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Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection
To study the cellular infiltrate that occurs within the airways of infants with respiratory syncytial virus bronchiolitis, samples of airways secretions were obtained by bronchial lavage from the lower respiratory tract of infants ventilated for this condition and from the upper airway of non-intuba...
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| Published in: | Archives of disease in childhood 1994-11, Vol.71 (5), p.428-432 |
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| container_end_page | 432 |
| container_issue | 5 |
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| container_title | Archives of disease in childhood |
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| creator | Everard, M L Swarbrick, A Wrightham, M McIntyre, J Dunkley, C James, P D Sewell, H F Milner, A D |
| description | To study the cellular infiltrate that occurs within the airways of infants with respiratory syncytial virus bronchiolitis, samples of airways secretions were obtained by bronchial lavage from the lower respiratory tract of infants ventilated for this condition and from the upper airway of non-intubated infants with this disorder using nasopharyngeal aspirates. Cytospin samples were prepared so that differential cell counts could be performed on the cells obtained and alkaline phosphatase-antialkaline phosphatase immunocytochemical analysis of lymphocyte subsets was carried out using a panel of monoclonal antibodies, which included anti-CD3, anti-CD4, anti-CD8, anti-CD19, and anti-TcR gamma delta. Results from the lower and upper airways were similar. Large numbers of inflammatory cells were obtained, of which neutrophils accounted for a median of 93% in the upper airway and 76% in the lower airway. The numbers of CD8 positive cells detected were small and consistently less than CD4 positive cells, median CD4:CD8 ratios being 22.5:1 and 15:1 for the lower and upper airways. CD19 positive cells were rarely observed and no gamma delta positive lymphocytes were detected. These results indicate that neutrophils probably play a major part in causing symptoms in these infants. They do not support the concept that excessive lymphocyte mediated cytotoxic activity is principally responsible for the pathology in respiratory syncytial virus bronchiolitis. |
| doi_str_mv | 10.1136/adc.71.5.428 |
| format | article |
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Cytospin samples were prepared so that differential cell counts could be performed on the cells obtained and alkaline phosphatase-antialkaline phosphatase immunocytochemical analysis of lymphocyte subsets was carried out using a panel of monoclonal antibodies, which included anti-CD3, anti-CD4, anti-CD8, anti-CD19, and anti-TcR gamma delta. Results from the lower and upper airways were similar. Large numbers of inflammatory cells were obtained, of which neutrophils accounted for a median of 93% in the upper airway and 76% in the lower airway. The numbers of CD8 positive cells detected were small and consistently less than CD4 positive cells, median CD4:CD8 ratios being 22.5:1 and 15:1 for the lower and upper airways. CD19 positive cells were rarely observed and no gamma delta positive lymphocytes were detected. These results indicate that neutrophils probably play a major part in causing symptoms in these infants. They do not support the concept that excessive lymphocyte mediated cytotoxic activity is principally responsible for the pathology in respiratory syncytial virus bronchiolitis.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/adc.71.5.428</identifier><identifier>PMID: 7826113</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Acute Disease ; Alkaline phosphatase ; Bronchiolitis, Viral - immunology ; Bronchiolitis, Viral - pathology ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoalveolar Lavage Fluid - immunology ; Bronchopneumonia ; CD19 antigen ; CD3 antigen ; CD4 antigen ; CD8 antigen ; Cell Movement ; Child, Preschool ; Cytotoxicity ; Humans ; Infant ; Infants ; Leukocytes (neutrophilic) ; Lymphocyte Subsets - pathology ; Lymphocytes ; Monoclonal antibodies ; Neutrophils ; Neutrophils - pathology ; Pediatrics ; Phosphatase ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Virus Infections - pathology ; Respiratory tract ; Specimen Handling - methods ; Ventilation ; Young Children</subject><ispartof>Archives of disease in childhood, 1994-11, Vol.71 (5), p.428-432</ispartof><rights>Copyright BMJ Publishing Group LTD Nov 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b508t-bf38890c68ca0307aa84d79e80ab6be110b19f5152c722c061a4536c39a890fa3</citedby><cites>FETCH-LOGICAL-b508t-bf38890c68ca0307aa84d79e80ab6be110b19f5152c722c061a4536c39a890fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3079737299/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3079737299?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,21406,21422,27957,27958,33646,33647,33912,33913,43768,43915,53827,53829,74578,74754</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7826113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Everard, M L</creatorcontrib><creatorcontrib>Swarbrick, A</creatorcontrib><creatorcontrib>Wrightham, M</creatorcontrib><creatorcontrib>McIntyre, J</creatorcontrib><creatorcontrib>Dunkley, C</creatorcontrib><creatorcontrib>James, P D</creatorcontrib><creatorcontrib>Sewell, H F</creatorcontrib><creatorcontrib>Milner, A D</creatorcontrib><title>Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>To study the cellular infiltrate that occurs within the airways of infants with respiratory syncytial virus bronchiolitis, samples of airways secretions were obtained by bronchial lavage from the lower respiratory tract of infants ventilated for this condition and from the upper airway of non-intubated infants with this disorder using nasopharyngeal aspirates. Cytospin samples were prepared so that differential cell counts could be performed on the cells obtained and alkaline phosphatase-antialkaline phosphatase immunocytochemical analysis of lymphocyte subsets was carried out using a panel of monoclonal antibodies, which included anti-CD3, anti-CD4, anti-CD8, anti-CD19, and anti-TcR gamma delta. Results from the lower and upper airways were similar. Large numbers of inflammatory cells were obtained, of which neutrophils accounted for a median of 93% in the upper airway and 76% in the lower airway. The numbers of CD8 positive cells detected were small and consistently less than CD4 positive cells, median CD4:CD8 ratios being 22.5:1 and 15:1 for the lower and upper airways. CD19 positive cells were rarely observed and no gamma delta positive lymphocytes were detected. These results indicate that neutrophils probably play a major part in causing symptoms in these infants. They do not support the concept that excessive lymphocyte mediated cytotoxic activity is principally responsible for the pathology in respiratory syncytial virus bronchiolitis.</description><subject>Acute Disease</subject><subject>Alkaline phosphatase</subject><subject>Bronchiolitis, Viral - immunology</subject><subject>Bronchiolitis, Viral - pathology</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchoalveolar Lavage Fluid - immunology</subject><subject>Bronchopneumonia</subject><subject>CD19 antigen</subject><subject>CD3 antigen</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>Cell Movement</subject><subject>Child, Preschool</subject><subject>Cytotoxicity</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocyte Subsets - pathology</subject><subject>Lymphocytes</subject><subject>Monoclonal antibodies</subject><subject>Neutrophils</subject><subject>Neutrophils - pathology</subject><subject>Pediatrics</subject><subject>Phosphatase</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Virus Infections - pathology</subject><subject>Respiratory tract</subject><subject>Specimen Handling - methods</subject><subject>Ventilation</subject><subject>Young Children</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>CJNVE</sourceid><recordid>eNqFkc2r1DAUxYMoz_Hpzq1QEHRjxyRtk3QjPAZ9KoOCXws34SZN32TsJGOSjva_N2WGQV3oKoHzu-d-HIQeErwkpGLPodNLTpbNsqbiFlqQmomS4rq-jRYY46pshRB30b0YtxgTKkR1gS64oCwXL1B35WCYoo2F7wtthiF_VALrTFeoqVDBO72xMBQDHODGzJR1PbgUix82bYpg4t4GSD5MRZycntIMH2wY4wwanax399GdHoZoHpzeS_T51ctPq9fl-v31m9XVulQNFqlUfSVEizUTGnCFOYCoO94agUExZQjBirR9QxqqOaUaMwJ1UzFdtZDLeqgu0Yuj735UO9Np41KAQe6D3UGYpAcr_1Sc3cgbf5Akt8ONyAZPTgbBfx9NTHJn43wVcMaPUXLW1pwS9l-QMEEEF20GH_8Fbv0Y8s2jzBu2vOK0nalnR0oHH2Mw_XlmguUcsswhS05kI3PIGX_0-55n-JRq1sujbmMyP88yhG-S5Y6NfPdlJT--_frhet1QWWf-6ZFXu-2_O_8CIO6_vw</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>Everard, M L</creator><creator>Swarbrick, A</creator><creator>Wrightham, M</creator><creator>McIntyre, J</creator><creator>Dunkley, C</creator><creator>James, P D</creator><creator>Sewell, H F</creator><creator>Milner, A D</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19941101</creationdate><title>Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection</title><author>Everard, M L ; Swarbrick, A ; Wrightham, M ; McIntyre, J ; Dunkley, C ; James, P D ; Sewell, H F ; Milner, A D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b508t-bf38890c68ca0307aa84d79e80ab6be110b19f5152c722c061a4536c39a890fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acute Disease</topic><topic>Alkaline phosphatase</topic><topic>Bronchiolitis, Viral - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Everard, M L</au><au>Swarbrick, A</au><au>Wrightham, M</au><au>McIntyre, J</au><au>Dunkley, C</au><au>James, P D</au><au>Sewell, H F</au><au>Milner, A D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>71</volume><issue>5</issue><spage>428</spage><epage>432</epage><pages>428-432</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><notes>href:archdischild-71-428.pdf</notes><notes>PMID:7826113</notes><notes>ark:/67375/NVC-SJZRGL52-4</notes><notes>istex:88A313B7FC99DA96AAE70B740F7B2003C08C7047</notes><notes>local:archdischild;71/5/428</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>To study the cellular infiltrate that occurs within the airways of infants with respiratory syncytial virus bronchiolitis, samples of airways secretions were obtained by bronchial lavage from the lower respiratory tract of infants ventilated for this condition and from the upper airway of non-intubated infants with this disorder using nasopharyngeal aspirates. Cytospin samples were prepared so that differential cell counts could be performed on the cells obtained and alkaline phosphatase-antialkaline phosphatase immunocytochemical analysis of lymphocyte subsets was carried out using a panel of monoclonal antibodies, which included anti-CD3, anti-CD4, anti-CD8, anti-CD19, and anti-TcR gamma delta. Results from the lower and upper airways were similar. Large numbers of inflammatory cells were obtained, of which neutrophils accounted for a median of 93% in the upper airway and 76% in the lower airway. The numbers of CD8 positive cells detected were small and consistently less than CD4 positive cells, median CD4:CD8 ratios being 22.5:1 and 15:1 for the lower and upper airways. CD19 positive cells were rarely observed and no gamma delta positive lymphocytes were detected. These results indicate that neutrophils probably play a major part in causing symptoms in these infants. They do not support the concept that excessive lymphocyte mediated cytotoxic activity is principally responsible for the pathology in respiratory syncytial virus bronchiolitis.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>7826113</pmid><doi>10.1136/adc.71.5.428</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of disease in childhood, 1994-11, Vol.71 (5), p.428-432 |
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| subjects | Acute Disease Alkaline phosphatase Bronchiolitis, Viral - immunology Bronchiolitis, Viral - pathology Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Bronchopneumonia CD19 antigen CD3 antigen CD4 antigen CD8 antigen Cell Movement Child, Preschool Cytotoxicity Humans Infant Infants Leukocytes (neutrophilic) Lymphocyte Subsets - pathology Lymphocytes Monoclonal antibodies Neutrophils Neutrophils - pathology Pediatrics Phosphatase Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - pathology Respiratory tract Specimen Handling - methods Ventilation Young Children |
| title | Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection |
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