Loading…
Chewing reduces sympathetic nervous response to stress and prevents poststress arrhythmias in rats
Reducing stress is important in preventing sudden death in patients with cardiovascular disease, as stressful events may cause autonomic imbalance and trigger fatal arrhythmias. Since chewing has been shown to inhibit stress-induced neuronal responses in the hypothalamus, we hypothesized that chewin...
Saved in:
| Published in: | American journal of physiology. Heart and circulatory physiology 2011-10, Vol.301 (4), p.H1551-H1558 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c397t-bb9fa854c6afb609a079d2fef87438235bb684405b9f723b3662a0fccafe83b93 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c397t-bb9fa854c6afb609a079d2fef87438235bb684405b9f723b3662a0fccafe83b93 |
| container_end_page | H1558 |
| container_issue | 4 |
| container_start_page | H1551 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 301 |
| creator | Koizumi, So Minamisawa, Susumu Sasaguri, Kenichi Onozuka, Minoru Sato, Sadao Ono, Yumie |
| description | Reducing stress is important in preventing sudden death in patients with cardiovascular disease, as stressful events may cause autonomic imbalance and trigger fatal arrhythmias. Since chewing has been shown to inhibit stress-induced neuronal responses in the hypothalamus, we hypothesized that chewing could ameliorate stress-induced autonomic imbalance and prevent arrhythmias. To test this hypothesis, we analyzed changes in radiotelemetered electrocardiograms in rats that were allowed to chew a wooden stick during a 1-h period of immobilization stress. Chewing significantly reduced the occurrence of ventricular premature beats (VPBs) and complex ventricular ectopy after immobilization and prevented stress-induced prolongation of the QT interval of VPBs throughout the 10-h experimental period. It also prevented prolongation of the QRS complex and fluctuations in the QT interval in normal sinus rhythm beats preceding VPBs during both immobilization and in the poststress period. Fast Fourier transform-based spectral analysis of heart-rate variability further showed that chewing significantly inhibited the stress-induced increase in the power ratio of low-to-high frequency activity (LF/HF: a marker of sympathetic activity) during immobilization and in addition was associated with blunting of the stress-induced increase in plasma noradrenaline observed at the termination of immobilization. Similar suppressive effects on the occurrence of VPBs and the LF/HF were observed in rats that were administered the β-adrenergic blocker propranolol before immobilization. These results indicate that chewing can ameliorate sympathetic hyperactivity during stress and prevent poststress arrhythmias and suggest that chewing may provide a nonpharmacological and cost-effective treatment option for patients with a high risk of stress-induced fatal arrhythmia. |
| doi_str_mv | 10.1152/ajpheart.01224.2010 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_895854574</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2491051241</sourcerecordid><originalsourceid>FETCH-LOGICAL-c397t-bb9fa854c6afb609a079d2fef87438235bb684405b9f723b3662a0fccafe83b93</originalsourceid><addsrcrecordid>eNpdkctOwzAQRS0EoqXwBUjIYsMqxY_YSZao4iVVYgPryE4mJFXzwOMU9e9xacsCb0b2PXM1nkvINWdzzpW4N6uhBuP8nHEh4rlgnJ2QaVBExJXMTsmUSS0jzaWakAvEFWNMJVqek4ngqeBJKqfELmr4brpP6qAcC0CK23YwvgbfFLQDt-lHDBoOfYdAfU_RhxtS05V0cLCBziMdevTHd-fqra_bxiBtOuqMx0tyVpk1wtWhzsjH0-P74iVavj2_Lh6WUSGzxEfWZpVJVVxoU1nNMsOSrBQVVGkSy1RIZa1O45ipwCVCWqm1MKwqClNBKm0mZ-Ru7zu4_msE9HnbYAHrtekg_CJPMxXsVXCbkdt_5KofXReGC1CmVTgyQHIPFa5HdFDlg2ta47Y5Z_kugPwYQP4bQL4LIHTdHKxH20L513PcuPwByO-Fxw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>899655553</pqid></control><display><type>article</type><title>Chewing reduces sympathetic nervous response to stress and prevents poststress arrhythmias in rats</title><source>American Physiological Society Free</source><creator>Koizumi, So ; Minamisawa, Susumu ; Sasaguri, Kenichi ; Onozuka, Minoru ; Sato, Sadao ; Ono, Yumie</creator><creatorcontrib>Koizumi, So ; Minamisawa, Susumu ; Sasaguri, Kenichi ; Onozuka, Minoru ; Sato, Sadao ; Ono, Yumie</creatorcontrib><description>Reducing stress is important in preventing sudden death in patients with cardiovascular disease, as stressful events may cause autonomic imbalance and trigger fatal arrhythmias. Since chewing has been shown to inhibit stress-induced neuronal responses in the hypothalamus, we hypothesized that chewing could ameliorate stress-induced autonomic imbalance and prevent arrhythmias. To test this hypothesis, we analyzed changes in radiotelemetered electrocardiograms in rats that were allowed to chew a wooden stick during a 1-h period of immobilization stress. Chewing significantly reduced the occurrence of ventricular premature beats (VPBs) and complex ventricular ectopy after immobilization and prevented stress-induced prolongation of the QT interval of VPBs throughout the 10-h experimental period. It also prevented prolongation of the QRS complex and fluctuations in the QT interval in normal sinus rhythm beats preceding VPBs during both immobilization and in the poststress period. Fast Fourier transform-based spectral analysis of heart-rate variability further showed that chewing significantly inhibited the stress-induced increase in the power ratio of low-to-high frequency activity (LF/HF: a marker of sympathetic activity) during immobilization and in addition was associated with blunting of the stress-induced increase in plasma noradrenaline observed at the termination of immobilization. Similar suppressive effects on the occurrence of VPBs and the LF/HF were observed in rats that were administered the β-adrenergic blocker propranolol before immobilization. These results indicate that chewing can ameliorate sympathetic hyperactivity during stress and prevent poststress arrhythmias and suggest that chewing may provide a nonpharmacological and cost-effective treatment option for patients with a high risk of stress-induced fatal arrhythmia.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.01224.2010</identifier><identifier>PMID: 21821783</identifier><identifier>CODEN: AJPPDI</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Animals ; Arrhythmias, Cardiac - prevention & control ; Brain ; Cardiac arrhythmia ; Cardiovascular disease ; Catecholamines - blood ; Electrocardiography - drug effects ; Heart Rate - drug effects ; Heart Rate - physiology ; Male ; Mastication - physiology ; Neurons ; Parasympathetic Nervous System - physiology ; Physiology ; Propranolol - pharmacology ; Rats ; Rats, Sprague-Dawley ; Restraint, Physical ; Rodents ; Stress, Psychological - complications ; Stress, Psychological - physiopathology ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiopathology ; Telemetry ; Ventricular Premature Complexes - prevention & control</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2011-10, Vol.301 (4), p.H1551-H1558</ispartof><rights>Copyright American Physiological Society Oct 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-bb9fa854c6afb609a079d2fef87438235bb684405b9f723b3662a0fccafe83b93</citedby><cites>FETCH-LOGICAL-c397t-bb9fa854c6afb609a079d2fef87438235bb684405b9f723b3662a0fccafe83b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21821783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koizumi, So</creatorcontrib><creatorcontrib>Minamisawa, Susumu</creatorcontrib><creatorcontrib>Sasaguri, Kenichi</creatorcontrib><creatorcontrib>Onozuka, Minoru</creatorcontrib><creatorcontrib>Sato, Sadao</creatorcontrib><creatorcontrib>Ono, Yumie</creatorcontrib><title>Chewing reduces sympathetic nervous response to stress and prevents poststress arrhythmias in rats</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>Reducing stress is important in preventing sudden death in patients with cardiovascular disease, as stressful events may cause autonomic imbalance and trigger fatal arrhythmias. Since chewing has been shown to inhibit stress-induced neuronal responses in the hypothalamus, we hypothesized that chewing could ameliorate stress-induced autonomic imbalance and prevent arrhythmias. To test this hypothesis, we analyzed changes in radiotelemetered electrocardiograms in rats that were allowed to chew a wooden stick during a 1-h period of immobilization stress. Chewing significantly reduced the occurrence of ventricular premature beats (VPBs) and complex ventricular ectopy after immobilization and prevented stress-induced prolongation of the QT interval of VPBs throughout the 10-h experimental period. It also prevented prolongation of the QRS complex and fluctuations in the QT interval in normal sinus rhythm beats preceding VPBs during both immobilization and in the poststress period. Fast Fourier transform-based spectral analysis of heart-rate variability further showed that chewing significantly inhibited the stress-induced increase in the power ratio of low-to-high frequency activity (LF/HF: a marker of sympathetic activity) during immobilization and in addition was associated with blunting of the stress-induced increase in plasma noradrenaline observed at the termination of immobilization. Similar suppressive effects on the occurrence of VPBs and the LF/HF were observed in rats that were administered the β-adrenergic blocker propranolol before immobilization. These results indicate that chewing can ameliorate sympathetic hyperactivity during stress and prevent poststress arrhythmias and suggest that chewing may provide a nonpharmacological and cost-effective treatment option for patients with a high risk of stress-induced fatal arrhythmia.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Arrhythmias, Cardiac - prevention & control</subject><subject>Brain</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Catecholamines - blood</subject><subject>Electrocardiography - drug effects</subject><subject>Heart Rate - drug effects</subject><subject>Heart Rate - physiology</subject><subject>Male</subject><subject>Mastication - physiology</subject><subject>Neurons</subject><subject>Parasympathetic Nervous System - physiology</subject><subject>Physiology</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Restraint, Physical</subject><subject>Rodents</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - physiopathology</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Telemetry</subject><subject>Ventricular Premature Complexes - prevention & control</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpdkctOwzAQRS0EoqXwBUjIYsMqxY_YSZao4iVVYgPryE4mJFXzwOMU9e9xacsCb0b2PXM1nkvINWdzzpW4N6uhBuP8nHEh4rlgnJ2QaVBExJXMTsmUSS0jzaWakAvEFWNMJVqek4ngqeBJKqfELmr4brpP6qAcC0CK23YwvgbfFLQDt-lHDBoOfYdAfU_RhxtS05V0cLCBziMdevTHd-fqra_bxiBtOuqMx0tyVpk1wtWhzsjH0-P74iVavj2_Lh6WUSGzxEfWZpVJVVxoU1nNMsOSrBQVVGkSy1RIZa1O45ipwCVCWqm1MKwqClNBKm0mZ-Ru7zu4_msE9HnbYAHrtekg_CJPMxXsVXCbkdt_5KofXReGC1CmVTgyQHIPFa5HdFDlg2ta47Y5Z_kugPwYQP4bQL4LIHTdHKxH20L513PcuPwByO-Fxw</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Koizumi, So</creator><creator>Minamisawa, Susumu</creator><creator>Sasaguri, Kenichi</creator><creator>Onozuka, Minoru</creator><creator>Sato, Sadao</creator><creator>Ono, Yumie</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Chewing reduces sympathetic nervous response to stress and prevents poststress arrhythmias in rats</title><author>Koizumi, So ; Minamisawa, Susumu ; Sasaguri, Kenichi ; Onozuka, Minoru ; Sato, Sadao ; Ono, Yumie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-bb9fa854c6afb609a079d2fef87438235bb684405b9f723b3662a0fccafe83b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Arrhythmias, Cardiac - prevention & control</topic><topic>Brain</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Catecholamines - blood</topic><topic>Electrocardiography - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>Heart Rate - physiology</topic><topic>Male</topic><topic>Mastication - physiology</topic><topic>Neurons</topic><topic>Parasympathetic Nervous System - physiology</topic><topic>Physiology</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Restraint, Physical</topic><topic>Rodents</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - physiopathology</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Telemetry</topic><topic>Ventricular Premature Complexes - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koizumi, So</creatorcontrib><creatorcontrib>Minamisawa, Susumu</creatorcontrib><creatorcontrib>Sasaguri, Kenichi</creatorcontrib><creatorcontrib>Onozuka, Minoru</creatorcontrib><creatorcontrib>Sato, Sadao</creatorcontrib><creatorcontrib>Ono, Yumie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koizumi, So</au><au>Minamisawa, Susumu</au><au>Sasaguri, Kenichi</au><au>Onozuka, Minoru</au><au>Sato, Sadao</au><au>Ono, Yumie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chewing reduces sympathetic nervous response to stress and prevents poststress arrhythmias in rats</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>301</volume><issue>4</issue><spage>H1551</spage><epage>H1558</epage><pages>H1551-H1558</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><coden>AJPPDI</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Reducing stress is important in preventing sudden death in patients with cardiovascular disease, as stressful events may cause autonomic imbalance and trigger fatal arrhythmias. Since chewing has been shown to inhibit stress-induced neuronal responses in the hypothalamus, we hypothesized that chewing could ameliorate stress-induced autonomic imbalance and prevent arrhythmias. To test this hypothesis, we analyzed changes in radiotelemetered electrocardiograms in rats that were allowed to chew a wooden stick during a 1-h period of immobilization stress. Chewing significantly reduced the occurrence of ventricular premature beats (VPBs) and complex ventricular ectopy after immobilization and prevented stress-induced prolongation of the QT interval of VPBs throughout the 10-h experimental period. It also prevented prolongation of the QRS complex and fluctuations in the QT interval in normal sinus rhythm beats preceding VPBs during both immobilization and in the poststress period. Fast Fourier transform-based spectral analysis of heart-rate variability further showed that chewing significantly inhibited the stress-induced increase in the power ratio of low-to-high frequency activity (LF/HF: a marker of sympathetic activity) during immobilization and in addition was associated with blunting of the stress-induced increase in plasma noradrenaline observed at the termination of immobilization. Similar suppressive effects on the occurrence of VPBs and the LF/HF were observed in rats that were administered the β-adrenergic blocker propranolol before immobilization. These results indicate that chewing can ameliorate sympathetic hyperactivity during stress and prevent poststress arrhythmias and suggest that chewing may provide a nonpharmacological and cost-effective treatment option for patients with a high risk of stress-induced fatal arrhythmia.</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>21821783</pmid><doi>10.1152/ajpheart.01224.2010</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2011-10, Vol.301 (4), p.H1551-H1558 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_895854574 |
| source | American Physiological Society Free |
| subjects | Adrenergic beta-Antagonists - pharmacology Animals Arrhythmias, Cardiac - prevention & control Brain Cardiac arrhythmia Cardiovascular disease Catecholamines - blood Electrocardiography - drug effects Heart Rate - drug effects Heart Rate - physiology Male Mastication - physiology Neurons Parasympathetic Nervous System - physiology Physiology Propranolol - pharmacology Rats Rats, Sprague-Dawley Restraint, Physical Rodents Stress, Psychological - complications Stress, Psychological - physiopathology Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology Telemetry Ventricular Premature Complexes - prevention & control |
| title | Chewing reduces sympathetic nervous response to stress and prevents poststress arrhythmias in rats |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-28T23%3A29%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chewing%20reduces%20sympathetic%20nervous%20response%20to%20stress%20and%20prevents%20poststress%20arrhythmias%20in%20rats&rft.jtitle=American%20journal%20of%20physiology.%20Heart%20and%20circulatory%20physiology&rft.au=Koizumi,%20So&rft.date=2011-10&rft.volume=301&rft.issue=4&rft.spage=H1551&rft.epage=H1558&rft.pages=H1551-H1558&rft.issn=0363-6135&rft.eissn=1522-1539&rft.coden=AJPPDI&rft_id=info:doi/10.1152/ajpheart.01224.2010&rft_dat=%3Cproquest_cross%3E2491051241%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c397t-bb9fa854c6afb609a079d2fef87438235bb684405b9f723b3662a0fccafe83b93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=899655553&rft_id=info:pmid/21821783&rfr_iscdi=true |