Determinants of plasma brain natriuretic peptide levels in untreated hypertensive patients

Background Plasma brain natriuretic peptide (BNP) level is elevated in patients with left ventricular (LV) hypertrophy reflecting not only altered LV geometry but LV systolic and/or diastolic dysfunction. However, the values and limitations of BNP measurements are unclear in patients with untreated...

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Bibliographic Details
Published in:Journal of echocardiography 2011-09, Vol.9 (3), p.103-108
Main Authors: Goda, Akiko, Nakao, Shinji, Tsujino, Takeshi, Yuba, Masao, Otsuka, Misato, Matsumoto, Mika, Yoshida, Chikako, Naito, Yoshiro, Lee-Kawabata, Masaaki, Ohyanagi, Mitsumasa, Masuyama, Tohru
Format: Article
Language:English
Subjects:
Brain natriuretic peptide
Cardiology
Echocardiography
Heart
Hypertension
Hypertrophy
Imaging
Medicine
Medicine & Public Health
Original Investigation
Radiology
Ultrasound
Ventricle
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Summary:Background Plasma brain natriuretic peptide (BNP) level is elevated in patients with left ventricular (LV) hypertrophy reflecting not only altered LV geometry but LV systolic and/or diastolic dysfunction. However, the values and limitations of BNP measurements are unclear in patients with untreated hypertension. In this study, plasma BNP level was compared with LV geometric and functional characteristics in patients with untreated hypertension. Methods Plasma BNP level was measured in 115 patients with untreated hypertension (72 males, 43 females, aged 60 ± 12 years). Routine echo parameters of LV geometry and LV systolic and diastolic performance were also determined. Results LV ejection fraction was 67 ± 6% and plasma BNP level was 32 ± 30 pg/ml. Plasma BNP levels correlated with age, LV mass index (LVMI), and mitral E velocity, respectively ( r  = 0.46, p  
ISSN:1349-0222
1880-344X
DOI:10.1007/s12574-011-0086-9