Establishing an experimental model of photodynamically induced anterior ischemic optic neuropathy

Numerous methods and drugs have been used to treat anterior ischemic optic neuropathy (AION); however, further investigations to determine the value of treatments for AION have been impeded by the lack of appropriate animal models of AION, significantly impacting on in-depth study of the disease. A...

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Published in:Visual neuroscience 2011-03, Vol.28 (2), p.155-162
Main Authors: WANG, R.S., LV, P.L., WANG, W.J., WANG, X.D., ZHANG, X.J., LI, S.N., WANG, J.Z., ZENG, Y.J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Disease Models, Animal
Evoked Potentials, Visual - physiology
Eye and associated structures. Visual pathways and centers. Vision
Fluorescein Angiography - methods
Fundamental and applied biological sciences. Psychology
Fundus Oculi
Hematoporphyrins - adverse effects
Lasers - adverse effects
Male
Optic Neuropathy, Ischemic - pathology
Optic Neuropathy, Ischemic - physiopathology
Papilledema - etiology
Photosensitizing Agents - adverse effects
Rats
Rats, Sprague-Dawley
Time Factors
Tomography, Optical Coherence - methods
Vertebrates: nervous system and sense organs
Visual Fields - physiology
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ZENG, Y.J.
description Numerous methods and drugs have been used to treat anterior ischemic optic neuropathy (AION); however, further investigations to determine the value of treatments for AION have been impeded by the lack of appropriate animal models of AION, significantly impacting on in-depth study of the disease. A rat model of AION was established, and corresponding functional changes of the fundus were observed using fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and flash visual-evoked potential (F-VEP) in order to confirm the reliability of the AION model histopathologically. One day after model establishment, histopathology demonstrated that portions of the optic disc were highly edematous, with edema of nerve fibers and loose tissue, accompanied by displacement of the surrounding retina. At 23 days, the optic disc and surrounding nerve fiber layers had become thinner. None of the above-mentioned changes was observed in the laser, hematoporphyrin derivative (HPD), or naive groups. The results of fundus, FFA, F-VEP, and OCT—within 90 days after model establishment—confirmed that krypton red laser irradiation (647 nm), applied 2 h after HPD injection, can establish an ideal animal model of AION.
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Psychology ; Fundus Oculi ; Hematoporphyrins - adverse effects ; Lasers - adverse effects ; Male ; Optic Neuropathy, Ischemic - pathology ; Optic Neuropathy, Ischemic - physiopathology ; Papilledema - etiology ; Photosensitizing Agents - adverse effects ; Rats ; Rats, Sprague-Dawley ; Time Factors ; Tomography, Optical Coherence - methods ; Vertebrates: nervous system and sense organs ; Visual Fields - physiology</subject><ispartof>Visual neuroscience, 2011-03, Vol.28 (2), p.155-162</ispartof><rights>Copyright © Cambridge University Press 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © Cambridge University Press, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-e7f584dba552d821defd1f404fe140cf89bca087bed2b47c347b829909e0aa583</citedby><cites>FETCH-LOGICAL-c499t-e7f584dba552d821defd1f404fe140cf89bca087bed2b47c347b829909e0aa583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0952523810000398/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,73317</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=24105040$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21356144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, R.S.</creatorcontrib><creatorcontrib>LV, P.L.</creatorcontrib><creatorcontrib>WANG, W.J.</creatorcontrib><creatorcontrib>WANG, X.D.</creatorcontrib><creatorcontrib>ZHANG, X.J.</creatorcontrib><creatorcontrib>LI, S.N.</creatorcontrib><creatorcontrib>WANG, J.Z.</creatorcontrib><creatorcontrib>ZENG, Y.J.</creatorcontrib><title>Establishing an experimental model of photodynamically induced anterior ischemic optic neuropathy</title><title>Visual neuroscience</title><addtitle>Vis Neurosci</addtitle><description>Numerous methods and drugs have been used to treat anterior ischemic optic neuropathy (AION); however, further investigations to determine the value of treatments for AION have been impeded by the lack of appropriate animal models of AION, significantly impacting on in-depth study of the disease. 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A rat model of AION was established, and corresponding functional changes of the fundus were observed using fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and flash visual-evoked potential (F-VEP) in order to confirm the reliability of the AION model histopathologically. One day after model establishment, histopathology demonstrated that portions of the optic disc were highly edematous, with edema of nerve fibers and loose tissue, accompanied by displacement of the surrounding retina. At 23 days, the optic disc and surrounding nerve fiber layers had become thinner. None of the above-mentioned changes was observed in the laser, hematoporphyrin derivative (HPD), or naive groups. 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source Cambridge University Press
subjects Animals
Biological and medical sciences
Disease Models, Animal
Evoked Potentials, Visual - physiology
Eye and associated structures. Visual pathways and centers. Vision
Fluorescein Angiography - methods
Fundamental and applied biological sciences. Psychology
Fundus Oculi
Hematoporphyrins - adverse effects
Lasers - adverse effects
Male
Optic Neuropathy, Ischemic - pathology
Optic Neuropathy, Ischemic - physiopathology
Papilledema - etiology
Photosensitizing Agents - adverse effects
Rats
Rats, Sprague-Dawley
Time Factors
Tomography, Optical Coherence - methods
Vertebrates: nervous system and sense organs
Visual Fields - physiology
title Establishing an experimental model of photodynamically induced anterior ischemic optic neuropathy
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