Investigation of control region sequences of mtDNA in Naqu Tibetan population from Northwestern China

The sequence polymorphisms of mitochondrial DNA (mtDNA) are valuable in forensic medicine and anthropological genetics. We analysed the sequences of the mtDNA control region in 207 unrelated Tibetan individuals from the Naqu region, Tibet Autonomous Region in the People's Republic of China, and...

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Bibliographic Details
Published in:Annals of human biology 2021-01, Vol.48 (1), p.70-77
Main Authors: Yue, Wen-qing, Sun, Mao-ling, Han, Feng, Li, Jiu-jun, Rigzin, Tsewang, Dhondup, Tashi, Liu, Hai-bo, Li, Dong-yue, Li, Xuan, Xu, Yan-ming, Li, Xiao-na
Format: Article
Language:English
Subjects:
DNA, Mitochondrial - analysis
Ethnicity - genetics
haplogroup
Haplotypes
Humans
mtDNA
Phylogeny
polymorphism
Polymorphism, Genetic
Sequence Analysis, DNA
Tibet
Tibetan
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Summary:The sequence polymorphisms of mitochondrial DNA (mtDNA) are valuable in forensic medicine and anthropological genetics. We analysed the sequences of the mtDNA control region in 207 unrelated Tibetan individuals from the Naqu region, Tibet Autonomous Region in the People's Republic of China, and investigated the population structure of the region by population comparison with other groups. Genomic DNA was extracted and hypervariable regions (HVS-I and HVS-II) were amplified and sequenced. Subsequently, sequences were aligned and compared with the revised Cambridge sequence. Moreover, population comparison was performed between the Naqu Tibetan group and the other groups. Our study provided available data for exploring the mtDNA haplotype of the Tibetan population in the Naqu region, and population comparisons found that the Naqu Tibetan population has its own unique structure.
ISSN:0301-4460
1464-5033
DOI:10.1080/03014460.2021.1877351