The role of non-human primates in the neurological safety of live viral vaccines (review)

This review covers comprehensive data accumulated during the long history of using monkeys in the determination of neurovirulence activity and safety of live poliomyelitis, flaviviral, smallpox and mumps vaccines, as well as newly developed transgenic mouse and molecular-biological tests. The review...

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Bibliographic Details
Published in:Biologicals 2011, Vol.39 (1), p.1-8
Main Author: Levenbook, Inessa
Format: Article
Language:English
Subjects:
Alternative infant rodent tests
Animals
Animals, Newborn
Central Nervous System - immunology
Central Nervous System - virology
genetically modified organisms
Haplorhini
Humans
Live viral vaccines
Mice
Models, Animal
Monkey safety tests
monkeys
Poliovirus
Primates
Rats
Vaccination - adverse effects
Vaccination - methods
Vaccines, Attenuated - adverse effects
Vaccines, Attenuated - immunology
viral vaccines
Viral Vaccines - adverse effects
Viral Vaccines - immunology
viruses
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Summary:This review covers comprehensive data accumulated during the long history of using monkeys in the determination of neurovirulence activity and safety of live poliomyelitis, flaviviral, smallpox and mumps vaccines, as well as newly developed transgenic mouse and molecular-biological tests. The review also analyzes processes caused by some of these viruses in infant rodents (mice, rats) and evaluates the role of these processes in vaccine safety control. Recommendations resulting from this analysis are presented.
ISSN:1045-1056
1095-8320
DOI:10.1016/j.biologicals.2010.11.003