Aerosol Therapy with Thiamphenicol Glycinate: A Retrospective Study on Efficacy and Safety in a Group of Sixty-Six Oncological Patients

The purpose of this paper is to present the effectiveness of aerosol administration of TG in a group of oncological patients. Thiamphenicol is an antimicrobial agent active in the treatment of infection of different etiology and localisation due to its broad spectrum of antimicrobial activity as wel...

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2011-01, Vol.24 (1), p.189-193
Main Authors: Macchi, A., Terranova, P., Macchi, S., Roselli, R., Castelnuovo, P.
Format: Article
Language:English
Subjects:
Adult
Aerosols
Aged
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Female
Head and Neck Neoplasms - complications
Humans
Male
Middle Aged
Respiratory Tract Infections - drug therapy
Retrospective Studies
Thiamphenicol - administration & dosage
Thiamphenicol - adverse effects
Thiamphenicol - analogs & derivatives
Thiamphenicol - pharmacology
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Summary:The purpose of this paper is to present the effectiveness of aerosol administration of TG in a group of oncological patients. Thiamphenicol is an antimicrobial agent active in the treatment of infection of different etiology and localisation due to its broad spectrum of antimicrobial activity as well as its pharmacokinetic properties. The data of the retrospective study analysis of the activity of TG, administered to oncological patients affected by infections of the respiratory tract, showed that TG administered alone or in association with other antibiotics was globally effective in more than 95% of patients. These positive results were obtained in immunologically compromised patients. The therapeutic advantages of using TG are: ease of use - aerosol therapy permits good local action; tolerability - no adverse reaction or intolerance; the possibility of using it in an ideal association with other antibiotics to combat the infectious pathology.
ISSN:0394-6320
2058-7384
DOI:10.1177/039463201102400122