Loading…
Additive Effects of Numbness and Muscle Aches on Fatigue Occurrence in Individuals with HIV/AIDS Who Are Taking Antiretroviral Therapy
Abstract Context Muscle aches, numbness in the feet/toes (neuropathy), and fatigue are often reported concurrently and are among the symptoms most frequently reported by individuals with HIV/AIDS, whether or not they are taking antiretroviral therapy (ART). Objectives This study used a longitudinal...
Saved in:
| Published in: | Journal of pain and symptom management 2011-02, Vol.41 (2), p.469-477 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c577t-7895352e9814b04af2238e3bfc51be241abe7cfb1018e3d336674b2d0a7f30ff3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c577t-7895352e9814b04af2238e3bfc51be241abe7cfb1018e3d336674b2d0a7f30ff3 |
| container_end_page | 477 |
| container_issue | 2 |
| container_start_page | 469 |
| container_title | Journal of pain and symptom management |
| container_volume | 41 |
| creator | Wantland, Dean J., PhD, RN Mullan, Joseph P., PhD Holzemer, William L., PhD, RN, FAAN Portillo, Carmen J., PhD, RN, FAAN Bakken, Suzanne, DNSc, RN, FAAN McGhee, Eva M., PhD |
| description | Abstract Context Muscle aches, numbness in the feet/toes (neuropathy), and fatigue are often reported concurrently and are among the symptoms most frequently reported by individuals with HIV/AIDS, whether or not they are taking antiretroviral therapy (ART). Objectives This study used a longitudinal analytical methodology to analyze these symptoms together to determine whether symptom clusters are maintained over time and to determine whether there is a temporal relationship between fatigue and reports of neuropathic pain and muscle aches. Methods This was a secondary analysis of a subset of data from a six-month, longitudinal, randomized, controlled trial of 243 HIV-positive individuals taking ART. Self-reported symptom frequency and intensity were recorded using the Revised Sign and Symptom Checklist for Persons with HIV disease at baseline (Month 0), one, three, and six months. Multilevel, logistic regression models were used to analyze time-lagged effects of muscle aches, numbness of the feet/toes, and fatigue to estimate any predictive and interactive effects that the symptoms have upon one another. Results A significant relationship between muscle aches and fatigue intercepts was noted (odds ratio [OR] = 1.80, P ≤ 0.05). Significant relationships between numbness and fatigue also were noted for the entire measurement period (OR = 2.70, P ≤ 0.05). Time-lagged models showed persons reporting neuropathic-related numbness in one period were nearly twice as likely to report fatigue in subsequent periods (OR = 1.89, P ≤ 0.05). The final model revealed that the addition of muscle aches and numbness explained 28% of the random variance in the occurrence of fatigue. Between-person descriptive variables including years living with HIV, age, having an AIDS diagnosis, ethnicity, and nucleoside reverse transcriptase inhibitor treatment regimens with stavudine, zalactabine, or didanosine did not significantly explain any additional model variation. Conclusion These findings are consistent with physiological research and provide evidence that analyzing multiple symptom change over time can provide a more accurate representation of an individual’s symptom experience. When evaluating patients with muscle aches or numbness, particularly when both symptoms are present, an evaluation of fatigue should be considered. Similarly, if fatigue is reported, underlying physiological assessments for neuropathic symptoms and muscle aches may be considered. |
| doi_str_mv | 10.1016/j.jpainsymman.2010.05.011 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_870996129</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0885392410006883</els_id><sourcerecordid>1125238454</sourcerecordid><originalsourceid>FETCH-LOGICAL-c577t-7895352e9814b04af2238e3bfc51be241abe7cfb1018e3d336674b2d0a7f30ff3</originalsourceid><addsrcrecordid>eNqNkktv1DAQgC0EokvhLyBzQHDJ1o84jwtStLR0pUIPXeBoOc64623ibO1kq_0D_d042uUhDoiTpfE3M_Z8g9AbSuaU0OxsM99slXVh33XKzRmJcSLmhNInaEaLnCeZoPwpmpGiEAkvWXqCXoSwIYQInvHn6IRRxllJ-Qw9Vk1jB7sDfG4M6CHg3uAvY1c7CAEr1-DPY9At4EqvIV46fKEGezsCvtZ69B6cBmwdXrrG7mwzqjbgBzus8eXy21m1_HiDv697XHnAK3Vn3S2u3GA9DL7fWa9avFqDV9v9S_TMxFR4dTxP0deL89XiMrm6_rRcVFeJFnk-JHlRCi4YlAVNa5IqwxgvgNdGC1oDS6mqIdemjlOK4YbzLMvTmjVE5YYTY_gpeneou_X9_QhhkJ0NGtpWOejHIIuclGVGWRnJ9_8kKWUiNk9FGtHygGrfh-DByK23nfJ7SYmchMmN_EOYnIRJImQUFnNfH9uMdQfNr8yfhiLw9giooFVrvHLaht8cL9P4y6nQ4sBBHN_OgpdB28lOE8etB9n09r-e8-GvKrq1zsbGd7CHsOlH76IfSWVgksibacOmBaNxt7Ki4PwHDx7O0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1125238454</pqid></control><display><type>article</type><title>Additive Effects of Numbness and Muscle Aches on Fatigue Occurrence in Individuals with HIV/AIDS Who Are Taking Antiretroviral Therapy</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Wantland, Dean J., PhD, RN ; Mullan, Joseph P., PhD ; Holzemer, William L., PhD, RN, FAAN ; Portillo, Carmen J., PhD, RN, FAAN ; Bakken, Suzanne, DNSc, RN, FAAN ; McGhee, Eva M., PhD</creator><creatorcontrib>Wantland, Dean J., PhD, RN ; Mullan, Joseph P., PhD ; Holzemer, William L., PhD, RN, FAAN ; Portillo, Carmen J., PhD, RN, FAAN ; Bakken, Suzanne, DNSc, RN, FAAN ; McGhee, Eva M., PhD</creatorcontrib><description>Abstract Context Muscle aches, numbness in the feet/toes (neuropathy), and fatigue are often reported concurrently and are among the symptoms most frequently reported by individuals with HIV/AIDS, whether or not they are taking antiretroviral therapy (ART). Objectives This study used a longitudinal analytical methodology to analyze these symptoms together to determine whether symptom clusters are maintained over time and to determine whether there is a temporal relationship between fatigue and reports of neuropathic pain and muscle aches. Methods This was a secondary analysis of a subset of data from a six-month, longitudinal, randomized, controlled trial of 243 HIV-positive individuals taking ART. Self-reported symptom frequency and intensity were recorded using the Revised Sign and Symptom Checklist for Persons with HIV disease at baseline (Month 0), one, three, and six months. Multilevel, logistic regression models were used to analyze time-lagged effects of muscle aches, numbness of the feet/toes, and fatigue to estimate any predictive and interactive effects that the symptoms have upon one another. Results A significant relationship between muscle aches and fatigue intercepts was noted (odds ratio [OR] = 1.80, P ≤ 0.05). Significant relationships between numbness and fatigue also were noted for the entire measurement period (OR = 2.70, P ≤ 0.05). Time-lagged models showed persons reporting neuropathic-related numbness in one period were nearly twice as likely to report fatigue in subsequent periods (OR = 1.89, P ≤ 0.05). The final model revealed that the addition of muscle aches and numbness explained 28% of the random variance in the occurrence of fatigue. Between-person descriptive variables including years living with HIV, age, having an AIDS diagnosis, ethnicity, and nucleoside reverse transcriptase inhibitor treatment regimens with stavudine, zalactabine, or didanosine did not significantly explain any additional model variation. Conclusion These findings are consistent with physiological research and provide evidence that analyzing multiple symptom change over time can provide a more accurate representation of an individual’s symptom experience. When evaluating patients with muscle aches or numbness, particularly when both symptoms are present, an evaluation of fatigue should be considered. Similarly, if fatigue is reported, underlying physiological assessments for neuropathic symptoms and muscle aches may be considered.</description><identifier>ISSN: 0885-3924</identifier><identifier>EISSN: 1873-6513</identifier><identifier>DOI: 10.1016/j.jpainsymman.2010.05.011</identifier><identifier>PMID: 21232913</identifier><identifier>CODEN: JSPME2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetylcholine ; Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - drug therapy ; Acquired Immunodeficiency Syndrome - physiopathology ; Adult ; Age ; Aged ; Anesthesia & Perioperative Care ; Anti-HIV Agents - therapeutic use ; Antiretroviral therapy ; Biological and medical sciences ; Check lists ; Clinical trials ; Data processing ; Didanosine ; Ethnic groups ; Fatigue ; Fatigue - complications ; Fatigue - physiopathology ; Female ; growth curve ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - physiopathology ; HIV/AIDS ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Hypesthesia - complications ; Hypesthesia - physiopathology ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Logistic Models ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Multilevel modeling ; muscle ache ; Muscle Fatigue ; Muscle, Skeletal - physiopathology ; Muscles ; Neuropathy ; nucleoside reverse transcriptase inhibitors ; Odds Ratio ; Pain ; Pain Medicine ; Pharmacology. Drug treatments ; Regression analysis ; Self Report ; Severity of Illness Index ; Stavudine ; symptom experience ; Symptoms ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Journal of pain and symptom management, 2011-02, Vol.41 (2), p.469-477</ispartof><rights>U.S. Cancer Pain Relief Committee</rights><rights>2011 U.S. Cancer Pain Relief Committee</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 U.S. Cancer Pain Relief Committee. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-7895352e9814b04af2238e3bfc51be241abe7cfb1018e3d336674b2d0a7f30ff3</citedby><cites>FETCH-LOGICAL-c577t-7895352e9814b04af2238e3bfc51be241abe7cfb1018e3d336674b2d0a7f30ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958,31035</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23943661$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21232913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wantland, Dean J., PhD, RN</creatorcontrib><creatorcontrib>Mullan, Joseph P., PhD</creatorcontrib><creatorcontrib>Holzemer, William L., PhD, RN, FAAN</creatorcontrib><creatorcontrib>Portillo, Carmen J., PhD, RN, FAAN</creatorcontrib><creatorcontrib>Bakken, Suzanne, DNSc, RN, FAAN</creatorcontrib><creatorcontrib>McGhee, Eva M., PhD</creatorcontrib><title>Additive Effects of Numbness and Muscle Aches on Fatigue Occurrence in Individuals with HIV/AIDS Who Are Taking Antiretroviral Therapy</title><title>Journal of pain and symptom management</title><addtitle>J Pain Symptom Manage</addtitle><description>Abstract Context Muscle aches, numbness in the feet/toes (neuropathy), and fatigue are often reported concurrently and are among the symptoms most frequently reported by individuals with HIV/AIDS, whether or not they are taking antiretroviral therapy (ART). Objectives This study used a longitudinal analytical methodology to analyze these symptoms together to determine whether symptom clusters are maintained over time and to determine whether there is a temporal relationship between fatigue and reports of neuropathic pain and muscle aches. Methods This was a secondary analysis of a subset of data from a six-month, longitudinal, randomized, controlled trial of 243 HIV-positive individuals taking ART. Self-reported symptom frequency and intensity were recorded using the Revised Sign and Symptom Checklist for Persons with HIV disease at baseline (Month 0), one, three, and six months. Multilevel, logistic regression models were used to analyze time-lagged effects of muscle aches, numbness of the feet/toes, and fatigue to estimate any predictive and interactive effects that the symptoms have upon one another. Results A significant relationship between muscle aches and fatigue intercepts was noted (odds ratio [OR] = 1.80, P ≤ 0.05). Significant relationships between numbness and fatigue also were noted for the entire measurement period (OR = 2.70, P ≤ 0.05). Time-lagged models showed persons reporting neuropathic-related numbness in one period were nearly twice as likely to report fatigue in subsequent periods (OR = 1.89, P ≤ 0.05). The final model revealed that the addition of muscle aches and numbness explained 28% of the random variance in the occurrence of fatigue. Between-person descriptive variables including years living with HIV, age, having an AIDS diagnosis, ethnicity, and nucleoside reverse transcriptase inhibitor treatment regimens with stavudine, zalactabine, or didanosine did not significantly explain any additional model variation. Conclusion These findings are consistent with physiological research and provide evidence that analyzing multiple symptom change over time can provide a more accurate representation of an individual’s symptom experience. When evaluating patients with muscle aches or numbness, particularly when both symptoms are present, an evaluation of fatigue should be considered. Similarly, if fatigue is reported, underlying physiological assessments for neuropathic symptoms and muscle aches may be considered.</description><subject>Acetylcholine</subject><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - drug therapy</subject><subject>Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Anesthesia & Perioperative Care</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral therapy</subject><subject>Biological and medical sciences</subject><subject>Check lists</subject><subject>Clinical trials</subject><subject>Data processing</subject><subject>Didanosine</subject><subject>Ethnic groups</subject><subject>Fatigue</subject><subject>Fatigue - complications</subject><subject>Fatigue - physiopathology</subject><subject>Female</subject><subject>growth curve</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - physiopathology</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Hypesthesia - complications</subject><subject>Hypesthesia - physiopathology</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infectious diseases</subject><subject>Logistic Models</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multilevel modeling</subject><subject>muscle ache</subject><subject>Muscle Fatigue</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscles</subject><subject>Neuropathy</subject><subject>nucleoside reverse transcriptase inhibitors</subject><subject>Odds Ratio</subject><subject>Pain</subject><subject>Pain Medicine</subject><subject>Pharmacology. Drug treatments</subject><subject>Regression analysis</subject><subject>Self Report</subject><subject>Severity of Illness Index</subject><subject>Stavudine</subject><subject>symptom experience</subject><subject>Symptoms</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0885-3924</issn><issn>1873-6513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><recordid>eNqNkktv1DAQgC0EokvhLyBzQHDJ1o84jwtStLR0pUIPXeBoOc64623ibO1kq_0D_d042uUhDoiTpfE3M_Z8g9AbSuaU0OxsM99slXVh33XKzRmJcSLmhNInaEaLnCeZoPwpmpGiEAkvWXqCXoSwIYQInvHn6IRRxllJ-Qw9Vk1jB7sDfG4M6CHg3uAvY1c7CAEr1-DPY9At4EqvIV46fKEGezsCvtZ69B6cBmwdXrrG7mwzqjbgBzus8eXy21m1_HiDv697XHnAK3Vn3S2u3GA9DL7fWa9avFqDV9v9S_TMxFR4dTxP0deL89XiMrm6_rRcVFeJFnk-JHlRCi4YlAVNa5IqwxgvgNdGC1oDS6mqIdemjlOK4YbzLMvTmjVE5YYTY_gpeneou_X9_QhhkJ0NGtpWOejHIIuclGVGWRnJ9_8kKWUiNk9FGtHygGrfh-DByK23nfJ7SYmchMmN_EOYnIRJImQUFnNfH9uMdQfNr8yfhiLw9giooFVrvHLaht8cL9P4y6nQ4sBBHN_OgpdB28lOE8etB9n09r-e8-GvKrq1zsbGd7CHsOlH76IfSWVgksibacOmBaNxt7Ki4PwHDx7O0A</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Wantland, Dean J., PhD, RN</creator><creator>Mullan, Joseph P., PhD</creator><creator>Holzemer, William L., PhD, RN, FAAN</creator><creator>Portillo, Carmen J., PhD, RN, FAAN</creator><creator>Bakken, Suzanne, DNSc, RN, FAAN</creator><creator>McGhee, Eva M., PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7QJ</scope></search><sort><creationdate>20110201</creationdate><title>Additive Effects of Numbness and Muscle Aches on Fatigue Occurrence in Individuals with HIV/AIDS Who Are Taking Antiretroviral Therapy</title><author>Wantland, Dean J., PhD, RN ; Mullan, Joseph P., PhD ; Holzemer, William L., PhD, RN, FAAN ; Portillo, Carmen J., PhD, RN, FAAN ; Bakken, Suzanne, DNSc, RN, FAAN ; McGhee, Eva M., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-7895352e9814b04af2238e3bfc51be241abe7cfb1018e3d336674b2d0a7f30ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acetylcholine</topic><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Acquired Immunodeficiency Syndrome - drug therapy</topic><topic>Acquired Immunodeficiency Syndrome - physiopathology</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Anesthesia & Perioperative Care</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antiretroviral therapy</topic><topic>Biological and medical sciences</topic><topic>Check lists</topic><topic>Clinical trials</topic><topic>Data processing</topic><topic>Didanosine</topic><topic>Ethnic groups</topic><topic>Fatigue</topic><topic>Fatigue - complications</topic><topic>Fatigue - physiopathology</topic><topic>Female</topic><topic>growth curve</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - physiopathology</topic><topic>HIV/AIDS</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Hypesthesia - complications</topic><topic>Hypesthesia - physiopathology</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infectious diseases</topic><topic>Logistic Models</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multilevel modeling</topic><topic>muscle ache</topic><topic>Muscle Fatigue</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscles</topic><topic>Neuropathy</topic><topic>nucleoside reverse transcriptase inhibitors</topic><topic>Odds Ratio</topic><topic>Pain</topic><topic>Pain Medicine</topic><topic>Pharmacology. Drug treatments</topic><topic>Regression analysis</topic><topic>Self Report</topic><topic>Severity of Illness Index</topic><topic>Stavudine</topic><topic>symptom experience</topic><topic>Symptoms</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wantland, Dean J., PhD, RN</creatorcontrib><creatorcontrib>Mullan, Joseph P., PhD</creatorcontrib><creatorcontrib>Holzemer, William L., PhD, RN, FAAN</creatorcontrib><creatorcontrib>Portillo, Carmen J., PhD, RN, FAAN</creatorcontrib><creatorcontrib>Bakken, Suzanne, DNSc, RN, FAAN</creatorcontrib><creatorcontrib>McGhee, Eva M., PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Journal of pain and symptom management</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wantland, Dean J., PhD, RN</au><au>Mullan, Joseph P., PhD</au><au>Holzemer, William L., PhD, RN, FAAN</au><au>Portillo, Carmen J., PhD, RN, FAAN</au><au>Bakken, Suzanne, DNSc, RN, FAAN</au><au>McGhee, Eva M., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additive Effects of Numbness and Muscle Aches on Fatigue Occurrence in Individuals with HIV/AIDS Who Are Taking Antiretroviral Therapy</atitle><jtitle>Journal of pain and symptom management</jtitle><addtitle>J Pain Symptom Manage</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>41</volume><issue>2</issue><spage>469</spage><epage>477</epage><pages>469-477</pages><issn>0885-3924</issn><eissn>1873-6513</eissn><coden>JSPME2</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Abstract Context Muscle aches, numbness in the feet/toes (neuropathy), and fatigue are often reported concurrently and are among the symptoms most frequently reported by individuals with HIV/AIDS, whether or not they are taking antiretroviral therapy (ART). Objectives This study used a longitudinal analytical methodology to analyze these symptoms together to determine whether symptom clusters are maintained over time and to determine whether there is a temporal relationship between fatigue and reports of neuropathic pain and muscle aches. Methods This was a secondary analysis of a subset of data from a six-month, longitudinal, randomized, controlled trial of 243 HIV-positive individuals taking ART. Self-reported symptom frequency and intensity were recorded using the Revised Sign and Symptom Checklist for Persons with HIV disease at baseline (Month 0), one, three, and six months. Multilevel, logistic regression models were used to analyze time-lagged effects of muscle aches, numbness of the feet/toes, and fatigue to estimate any predictive and interactive effects that the symptoms have upon one another. Results A significant relationship between muscle aches and fatigue intercepts was noted (odds ratio [OR] = 1.80, P ≤ 0.05). Significant relationships between numbness and fatigue also were noted for the entire measurement period (OR = 2.70, P ≤ 0.05). Time-lagged models showed persons reporting neuropathic-related numbness in one period were nearly twice as likely to report fatigue in subsequent periods (OR = 1.89, P ≤ 0.05). The final model revealed that the addition of muscle aches and numbness explained 28% of the random variance in the occurrence of fatigue. Between-person descriptive variables including years living with HIV, age, having an AIDS diagnosis, ethnicity, and nucleoside reverse transcriptase inhibitor treatment regimens with stavudine, zalactabine, or didanosine did not significantly explain any additional model variation. Conclusion These findings are consistent with physiological research and provide evidence that analyzing multiple symptom change over time can provide a more accurate representation of an individual’s symptom experience. When evaluating patients with muscle aches or numbness, particularly when both symptoms are present, an evaluation of fatigue should be considered. Similarly, if fatigue is reported, underlying physiological assessments for neuropathic symptoms and muscle aches may be considered.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21232913</pmid><doi>10.1016/j.jpainsymman.2010.05.011</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-3924 |
| ispartof | Journal of pain and symptom management, 2011-02, Vol.41 (2), p.469-477 |
| issn | 0885-3924 1873-6513 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_870996129 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); ScienceDirect Freedom Collection 2022-2024 |
| subjects | Acetylcholine Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - physiopathology Adult Age Aged Anesthesia & Perioperative Care Anti-HIV Agents - therapeutic use Antiretroviral therapy Biological and medical sciences Check lists Clinical trials Data processing Didanosine Ethnic groups Fatigue Fatigue - complications Fatigue - physiopathology Female growth curve HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - physiopathology HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Hypesthesia - complications Hypesthesia - physiopathology Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Logistic Models Longitudinal Studies Male Medical sciences Middle Aged Multilevel modeling muscle ache Muscle Fatigue Muscle, Skeletal - physiopathology Muscles Neuropathy nucleoside reverse transcriptase inhibitors Odds Ratio Pain Pain Medicine Pharmacology. Drug treatments Regression analysis Self Report Severity of Illness Index Stavudine symptom experience Symptoms Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Additive Effects of Numbness and Muscle Aches on Fatigue Occurrence in Individuals with HIV/AIDS Who Are Taking Antiretroviral Therapy |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T07%3A51%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Additive%20Effects%20of%20Numbness%20and%20Muscle%20Aches%20on%20Fatigue%20Occurrence%20in%20Individuals%20with%20HIV/AIDS%20Who%20Are%20Taking%20Antiretroviral%20Therapy&rft.jtitle=Journal%20of%20pain%20and%20symptom%20management&rft.au=Wantland,%20Dean%20J.,%20PhD,%20RN&rft.date=2011-02-01&rft.volume=41&rft.issue=2&rft.spage=469&rft.epage=477&rft.pages=469-477&rft.issn=0885-3924&rft.eissn=1873-6513&rft.coden=JSPME2&rft_id=info:doi/10.1016/j.jpainsymman.2010.05.011&rft_dat=%3Cproquest_cross%3E1125238454%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c577t-7895352e9814b04af2238e3bfc51be241abe7cfb1018e3d336674b2d0a7f30ff3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1125238454&rft_id=info:pmid/21232913&rfr_iscdi=true |