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Corticotrophin-releasing factor mediates hypophagia after adrenalectomy, increasing meal-related satiety responses
Adrenalectomy-induced hypophagia is associated with increased satiety-related responses, which involve neuronal activation of the nucleus of the solitary tract (NTS). Besides its effects on the pituitary–adrenal axis, corticotrophin-releasing factor (CRF) has been shown to play an important role in...
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| Published in: | Hormones and behavior 2010-11, Vol.58 (5), p.714-719 |
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| creator | Uchoa, Ernane Torres da Silva, Lilian Eslaine Costa Mendes de Castro, Margaret Antunes-Rodrigues, Jose Elias, Lucila Leico K. |
| description | Adrenalectomy-induced hypophagia is associated with increased satiety-related responses, which involve neuronal activation of the nucleus of the solitary tract (NTS). Besides its effects on the pituitary–adrenal axis, corticotrophin-releasing factor (CRF) has been shown to play an important role in feeding behaviour, as it possesses anorexigenic effects. We evaluated feeding-induced CRF mRNA expression in the paraventricular nucleus (PVN) and the effects of pretreatment with CRF
2 receptor antagonist (Antisauvagine-30, AS30) on food intake and activation of NTS neurons in response to feeding in adrenalectomised (ADX) rats. Compared to the sham group, ADX increased CRF mRNA levels in the PVN of fasted animals, which was further augmented by refeeding. AS30 treatment did not affect food intake in the sham and ADX
+
corticosterone (B) groups; however, it reversed hypophagia in the ADX group. In vehicle-pretreated animals, refeeding increased the number of Fos and Fos/TH-immunoreactive neurons in the NTS in the sham, ADX and ADX
+
B groups, with the highest number of neurons in the ADX animals. Similarly to its effect on food intake, pretreatment with AS30 in the ADX group also reversed the increased activation of NTS neurons induced by refeeding while having no effect in the sham and ADX
+
B animals. The present results show that adrenalectomy induces an increase in CRF mRNA expression in the PVN potentiated by feeding and that CRF
2 receptor antagonist abolishes the anorexigenic effect and the increased activation of NTS induced by feeding in the ADX animals. These data indicate that increased activity of PVN CRF neurons modulates brainstem satiety-related responses, contributing to hypophagia after adrenalectomy.
►Primary adrenal insufficiency increases meal-related satiety responses. ►Adrenalectomy-induced hypophagia is associated with increased CRF mRNA expression in the hypothalamic paraventricular nucleus (PVN) and increased NTS neuron activation in the brainstem. ►The increased activity of PVN CRF neurons modulates brainstem satiety-related responses. ►CRF type 2 receptor mediates CRF suppressing effect on food intake after adrenalectomy. |
| doi_str_mv | 10.1016/j.yhbeh.2010.07.003 |
| format | article |
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2 receptor antagonist (Antisauvagine-30, AS30) on food intake and activation of NTS neurons in response to feeding in adrenalectomised (ADX) rats. Compared to the sham group, ADX increased CRF mRNA levels in the PVN of fasted animals, which was further augmented by refeeding. AS30 treatment did not affect food intake in the sham and ADX
+
corticosterone (B) groups; however, it reversed hypophagia in the ADX group. In vehicle-pretreated animals, refeeding increased the number of Fos and Fos/TH-immunoreactive neurons in the NTS in the sham, ADX and ADX
+
B groups, with the highest number of neurons in the ADX animals. Similarly to its effect on food intake, pretreatment with AS30 in the ADX group also reversed the increased activation of NTS neurons induced by refeeding while having no effect in the sham and ADX
+
B animals. The present results show that adrenalectomy induces an increase in CRF mRNA expression in the PVN potentiated by feeding and that CRF
2 receptor antagonist abolishes the anorexigenic effect and the increased activation of NTS induced by feeding in the ADX animals. These data indicate that increased activity of PVN CRF neurons modulates brainstem satiety-related responses, contributing to hypophagia after adrenalectomy.
►Primary adrenal insufficiency increases meal-related satiety responses. ►Adrenalectomy-induced hypophagia is associated with increased CRF mRNA expression in the hypothalamic paraventricular nucleus (PVN) and increased NTS neuron activation in the brainstem. ►The increased activity of PVN CRF neurons modulates brainstem satiety-related responses. ►CRF type 2 receptor mediates CRF suppressing effect on food intake after adrenalectomy.</description><identifier>ISSN: 0018-506X</identifier><identifier>EISSN: 1095-6867</identifier><identifier>DOI: 10.1016/j.yhbeh.2010.07.003</identifier><identifier>PMID: 20688066</identifier><identifier>CODEN: HOBEAO</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adrenal glands ; Adrenalectomy - rehabilitation ; Animal behavior ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Corticosterone - pharmacology ; Corticotrophin-releasing factor ; Corticotropin-Releasing Hormone - genetics ; Corticotropin-Releasing Hormone - metabolism ; Corticotropin-Releasing Hormone - physiology ; Down-Regulation - drug effects ; Eating - drug effects ; Eating - genetics ; Eating - physiology ; Feeding and Eating Disorders - chemically induced ; Feeding and Eating Disorders - genetics ; Feeding and Eating Disorders - metabolism ; Food ; Food intake ; Fundamental and applied biological sciences. Psychology ; Gene Expression - drug effects ; Glucocorticoids ; Hormone Antagonists - pharmacology ; Hormones ; Hormones and behavior ; Neurons ; Neurons - drug effects ; Neurons - metabolism ; Nucleus of the solitary tract ; Paraventricular Hypothalamic Nucleus - drug effects ; Paraventricular Hypothalamic Nucleus - metabolism ; Paraventricular nucleus of the hypothalamus ; Peptide Fragments - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors ; Rodents ; Satiety Response - drug effects ; Satiety Response - physiology</subject><ispartof>Hormones and behavior, 2010-11, Vol.58 (5), p.714-719</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-400573f0cc2c6a354ebde011daeac0c8e2ee90093a0ff011b25b19d90012fa873</citedby><cites>FETCH-LOGICAL-c492t-400573f0cc2c6a354ebde011daeac0c8e2ee90093a0ff011b25b19d90012fa873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23598482$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20688066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uchoa, Ernane Torres</creatorcontrib><creatorcontrib>da Silva, Lilian Eslaine Costa Mendes</creatorcontrib><creatorcontrib>de Castro, Margaret</creatorcontrib><creatorcontrib>Antunes-Rodrigues, Jose</creatorcontrib><creatorcontrib>Elias, Lucila Leico K.</creatorcontrib><title>Corticotrophin-releasing factor mediates hypophagia after adrenalectomy, increasing meal-related satiety responses</title><title>Hormones and behavior</title><addtitle>Horm Behav</addtitle><description>Adrenalectomy-induced hypophagia is associated with increased satiety-related responses, which involve neuronal activation of the nucleus of the solitary tract (NTS). Besides its effects on the pituitary–adrenal axis, corticotrophin-releasing factor (CRF) has been shown to play an important role in feeding behaviour, as it possesses anorexigenic effects. We evaluated feeding-induced CRF mRNA expression in the paraventricular nucleus (PVN) and the effects of pretreatment with CRF
2 receptor antagonist (Antisauvagine-30, AS30) on food intake and activation of NTS neurons in response to feeding in adrenalectomised (ADX) rats. Compared to the sham group, ADX increased CRF mRNA levels in the PVN of fasted animals, which was further augmented by refeeding. AS30 treatment did not affect food intake in the sham and ADX
+
corticosterone (B) groups; however, it reversed hypophagia in the ADX group. In vehicle-pretreated animals, refeeding increased the number of Fos and Fos/TH-immunoreactive neurons in the NTS in the sham, ADX and ADX
+
B groups, with the highest number of neurons in the ADX animals. Similarly to its effect on food intake, pretreatment with AS30 in the ADX group also reversed the increased activation of NTS neurons induced by refeeding while having no effect in the sham and ADX
+
B animals. The present results show that adrenalectomy induces an increase in CRF mRNA expression in the PVN potentiated by feeding and that CRF
2 receptor antagonist abolishes the anorexigenic effect and the increased activation of NTS induced by feeding in the ADX animals. These data indicate that increased activity of PVN CRF neurons modulates brainstem satiety-related responses, contributing to hypophagia after adrenalectomy.
►Primary adrenal insufficiency increases meal-related satiety responses. ►Adrenalectomy-induced hypophagia is associated with increased CRF mRNA expression in the hypothalamic paraventricular nucleus (PVN) and increased NTS neuron activation in the brainstem. ►The increased activity of PVN CRF neurons modulates brainstem satiety-related responses. ►CRF type 2 receptor mediates CRF suppressing effect on food intake after adrenalectomy.</description><subject>Adrenal glands</subject><subject>Adrenalectomy - rehabilitation</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Corticosterone - pharmacology</subject><subject>Corticotrophin-releasing factor</subject><subject>Corticotropin-Releasing Hormone - genetics</subject><subject>Corticotropin-Releasing Hormone - metabolism</subject><subject>Corticotropin-Releasing Hormone - physiology</subject><subject>Down-Regulation - drug effects</subject><subject>Eating - drug effects</subject><subject>Eating - genetics</subject><subject>Eating - physiology</subject><subject>Feeding and Eating Disorders - chemically induced</subject><subject>Feeding and Eating Disorders - genetics</subject><subject>Feeding and Eating Disorders - metabolism</subject><subject>Food</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - drug effects</subject><subject>Glucocorticoids</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Hormones</subject><subject>Hormones and behavior</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Nucleus of the solitary tract</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Paraventricular nucleus of the hypothalamus</subject><subject>Peptide Fragments - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Rodents</subject><subject>Satiety Response - drug effects</subject><subject>Satiety Response - physiology</subject><issn>0018-506X</issn><issn>1095-6867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkU2r1DAUhoMo3vHqLxCkCOLGjidtkzaLu5DBL7jgRsFdOE1P72Rom5p0hP57zzijggsli5LD876k5xHiqYStBKlfH7brvqX9tgCeQL0FKO-JjQSjct3o-r7YAMgmV6C_XolHKR34KlVVPRRXBeimAa03Iu5CXLwLSwzz3k95pIEw-eku69EtIWYjdR4XStl-nRnBO48Z9gvFDLtIEw7E2Li-yvzk4iU6Eg6nJs51WcLF07JmkdIcpkTpsXjQ45DoyeV7Lb68e_t59yG__fT-4-7Nbe4qUyx5BaDqsgfnCqexVBW1HfEfdEjowDVUEBkAUyL0Pc_bQrXSdDySRY9NXV6Ll-feOYZvR0qLHX1yNAw4UTgm2yhdayiN-i9ZG1PzkcDk87_IQzhG3gLXQV2xiqJkqDxDLoaUIvV2jn7EuFoJ9qTOHuxPdfakzkJtWR2nnl2qjy0v_XfmlysGXlwATA6HPuLkfPrDlco0VVMwd3PmiJf73VO0yXmaHIuMLMt2wf_zIT8AJJ26HQ</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Uchoa, Ernane Torres</creator><creator>da Silva, Lilian Eslaine Costa Mendes</creator><creator>de Castro, Margaret</creator><creator>Antunes-Rodrigues, Jose</creator><creator>Elias, Lucila Leico K.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier BV</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Corticotrophin-releasing factor mediates hypophagia after adrenalectomy, increasing meal-related satiety responses</title><author>Uchoa, Ernane Torres ; da Silva, Lilian Eslaine Costa Mendes ; de Castro, Margaret ; Antunes-Rodrigues, Jose ; Elias, Lucila Leico K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-400573f0cc2c6a354ebde011daeac0c8e2ee90093a0ff011b25b19d90012fa873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adrenal glands</topic><topic>Adrenalectomy - rehabilitation</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Corticosterone - pharmacology</topic><topic>Corticotrophin-releasing factor</topic><topic>Corticotropin-Releasing Hormone - genetics</topic><topic>Corticotropin-Releasing Hormone - metabolism</topic><topic>Corticotropin-Releasing Hormone - physiology</topic><topic>Down-Regulation - drug effects</topic><topic>Eating - drug effects</topic><topic>Eating - genetics</topic><topic>Eating - physiology</topic><topic>Feeding and Eating Disorders - chemically induced</topic><topic>Feeding and Eating Disorders - genetics</topic><topic>Feeding and Eating Disorders - metabolism</topic><topic>Food</topic><topic>Food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - drug effects</topic><topic>Glucocorticoids</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Hormones</topic><topic>Hormones and behavior</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Nucleus of the solitary tract</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Paraventricular nucleus of the hypothalamus</topic><topic>Peptide Fragments - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Rodents</topic><topic>Satiety Response - drug effects</topic><topic>Satiety Response - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uchoa, Ernane Torres</creatorcontrib><creatorcontrib>da Silva, Lilian Eslaine Costa Mendes</creatorcontrib><creatorcontrib>de Castro, Margaret</creatorcontrib><creatorcontrib>Antunes-Rodrigues, Jose</creatorcontrib><creatorcontrib>Elias, Lucila Leico K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uchoa, Ernane Torres</au><au>da Silva, Lilian Eslaine Costa Mendes</au><au>de Castro, Margaret</au><au>Antunes-Rodrigues, Jose</au><au>Elias, Lucila Leico K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corticotrophin-releasing factor mediates hypophagia after adrenalectomy, increasing meal-related satiety responses</atitle><jtitle>Hormones and behavior</jtitle><addtitle>Horm Behav</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>58</volume><issue>5</issue><spage>714</spage><epage>719</epage><pages>714-719</pages><issn>0018-506X</issn><eissn>1095-6867</eissn><coden>HOBEAO</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Adrenalectomy-induced hypophagia is associated with increased satiety-related responses, which involve neuronal activation of the nucleus of the solitary tract (NTS). Besides its effects on the pituitary–adrenal axis, corticotrophin-releasing factor (CRF) has been shown to play an important role in feeding behaviour, as it possesses anorexigenic effects. We evaluated feeding-induced CRF mRNA expression in the paraventricular nucleus (PVN) and the effects of pretreatment with CRF
2 receptor antagonist (Antisauvagine-30, AS30) on food intake and activation of NTS neurons in response to feeding in adrenalectomised (ADX) rats. Compared to the sham group, ADX increased CRF mRNA levels in the PVN of fasted animals, which was further augmented by refeeding. AS30 treatment did not affect food intake in the sham and ADX
+
corticosterone (B) groups; however, it reversed hypophagia in the ADX group. In vehicle-pretreated animals, refeeding increased the number of Fos and Fos/TH-immunoreactive neurons in the NTS in the sham, ADX and ADX
+
B groups, with the highest number of neurons in the ADX animals. Similarly to its effect on food intake, pretreatment with AS30 in the ADX group also reversed the increased activation of NTS neurons induced by refeeding while having no effect in the sham and ADX
+
B animals. The present results show that adrenalectomy induces an increase in CRF mRNA expression in the PVN potentiated by feeding and that CRF
2 receptor antagonist abolishes the anorexigenic effect and the increased activation of NTS induced by feeding in the ADX animals. These data indicate that increased activity of PVN CRF neurons modulates brainstem satiety-related responses, contributing to hypophagia after adrenalectomy.
►Primary adrenal insufficiency increases meal-related satiety responses. ►Adrenalectomy-induced hypophagia is associated with increased CRF mRNA expression in the hypothalamic paraventricular nucleus (PVN) and increased NTS neuron activation in the brainstem. ►The increased activity of PVN CRF neurons modulates brainstem satiety-related responses. ►CRF type 2 receptor mediates CRF suppressing effect on food intake after adrenalectomy.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20688066</pmid><doi>10.1016/j.yhbeh.2010.07.003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adrenal glands Adrenalectomy - rehabilitation Animal behavior Animals Behavioral psychophysiology Biological and medical sciences Corticosterone - pharmacology Corticotrophin-releasing factor Corticotropin-Releasing Hormone - genetics Corticotropin-Releasing Hormone - metabolism Corticotropin-Releasing Hormone - physiology Down-Regulation - drug effects Eating - drug effects Eating - genetics Eating - physiology Feeding and Eating Disorders - chemically induced Feeding and Eating Disorders - genetics Feeding and Eating Disorders - metabolism Food Food intake Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Glucocorticoids Hormone Antagonists - pharmacology Hormones Hormones and behavior Neurons Neurons - drug effects Neurons - metabolism Nucleus of the solitary tract Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - metabolism Paraventricular nucleus of the hypothalamus Peptide Fragments - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Rodents Satiety Response - drug effects Satiety Response - physiology |
| title | Corticotrophin-releasing factor mediates hypophagia after adrenalectomy, increasing meal-related satiety responses |
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