TERBUTALINE IMPROVES ISCHEMIA-REPERFUSION INJURY AFTER LEFT-SIDED ORTHOTOPIC RAT LUNG TRANSPLANTATION

β2-Agonists have been shown to increase alveolar fluid reabsorption, and at least part of their effect depends on active sodium transport from the alveolus into the epithelial cell by the amiloride-sensitive epithelial sodium channel (ENaC). Few data exist on their effect in the injured lung. The au...

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Bibliographic Details
Published in:Experimental lung research 2009-01, Vol.35 (3), p.175-185
Main Authors: Hamacher, Jürg, Lucas, Rudolf, Stammberger, Uz, Wendel, Albrecht
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - pharmacology
Adrenergic beta-Agonists - therapeutic use
Animals
Biological Transport
Female
lung injury
lung transplantation
Lung Transplantation - adverse effects
Oxygen - metabolism
Pulmonary Alveoli - metabolism
pulmonary edema
rat
Rats
Rats, Wistar
reperfusion injury
Reperfusion Injury - drug therapy
Sodium - metabolism
terbutaline
Terbutaline - pharmacology
Terbutaline - therapeutic use
therapeutics
Treatment Outcome
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Summary:β2-Agonists have been shown to increase alveolar fluid reabsorption, and at least part of their effect depends on active sodium transport from the alveolus into the epithelial cell by the amiloride-sensitive epithelial sodium channel (ENaC). Few data exist on their effect in the injured lung. The authors therefore investigated the effect of intrabronchially administered terbutaline pretransplantation by measuring outcome 1 day after experimental donor lung transplantation with severe injury due to prolonged ischemia. Orthotopic single left-sided lung allotransplantation was performed in female rats (Wistar to Wistar) after a total ischemic time of 20 hours. Graft PaO2/FiO2 in 6 recipients treated with 10−4 M terbutaline in 500 μ L NaCl 0.9% was superior 24 hours after transplantation, with a PaO2 of 329 (111 [SD]) mm Hg versus 5 vehicle controls with 44 (15) mm Hg (P =. 002). The beneficial effect of 10−4 M terbutaline was abrogated by 10−4 M of the sodium channel blocker amiloride to 71 (34) mm Hg in 3 recipients (P =. 028 versus terbutaline 10−4 M). Ten recipients receiving 10−5 M terbutaline in 500 μ L NaCl 0.9% showed inconsistent improvements of gas exchange, with a PaO2 of 158 (± 153) mm Hg (P =. 058). Terbutaline at a high dose significantly improved the transplanted rat lung function at 24 hours after transplantation. Part of it may be via activating epithelial sodium transport, thus suggesting an important role of alveolar fluid transport in such a model of acute lung injury.
ISSN:0190-2148
1521-0499
DOI:10.1080/01902140802488446