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Oral Diseases and Oral Health–Related Quality of Life among Kenyan Children and Adolescents with HIV
Introduction: Children and adolescents living with HIV (CALHIV) have a higher risk of hard and soft oral tissue diseases as compared with their healthy peers. It is important to increase awareness regarding the need to integrate oral health within medical care among pediatric HIV populations. Studie...
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| Published in: | JDR clinical and translational research 2023-04, Vol.8 (2), p.168-177 |
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| container_title | JDR clinical and translational research |
| container_volume | 8 |
| creator | Wang, Y. Ramos-Gomez, F. Kemoli, A.M. John-Stewart, G. Wamalwa, D. Benki-Nugent, S. Slyker, J. Seminario, A.L. |
| description | Introduction:
Children and adolescents living with HIV (CALHIV) have a higher risk of hard and soft oral tissue diseases as compared with their healthy peers. It is important to increase awareness regarding the need to integrate oral health within medical care among pediatric HIV populations. Studies on associations of oral diseases with oral health–related quality of life (OHRQoL) in CALHIV are lacking. This study examined the association between oral diseases and OHRQoL in Kenyan CALHIV.
Methods:
This cross-sectional analysis was nested in a longitudinal cohort study of CALHIV in Nairobi. CALHIV received oral examinations, and the World Health Organization’s Oral Health Surveys and Record Form was administered. OHRQoL was measured with the Parental-Caregiver Perceptions Questionnaire, with the subdomains of global, oral symptoms, function limitations, and emotional and social well-being, with higher scores indicating poorer OHRQoL. Linear regression was used to model associations between OHRQoL and oral diseases, adjusting for age at the time of oral examination, CD4 counts, and caregiver’s education.
Results:
Among 71 CALHIV, the mean age was 12.6 y (SD, 2.9; range, 10 to |
| doi_str_mv | 10.1177/23800844221087951 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10026160</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_23800844221087951</sage_id><sourcerecordid>2645857665</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-b9d68bb043ff499762d9b76bd5da7f3161806238c05afef41ecb40c2dc84e5953</originalsourceid><addsrcrecordid>eNp9UU1vEzEQtRAVrdr-AC7IRy4p4_XX7glVgZKKSBUIuFre9Thx5dhlvUuVG_-Bf8gvYdOUCITEaUbj997M8yPkOYMLxrR-VfEaoBaiqhjUupHsCTnZzWZQy-rpoRfimJyXcgsATHGtJX9GjrnkUnDQJ8Tf9DbSN6GgLVioTY4-TBZo47D--f3HR4x2QEc_jDaGYUuzp8vgkdpNTiv6HtPWJjpfh-h6TA_8S5cjlg7TUOh9GNZ0cf3ljBx5GwueP9ZT8vnq7af5Yra8eXc9v1zOOt6wYdY2TtVtC4J7L5pGq8o1rVatk85qz5liNajJWAfSevSCYdcK6CrX1QJlI_kpeb3XvRvbDbrdEZMbc9eHje23Jttg_n5JYW1W-ZthAJViCiaFl48Kff46YhnMJkxmYrQJ81hMpYSspVZqt4ztoV2fS-nRH_YwMLuMzD8ZTZwXfx54YPxOZAJc7AHFrtDc5rFP04f9R_EXt4yacQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2645857665</pqid></control><display><type>article</type><title>Oral Diseases and Oral Health–Related Quality of Life among Kenyan Children and Adolescents with HIV</title><source>Sage Journals Online</source><creator>Wang, Y. ; Ramos-Gomez, F. ; Kemoli, A.M. ; John-Stewart, G. ; Wamalwa, D. ; Benki-Nugent, S. ; Slyker, J. ; Seminario, A.L.</creator><creatorcontrib>Wang, Y. ; Ramos-Gomez, F. ; Kemoli, A.M. ; John-Stewart, G. ; Wamalwa, D. ; Benki-Nugent, S. ; Slyker, J. ; Seminario, A.L.</creatorcontrib><description>Introduction:
Children and adolescents living with HIV (CALHIV) have a higher risk of hard and soft oral tissue diseases as compared with their healthy peers. It is important to increase awareness regarding the need to integrate oral health within medical care among pediatric HIV populations. Studies on associations of oral diseases with oral health–related quality of life (OHRQoL) in CALHIV are lacking. This study examined the association between oral diseases and OHRQoL in Kenyan CALHIV.
Methods:
This cross-sectional analysis was nested in a longitudinal cohort study of CALHIV in Nairobi. CALHIV received oral examinations, and the World Health Organization’s Oral Health Surveys and Record Form was administered. OHRQoL was measured with the Parental-Caregiver Perceptions Questionnaire, with the subdomains of global, oral symptoms, function limitations, and emotional and social well-being, with higher scores indicating poorer OHRQoL. Linear regression was used to model associations between OHRQoL and oral diseases, adjusting for age at the time of oral examination, CD4 counts, and caregiver’s education.
Results:
Among 71 CALHIV, the mean age was 12.6 y (SD, 2.9; range, 10 to <21), and the mean composite OHRQoL score was 12.6 (SD, 11.2). Ulcers (not herpes simplex virus or aphthous) were associated with the worst overall OHRQoL (mean, 21.8; SD, 11.1; P = 0.055) and oral symptoms subdomain (mean, 7.0, SD, 2.5; P = 0.003). Children with dry mouth and untreated caries had significantly higher mean global OHRQoL scores than those without disease (P < 0.0001). In the multivariate analysis, the OHRQoL composite score was 6.3 units (95% CI, –0.3 to 12.9) higher for those who had dry mouth and untreated dental caries; dry mouth accounted for the highest percentage of variability of OHRQoL (9.6%) and the global subdomain (31.9%). Ulcers accounted for the highest percentage of variability of the oral symptoms domain (15.4%).
Conclusions:
Oral ulcers, dry mouth, and untreated caries were associated with poorer OHRQoL in CALHIV. Integrating oral health into the primary care of CALHIV may improve their OHRQoL.
Knowledge Transfer Statement:
This study aimed to determine the association of oral diseases with the oral health–related quality of life of children and adolescents living with HIV (CALHIV). The findings will form part of the evidence to incorporate oral health protocols into care programs for CALHIV. Oral health monitoring has the potential to increase the surveillance of HIV clinical status, monitor the effectiveness of antiretroviral therapy, and improve the oral health–related quality of life of CALHIV.</description><identifier>ISSN: 2380-0844</identifier><identifier>EISSN: 2380-0852</identifier><identifier>DOI: 10.1177/23800844221087951</identifier><identifier>PMID: 35354307</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Child ; Cross-Sectional Studies ; Dental Caries - epidemiology ; Dental Caries - psychology ; HIV Infections - epidemiology ; Humans ; Kenya - epidemiology ; Longitudinal Studies ; Mouth Diseases - epidemiology ; Original Reports ; Quality of Life ; Ulcer ; Xerostomia ; Young Adult</subject><ispartof>JDR clinical and translational research, 2023-04, Vol.8 (2), p.168-177</ispartof><rights>International Association for Dental Research and American Association for Dental, Oral, and Craniofacial Research 2022</rights><rights>International Association for Dental Research and American Association for Dental, Oral, and Craniofacial Research 2022 2022 International Assosciation Dental Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c391t-b9d68bb043ff499762d9b76bd5da7f3161806238c05afef41ecb40c2dc84e5953</cites><orcidid>0000-0002-4822-6514</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35354307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Y.</creatorcontrib><creatorcontrib>Ramos-Gomez, F.</creatorcontrib><creatorcontrib>Kemoli, A.M.</creatorcontrib><creatorcontrib>John-Stewart, G.</creatorcontrib><creatorcontrib>Wamalwa, D.</creatorcontrib><creatorcontrib>Benki-Nugent, S.</creatorcontrib><creatorcontrib>Slyker, J.</creatorcontrib><creatorcontrib>Seminario, A.L.</creatorcontrib><title>Oral Diseases and Oral Health–Related Quality of Life among Kenyan Children and Adolescents with HIV</title><title>JDR clinical and translational research</title><addtitle>JDR Clin Trans Res</addtitle><description>Introduction:
Children and adolescents living with HIV (CALHIV) have a higher risk of hard and soft oral tissue diseases as compared with their healthy peers. It is important to increase awareness regarding the need to integrate oral health within medical care among pediatric HIV populations. Studies on associations of oral diseases with oral health–related quality of life (OHRQoL) in CALHIV are lacking. This study examined the association between oral diseases and OHRQoL in Kenyan CALHIV.
Methods:
This cross-sectional analysis was nested in a longitudinal cohort study of CALHIV in Nairobi. CALHIV received oral examinations, and the World Health Organization’s Oral Health Surveys and Record Form was administered. OHRQoL was measured with the Parental-Caregiver Perceptions Questionnaire, with the subdomains of global, oral symptoms, function limitations, and emotional and social well-being, with higher scores indicating poorer OHRQoL. Linear regression was used to model associations between OHRQoL and oral diseases, adjusting for age at the time of oral examination, CD4 counts, and caregiver’s education.
Results:
Among 71 CALHIV, the mean age was 12.6 y (SD, 2.9; range, 10 to <21), and the mean composite OHRQoL score was 12.6 (SD, 11.2). Ulcers (not herpes simplex virus or aphthous) were associated with the worst overall OHRQoL (mean, 21.8; SD, 11.1; P = 0.055) and oral symptoms subdomain (mean, 7.0, SD, 2.5; P = 0.003). Children with dry mouth and untreated caries had significantly higher mean global OHRQoL scores than those without disease (P < 0.0001). In the multivariate analysis, the OHRQoL composite score was 6.3 units (95% CI, –0.3 to 12.9) higher for those who had dry mouth and untreated dental caries; dry mouth accounted for the highest percentage of variability of OHRQoL (9.6%) and the global subdomain (31.9%). Ulcers accounted for the highest percentage of variability of the oral symptoms domain (15.4%).
Conclusions:
Oral ulcers, dry mouth, and untreated caries were associated with poorer OHRQoL in CALHIV. Integrating oral health into the primary care of CALHIV may improve their OHRQoL.
Knowledge Transfer Statement:
This study aimed to determine the association of oral diseases with the oral health–related quality of life of children and adolescents living with HIV (CALHIV). The findings will form part of the evidence to incorporate oral health protocols into care programs for CALHIV. Oral health monitoring has the potential to increase the surveillance of HIV clinical status, monitor the effectiveness of antiretroviral therapy, and improve the oral health–related quality of life of CALHIV.</description><subject>Adolescent</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Dental Caries - epidemiology</subject><subject>Dental Caries - psychology</subject><subject>HIV Infections - epidemiology</subject><subject>Humans</subject><subject>Kenya - epidemiology</subject><subject>Longitudinal Studies</subject><subject>Mouth Diseases - epidemiology</subject><subject>Original Reports</subject><subject>Quality of Life</subject><subject>Ulcer</subject><subject>Xerostomia</subject><subject>Young Adult</subject><issn>2380-0844</issn><issn>2380-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNp9UU1vEzEQtRAVrdr-AC7IRy4p4_XX7glVgZKKSBUIuFre9Thx5dhlvUuVG_-Bf8gvYdOUCITEaUbj997M8yPkOYMLxrR-VfEaoBaiqhjUupHsCTnZzWZQy-rpoRfimJyXcgsATHGtJX9GjrnkUnDQJ8Tf9DbSN6GgLVioTY4-TBZo47D--f3HR4x2QEc_jDaGYUuzp8vgkdpNTiv6HtPWJjpfh-h6TA_8S5cjlg7TUOh9GNZ0cf3ljBx5GwueP9ZT8vnq7af5Yra8eXc9v1zOOt6wYdY2TtVtC4J7L5pGq8o1rVatk85qz5liNajJWAfSevSCYdcK6CrX1QJlI_kpeb3XvRvbDbrdEZMbc9eHje23Jttg_n5JYW1W-ZthAJViCiaFl48Kff46YhnMJkxmYrQJ81hMpYSspVZqt4ztoV2fS-nRH_YwMLuMzD8ZTZwXfx54YPxOZAJc7AHFrtDc5rFP04f9R_EXt4yacQ</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Wang, Y.</creator><creator>Ramos-Gomez, F.</creator><creator>Kemoli, A.M.</creator><creator>John-Stewart, G.</creator><creator>Wamalwa, D.</creator><creator>Benki-Nugent, S.</creator><creator>Slyker, J.</creator><creator>Seminario, A.L.</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4822-6514</orcidid></search><sort><creationdate>20230401</creationdate><title>Oral Diseases and Oral Health–Related Quality of Life among Kenyan Children and Adolescents with HIV</title><author>Wang, Y. ; Ramos-Gomez, F. ; Kemoli, A.M. ; John-Stewart, G. ; Wamalwa, D. ; Benki-Nugent, S. ; Slyker, J. ; Seminario, A.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-b9d68bb043ff499762d9b76bd5da7f3161806238c05afef41ecb40c2dc84e5953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Dental Caries - epidemiology</topic><topic>Dental Caries - psychology</topic><topic>HIV Infections - epidemiology</topic><topic>Humans</topic><topic>Kenya - epidemiology</topic><topic>Longitudinal Studies</topic><topic>Mouth Diseases - epidemiology</topic><topic>Original Reports</topic><topic>Quality of Life</topic><topic>Ulcer</topic><topic>Xerostomia</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Y.</creatorcontrib><creatorcontrib>Ramos-Gomez, F.</creatorcontrib><creatorcontrib>Kemoli, A.M.</creatorcontrib><creatorcontrib>John-Stewart, G.</creatorcontrib><creatorcontrib>Wamalwa, D.</creatorcontrib><creatorcontrib>Benki-Nugent, S.</creatorcontrib><creatorcontrib>Slyker, J.</creatorcontrib><creatorcontrib>Seminario, A.L.</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>JDR clinical and translational research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Y.</au><au>Ramos-Gomez, F.</au><au>Kemoli, A.M.</au><au>John-Stewart, G.</au><au>Wamalwa, D.</au><au>Benki-Nugent, S.</au><au>Slyker, J.</au><au>Seminario, A.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Diseases and Oral Health–Related Quality of Life among Kenyan Children and Adolescents with HIV</atitle><jtitle>JDR clinical and translational research</jtitle><addtitle>JDR Clin Trans Res</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>8</volume><issue>2</issue><spage>168</spage><epage>177</epage><pages>168-177</pages><issn>2380-0844</issn><eissn>2380-0852</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Introduction:
Children and adolescents living with HIV (CALHIV) have a higher risk of hard and soft oral tissue diseases as compared with their healthy peers. It is important to increase awareness regarding the need to integrate oral health within medical care among pediatric HIV populations. Studies on associations of oral diseases with oral health–related quality of life (OHRQoL) in CALHIV are lacking. This study examined the association between oral diseases and OHRQoL in Kenyan CALHIV.
Methods:
This cross-sectional analysis was nested in a longitudinal cohort study of CALHIV in Nairobi. CALHIV received oral examinations, and the World Health Organization’s Oral Health Surveys and Record Form was administered. OHRQoL was measured with the Parental-Caregiver Perceptions Questionnaire, with the subdomains of global, oral symptoms, function limitations, and emotional and social well-being, with higher scores indicating poorer OHRQoL. Linear regression was used to model associations between OHRQoL and oral diseases, adjusting for age at the time of oral examination, CD4 counts, and caregiver’s education.
Results:
Among 71 CALHIV, the mean age was 12.6 y (SD, 2.9; range, 10 to <21), and the mean composite OHRQoL score was 12.6 (SD, 11.2). Ulcers (not herpes simplex virus or aphthous) were associated with the worst overall OHRQoL (mean, 21.8; SD, 11.1; P = 0.055) and oral symptoms subdomain (mean, 7.0, SD, 2.5; P = 0.003). Children with dry mouth and untreated caries had significantly higher mean global OHRQoL scores than those without disease (P < 0.0001). In the multivariate analysis, the OHRQoL composite score was 6.3 units (95% CI, –0.3 to 12.9) higher for those who had dry mouth and untreated dental caries; dry mouth accounted for the highest percentage of variability of OHRQoL (9.6%) and the global subdomain (31.9%). Ulcers accounted for the highest percentage of variability of the oral symptoms domain (15.4%).
Conclusions:
Oral ulcers, dry mouth, and untreated caries were associated with poorer OHRQoL in CALHIV. Integrating oral health into the primary care of CALHIV may improve their OHRQoL.
Knowledge Transfer Statement:
This study aimed to determine the association of oral diseases with the oral health–related quality of life of children and adolescents living with HIV (CALHIV). The findings will form part of the evidence to incorporate oral health protocols into care programs for CALHIV. Oral health monitoring has the potential to increase the surveillance of HIV clinical status, monitor the effectiveness of antiretroviral therapy, and improve the oral health–related quality of life of CALHIV.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>35354307</pmid><doi>10.1177/23800844221087951</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4822-6514</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | JDR clinical and translational research, 2023-04, Vol.8 (2), p.168-177 |
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| source | Sage Journals Online |
| subjects | Adolescent Child Cross-Sectional Studies Dental Caries - epidemiology Dental Caries - psychology HIV Infections - epidemiology Humans Kenya - epidemiology Longitudinal Studies Mouth Diseases - epidemiology Original Reports Quality of Life Ulcer Xerostomia Young Adult |
| title | Oral Diseases and Oral Health–Related Quality of Life among Kenyan Children and Adolescents with HIV |
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