Gonadal histology and characteristic histopathology associated with endocrine disruption in the adult fathead minnow ( Pimephales promelas)

Examination of gonadal histopathology has been beneficial in understanding and assessing the effects of potential endocrine disrupting chemicals in fish and other organisms. The present study describes the normal gonadal histology of the fathead minnow ( Pimephales promelas), a widely used test orga...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2005, Vol.19 (1), p.85-98
Main Authors: Leino, Richard L., Jensen, Kathleen M., Ankley, Gerald T.
Format: Article
Language:English
Subjects:
Endocrine disruptors
Fish
Histology
Ovary
Pimephales promelas
Testis
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Summary:Examination of gonadal histopathology has been beneficial in understanding and assessing the effects of potential endocrine disrupting chemicals in fish and other organisms. The present study describes the normal gonadal histology of the fathead minnow ( Pimephales promelas), a widely used test organism, reviews typical effects of endocrine disrupting chemicals with different modes/mechanisms of action on the histological structure of the ovaries and testes, and recommends methods for optimizing histopathological results.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2004.05.010