Loading…
Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins
The aim of this study was to investigate whether single or combined radio frequency (RF) radiation exposure has effects on the cell cycle and its regulatory proteins. Exposure of MCF7 cells to either single (837 MHz) or combined (837 and 1950 MHz) RF radiation was conducted at specific absorption ra...
Saved in:
Published in: | Bioelectromagnetics 2011-04, Vol.32 (3), p.169-178 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c4618-d02c5811d9bd5d23243827f1c94f676b50007f3a2f0adce23407dea5215231d23 |
---|---|
cites | cdi_FETCH-LOGICAL-c4618-d02c5811d9bd5d23243827f1c94f676b50007f3a2f0adce23407dea5215231d23 |
container_end_page | 178 |
container_issue | 3 |
container_start_page | 169 |
container_title | Bioelectromagnetics |
container_volume | 32 |
creator | Lee, Kwan-Yong Kim, Bong Cho Han, Na-Kyung Lee, Yun-Sil Kim, Taehong Yun, Jae-Hoon Kim, Nam Pack, Jeong-Ki Lee, Jae-Seon |
description | The aim of this study was to investigate whether single or combined radio frequency (RF) radiation exposure has effects on the cell cycle and its regulatory proteins. Exposure of MCF7 cells to either single (837 MHz) or combined (837 and 1950 MHz) RF radiation was conducted at specific absorption rate values of 4 W/kg for 1 h. During the exposure period, the chamber was made isothermal by circulating water through the cavity. After RF radiation exposure, DNA synthesis rate and cell cycle distribution were assessed. The levels of cell cycle regulatory proteins, p53, p21, cyclins, and cyclin‐dependent kinases were also examined. The positive control group was exposed to 0.5 and 4 Gy doses of ionizing radiation (IR) and showed changes in DNA synthesis and cell cycle distribution. The levels of p53, p21, cyclin A, cyclin B1, and cyclin D1 were also affected by IR exposure. In contrast to the IR‐exposed group, neither the single RF radiation‐ nor the combined RF radiation‐exposed group elicited alterations in DNA synthesis, cell cycle distribution, and levels of cell cycle regulatory proteins. These results indicate that neither single nor combined RF radiation affect cell cycle progression. Bioelectromagnetics 32:169–178, 2011. © 2010 Wiley‐Liss, Inc. |
doi_str_mv | 10.1002/bem.20618 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_855207007</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>855207007</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4618-d02c5811d9bd5d23243827f1c94f676b50007f3a2f0adce23407dea5215231d23</originalsourceid><addsrcrecordid>eNp9kE1PFTEUhhuigQuy8A-Q7pTFQD-mnd6l4gWN4EfE6K7ptKdQnJle25nI_HsLF9jpqm3ynKfveRF6SckRJYQdt9AfMSKp2kILKhitqJI_n6EFocumUrVkO2g35xtCiFKEb6MdRrkUUtIFsivvwY4ZR49t7NswgMPJuBB9gt8TDHa-f5oxxAHD7TrmKQEu9_EasIWuw3a2HWAzOByKJ8HV1JkxphmvUxwhDPkFeu5Nl2H_4dxD309Xlyfvq_PPZx9O3pxXti7ZK0eYFYpSt2ydcIyzmivWeGqXtZeNbEXJ33humCfGWWC8Jo0DU_YVjNMysIdebbzl4xI9j7oP-S6iGSBOWSshGGmKpJCv_0tSzrgiUjBR0MMNalPMOYHX6xR6k2ZNib5rX5f29X37hT140E5tD-6JfKy7AMcb4E_oYP63Sb9dXTwqq81EyCPcPk2Y9EvLhjdC__h0pj9-W9IvX9-d6gv-F5UInW4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1323806525</pqid></control><display><type>article</type><title>Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins</title><source>Wiley-Blackwell Journals</source><creator>Lee, Kwan-Yong ; Kim, Bong Cho ; Han, Na-Kyung ; Lee, Yun-Sil ; Kim, Taehong ; Yun, Jae-Hoon ; Kim, Nam ; Pack, Jeong-Ki ; Lee, Jae-Seon</creator><creatorcontrib>Lee, Kwan-Yong ; Kim, Bong Cho ; Han, Na-Kyung ; Lee, Yun-Sil ; Kim, Taehong ; Yun, Jae-Hoon ; Kim, Nam ; Pack, Jeong-Ki ; Lee, Jae-Seon</creatorcontrib><description>The aim of this study was to investigate whether single or combined radio frequency (RF) radiation exposure has effects on the cell cycle and its regulatory proteins. Exposure of MCF7 cells to either single (837 MHz) or combined (837 and 1950 MHz) RF radiation was conducted at specific absorption rate values of 4 W/kg for 1 h. During the exposure period, the chamber was made isothermal by circulating water through the cavity. After RF radiation exposure, DNA synthesis rate and cell cycle distribution were assessed. The levels of cell cycle regulatory proteins, p53, p21, cyclins, and cyclin‐dependent kinases were also examined. The positive control group was exposed to 0.5 and 4 Gy doses of ionizing radiation (IR) and showed changes in DNA synthesis and cell cycle distribution. The levels of p53, p21, cyclin A, cyclin B1, and cyclin D1 were also affected by IR exposure. In contrast to the IR‐exposed group, neither the single RF radiation‐ nor the combined RF radiation‐exposed group elicited alterations in DNA synthesis, cell cycle distribution, and levels of cell cycle regulatory proteins. These results indicate that neither single nor combined RF radiation affect cell cycle progression. Bioelectromagnetics 32:169–178, 2011. © 2010 Wiley‐Liss, Inc.</description><identifier>ISSN: 0197-8462</identifier><identifier>EISSN: 1521-186X</identifier><identifier>DOI: 10.1002/bem.20618</identifier><identifier>PMID: 21365661</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Bromodeoxyuridine - metabolism ; cell cycle ; Cell Cycle - radiation effects ; Cell Cycle Proteins - metabolism ; Cell Line, Tumor ; DNA - biosynthesis ; DNA synthesis ; Humans ; MCF7 cells ; Radio Waves ; RF radiation</subject><ispartof>Bioelectromagnetics, 2011-04, Vol.32 (3), p.169-178</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>Copyright © 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4618-d02c5811d9bd5d23243827f1c94f676b50007f3a2f0adce23407dea5215231d23</citedby><cites>FETCH-LOGICAL-c4618-d02c5811d9bd5d23243827f1c94f676b50007f3a2f0adce23407dea5215231d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbem.20618$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbem.20618$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21365661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Kwan-Yong</creatorcontrib><creatorcontrib>Kim, Bong Cho</creatorcontrib><creatorcontrib>Han, Na-Kyung</creatorcontrib><creatorcontrib>Lee, Yun-Sil</creatorcontrib><creatorcontrib>Kim, Taehong</creatorcontrib><creatorcontrib>Yun, Jae-Hoon</creatorcontrib><creatorcontrib>Kim, Nam</creatorcontrib><creatorcontrib>Pack, Jeong-Ki</creatorcontrib><creatorcontrib>Lee, Jae-Seon</creatorcontrib><title>Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins</title><title>Bioelectromagnetics</title><addtitle>Bioelectromagnetics</addtitle><description>The aim of this study was to investigate whether single or combined radio frequency (RF) radiation exposure has effects on the cell cycle and its regulatory proteins. Exposure of MCF7 cells to either single (837 MHz) or combined (837 and 1950 MHz) RF radiation was conducted at specific absorption rate values of 4 W/kg for 1 h. During the exposure period, the chamber was made isothermal by circulating water through the cavity. After RF radiation exposure, DNA synthesis rate and cell cycle distribution were assessed. The levels of cell cycle regulatory proteins, p53, p21, cyclins, and cyclin‐dependent kinases were also examined. The positive control group was exposed to 0.5 and 4 Gy doses of ionizing radiation (IR) and showed changes in DNA synthesis and cell cycle distribution. The levels of p53, p21, cyclin A, cyclin B1, and cyclin D1 were also affected by IR exposure. In contrast to the IR‐exposed group, neither the single RF radiation‐ nor the combined RF radiation‐exposed group elicited alterations in DNA synthesis, cell cycle distribution, and levels of cell cycle regulatory proteins. These results indicate that neither single nor combined RF radiation affect cell cycle progression. Bioelectromagnetics 32:169–178, 2011. © 2010 Wiley‐Liss, Inc.</description><subject>Bromodeoxyuridine - metabolism</subject><subject>cell cycle</subject><subject>Cell Cycle - radiation effects</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Line, Tumor</subject><subject>DNA - biosynthesis</subject><subject>DNA synthesis</subject><subject>Humans</subject><subject>MCF7 cells</subject><subject>Radio Waves</subject><subject>RF radiation</subject><issn>0197-8462</issn><issn>1521-186X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PFTEUhhuigQuy8A-Q7pTFQD-mnd6l4gWN4EfE6K7ptKdQnJle25nI_HsLF9jpqm3ynKfveRF6SckRJYQdt9AfMSKp2kILKhitqJI_n6EFocumUrVkO2g35xtCiFKEb6MdRrkUUtIFsivvwY4ZR49t7NswgMPJuBB9gt8TDHa-f5oxxAHD7TrmKQEu9_EasIWuw3a2HWAzOByKJ8HV1JkxphmvUxwhDPkFeu5Nl2H_4dxD309Xlyfvq_PPZx9O3pxXti7ZK0eYFYpSt2ydcIyzmivWeGqXtZeNbEXJ33humCfGWWC8Jo0DU_YVjNMysIdebbzl4xI9j7oP-S6iGSBOWSshGGmKpJCv_0tSzrgiUjBR0MMNalPMOYHX6xR6k2ZNib5rX5f29X37hT140E5tD-6JfKy7AMcb4E_oYP63Sb9dXTwqq81EyCPcPk2Y9EvLhjdC__h0pj9-W9IvX9-d6gv-F5UInW4</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Lee, Kwan-Yong</creator><creator>Kim, Bong Cho</creator><creator>Han, Na-Kyung</creator><creator>Lee, Yun-Sil</creator><creator>Kim, Taehong</creator><creator>Yun, Jae-Hoon</creator><creator>Kim, Nam</creator><creator>Pack, Jeong-Ki</creator><creator>Lee, Jae-Seon</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins</title><author>Lee, Kwan-Yong ; Kim, Bong Cho ; Han, Na-Kyung ; Lee, Yun-Sil ; Kim, Taehong ; Yun, Jae-Hoon ; Kim, Nam ; Pack, Jeong-Ki ; Lee, Jae-Seon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4618-d02c5811d9bd5d23243827f1c94f676b50007f3a2f0adce23407dea5215231d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Bromodeoxyuridine - metabolism</topic><topic>cell cycle</topic><topic>Cell Cycle - radiation effects</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Line, Tumor</topic><topic>DNA - biosynthesis</topic><topic>DNA synthesis</topic><topic>Humans</topic><topic>MCF7 cells</topic><topic>Radio Waves</topic><topic>RF radiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kwan-Yong</creatorcontrib><creatorcontrib>Kim, Bong Cho</creatorcontrib><creatorcontrib>Han, Na-Kyung</creatorcontrib><creatorcontrib>Lee, Yun-Sil</creatorcontrib><creatorcontrib>Kim, Taehong</creatorcontrib><creatorcontrib>Yun, Jae-Hoon</creatorcontrib><creatorcontrib>Kim, Nam</creatorcontrib><creatorcontrib>Pack, Jeong-Ki</creatorcontrib><creatorcontrib>Lee, Jae-Seon</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioelectromagnetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kwan-Yong</au><au>Kim, Bong Cho</au><au>Han, Na-Kyung</au><au>Lee, Yun-Sil</au><au>Kim, Taehong</au><au>Yun, Jae-Hoon</au><au>Kim, Nam</au><au>Pack, Jeong-Ki</au><au>Lee, Jae-Seon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins</atitle><jtitle>Bioelectromagnetics</jtitle><addtitle>Bioelectromagnetics</addtitle><date>2011-04</date><risdate>2011</risdate><volume>32</volume><issue>3</issue><spage>169</spage><epage>178</epage><pages>169-178</pages><issn>0197-8462</issn><eissn>1521-186X</eissn><notes>ArticleID:BEM20618</notes><notes>ark:/67375/WNG-KS91PQDF-M</notes><notes>Korea Communications Commission (2009)</notes><notes>istex:FC9123118D9B5EE5F561EB51909FAC0D9B81978A</notes><notes>Kwan‐Yong Lee and Bong Cho Kim contributed equally to this work.</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>The aim of this study was to investigate whether single or combined radio frequency (RF) radiation exposure has effects on the cell cycle and its regulatory proteins. Exposure of MCF7 cells to either single (837 MHz) or combined (837 and 1950 MHz) RF radiation was conducted at specific absorption rate values of 4 W/kg for 1 h. During the exposure period, the chamber was made isothermal by circulating water through the cavity. After RF radiation exposure, DNA synthesis rate and cell cycle distribution were assessed. The levels of cell cycle regulatory proteins, p53, p21, cyclins, and cyclin‐dependent kinases were also examined. The positive control group was exposed to 0.5 and 4 Gy doses of ionizing radiation (IR) and showed changes in DNA synthesis and cell cycle distribution. The levels of p53, p21, cyclin A, cyclin B1, and cyclin D1 were also affected by IR exposure. In contrast to the IR‐exposed group, neither the single RF radiation‐ nor the combined RF radiation‐exposed group elicited alterations in DNA synthesis, cell cycle distribution, and levels of cell cycle regulatory proteins. These results indicate that neither single nor combined RF radiation affect cell cycle progression. Bioelectromagnetics 32:169–178, 2011. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21365661</pmid><doi>10.1002/bem.20618</doi><tpages>10</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0197-8462 |
ispartof | Bioelectromagnetics, 2011-04, Vol.32 (3), p.169-178 |
issn | 0197-8462 1521-186X |
language | eng |
recordid | cdi_proquest_miscellaneous_855207007 |
source | Wiley-Blackwell Journals |
subjects | Bromodeoxyuridine - metabolism cell cycle Cell Cycle - radiation effects Cell Cycle Proteins - metabolism Cell Line, Tumor DNA - biosynthesis DNA synthesis Humans MCF7 cells Radio Waves RF radiation |
title | Effects of combined radiofrequency radiation exposure on the cell cycle and its regulatory proteins |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T20%3A22%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20combined%20radiofrequency%20radiation%20exposure%20on%20the%20cell%20cycle%20and%20its%20regulatory%20proteins&rft.jtitle=Bioelectromagnetics&rft.au=Lee,%20Kwan-Yong&rft.date=2011-04&rft.volume=32&rft.issue=3&rft.spage=169&rft.epage=178&rft.pages=169-178&rft.issn=0197-8462&rft.eissn=1521-186X&rft_id=info:doi/10.1002/bem.20618&rft_dat=%3Cproquest_cross%3E855207007%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4618-d02c5811d9bd5d23243827f1c94f676b50007f3a2f0adce23407dea5215231d23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1323806525&rft_id=info:pmid/21365661&rfr_iscdi=true |