Determination of the elastic modulus of ascending thoracic aortic aneurysm at different ranges of pressure using uniaxial tensile testing

Objective The purpose of this study is to provide measurements of the elastic modulus of the aortic wall of ascending thoracic aortic aneurysms for different ranges of pressure (physiologic, hypertensive). In addition, pre-failure stress, taken as the peak stress obtained before specimen failure, wa...

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Published in:The Journal of thoracic and cardiovascular surgery 2011-09, Vol.142 (3), p.682-686
Main Authors: Khanafer, Khalil, PhD, Duprey, Ambroise, MD, Zainal, Mohammad, PhD, Schlicht, Marty, PhD, Williams, David, MD, Berguer, Ramon, PhD, MD
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Aorta, Thoracic - physiopathology
Aortic Aneurysm, Thoracic - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiothoracic Surgery
Diseases of the aorta
Elasticity
Female
Humans
Male
Medical sciences
Middle Aged
Models, Cardiovascular
Pneumology
Pressure
Stress, Mechanical
Tensile Strength
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cited_by cdi_FETCH-LOGICAL-c554t-f6358d3b96ac00385d8da397e168e1c695300dc66e3c678b62ab6d5cabda539b3
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container_title The Journal of thoracic and cardiovascular surgery
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Duprey, Ambroise, MD
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Schlicht, Marty, PhD
Williams, David, MD
Berguer, Ramon, PhD, MD
description Objective The purpose of this study is to provide measurements of the elastic modulus of the aortic wall of ascending thoracic aortic aneurysms for different ranges of pressure (physiologic, hypertensive). In addition, pre-failure stress, taken as the peak stress obtained before specimen failure, was recorded for each test. Methods Ninety-seven aortic samples freshly excised from 13 patients with ascending thoracic aortic aneurysms were obtained from greater and lesser curvatures and tested uniaxially in circumferential and longitudinal orientations. Results The maximum elastic moduli, overall, and particularly in the lesser curvature were significantly higher in the circumferential orientation (9.19 MPa) than in the longitudinal (3.13 MPa). Results of peak stress showed positive correlation with maximum elastic modulus and inverse correlation with tissue wall thickness. Conclusions This study provides new data on the elastic modulus in the physiologic and hypertensive range that can be used in computational analysis and the design of bench-top models. The accuracy of computational analysis and bench-top models strongly depends on the knowledge of the elastic properties of the aortic wall. The mechanical properties presented in this study, with specific values for 2 locations (greater and lesser curvature) and 2 directions (circumferential, longitudinal), will increase our understanding of the mechanisms that precede rupture of an ascending aortic aneurysm.
doi_str_mv 10.1016/j.jtcvs.2010.09.068
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In addition, pre-failure stress, taken as the peak stress obtained before specimen failure, was recorded for each test. Methods Ninety-seven aortic samples freshly excised from 13 patients with ascending thoracic aortic aneurysms were obtained from greater and lesser curvatures and tested uniaxially in circumferential and longitudinal orientations. Results The maximum elastic moduli, overall, and particularly in the lesser curvature were significantly higher in the circumferential orientation (9.19 MPa) than in the longitudinal (3.13 MPa). Results of peak stress showed positive correlation with maximum elastic modulus and inverse correlation with tissue wall thickness. Conclusions This study provides new data on the elastic modulus in the physiologic and hypertensive range that can be used in computational analysis and the design of bench-top models. The accuracy of computational analysis and bench-top models strongly depends on the knowledge of the elastic properties of the aortic wall. The mechanical properties presented in this study, with specific values for 2 locations (greater and lesser curvature) and 2 directions (circumferential, longitudinal), will increase our understanding of the mechanisms that precede rupture of an ascending aortic aneurysm.</description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1016/j.jtcvs.2010.09.068</identifier><identifier>PMID: 21616506</identifier><identifier>CODEN: JTCSAQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Aorta, Thoracic - physiopathology ; Aortic Aneurysm, Thoracic - physiopathology ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiothoracic Surgery ; Diseases of the aorta ; Elasticity ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Models, Cardiovascular ; Pneumology ; Pressure ; Stress, Mechanical ; Tensile Strength</subject><ispartof>The Journal of thoracic and cardiovascular surgery, 2011-09, Vol.142 (3), p.682-686</ispartof><rights>The American Association for Thoracic Surgery</rights><rights>2011 The American Association for Thoracic Surgery</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. 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In addition, pre-failure stress, taken as the peak stress obtained before specimen failure, was recorded for each test. Methods Ninety-seven aortic samples freshly excised from 13 patients with ascending thoracic aortic aneurysms were obtained from greater and lesser curvatures and tested uniaxially in circumferential and longitudinal orientations. Results The maximum elastic moduli, overall, and particularly in the lesser curvature were significantly higher in the circumferential orientation (9.19 MPa) than in the longitudinal (3.13 MPa). Results of peak stress showed positive correlation with maximum elastic modulus and inverse correlation with tissue wall thickness. Conclusions This study provides new data on the elastic modulus in the physiologic and hypertensive range that can be used in computational analysis and the design of bench-top models. The accuracy of computational analysis and bench-top models strongly depends on the knowledge of the elastic properties of the aortic wall. The mechanical properties presented in this study, with specific values for 2 locations (greater and lesser curvature) and 2 directions (circumferential, longitudinal), will increase our understanding of the mechanisms that precede rupture of an ascending aortic aneurysm.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Aorta, Thoracic - physiopathology</subject><subject>Aortic Aneurysm, Thoracic - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiothoracic Surgery</subject><subject>Diseases of the aorta</subject><subject>Elasticity</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Models, Cardiovascular</subject><subject>Pneumology</subject><subject>Pressure</subject><subject>Stress, Mechanical</subject><subject>Tensile Strength</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFksGO0zAQhi0EYruFJ0BCuSBOKWM7dpMDSKuFBaSVOAASN8uxJ8UhcYrtrOgj8NY4bQGJCwdrJPv7Zzz_DCFPKGwoUPmi3_TJ3MUNg3wDzQZkfY-sKDTbUtbiy32yAmCsFIzxC3IZYw8AW6DNQ3LBqKRSgFyRn68xYRid18lNvpi6In3FAgcdkzPFONl5mONyraNBb53fZWAK2uRXPYUF0h7ncIhjoVNhXddhQJ-KoP0Oj8p9wBjngMUcF_nsnf7h9FAk9NENmGOu5XePyINODxEfn-OafL558-n6XXn74e3766vb0ghRpbKTXNSWt43UBoDXwtZW82aLVNZIjWwEB7BGSuRGbutWMt1KK4xurRa8afmaPD_l3Yfp-5xrq9Hl3oYh9zHNUdV1RRkX-awJP5EmTDEG7NQ-uFGHg6KglhGoXh1HoJYRKGhUHkFWPT3nn9sR7R_Nb88z8OwMZE_10GWnjIt_uapqGD1yL08cZjfuHAYVjUNv0LqAJik7uf985NU_ejM473LJb3jA2E9z8NloRVVkCtTHZVuWZaEUoGKi4b8AbxK-BQ</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Khanafer, Khalil, PhD</creator><creator>Duprey, Ambroise, MD</creator><creator>Zainal, Mohammad, PhD</creator><creator>Schlicht, Marty, PhD</creator><creator>Williams, David, MD</creator><creator>Berguer, Ramon, PhD, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Determination of the elastic modulus of ascending thoracic aortic aneurysm at different ranges of pressure using uniaxial tensile testing</title><author>Khanafer, Khalil, PhD ; Duprey, Ambroise, MD ; Zainal, Mohammad, PhD ; Schlicht, Marty, PhD ; Williams, David, MD ; Berguer, Ramon, PhD, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-f6358d3b96ac00385d8da397e168e1c695300dc66e3c678b62ab6d5cabda539b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Aorta, Thoracic - physiopathology</topic><topic>Aortic Aneurysm, Thoracic - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiothoracic Surgery</topic><topic>Diseases of the aorta</topic><topic>Elasticity</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Models, Cardiovascular</topic><topic>Pneumology</topic><topic>Pressure</topic><topic>Stress, Mechanical</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khanafer, Khalil, PhD</creatorcontrib><creatorcontrib>Duprey, Ambroise, MD</creatorcontrib><creatorcontrib>Zainal, Mohammad, PhD</creatorcontrib><creatorcontrib>Schlicht, Marty, PhD</creatorcontrib><creatorcontrib>Williams, David, MD</creatorcontrib><creatorcontrib>Berguer, Ramon, PhD, MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khanafer, Khalil, PhD</au><au>Duprey, Ambroise, MD</au><au>Zainal, Mohammad, PhD</au><au>Schlicht, Marty, PhD</au><au>Williams, David, MD</au><au>Berguer, Ramon, PhD, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of the elastic modulus of ascending thoracic aortic aneurysm at different ranges of pressure using uniaxial tensile testing</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>142</volume><issue>3</issue><spage>682</spage><epage>686</epage><pages>682-686</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><coden>JTCSAQ</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Objective The purpose of this study is to provide measurements of the elastic modulus of the aortic wall of ascending thoracic aortic aneurysms for different ranges of pressure (physiologic, hypertensive). In addition, pre-failure stress, taken as the peak stress obtained before specimen failure, was recorded for each test. Methods Ninety-seven aortic samples freshly excised from 13 patients with ascending thoracic aortic aneurysms were obtained from greater and lesser curvatures and tested uniaxially in circumferential and longitudinal orientations. Results The maximum elastic moduli, overall, and particularly in the lesser curvature were significantly higher in the circumferential orientation (9.19 MPa) than in the longitudinal (3.13 MPa). Results of peak stress showed positive correlation with maximum elastic modulus and inverse correlation with tissue wall thickness. Conclusions This study provides new data on the elastic modulus in the physiologic and hypertensive range that can be used in computational analysis and the design of bench-top models. The accuracy of computational analysis and bench-top models strongly depends on the knowledge of the elastic properties of the aortic wall. The mechanical properties presented in this study, with specific values for 2 locations (greater and lesser curvature) and 2 directions (circumferential, longitudinal), will increase our understanding of the mechanisms that precede rupture of an ascending aortic aneurysm.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>21616506</pmid><doi>10.1016/j.jtcvs.2010.09.068</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Aorta, Thoracic - physiopathology
Aortic Aneurysm, Thoracic - physiopathology
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiothoracic Surgery
Diseases of the aorta
Elasticity
Female
Humans
Male
Medical sciences
Middle Aged
Models, Cardiovascular
Pneumology
Pressure
Stress, Mechanical
Tensile Strength
title Determination of the elastic modulus of ascending thoracic aortic aneurysm at different ranges of pressure using uniaxial tensile testing
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