Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton

In the past decades, a range of post-translational modifications has been discovered on tubulins, the major constituents of microtubules. Pioneering studies have described the occurrence and dynamics of these modifications and provided first insights into their potential functions in regulating the...

Full description

Saved in:
Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2010-08, Vol.33 (8), p.362-372
Main Authors: Janke, Carsten, Kneussel, Matthias
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cytoskeleton
Cytoskeleton - genetics
Cytoskeleton - metabolism
Electrodiagnosis. Electric activity recording
Enzymes
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Microtubules - genetics
Microtubules - metabolism
Molecules
Nervous system
Neurology
Neurons
Neurons - metabolism
Neurosciences
Protein Processing, Post-Translational
Tubulin - genetics
Tubulin - metabolism
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the past decades, a range of post-translational modifications has been discovered on tubulins, the major constituents of microtubules. Pioneering studies have described the occurrence and dynamics of these modifications and provided first insights into their potential functions in regulating the microtubule cytoskeleton. By contrast, several tubulin-modifying enzymes were only discovered in the last few years, and studies on molecular mechanisms and cellular functions of tubulin modifications are just beginning to emerge. This review highlights the roles of tubulin modifications in neurons. Recent studies are also discussed in relation to how the combinatorial use of tubulin modifications could generate a dynamic microtubule code, and how such a code might regulate basic as well as higher-order neuronal functions.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2010.05.001