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Association between being breastfed and cardiovascular disease: a population cohort study of 320 249 participants
Abstract Background Being breastfed is associated with lower cardiovascular risk factors but, to date, no studies have demonstrated a protective effect on cardiovascular disease (CVD). This study aims to address the limitations of previous studies, specifically insufficient statistical power and res...
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| Published in: | Journal of public health (Oxford, England) England), 2023-03, Vol.45 (3), p.569-576 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c425t-f1d211f99fb71232d8caf10ac13d9f00578bd764beaa450674f01173d811f4303 |
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| cites | cdi_FETCH-LOGICAL-c425t-f1d211f99fb71232d8caf10ac13d9f00578bd764beaa450674f01173d811f4303 |
| container_end_page | 576 |
| container_issue | 3 |
| container_start_page | 569 |
| container_title | Journal of public health (Oxford, England) |
| container_volume | 45 |
| creator | Nakada, Shinya Ho, Frederick K Celis-Morales, Carlos Pell, Jill P |
| description | Abstract
Background
Being breastfed is associated with lower cardiovascular risk factors but, to date, no studies have demonstrated a protective effect on cardiovascular disease (CVD). This study aims to address the limitations of previous studies, specifically insufficient statistical power and residual confounding, to determine if such association exists.
Methods
This is a population-based retrospective cohort study of 320 249 men and women aged 40–69 years. Breastfeeding status was self-reported. CVD and myocardial infarction (MI) events and deaths based via linkage to hospitalization and death records.
Results
Overall, 28 469 (8.4%) participants experienced a CVD event and 5174 (1.6%) experienced an MI. Following adjustment for sociodemographic, lifestyle and early life confounders, breastfeeding was associated with a reduced risk of CVD events (HR 0.97, 95% CI 0.94–1.00, P = 0.041), CVD deaths (HR 0.91, 95% CI 0.84–0.98, P = 0.017), MI events (HR 0.93, 95% CI 0.87–0.99, P = 0.033) and MI deaths (HR 0.81, 95% CI 0.67–0.98, P = 0.026).
Conclusions
Child health benefits of breastfeeding are well established. However, the benefits of breastfeeding may extend into later life reinforcing the need to encourage and support breastfeeding. |
| doi_str_mv | 10.1093/pubmed/fdad016 |
| format | article |
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Background
Being breastfed is associated with lower cardiovascular risk factors but, to date, no studies have demonstrated a protective effect on cardiovascular disease (CVD). This study aims to address the limitations of previous studies, specifically insufficient statistical power and residual confounding, to determine if such association exists.
Methods
This is a population-based retrospective cohort study of 320 249 men and women aged 40–69 years. Breastfeeding status was self-reported. CVD and myocardial infarction (MI) events and deaths based via linkage to hospitalization and death records.
Results
Overall, 28 469 (8.4%) participants experienced a CVD event and 5174 (1.6%) experienced an MI. Following adjustment for sociodemographic, lifestyle and early life confounders, breastfeeding was associated with a reduced risk of CVD events (HR 0.97, 95% CI 0.94–1.00, P = 0.041), CVD deaths (HR 0.91, 95% CI 0.84–0.98, P = 0.017), MI events (HR 0.93, 95% CI 0.87–0.99, P = 0.033) and MI deaths (HR 0.81, 95% CI 0.67–0.98, P = 0.026).
Conclusions
Child health benefits of breastfeeding are well established. However, the benefits of breastfeeding may extend into later life reinforcing the need to encourage and support breastfeeding.</description><identifier>ISSN: 1741-3842</identifier><identifier>EISSN: 1741-3850</identifier><identifier>DOI: 10.1093/pubmed/fdad016</identifier><identifier>PMID: 36879421</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Original</subject><ispartof>Journal of public health (Oxford, England), 2023-03, Vol.45 (3), p.569-576</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Faculty of Public Health. 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Faculty of Public Health.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-f1d211f99fb71232d8caf10ac13d9f00578bd764beaa450674f01173d811f4303</citedby><cites>FETCH-LOGICAL-c425t-f1d211f99fb71232d8caf10ac13d9f00578bd764beaa450674f01173d811f4303</cites><orcidid>0000-0001-8711-8420 ; 0000-0003-2612-3917</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,1591,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36879421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakada, Shinya</creatorcontrib><creatorcontrib>Ho, Frederick K</creatorcontrib><creatorcontrib>Celis-Morales, Carlos</creatorcontrib><creatorcontrib>Pell, Jill P</creatorcontrib><title>Association between being breastfed and cardiovascular disease: a population cohort study of 320 249 participants</title><title>Journal of public health (Oxford, England)</title><addtitle>J Public Health (Oxf)</addtitle><description>Abstract
Background
Being breastfed is associated with lower cardiovascular risk factors but, to date, no studies have demonstrated a protective effect on cardiovascular disease (CVD). This study aims to address the limitations of previous studies, specifically insufficient statistical power and residual confounding, to determine if such association exists.
Methods
This is a population-based retrospective cohort study of 320 249 men and women aged 40–69 years. Breastfeeding status was self-reported. CVD and myocardial infarction (MI) events and deaths based via linkage to hospitalization and death records.
Results
Overall, 28 469 (8.4%) participants experienced a CVD event and 5174 (1.6%) experienced an MI. Following adjustment for sociodemographic, lifestyle and early life confounders, breastfeeding was associated with a reduced risk of CVD events (HR 0.97, 95% CI 0.94–1.00, P = 0.041), CVD deaths (HR 0.91, 95% CI 0.84–0.98, P = 0.017), MI events (HR 0.93, 95% CI 0.87–0.99, P = 0.033) and MI deaths (HR 0.81, 95% CI 0.67–0.98, P = 0.026).
Conclusions
Child health benefits of breastfeeding are well established. However, the benefits of breastfeeding may extend into later life reinforcing the need to encourage and support breastfeeding.</description><subject>Original</subject><issn>1741-3842</issn><issn>1741-3850</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkctu1TAQhi0EohfYskRewuK0M7YTJ2xQVVFAqsQG1tbEl9YoJw62U9S34Vl4MlLO4QhWrMbyfPON5Z-xFwhnCL08n5dh6915cOQA20fsGLXCjewaeHw4K3HETkr5CiB6Ac1TdiTbTvdK4DHLF6UkG6nGNPHB1-_eP9Q43fAheyo1eMdpctxSdjHdUbHLSJm7WNauf8OJz2ler34LbLpNufJSF3fPU-BSwM8fQvV8plyjjTNNtTxjTwKNxT_f11P25erd58sPm-tP7z9eXlxvrBJN3QR0AjH0fRg0CilcZykgkEXp-gDQ6G5wulWDJ1INtFoFQNTSdeuUkiBP2dudd_dH1k8102jmHLeU702iaP7tTPHW3KQ7g6A0SKFXw6u9Iadviy_VbGOxfhxp8mkpRuhOya5tFa7o2Q61OZWSfTjsQTAPSe13mX1S68DLv193wP9EswKvd0Ba5v_JfgF24qJK</recordid><startdate>20230302</startdate><enddate>20230302</enddate><creator>Nakada, Shinya</creator><creator>Ho, Frederick K</creator><creator>Celis-Morales, Carlos</creator><creator>Pell, Jill P</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8711-8420</orcidid><orcidid>https://orcid.org/0000-0003-2612-3917</orcidid></search><sort><creationdate>20230302</creationdate><title>Association between being breastfed and cardiovascular disease: a population cohort study of 320 249 participants</title><author>Nakada, Shinya ; Ho, Frederick K ; Celis-Morales, Carlos ; Pell, Jill P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-f1d211f99fb71232d8caf10ac13d9f00578bd764beaa450674f01173d811f4303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakada, Shinya</creatorcontrib><creatorcontrib>Ho, Frederick K</creatorcontrib><creatorcontrib>Celis-Morales, Carlos</creatorcontrib><creatorcontrib>Pell, Jill P</creatorcontrib><collection>Open Access: Oxford University Press Open Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of public health (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakada, Shinya</au><au>Ho, Frederick K</au><au>Celis-Morales, Carlos</au><au>Pell, Jill P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between being breastfed and cardiovascular disease: a population cohort study of 320 249 participants</atitle><jtitle>Journal of public health (Oxford, England)</jtitle><addtitle>J Public Health (Oxf)</addtitle><date>2023-03-02</date><risdate>2023</risdate><volume>45</volume><issue>3</issue><spage>569</spage><epage>576</epage><pages>569-576</pages><issn>1741-3842</issn><eissn>1741-3850</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Abstract
Background
Being breastfed is associated with lower cardiovascular risk factors but, to date, no studies have demonstrated a protective effect on cardiovascular disease (CVD). This study aims to address the limitations of previous studies, specifically insufficient statistical power and residual confounding, to determine if such association exists.
Methods
This is a population-based retrospective cohort study of 320 249 men and women aged 40–69 years. Breastfeeding status was self-reported. CVD and myocardial infarction (MI) events and deaths based via linkage to hospitalization and death records.
Results
Overall, 28 469 (8.4%) participants experienced a CVD event and 5174 (1.6%) experienced an MI. Following adjustment for sociodemographic, lifestyle and early life confounders, breastfeeding was associated with a reduced risk of CVD events (HR 0.97, 95% CI 0.94–1.00, P = 0.041), CVD deaths (HR 0.91, 95% CI 0.84–0.98, P = 0.017), MI events (HR 0.93, 95% CI 0.87–0.99, P = 0.033) and MI deaths (HR 0.81, 95% CI 0.67–0.98, P = 0.026).
Conclusions
Child health benefits of breastfeeding are well established. However, the benefits of breastfeeding may extend into later life reinforcing the need to encourage and support breastfeeding.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>36879421</pmid><doi>10.1093/pubmed/fdad016</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8711-8420</orcidid><orcidid>https://orcid.org/0000-0003-2612-3917</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of public health (Oxford, England), 2023-03, Vol.45 (3), p.569-576 |
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| source | Oxford Journals |
| subjects | Original |
| title | Association between being breastfed and cardiovascular disease: a population cohort study of 320 249 participants |
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