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A case report of T cell/histiocyte-rich large B cell lymphoma misdiagnosed as lymphomatoid papulosis
T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is an uncommon B cell lymphoma characterized by < 10% large neoplastic B cells in a background of abundant T cells and frequent histiocytes. If a skin lesion is the first clinical sign of lymphoma, the diagnosis might be difficult and misdiag...
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| Published in: | Medicine (Baltimore) 2023-03, Vol.102 (13), p.e33407-e33407 |
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| container_end_page | e33407 |
| container_issue | 13 |
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| container_title | Medicine (Baltimore) |
| container_volume | 102 |
| creator | Kim, Taekwoon Kim, Jisung Park, Joonsoo |
| description | T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is an uncommon B cell lymphoma characterized by < 10% large neoplastic B cells in a background of abundant T cells and frequent histiocytes. If a skin lesion is the first clinical sign of lymphoma, the diagnosis might be difficult and misdiagnosed.
A 60-year-old woman presented with multiple erythematous umbilicated nodules on her left upper back for 3 months.
Through punch biopsy of the back lesion and additional excisional right inguinal lymph node biopsy, the patient was diagnosed with cutaneous metastasis of THRLBCL.
The patient was referred to the Hemato-oncology Department for chemotherapy.
R-CHOP chemotherapy is currently in progress, and some skin lesions show improvement.
Skin lesions might be the first clinical sign of THRLBCL and when THRLBCL is suspected, careful further evaluation is essential for accurate diagnosis and treatment. |
| doi_str_mv | 10.1097/MD.0000000000033407 |
| format | article |
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A 60-year-old woman presented with multiple erythematous umbilicated nodules on her left upper back for 3 months.
Through punch biopsy of the back lesion and additional excisional right inguinal lymph node biopsy, the patient was diagnosed with cutaneous metastasis of THRLBCL.
The patient was referred to the Hemato-oncology Department for chemotherapy.
R-CHOP chemotherapy is currently in progress, and some skin lesions show improvement.
Skin lesions might be the first clinical sign of THRLBCL and when THRLBCL is suspected, careful further evaluation is essential for accurate diagnosis and treatment.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000033407</identifier><identifier>PMID: 37000052</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Clinical Case Report ; Diagnostic Errors ; Female ; Histiocytes - pathology ; Humans ; Lymphoma, Large B-Cell, Diffuse - diagnosis ; Lymphoma, Large B-Cell, Diffuse - pathology ; Lymphomatoid Papulosis - diagnosis ; Lymphomatoid Papulosis - pathology ; Middle Aged ; T-Lymphocytes - pathology</subject><ispartof>Medicine (Baltimore), 2023-03, Vol.102 (13), p.e33407-e33407</ispartof><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-6ab73b29394f6ad7f04cb3f3668032497021c6627c55ed7805d443f817276d603</cites><orcidid>0000-0003-0399-4920</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063299/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063299/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37000052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Taekwoon</creatorcontrib><creatorcontrib>Kim, Jisung</creatorcontrib><creatorcontrib>Park, Joonsoo</creatorcontrib><title>A case report of T cell/histiocyte-rich large B cell lymphoma misdiagnosed as lymphomatoid papulosis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is an uncommon B cell lymphoma characterized by < 10% large neoplastic B cells in a background of abundant T cells and frequent histiocytes. If a skin lesion is the first clinical sign of lymphoma, the diagnosis might be difficult and misdiagnosed.
A 60-year-old woman presented with multiple erythematous umbilicated nodules on her left upper back for 3 months.
Through punch biopsy of the back lesion and additional excisional right inguinal lymph node biopsy, the patient was diagnosed with cutaneous metastasis of THRLBCL.
The patient was referred to the Hemato-oncology Department for chemotherapy.
R-CHOP chemotherapy is currently in progress, and some skin lesions show improvement.
Skin lesions might be the first clinical sign of THRLBCL and when THRLBCL is suspected, careful further evaluation is essential for accurate diagnosis and treatment.</description><subject>Clinical Case Report</subject><subject>Diagnostic Errors</subject><subject>Female</subject><subject>Histiocytes - pathology</subject><subject>Humans</subject><subject>Lymphoma, Large B-Cell, Diffuse - diagnosis</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Lymphomatoid Papulosis - diagnosis</subject><subject>Lymphomatoid Papulosis - pathology</subject><subject>Middle Aged</subject><subject>T-Lymphocytes - pathology</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdUctOAjEUbYxG8PEFJqZLNwOdPunKIPhKIG5w3ZS2AzUzdGwHE_7eQRAfd3MX555zz8kB4CpHvRxJ0Z-Oe-hnCKFIHIFuzgjPmOT0GHQRwiwTUtAOOEvpDaGcCExPQYeILYXhLrBDaHRyMLo6xAaGAs6gcWXZX_rU-GA2jcuiN0tY6rhw8O4LhOWmqpeh0rDyyXq9WIXkLNTpADTBW1jrel2G5NMFOCl0mdzlfp-D14f72egpm7w8Po-Gk8wQxpuM67kgcyyJpAXXVhSImjkpCOcDRDCVAuHccI6FYcxZMUDMUkqKQS6w4JYjcg5ud7r1el45a9yqibpUdfSVjhsVtFd_kZVfqkX4UDlCnGApW4WbvUIM72uXGtUm3EbWKxfWSWHRuhtwybanZHdqYkgpuuLwJ0dqW5CajtX_glrW9W-LB853I-QT6H2L7w</recordid><startdate>20230331</startdate><enddate>20230331</enddate><creator>Kim, Taekwoon</creator><creator>Kim, Jisung</creator><creator>Park, Joonsoo</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0399-4920</orcidid></search><sort><creationdate>20230331</creationdate><title>A case report of T cell/histiocyte-rich large B cell lymphoma misdiagnosed as lymphomatoid papulosis</title><author>Kim, Taekwoon ; Kim, Jisung ; Park, Joonsoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-6ab73b29394f6ad7f04cb3f3668032497021c6627c55ed7805d443f817276d603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Clinical Case Report</topic><topic>Diagnostic Errors</topic><topic>Female</topic><topic>Histiocytes - pathology</topic><topic>Humans</topic><topic>Lymphoma, Large B-Cell, Diffuse - diagnosis</topic><topic>Lymphoma, Large B-Cell, Diffuse - pathology</topic><topic>Lymphomatoid Papulosis - diagnosis</topic><topic>Lymphomatoid Papulosis - pathology</topic><topic>Middle Aged</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Taekwoon</creatorcontrib><creatorcontrib>Kim, Jisung</creatorcontrib><creatorcontrib>Park, Joonsoo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Taekwoon</au><au>Kim, Jisung</au><au>Park, Joonsoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case report of T cell/histiocyte-rich large B cell lymphoma misdiagnosed as lymphomatoid papulosis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2023-03-31</date><risdate>2023</risdate><volume>102</volume><issue>13</issue><spage>e33407</spage><epage>e33407</epage><pages>e33407-e33407</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><notes>ObjectType-Case Study-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-4</notes><notes>content type line 23</notes><notes>ObjectType-Report-1</notes><notes>ObjectType-Article-3</notes><abstract>T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is an uncommon B cell lymphoma characterized by < 10% large neoplastic B cells in a background of abundant T cells and frequent histiocytes. If a skin lesion is the first clinical sign of lymphoma, the diagnosis might be difficult and misdiagnosed.
A 60-year-old woman presented with multiple erythematous umbilicated nodules on her left upper back for 3 months.
Through punch biopsy of the back lesion and additional excisional right inguinal lymph node biopsy, the patient was diagnosed with cutaneous metastasis of THRLBCL.
The patient was referred to the Hemato-oncology Department for chemotherapy.
R-CHOP chemotherapy is currently in progress, and some skin lesions show improvement.
Skin lesions might be the first clinical sign of THRLBCL and when THRLBCL is suspected, careful further evaluation is essential for accurate diagnosis and treatment.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>37000052</pmid><doi>10.1097/MD.0000000000033407</doi><orcidid>https://orcid.org/0000-0003-0399-4920</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline); HEAL-Link subscriptions: Lippincott Williams & Wilkins; IngentaConnect Journals |
| subjects | Clinical Case Report Diagnostic Errors Female Histiocytes - pathology Humans Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - pathology Lymphomatoid Papulosis - diagnosis Lymphomatoid Papulosis - pathology Middle Aged T-Lymphocytes - pathology |
| title | A case report of T cell/histiocyte-rich large B cell lymphoma misdiagnosed as lymphomatoid papulosis |
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