Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF®, represents the water soluble fraction containi...

Full description

Saved in:
Bibliographic Details
Published in:Pathobiology of aging & age related diseases 2012-01, Vol.2 (1), p.11905
Main Authors: Rafehi, Haloom, Ververis, Katherine, Balcerczyk, Aneta, Ziemann, Mark, Ooi, Jenny, Hu, Sean, Kwa, Faith A. A., Loveridge, Shanon J., Georgiadis, George T., El-Osta, Assam, Karagiannis, TomC
Format: Article
Language:English
Subjects:
cinnulin PF
diabetes
diabetic complications
diabetic ulcer
mRNA-Seq
Research Paper
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c370t-fd4afb52e0c80967c672ad498e5d4656ba1a2065bf8886a1e8ebe98bb7b6ef253
cites cdi_FETCH-LOGICAL-c370t-fd4afb52e0c80967c672ad498e5d4656ba1a2065bf8886a1e8ebe98bb7b6ef253
container_end_page
container_issue 1
container_start_page 11905
container_title Pathobiology of aging & age related diseases
container_volume 2
creator Rafehi, Haloom
Ververis, Katherine
Balcerczyk, Aneta
Ziemann, Mark
Ooi, Jenny
Hu, Sean
Kwa, Faith A. A.
Loveridge, Shanon J.
Georgiadis, George T.
El-Osta, Assam
Karagiannis, TomC
description The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF®, represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.
doi_str_mv 10.3402/pba.v2i0.11905
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_22953038</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1038592067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-fd4afb52e0c80967c672ad498e5d4656ba1a2065bf8886a1e8ebe98bb7b6ef253</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhk1paUKaa49Fx168lb_tHgphSdpASEs_zmIkj71TZMmRtJvub8ifjpxNQ3ooiNHA--jVMG-SvM34qih5_mGWsNrlxFdZ1vHqRXKcc56lPJaXz_qj5NT737HjdTxd-To5yvOuKnjRHid3l2aHPtAIgaxhdmBhg0yS1XYkBZrNzs7oAqFfxDUZs9Vk2LcLFuvCKmsC_gmL2hNIDOg_sgnVBgxFYxU5T-MmeCb3bERjJ0xvqUc2fb8-S3_gDQMDeu_Jv0leDaA9nj7eJ8mvi_Of6y_p1dfPl-uzq1QVDQ_p0JcwyCpHrlre1Y2qmxz6smux6su6qiVkkPO6kkPbtjVk2KLErpWykTUOeVWcJJ8OvvNWTtgrNMGBFrOjCdxeWCDxr2JoI0a7E0WZNXXXRIP3jwbO3mzj-sREXqHWYNBuvcjiaqsuzrCgqwOqnPXe4fD0TcbFEqKIIYolRPEQYnzw7vlwT_jfyCLQHQAyg3UT3FqnexFgr60bHBhFXhT_Mb8H39SwDg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1038592067</pqid></control><display><type>article</type><title>Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis</title><source>Taylor &amp; Francis Open Access</source><source>PubMed Central（OA）</source><creator>Rafehi, Haloom ; Ververis, Katherine ; Balcerczyk, Aneta ; Ziemann, Mark ; Ooi, Jenny ; Hu, Sean ; Kwa, Faith A. A. ; Loveridge, Shanon J. ; Georgiadis, George T. ; El-Osta, Assam ; Karagiannis, TomC</creator><creatorcontrib>Rafehi, Haloom ; Ververis, Katherine ; Balcerczyk, Aneta ; Ziemann, Mark ; Ooi, Jenny ; Hu, Sean ; Kwa, Faith A. A. ; Loveridge, Shanon J. ; Georgiadis, George T. ; El-Osta, Assam ; Karagiannis, TomC</creatorcontrib><description>The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF®, represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.</description><identifier>ISSN: 2001-0001</identifier><identifier>EISSN: 2001-0001</identifier><identifier>DOI: 10.3402/pba.v2i0.11905</identifier><identifier>PMID: 22953038</identifier><language>eng</language><publisher>United States: Taylor &amp; Francis</publisher><subject>cinnulin PF ; diabetes ; diabetic complications ; diabetic ulcer ; mRNA-Seq ; Research Paper</subject><ispartof>Pathobiology of aging &amp; age related diseases, 2012-01, Vol.2 (1), p.11905</ispartof><rights>2012 Haloom Rafehi et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-fd4afb52e0c80967c672ad498e5d4656ba1a2065bf8886a1e8ebe98bb7b6ef253</citedby><cites>FETCH-LOGICAL-c370t-fd4afb52e0c80967c672ad498e5d4656ba1a2065bf8886a1e8ebe98bb7b6ef253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417697/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417697/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27535,27957,27958,53827,53829,59498,59499</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22953038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rafehi, Haloom</creatorcontrib><creatorcontrib>Ververis, Katherine</creatorcontrib><creatorcontrib>Balcerczyk, Aneta</creatorcontrib><creatorcontrib>Ziemann, Mark</creatorcontrib><creatorcontrib>Ooi, Jenny</creatorcontrib><creatorcontrib>Hu, Sean</creatorcontrib><creatorcontrib>Kwa, Faith A. A.</creatorcontrib><creatorcontrib>Loveridge, Shanon J.</creatorcontrib><creatorcontrib>Georgiadis, George T.</creatorcontrib><creatorcontrib>El-Osta, Assam</creatorcontrib><creatorcontrib>Karagiannis, TomC</creatorcontrib><title>Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis</title><title>Pathobiology of aging &amp; age related diseases</title><addtitle>Pathobiol Aging Age Relat Dis</addtitle><description>The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF®, represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.</description><subject>cinnulin PF</subject><subject>diabetes</subject><subject>diabetic complications</subject><subject>diabetic ulcer</subject><subject>mRNA-Seq</subject><subject>Research Paper</subject><issn>2001-0001</issn><issn>2001-0001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><recordid>eNp1kU1r3DAQhk1paUKaa49Fx168lb_tHgphSdpASEs_zmIkj71TZMmRtJvub8ifjpxNQ3ooiNHA--jVMG-SvM34qih5_mGWsNrlxFdZ1vHqRXKcc56lPJaXz_qj5NT737HjdTxd-To5yvOuKnjRHid3l2aHPtAIgaxhdmBhg0yS1XYkBZrNzs7oAqFfxDUZs9Vk2LcLFuvCKmsC_gmL2hNIDOg_sgnVBgxFYxU5T-MmeCb3bERjJ0xvqUc2fb8-S3_gDQMDeu_Jv0leDaA9nj7eJ8mvi_Of6y_p1dfPl-uzq1QVDQ_p0JcwyCpHrlre1Y2qmxz6smux6su6qiVkkPO6kkPbtjVk2KLErpWykTUOeVWcJJ8OvvNWTtgrNMGBFrOjCdxeWCDxr2JoI0a7E0WZNXXXRIP3jwbO3mzj-sREXqHWYNBuvcjiaqsuzrCgqwOqnPXe4fD0TcbFEqKIIYolRPEQYnzw7vlwT_jfyCLQHQAyg3UT3FqnexFgr60bHBhFXhT_Mb8H39SwDg</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Rafehi, Haloom</creator><creator>Ververis, Katherine</creator><creator>Balcerczyk, Aneta</creator><creator>Ziemann, Mark</creator><creator>Ooi, Jenny</creator><creator>Hu, Sean</creator><creator>Kwa, Faith A. A.</creator><creator>Loveridge, Shanon J.</creator><creator>Georgiadis, George T.</creator><creator>El-Osta, Assam</creator><creator>Karagiannis, TomC</creator><general>Taylor &amp; Francis</general><general>Co-Action Publishing</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis</title><author>Rafehi, Haloom ; Ververis, Katherine ; Balcerczyk, Aneta ; Ziemann, Mark ; Ooi, Jenny ; Hu, Sean ; Kwa, Faith A. A. ; Loveridge, Shanon J. ; Georgiadis, George T. ; El-Osta, Assam ; Karagiannis, TomC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-fd4afb52e0c80967c672ad498e5d4656ba1a2065bf8886a1e8ebe98bb7b6ef253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>cinnulin PF</topic><topic>diabetes</topic><topic>diabetic complications</topic><topic>diabetic ulcer</topic><topic>mRNA-Seq</topic><topic>Research Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rafehi, Haloom</creatorcontrib><creatorcontrib>Ververis, Katherine</creatorcontrib><creatorcontrib>Balcerczyk, Aneta</creatorcontrib><creatorcontrib>Ziemann, Mark</creatorcontrib><creatorcontrib>Ooi, Jenny</creatorcontrib><creatorcontrib>Hu, Sean</creatorcontrib><creatorcontrib>Kwa, Faith A. A.</creatorcontrib><creatorcontrib>Loveridge, Shanon J.</creatorcontrib><creatorcontrib>Georgiadis, George T.</creatorcontrib><creatorcontrib>El-Osta, Assam</creatorcontrib><creatorcontrib>Karagiannis, TomC</creatorcontrib><collection>Taylor &amp; Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pathobiology of aging &amp; age related diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rafehi, Haloom</au><au>Ververis, Katherine</au><au>Balcerczyk, Aneta</au><au>Ziemann, Mark</au><au>Ooi, Jenny</au><au>Hu, Sean</au><au>Kwa, Faith A. A.</au><au>Loveridge, Shanon J.</au><au>Georgiadis, George T.</au><au>El-Osta, Assam</au><au>Karagiannis, TomC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis</atitle><jtitle>Pathobiology of aging &amp; age related diseases</jtitle><addtitle>Pathobiol Aging Age Relat Dis</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>2</volume><issue>1</issue><spage>11905</spage><pages>11905-</pages><issn>2001-0001</issn><eissn>2001-0001</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF®, represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.</abstract><cop>United States</cop><pub>Taylor &amp; Francis</pub><pmid>22953038</pmid><doi>10.3402/pba.v2i0.11905</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2001-0001
ispartof Pathobiology of aging & age related diseases, 2012-01, Vol.2 (1), p.11905
issn 2001-0001
2001-0001
language eng
recordid cdi_pubmed_primary_22953038
source Taylor & Francis Open Access; PubMed Central（OA）
subjects cinnulin PF
diabetes
diabetic complications
diabetic ulcer
mRNA-Seq
Research Paper
title Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T14%3A58%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigation%20of%20the%20biological%20properties%20of%20Cinnulin%20PF%20in%20the%20context%20of%20diabetes:%20mechanistic%20insights%20by%20genome-wide%20mRNA-Seq%20analysis&rft.jtitle=Pathobiology%20of%20aging%20&%20age%20related%20diseases&rft.au=Rafehi,%20Haloom&rft.date=2012-01-01&rft.volume=2&rft.issue=1&rft.spage=11905&rft.pages=11905-&rft.issn=2001-0001&rft.eissn=2001-0001&rft_id=info:doi/10.3402/pba.v2i0.11905&rft_dat=%3Cproquest_pubme%3E1038592067%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c370t-fd4afb52e0c80967c672ad498e5d4656ba1a2065bf8886a1e8ebe98bb7b6ef253%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1038592067&rft_id=info:pmid/22953038&rfr_iscdi=true