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Age and Breeding Effort as Sources of Individual Variability in Oxidative Stress Markers in a Bird Species

Oxidative stress is the imbalance between the production of pro‐oxidant substances and the level of antioxidant defenses, which leads to oxidative damage. It has been proposed that senescence is the result of accumulated oxidative damage throughout life. In birds, the sources of individual variabili...

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Published in:	Physiological and biochemical zoology 2010-01, Vol.83 (1), p.110-118
Main Authors:	Alonso‐Álvarez, Carlos, Pérez‐Rodríguez, Lorenzo, García, Jesus T., Viñuela, Javier, Mateo, Rafael
Format:	Article
Language:	English
Subjects:	Age Age Factors Aging - physiology Animals Antioxidants Aviculture Birds Blood plasma Carotenoids Carotenoids - blood Cross-Sectional Studies Erythrocytes Erythrocytes - metabolism Female Galliformes - blood Galliformes - physiology Glutathione Disulfide - blood Linear Models Lipid Peroxides - blood Lipids Male Oviposition - physiology Oxidative stress Oxidative Stress - physiology Reproduction - physiology Uric acid Uric Acid - blood
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cited_by	cdi_FETCH-LOGICAL-c400t-a9df36ac446b13296b79b69f3c2d658df2a8a71ee59a24fda883c8749a7d39323
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container_title	Physiological and biochemical zoology
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creator	Alonso‐Álvarez, Carlos Pérez‐Rodríguez, Lorenzo García, Jesus T. Viñuela, Javier Mateo, Rafael
description	Oxidative stress is the imbalance between the production of pro‐oxidant substances and the level of antioxidant defenses, which leads to oxidative damage. It has been proposed that senescence is the result of accumulated oxidative damage throughout life. In birds, the sources of individual variability in oxidative stress are still poorly understood. Among these sources, age, as related to senescence, should be particularly relevant. Furthermore, recent findings suggest that breeding effort may also deeply influence susceptibility to oxidative stress. However, there is still no evidence of a link between breeding effort and oxidative damage in any vertebrate. Here we analyzed 288 captive red‐legged partridges (Alectoris rufa) across a wide age range (i.e., 1–8 yr old), thus including potentially senescent birds. In spite of limitations due to the cross‐sectional approach, results revealed that old birds produced less offspring and endured higher levels of oxidized glutathione and peroxidized lipids in erythrocytes than did middle‐aged individuals. Old birds also showed higher plasma total antioxidant status and uric acid levels than did younger birds, but lower amounts of circulating carotenoids. Furthermore, hatching success was negatively correlated to lipid peroxidation in females but not in males, supporting the hypothesis that breeding effort promotes oxidative damage.
doi_str_mv	10.1086/605395
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It has been proposed that senescence is the result of accumulated oxidative damage throughout life. In birds, the sources of individual variability in oxidative stress are still poorly understood. Among these sources, age, as related to senescence, should be particularly relevant. Furthermore, recent findings suggest that breeding effort may also deeply influence susceptibility to oxidative stress. However, there is still no evidence of a link between breeding effort and oxidative damage in any vertebrate. Here we analyzed 288 captive red‐legged partridges (Alectoris rufa) across a wide age range (i.e., 1–8 yr old), thus including potentially senescent birds. In spite of limitations due to the cross‐sectional approach, results revealed that old birds produced less offspring and endured higher levels of oxidized glutathione and peroxidized lipids in erythrocytes than did middle‐aged individuals. 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Furthermore, hatching success was negatively correlated to lipid peroxidation in females but not in males, supporting the hypothesis that breeding effort promotes oxidative damage.</description><subject>Age</subject><subject>Age Factors</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Aviculture</subject><subject>Birds</subject><subject>Blood plasma</subject><subject>Carotenoids</subject><subject>Carotenoids - blood</subject><subject>Cross-Sectional Studies</subject><subject>Erythrocytes</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Galliformes - blood</subject><subject>Galliformes - physiology</subject><subject>Glutathione Disulfide - blood</subject><subject>Linear Models</subject><subject>Lipid Peroxides - blood</subject><subject>Lipids</subject><subject>Male</subject><subject>Oviposition - physiology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Reproduction - physiology</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><issn>1522-2152</issn><issn>1537-5293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkEtLxDAQx4MoPlb9CBJQ1Es1j75yVPEFiodVr2WaTNas3bYmrei3t0sXPAleZgbmx5-ZHyH7nJ1xlqfnKUukStbINk9kFiVCyfXlLEQkhrpFdkKYM8Z5ztQm2eJKCSHybJvML2ZIoTb00iMaV8_otbWN7ygEOm16rzHQxtL72rhPZ3qo6Ct4B6WrXPdNXU2fvpyBzn0inXYeQ6CP4N_Rh-UO6KXzhk5b1A7DLtmwUAXcW_UJebm5fr66ix6ebu-vLh4iHTPWRaCMlSnoOE5LLoVKy0yVqbJSC5MmubECcsg4YqJAxNZAnkudZ7GCzEglhZyQkzG39c1Hj6ErFi5orCqoselDkUmZqTQRciCPR1L7JgSPtmi9W4D_LjgrllqLUesAHqwi-3KB5hdbeRyAoxHo9ZvTMGvapYtiPhish19_c07_gRXtYGBCDkd0HrrG_3XYD6qVl4E</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Alonso‐Álvarez, Carlos</creator><creator>Pérez‐Rodríguez, Lorenzo</creator><creator>García, Jesus T.</creator><creator>Viñuela, Javier</creator><creator>Mateo, Rafael</creator><general>The University of Chicago Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Age and Breeding Effort as Sources of Individual Variability in Oxidative Stress Markers in a Bird Species</title><author>Alonso‐Álvarez, Carlos ; 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subjects	Age Age Factors Aging - physiology Animals Antioxidants Aviculture Birds Blood plasma Carotenoids Carotenoids - blood Cross-Sectional Studies Erythrocytes Erythrocytes - metabolism Female Galliformes - blood Galliformes - physiology Glutathione Disulfide - blood Linear Models Lipid Peroxides - blood Lipids Male Oviposition - physiology Oxidative stress Oxidative Stress - physiology Reproduction - physiology Uric acid Uric Acid - blood
title	Age and Breeding Effort as Sources of Individual Variability in Oxidative Stress Markers in a Bird Species
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