Blockade of noradrenaline re-uptake sites improves accuracy and impulse control in rats performing a five-choice serial reaction time tasks

Rationale Atomoxetine, reboxetine and methylphenidate all act at the noradrenaline transporter (NAT) and atomoxetine and methylphenidate are licensed for the treatment of ADHD. The five-choice serial reaction time task (5CSRTT) provides a valid model to study attention and impulsivity in rodents. St...

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Published in:	Psychopharmacology 2012-01, Vol.219 (2), p.303-312
Main Author:	Robinson, Emma S. J.
Format:	Article
Language:	eng
Subjects:	Adrenergic Uptake Inhibitors - pharmacology Adrenergic Uptake Inhibitors - therapeutic use Animal behavior Animals Animals, Outbred Strains Atomoxetine Hydrochloride Attention Attention - drug effects Attention deficit hyperactivity disorder Biomedical and Life Sciences Biomedicine Choice Behavior - drug effects Data processing Dose-Response Relationship, Drug Drugs impulsive behavior Impulsive Behavior - drug therapy Male Methylphenidate Methylphenidate - pharmacology Methylphenidate - therapeutic use Morpholines - pharmacology Morpholines - therapeutic use Nervous system agents Neurosciences Neurotransmitters Noradrenaline Norepinephrine Original Investigation Pharmacology/Toxicology Phenols Propylamines - pharmacology Propylamines - therapeutic use Psychiatry Psychopharmacology Psychotropic drugs Rats Reaction Time - drug effects Reaction time task reboxetine Rodents Serial Learning - drug effects Time Factors Vitis
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Summary:	Rationale Atomoxetine, reboxetine and methylphenidate all act at the noradrenaline transporter (NAT) and atomoxetine and methylphenidate are licensed for the treatment of ADHD. The five-choice serial reaction time task (5CSRTT) provides a valid model to study attention and impulsivity in rodents. Studies using this task have largely failed to demonstrate improvements in attention with atomoxetine and methylphenidate and reboxetine has not been investigated previously. Objectives The present study used modifications to the standard rat 5CSRTT and demonstrated that blockade of NAT improves attention and reduces premature responding. Methods Rats were trained in a fixed inter-trial interval (ITI), 5CSRTT then tested at baseline and under conditions to acutely challenge attention and/or impulse control following vehicle or atomoxetine (0.3 mg/kg, i.p.). Results Atomoxetine (0.3 mg/kg, i.p.) significantly improved impulse control under all conditions ( p
ISSN:	0033-3158 1432-2072