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Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences
Despite behavioural signs of flattened affect, patients affected by schizophrenia show enhanced sensitivity to negative stimuli. The current literature concerning neural circuitry for emotions supports dysregulations of cortico-limbic networks, but gives contrasting results. Adverse childhood experi...
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| Published in: | Psychological medicine 2011-03, Vol.41 (3), p.509-519 |
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| container_title | Psychological medicine |
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| creator | Benedetti, F. Radaelli, D. Poletti, S. Falini, A. Cavallaro, R. Dallaspezia, S. Riccaboni, R. Scotti, G. Smeraldi, E. |
| description | Despite behavioural signs of flattened affect, patients affected by schizophrenia show enhanced sensitivity to negative stimuli. The current literature concerning neural circuitry for emotions supports dysregulations of cortico-limbic networks, but gives contrasting results. Adverse childhood experiences (ACEs) could persistently influence emotional regulation and neural correlates of response to emotional stimuli in healthy humans. This study evaluated the effect of ACEs and chronic undifferentiated schizophrenia on neural responses to emotional stimuli (negative facial expression).
Brain blood-oxygen-level-dependent functional magnetic resonance imaging neural responses to a face-matching paradigm, and regional grey matter (GM) volumes were studied at 3.0 T in the amygdala, hippocampus, anterior cingulated cortex (ACC) and prefrontal cortex (PFC). The severity of ACEs was assessed. Participants included 20 consecutively admitted in-patients affected by chronic undifferentiated schizophrenia, and 20 unrelated healthy volunteers from the general population.
Patients reported higher ACEs than controls. Worse ACEs proportionally led to decreasing responses in the amygdala and hippocampus, and to increasing responses in the PFC and ACC in all participants. Patients showed higher activations in the amygdala and hippocampus, and lower activations in the PFC and ACC. Higher ACEs were associated with higher GM volumes in the PFC and ACC, and schizophrenia was associated with GM reduction in all studied regions.
Structural and functional brain correlates of emotional reactivity are influenced by both current chronic undifferentiated schizophrenia and the severity of past ACEs. |
| doi_str_mv | 10.1017/S0033291710001108 |
| format | article |
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Brain blood-oxygen-level-dependent functional magnetic resonance imaging neural responses to a face-matching paradigm, and regional grey matter (GM) volumes were studied at 3.0 T in the amygdala, hippocampus, anterior cingulated cortex (ACC) and prefrontal cortex (PFC). The severity of ACEs was assessed. Participants included 20 consecutively admitted in-patients affected by chronic undifferentiated schizophrenia, and 20 unrelated healthy volunteers from the general population.
Patients reported higher ACEs than controls. Worse ACEs proportionally led to decreasing responses in the amygdala and hippocampus, and to increasing responses in the PFC and ACC in all participants. Patients showed higher activations in the amygdala and hippocampus, and lower activations in the PFC and ACC. Higher ACEs were associated with higher GM volumes in the PFC and ACC, and schizophrenia was associated with GM reduction in all studied regions.
Structural and functional brain correlates of emotional reactivity are influenced by both current chronic undifferentiated schizophrenia and the severity of past ACEs.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291710001108</identifier><identifier>PMID: 20529416</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Adult and adolescent clinical studies ; Amygdala - physiopathology ; Biological and medical sciences ; Brain - physiopathology ; Case-Control Studies ; Child development ; Childhood experiences ; Cortex ; Emotions ; Emotions - physiology ; Female ; Genetic engineering ; Gyrus Cinguli - physiopathology ; Hippocampus ; Hippocampus - physiopathology ; Humans ; Life Change Events ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Neuropsychology ; Prefrontal Cortex - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Reactivity ; Schizophrenia ; Schizophrenia - etiology ; Schizophrenia - physiopathology ; Schizophrenic Psychology</subject><ispartof>Psychological medicine, 2011-03, Vol.41 (3), p.509-519</ispartof><rights>Copyright © Cambridge University Press 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-c75064fdd355a50e0d4e216745cd63221d19eb540d5e2914d34965fd69425e5e3</citedby><cites>FETCH-LOGICAL-c465t-c75064fdd355a50e0d4e216745cd63221d19eb540d5e2914d34965fd69425e5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/847536858/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/847536858?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,786,790,12873,21422,21423,27957,27958,31034,31035,33646,33647,34565,34566,43768,44150,73317,74578,74996</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24060417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20529416$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benedetti, F.</creatorcontrib><creatorcontrib>Radaelli, D.</creatorcontrib><creatorcontrib>Poletti, S.</creatorcontrib><creatorcontrib>Falini, A.</creatorcontrib><creatorcontrib>Cavallaro, R.</creatorcontrib><creatorcontrib>Dallaspezia, S.</creatorcontrib><creatorcontrib>Riccaboni, R.</creatorcontrib><creatorcontrib>Scotti, G.</creatorcontrib><creatorcontrib>Smeraldi, E.</creatorcontrib><title>Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences</title><title>Psychological medicine</title><addtitle>Psychol Med</addtitle><description>Despite behavioural signs of flattened affect, patients affected by schizophrenia show enhanced sensitivity to negative stimuli. The current literature concerning neural circuitry for emotions supports dysregulations of cortico-limbic networks, but gives contrasting results. Adverse childhood experiences (ACEs) could persistently influence emotional regulation and neural correlates of response to emotional stimuli in healthy humans. This study evaluated the effect of ACEs and chronic undifferentiated schizophrenia on neural responses to emotional stimuli (negative facial expression).
Brain blood-oxygen-level-dependent functional magnetic resonance imaging neural responses to a face-matching paradigm, and regional grey matter (GM) volumes were studied at 3.0 T in the amygdala, hippocampus, anterior cingulated cortex (ACC) and prefrontal cortex (PFC). The severity of ACEs was assessed. Participants included 20 consecutively admitted in-patients affected by chronic undifferentiated schizophrenia, and 20 unrelated healthy volunteers from the general population.
Patients reported higher ACEs than controls. Worse ACEs proportionally led to decreasing responses in the amygdala and hippocampus, and to increasing responses in the PFC and ACC in all participants. Patients showed higher activations in the amygdala and hippocampus, and lower activations in the PFC and ACC. Higher ACEs were associated with higher GM volumes in the PFC and ACC, and schizophrenia was associated with GM reduction in all studied regions.
Structural and functional brain correlates of emotional reactivity are influenced by both current chronic undifferentiated schizophrenia and the severity of past ACEs.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Amygdala - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain - physiopathology</subject><subject>Case-Control Studies</subject><subject>Child development</subject><subject>Childhood experiences</subject><subject>Cortex</subject><subject>Emotions</subject><subject>Emotions - physiology</subject><subject>Female</subject><subject>Genetic engineering</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Hippocampus</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Life Change Events</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropsychology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. 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The current literature concerning neural circuitry for emotions supports dysregulations of cortico-limbic networks, but gives contrasting results. Adverse childhood experiences (ACEs) could persistently influence emotional regulation and neural correlates of response to emotional stimuli in healthy humans. This study evaluated the effect of ACEs and chronic undifferentiated schizophrenia on neural responses to emotional stimuli (negative facial expression).
Brain blood-oxygen-level-dependent functional magnetic resonance imaging neural responses to a face-matching paradigm, and regional grey matter (GM) volumes were studied at 3.0 T in the amygdala, hippocampus, anterior cingulated cortex (ACC) and prefrontal cortex (PFC). The severity of ACEs was assessed. Participants included 20 consecutively admitted in-patients affected by chronic undifferentiated schizophrenia, and 20 unrelated healthy volunteers from the general population.
Patients reported higher ACEs than controls. Worse ACEs proportionally led to decreasing responses in the amygdala and hippocampus, and to increasing responses in the PFC and ACC in all participants. Patients showed higher activations in the amygdala and hippocampus, and lower activations in the PFC and ACC. Higher ACEs were associated with higher GM volumes in the PFC and ACC, and schizophrenia was associated with GM reduction in all studied regions.
Structural and functional brain correlates of emotional reactivity are influenced by both current chronic undifferentiated schizophrenia and the severity of past ACEs.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>20529416</pmid><doi>10.1017/S0033291710001108</doi><tpages>11</tpages></addata></record> |
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| ispartof | Psychological medicine, 2011-03, Vol.41 (3), p.509-519 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Social Science Premium Collection; Sociology Collection; Cambridge University Press |
| subjects | Adult Adult and adolescent clinical studies Amygdala - physiopathology Biological and medical sciences Brain - physiopathology Case-Control Studies Child development Childhood experiences Cortex Emotions Emotions - physiology Female Genetic engineering Gyrus Cinguli - physiopathology Hippocampus Hippocampus - physiopathology Humans Life Change Events Magnetic Resonance Imaging Male Medical sciences Neuropsychology Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reactivity Schizophrenia Schizophrenia - etiology Schizophrenia - physiopathology Schizophrenic Psychology |
| title | Emotional reactivity in chronic schizophrenia: structural and functional brain correlates and the influence of adverse childhood experiences |
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