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Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial
Objective To evaluate the association of timing of hCG administration and probability of pregnancy in patients stimulated with recombinant FSH/GnRH antagonists for IVF. Design Prospective randomized controlled clinical trial. Setting Dutch-speaking Free University of Brussels. Patient(s) One hundred...
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| Published in: | Fertility and sterility 2011-11, Vol.96 (5), p.1112-1115 |
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| container_title | Fertility and sterility |
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| creator | Kyrou, Dimitra, Ph.D Kolibianakis, Efstratios M., Ph.D Fatemi, Human M., Ph.D Tarlatzis, Basil C., Ph.D Tournaye, Herman, Ph.D Devroey, Paul, Ph.D |
| description | Objective To evaluate the association of timing of hCG administration and probability of pregnancy in patients stimulated with recombinant FSH/GnRH antagonists for IVF. Design Prospective randomized controlled clinical trial. Setting Dutch-speaking Free University of Brussels. Patient(s) One hundred twenty patients, aged |
| doi_str_mv | 10.1016/j.fertnstert.2011.08.029 |
| format | article |
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A prospective randomized trial</title><source>ScienceDirect (Online service)</source><creator>Kyrou, Dimitra, Ph.D ; Kolibianakis, Efstratios M., Ph.D ; Fatemi, Human M., Ph.D ; Tarlatzis, Basil C., Ph.D ; Tournaye, Herman, Ph.D ; Devroey, Paul, Ph.D</creator><creatorcontrib>Kyrou, Dimitra, Ph.D ; Kolibianakis, Efstratios M., Ph.D ; Fatemi, Human M., Ph.D ; Tarlatzis, Basil C., Ph.D ; Tournaye, Herman, Ph.D ; Devroey, Paul, Ph.D</creatorcontrib><description>Objective To evaluate the association of timing of hCG administration and probability of pregnancy in patients stimulated with recombinant FSH/GnRH antagonists for IVF. Design Prospective randomized controlled clinical trial. Setting Dutch-speaking Free University of Brussels. Patient(s) One hundred twenty patients, aged <40 years, treated by IVF or intracytoplasmic sperm injection. Intervention(s) Ovarian stimulation was achieved using recombinant FSH starting on day 2 of the menstrual cycle at a fixed dose. To inhibit premature LH surge, daily GnRH antagonist was used from day 6 of stimulation. Triggering of final oocyte maturation was performed using 10,000 IU of hCG. Patients were randomized to receive hCG either as soon as three or more follicles of size ≥16 mm were present on ultrasonography (early-hCG group) or 1 day after the above criterion was met (late-hCG group). Main Outcome Measure(s) Ongoing pregnancy rate. Result(s) Significant differences were observed between the early-hCG and the late-hCG group regarding E2 (1,388 ± 931 [mean ± SD] vs. 2,040 ± 1,231 pg/mL, respectively) and P (0.8 ± 0.3 vs. 1.1 ± 0.5 ng/mL, respectively) levels on the day of hCG administration and the number of metaphase II oocytes (9.2 ± 7.1 vs. 6.1 ± 4.9, respectively). No significant differences were observed between the early-hCG and the late-hCG group regarding positive hCG (46.2% vs. 50%, respectively) and ongoing pregnancy rates (34.6% vs. 40.7%, respectively). Conclusion(s) The current study provides evidence that earlier administration of hCG is not associated with the probability of pregnancy in cycles stimulated with recombinant FSH and GnRH antagonists.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2011.08.029</identifier><identifier>PMID: 21924414</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject><![CDATA[Adult ; antagonists ; Belgium ; Biological and medical sciences ; Chorionic Gonadotropin - administration & dosage ; clinical trials ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Fertility Agents, Female - administration & dosage ; Fertilization in Vitro ; Follicle Stimulating Hormone, Human - administration & dosage ; follicle-stimulating hormone ; GnRH antagonist ; gonadotropin-releasing hormone ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Gynecology. Andrology. Obstetrics ; hCG administration ; Hormone Antagonists - administration & dosage ; human chorionic gonadotropin ; Humans ; Infertility - diagnostic imaging ; Infertility - physiopathology ; Infertility - therapy ; Internal Medicine ; intracytoplasmic sperm injection ; IVF/ICSI ; luteinizing hormone ; Medical sciences ; menstrual cycle ; metaphase ; Obstetrics and Gynecology ; oocytes ; Ovulation Induction - methods ; patients ; Pilot Projects ; Pregnancy ; Pregnancy Rate ; probability ; Prospective Studies ; Recombinant Proteins - administration & dosage ; Sperm Injections, Intracytoplasmic ; Time Factors ; Treatment Outcome ; Ultrasonography]]></subject><ispartof>Fertility and sterility, 2011-11, Vol.96 (5), p.1112-1115</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2011 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-ac594b7b4b05c380a1ae5ed18486ba87da6a5a6cdd3a0fa2cd0446b3f4cd06523</citedby><cites>FETCH-LOGICAL-c532t-ac594b7b4b05c380a1ae5ed18486ba87da6a5a6cdd3a0fa2cd0446b3f4cd06523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028211024745$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,786,790,3568,27957,27958,45815</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24782461$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21924414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kyrou, Dimitra, Ph.D</creatorcontrib><creatorcontrib>Kolibianakis, Efstratios M., Ph.D</creatorcontrib><creatorcontrib>Fatemi, Human M., Ph.D</creatorcontrib><creatorcontrib>Tarlatzis, Basil C., Ph.D</creatorcontrib><creatorcontrib>Tournaye, Herman, Ph.D</creatorcontrib><creatorcontrib>Devroey, Paul, Ph.D</creatorcontrib><title>Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To evaluate the association of timing of hCG administration and probability of pregnancy in patients stimulated with recombinant FSH/GnRH antagonists for IVF. Design Prospective randomized controlled clinical trial. Setting Dutch-speaking Free University of Brussels. Patient(s) One hundred twenty patients, aged <40 years, treated by IVF or intracytoplasmic sperm injection. Intervention(s) Ovarian stimulation was achieved using recombinant FSH starting on day 2 of the menstrual cycle at a fixed dose. To inhibit premature LH surge, daily GnRH antagonist was used from day 6 of stimulation. Triggering of final oocyte maturation was performed using 10,000 IU of hCG. Patients were randomized to receive hCG either as soon as three or more follicles of size ≥16 mm were present on ultrasonography (early-hCG group) or 1 day after the above criterion was met (late-hCG group). Main Outcome Measure(s) Ongoing pregnancy rate. Result(s) Significant differences were observed between the early-hCG and the late-hCG group regarding E2 (1,388 ± 931 [mean ± SD] vs. 2,040 ± 1,231 pg/mL, respectively) and P (0.8 ± 0.3 vs. 1.1 ± 0.5 ng/mL, respectively) levels on the day of hCG administration and the number of metaphase II oocytes (9.2 ± 7.1 vs. 6.1 ± 4.9, respectively). No significant differences were observed between the early-hCG and the late-hCG group regarding positive hCG (46.2% vs. 50%, respectively) and ongoing pregnancy rates (34.6% vs. 40.7%, respectively). Conclusion(s) The current study provides evidence that earlier administration of hCG is not associated with the probability of pregnancy in cycles stimulated with recombinant FSH and GnRH antagonists.</description><subject>Adult</subject><subject>antagonists</subject><subject>Belgium</subject><subject>Biological and medical sciences</subject><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>clinical trials</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fertility Agents, Female - administration & dosage</subject><subject>Fertilization in Vitro</subject><subject>Follicle Stimulating Hormone, Human - administration & dosage</subject><subject>follicle-stimulating hormone</subject><subject>GnRH antagonist</subject><subject>gonadotropin-releasing hormone</subject><subject>Gonadotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>hCG administration</subject><subject>Hormone Antagonists - administration & dosage</subject><subject>human chorionic gonadotropin</subject><subject>Humans</subject><subject>Infertility - diagnostic imaging</subject><subject>Infertility - physiopathology</subject><subject>Infertility - therapy</subject><subject>Internal Medicine</subject><subject>intracytoplasmic sperm injection</subject><subject>IVF/ICSI</subject><subject>luteinizing hormone</subject><subject>Medical sciences</subject><subject>menstrual cycle</subject><subject>metaphase</subject><subject>Obstetrics and Gynecology</subject><subject>oocytes</subject><subject>Ovulation Induction - methods</subject><subject>patients</subject><subject>Pilot Projects</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>probability</subject><subject>Prospective Studies</subject><subject>Recombinant Proteins - administration & dosage</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ultrasonography</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqNks9u1DAQhwPiT0vhFcAXRDlksR07m72ASgVtpUpIlJ6tiTPZ9ZLYi-0tWp6GZ-HJmGVbCpy4JFH0zcxnz68omOATwUX9ajnpMWafMj0nkgsx4c2Ey9ndYl9oXZe61tW9Yp9zoUsuG7lXPEppyTmvxVQ-LPakmEmlhNq_8-AsMYQ4OIwMutF5l3KE7IJnoWeL9Qie2UWI9MNZNg8eupBjWDnPDhfHJy8ZpBSsg4wd--ryguUFslUMLbRucHlDXX58X0Wce_B2w6jMbuyAiaXsxvVwWxfRhrF1hGXWh2FwRJU3kPNzRhJj8MjAd395lBEHhPQncnjiP56Sms9AJJ0ovWFHW6u0QpvdFbJIXcLovtH0HB0Mj4v7PQwJn1y_D4rL9-8-HZ-W5x9Ozo6PzkurK5lLsHqm2mmrWq5t1XAQgBo70aimbqGZdlCDhtp2XQW8B2k7rlTdVr2ir1rL6qB4setLMl_WmLIZXbI4DOAxrJOZcVFxXSlBZLMjLWmniL1ZRTdC3BjBzTYEZmluQ2C2ITC8MRQCKn16PWTdjtj9LrzZOgHPrwFIFoaebsO6dMupaSNVvXV4tuN6CAbmkZjLC5qkKViyEb_O83ZHIF3aFYXIJOvQW-wcLTSbLrj_8X39TxM7UBDJ7DNuMC3DOnpaihEmScPNxTbW21QLwUlV6eonZkT8_Q</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Kyrou, Dimitra, Ph.D</creator><creator>Kolibianakis, Efstratios M., Ph.D</creator><creator>Fatemi, Human M., Ph.D</creator><creator>Tarlatzis, Basil C., Ph.D</creator><creator>Tournaye, Herman, Ph.D</creator><creator>Devroey, Paul, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial</title><author>Kyrou, Dimitra, Ph.D ; Kolibianakis, Efstratios M., Ph.D ; Fatemi, Human M., Ph.D ; Tarlatzis, Basil C., Ph.D ; Tournaye, Herman, Ph.D ; Devroey, Paul, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-ac594b7b4b05c380a1ae5ed18486ba87da6a5a6cdd3a0fa2cd0446b3f4cd06523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>antagonists</topic><topic>Belgium</topic><topic>Biological and medical sciences</topic><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>clinical trials</topic><topic>Drug Administration Schedule</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Fertility Agents, Female - administration & dosage</topic><topic>Fertilization in Vitro</topic><topic>Follicle Stimulating Hormone, Human - administration & dosage</topic><topic>follicle-stimulating hormone</topic><topic>GnRH antagonist</topic><topic>gonadotropin-releasing hormone</topic><topic>Gonadotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>hCG administration</topic><topic>Hormone Antagonists - administration & dosage</topic><topic>human chorionic gonadotropin</topic><topic>Humans</topic><topic>Infertility - diagnostic imaging</topic><topic>Infertility - physiopathology</topic><topic>Infertility - therapy</topic><topic>Internal Medicine</topic><topic>intracytoplasmic sperm injection</topic><topic>IVF/ICSI</topic><topic>luteinizing hormone</topic><topic>Medical sciences</topic><topic>menstrual cycle</topic><topic>metaphase</topic><topic>Obstetrics and Gynecology</topic><topic>oocytes</topic><topic>Ovulation Induction - methods</topic><topic>patients</topic><topic>Pilot Projects</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>probability</topic><topic>Prospective Studies</topic><topic>Recombinant Proteins - administration & dosage</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kyrou, Dimitra, Ph.D</creatorcontrib><creatorcontrib>Kolibianakis, Efstratios M., Ph.D</creatorcontrib><creatorcontrib>Fatemi, Human M., Ph.D</creatorcontrib><creatorcontrib>Tarlatzis, Basil C., Ph.D</creatorcontrib><creatorcontrib>Tournaye, Herman, Ph.D</creatorcontrib><creatorcontrib>Devroey, Paul, Ph.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kyrou, Dimitra, Ph.D</au><au>Kolibianakis, Efstratios M., Ph.D</au><au>Fatemi, Human M., Ph.D</au><au>Tarlatzis, Basil C., Ph.D</au><au>Tournaye, Herman, Ph.D</au><au>Devroey, Paul, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>96</volume><issue>5</issue><spage>1112</spage><epage>1115</epage><pages>1112-1115</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><notes>http://dx.doi.org/10.1016/j.fertnstert.2011.08.029</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-News-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><abstract>Objective To evaluate the association of timing of hCG administration and probability of pregnancy in patients stimulated with recombinant FSH/GnRH antagonists for IVF. Design Prospective randomized controlled clinical trial. Setting Dutch-speaking Free University of Brussels. Patient(s) One hundred twenty patients, aged <40 years, treated by IVF or intracytoplasmic sperm injection. Intervention(s) Ovarian stimulation was achieved using recombinant FSH starting on day 2 of the menstrual cycle at a fixed dose. To inhibit premature LH surge, daily GnRH antagonist was used from day 6 of stimulation. Triggering of final oocyte maturation was performed using 10,000 IU of hCG. Patients were randomized to receive hCG either as soon as three or more follicles of size ≥16 mm were present on ultrasonography (early-hCG group) or 1 day after the above criterion was met (late-hCG group). Main Outcome Measure(s) Ongoing pregnancy rate. Result(s) Significant differences were observed between the early-hCG and the late-hCG group regarding E2 (1,388 ± 931 [mean ± SD] vs. 2,040 ± 1,231 pg/mL, respectively) and P (0.8 ± 0.3 vs. 1.1 ± 0.5 ng/mL, respectively) levels on the day of hCG administration and the number of metaphase II oocytes (9.2 ± 7.1 vs. 6.1 ± 4.9, respectively). No significant differences were observed between the early-hCG and the late-hCG group regarding positive hCG (46.2% vs. 50%, respectively) and ongoing pregnancy rates (34.6% vs. 40.7%, respectively). Conclusion(s) The current study provides evidence that earlier administration of hCG is not associated with the probability of pregnancy in cycles stimulated with recombinant FSH and GnRH antagonists.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21924414</pmid><doi>10.1016/j.fertnstert.2011.08.029</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 2011-11, Vol.96 (5), p.1112-1115 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | ScienceDirect (Online service) |
| subjects | Adult antagonists Belgium Biological and medical sciences Chorionic Gonadotropin - administration & dosage clinical trials Drug Administration Schedule Drug Therapy, Combination Female Fertility Agents, Female - administration & dosage Fertilization in Vitro Follicle Stimulating Hormone, Human - administration & dosage follicle-stimulating hormone GnRH antagonist gonadotropin-releasing hormone Gonadotropin-Releasing Hormone - antagonists & inhibitors Gynecology. Andrology. Obstetrics hCG administration Hormone Antagonists - administration & dosage human chorionic gonadotropin Humans Infertility - diagnostic imaging Infertility - physiopathology Infertility - therapy Internal Medicine intracytoplasmic sperm injection IVF/ICSI luteinizing hormone Medical sciences menstrual cycle metaphase Obstetrics and Gynecology oocytes Ovulation Induction - methods patients Pilot Projects Pregnancy Pregnancy Rate probability Prospective Studies Recombinant Proteins - administration & dosage Sperm Injections, Intracytoplasmic Time Factors Treatment Outcome Ultrasonography |
| title | Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial |
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