A case report of T cell/histiocyte-rich large B cell lymphoma misdiagnosed as lymphomatoid papulosis

T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is an uncommon B cell lymphoma characterized by < 10% large neoplastic B cells in a background of abundant T cells and frequent histiocytes. If a skin lesion is the first clinical sign of lymphoma, the diagnosis might be difficult and misdiag...

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Bibliographic Details
Published in:Medicine (Baltimore) 2023-03, Vol.102 (13), p.e33407-e33407
Main Authors: Kim, Taekwoon, Kim, Jisung, Park, Joonsoo
Format: Article
Language:English
Subjects:
Clinical Case Report
Diagnostic Errors
Female
Histiocytes - pathology
Humans
Lymphoma, Large B-Cell, Diffuse - diagnosis
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphomatoid Papulosis - diagnosis
Lymphomatoid Papulosis - pathology
Middle Aged
T-Lymphocytes - pathology
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Summary:T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is an uncommon B cell lymphoma characterized by < 10% large neoplastic B cells in a background of abundant T cells and frequent histiocytes. If a skin lesion is the first clinical sign of lymphoma, the diagnosis might be difficult and misdiagnosed. A 60-year-old woman presented with multiple erythematous umbilicated nodules on her left upper back for 3 months. Through punch biopsy of the back lesion and additional excisional right inguinal lymph node biopsy, the patient was diagnosed with cutaneous metastasis of THRLBCL. The patient was referred to the Hemato-oncology Department for chemotherapy. R-CHOP chemotherapy is currently in progress, and some skin lesions show improvement. Skin lesions might be the first clinical sign of THRLBCL and when THRLBCL is suspected, careful further evaluation is essential for accurate diagnosis and treatment.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000033407