathogens compared to the same concentrations of the plain extract. Furthermore,
wound healing was evaluated in
rats over a period of 14 days.
results demonstrated that nanofiber mats containing SCLE and collagen significantly improved wound healing within two weeks, compared to the control untreated group. These findings highlight the potential of fabricated nanofibers in accelerating wound healing and management of topical acute wounds. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/d3ra06355k |