Loading…
Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype
Although chronic nicotine produces dependence in mice, the role of specific nicotinic receptors has not been examined in knockout animals. The present study utilized alpha7 nicotinic receptor knockout mice to explore the role of this receptor subunit in nicotine dependence. Mice were chronically exp...
Saved in:
| Published in: | European journal of pharmacology 2005-05, Vol.515 (1-3), p.90 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | |
| container_issue | 1-3 |
| container_start_page | 90 |
| container_title | European journal of pharmacology |
| container_volume | 515 |
| creator | Grabus, Sheri D Martin, Billy R Imad Damaj, M |
| description | Although chronic nicotine produces dependence in mice, the role of specific nicotinic receptors has not been examined in knockout animals. The present study utilized alpha7 nicotinic receptor knockout mice to explore the role of this receptor subunit in nicotine dependence. Mice were chronically exposed to nicotine (0 or 200 microg/ml) in their drinking water and assayed for somatic withdrawal signs, hyperalgesia (tail-flick and hot-plate) and spontaneous activity following nicotine cessation. Nicotine withdrawal produced increased somatic signs in both strains and hyperalgesia in wild-type, but not in knockout animals. These results indicate that the alpha7 nicotinic receptor subunit may mediate some aspects of nicotine dependence. |
| format | article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_15896732</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15896732</sourcerecordid><originalsourceid>FETCH-LOGICAL-p542-4aa3db926680e91d9aa7ae58c0a4035a2e26792e46d727be3e0aedeb952c10c43</originalsourceid><addsrcrecordid>eNo1j9tKxDAURYMoTh39BckPFHJtGt9k8DIw6Mu8l9PkDI20aWjagf694ujTZrFgwb4iBa-NLZnh4poUjHFVCmvthtzl_MUY01boW7LhuraVkaIgzUdw4xwi0tStOTjoqceE0WN0SEOkc4d0GJeMTz90HvszDhhnOp5-DfSpA0PjJRIcndBhmseJ5qWd14T35OYEfcaHv92S4-vLcfdeHj7f9rvnQ5m0EqUCkL61oqpqhpZ7C2AAde0YKCY1CBSVsQJV5Y0wLUpkgB5bq4XjzCm5JY-XbFraAX2TpjDAtDb_R-U3AGRR6A</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype</title><source>ScienceDirect Journals</source><creator>Grabus, Sheri D ; Martin, Billy R ; Imad Damaj, M</creator><creatorcontrib>Grabus, Sheri D ; Martin, Billy R ; Imad Damaj, M</creatorcontrib><description>Although chronic nicotine produces dependence in mice, the role of specific nicotinic receptors has not been examined in knockout animals. The present study utilized alpha7 nicotinic receptor knockout mice to explore the role of this receptor subunit in nicotine dependence. Mice were chronically exposed to nicotine (0 or 200 microg/ml) in their drinking water and assayed for somatic withdrawal signs, hyperalgesia (tail-flick and hot-plate) and spontaneous activity following nicotine cessation. Nicotine withdrawal produced increased somatic signs in both strains and hyperalgesia in wild-type, but not in knockout animals. These results indicate that the alpha7 nicotinic receptor subunit may mediate some aspects of nicotine dependence.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>PMID: 15896732</identifier><language>eng</language><publisher>Netherlands</publisher><subject>alpha7 Nicotinic Acetylcholine Receptor ; Animals ; Behavior, Animal - drug effects ; Body Weight - drug effects ; Female ; Genotype ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity - drug effects ; Nicotine - administration & dosage ; Nicotine - toxicity ; Nicotinic Agonists - administration & dosage ; Nicotinic Agonists - toxicity ; Receptors, Nicotinic - genetics ; Receptors, Nicotinic - physiology ; Substance Withdrawal Syndrome - etiology ; Substance Withdrawal Syndrome - physiopathology ; Substance-Related Disorders ; Time Factors ; Tobacco Use Disorder - etiology ; Tobacco Use Disorder - physiopathology</subject><ispartof>European journal of pharmacology, 2005-05, Vol.515 (1-3), p.90</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15896732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grabus, Sheri D</creatorcontrib><creatorcontrib>Martin, Billy R</creatorcontrib><creatorcontrib>Imad Damaj, M</creatorcontrib><title>Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Although chronic nicotine produces dependence in mice, the role of specific nicotinic receptors has not been examined in knockout animals. The present study utilized alpha7 nicotinic receptor knockout mice to explore the role of this receptor subunit in nicotine dependence. Mice were chronically exposed to nicotine (0 or 200 microg/ml) in their drinking water and assayed for somatic withdrawal signs, hyperalgesia (tail-flick and hot-plate) and spontaneous activity following nicotine cessation. Nicotine withdrawal produced increased somatic signs in both strains and hyperalgesia in wild-type, but not in knockout animals. These results indicate that the alpha7 nicotinic receptor subunit may mediate some aspects of nicotine dependence.</description><subject>alpha7 Nicotinic Acetylcholine Receptor</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Female</subject><subject>Genotype</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Motor Activity - drug effects</subject><subject>Nicotine - administration & dosage</subject><subject>Nicotine - toxicity</subject><subject>Nicotinic Agonists - administration & dosage</subject><subject>Nicotinic Agonists - toxicity</subject><subject>Receptors, Nicotinic - genetics</subject><subject>Receptors, Nicotinic - physiology</subject><subject>Substance Withdrawal Syndrome - etiology</subject><subject>Substance Withdrawal Syndrome - physiopathology</subject><subject>Substance-Related Disorders</subject><subject>Time Factors</subject><subject>Tobacco Use Disorder - etiology</subject><subject>Tobacco Use Disorder - physiopathology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNo1j9tKxDAURYMoTh39BckPFHJtGt9k8DIw6Mu8l9PkDI20aWjagf694ujTZrFgwb4iBa-NLZnh4poUjHFVCmvthtzl_MUY01boW7LhuraVkaIgzUdw4xwi0tStOTjoqceE0WN0SEOkc4d0GJeMTz90HvszDhhnOp5-DfSpA0PjJRIcndBhmseJ5qWd14T35OYEfcaHv92S4-vLcfdeHj7f9rvnQ5m0EqUCkL61oqpqhpZ7C2AAde0YKCY1CBSVsQJV5Y0wLUpkgB5bq4XjzCm5JY-XbFraAX2TpjDAtDb_R-U3AGRR6A</recordid><startdate>20050516</startdate><enddate>20050516</enddate><creator>Grabus, Sheri D</creator><creator>Martin, Billy R</creator><creator>Imad Damaj, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20050516</creationdate><title>Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype</title><author>Grabus, Sheri D ; Martin, Billy R ; Imad Damaj, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p542-4aa3db926680e91d9aa7ae58c0a4035a2e26792e46d727be3e0aedeb952c10c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>alpha7 Nicotinic Acetylcholine Receptor</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Female</topic><topic>Genotype</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Motor Activity - drug effects</topic><topic>Nicotine - administration & dosage</topic><topic>Nicotine - toxicity</topic><topic>Nicotinic Agonists - administration & dosage</topic><topic>Nicotinic Agonists - toxicity</topic><topic>Receptors, Nicotinic - genetics</topic><topic>Receptors, Nicotinic - physiology</topic><topic>Substance Withdrawal Syndrome - etiology</topic><topic>Substance Withdrawal Syndrome - physiopathology</topic><topic>Substance-Related Disorders</topic><topic>Time Factors</topic><topic>Tobacco Use Disorder - etiology</topic><topic>Tobacco Use Disorder - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grabus, Sheri D</creatorcontrib><creatorcontrib>Martin, Billy R</creatorcontrib><creatorcontrib>Imad Damaj, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grabus, Sheri D</au><au>Martin, Billy R</au><au>Imad Damaj, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2005-05-16</date><risdate>2005</risdate><volume>515</volume><issue>1-3</issue><spage>90</spage><pages>90-</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Although chronic nicotine produces dependence in mice, the role of specific nicotinic receptors has not been examined in knockout animals. The present study utilized alpha7 nicotinic receptor knockout mice to explore the role of this receptor subunit in nicotine dependence. Mice were chronically exposed to nicotine (0 or 200 microg/ml) in their drinking water and assayed for somatic withdrawal signs, hyperalgesia (tail-flick and hot-plate) and spontaneous activity following nicotine cessation. Nicotine withdrawal produced increased somatic signs in both strains and hyperalgesia in wild-type, but not in knockout animals. These results indicate that the alpha7 nicotinic receptor subunit may mediate some aspects of nicotine dependence.</abstract><cop>Netherlands</cop><pmid>15896732</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 2005-05, Vol.515 (1-3), p.90 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_pubmed_primary_15896732 |
| source | ScienceDirect Journals |
| subjects | alpha7 Nicotinic Acetylcholine Receptor Animals Behavior, Animal - drug effects Body Weight - drug effects Female Genotype Male Mice Mice, Inbred C57BL Mice, Knockout Motor Activity - drug effects Nicotine - administration & dosage Nicotine - toxicity Nicotinic Agonists - administration & dosage Nicotinic Agonists - toxicity Receptors, Nicotinic - genetics Receptors, Nicotinic - physiology Substance Withdrawal Syndrome - etiology Substance Withdrawal Syndrome - physiopathology Substance-Related Disorders Time Factors Tobacco Use Disorder - etiology Tobacco Use Disorder - physiopathology |
| title | Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T18%3A21%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nicotine%20physical%20dependence%20in%20the%20mouse:%20involvement%20of%20the%20alpha7%20nicotinic%20receptor%20subtype&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Grabus,%20Sheri%20D&rft.date=2005-05-16&rft.volume=515&rft.issue=1-3&rft.spage=90&rft.pages=90-&rft.issn=0014-2999&rft.eissn=1879-0712&rft_id=info:doi/&rft_dat=%3Cpubmed%3E15896732%3C/pubmed%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p542-4aa3db926680e91d9aa7ae58c0a4035a2e26792e46d727be3e0aedeb952c10c43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/15896732&rfr_iscdi=true |