Loading…
Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats
▶ Locomotor activity measured in the EPM was decreased in 6-OHDA lesioned rats and could not be reversed by transplantation of differentiated progenitor cells. ▶ Anxiety-like behavior analyzed in the OF was increased after 6-OHDA lesions. ▶ Level of anxiety-like behavior and locomotor activity in tr...
Saved in:
| Published in: | Behavioural brain research 2011, Vol.216 (1), p.129-135 |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c414t-eafcf951ce3fabbe211c3d7cb64bdbf9c1699ce3854c107d81f69180a5d96c943 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c414t-eafcf951ce3fabbe211c3d7cb64bdbf9c1699ce3854c107d81f69180a5d96c943 |
| container_end_page | 135 |
| container_issue | 1 |
| container_start_page | 129 |
| container_title | Behavioural brain research |
| container_volume | 216 |
| creator | Jungnickel, Julia Kalve, Ieva Reimers, Linda Nobre, André Wesemann, Maike Ratzka, Andreas Halfer, Nina Lindemann, Christoph Schwabe, Kerstin Töllner, Kathrin Gernert, Manuela Grothe, Claudia |
| description | ▶ Locomotor activity measured in the EPM was decreased in 6-OHDA lesioned rats and could not be reversed by transplantation of differentiated progenitor cells. ▶ Anxiety-like behavior analyzed in the OF was increased after 6-OHDA lesions. ▶ Level of anxiety-like behavior and locomotor activity in transplanted animals correlated with the topology of the grafts.
Many Parkinson's disease (PD) patients suffer from anxiety disorders, which often precede the onset of classical motor symptoms. So far, there is no evidence from randomized, placebo-controlled trials for successful treatment of anxiety in patients with PD. Grafts of fetal nigral neurons are currently explored as a restorative cell therapy for PD. In PD animal models, intrastriatal transplantations of embryonic dopaminergic neurons have been shown to ameliorate behavioral defects. In our previous study we showed that expanded and differentiated neural progenitors improved drug-induced rotation behavior and posture balance as a more complex motor task. However, it is not clear whether grafting of these cells affected spontaneous locomotor activity and anxiety-like behavior in 6-OHDA lesioned rats. Therefore, we analyzed behavior of control, lesioned, sham-transplanted, and transplanted rats using open field (OF) and elevated plus maze (EPM). After unilateral 6-OHDA lesion of the medial forebrain bundle, we observed reduced locomotor activity in the EPM (wall-rearing, entries in closed arms) in lesioned and sham-transplanted rats, which correlated with the loss of dopaminergic neurons and apomorphine-induced rotation behavior. Furthermore, anxiety-like behavior in the EPM (entries and time in open arms) was increased in lesioned and sham-transplanted rats. Although exogenous cell replacement improved apomorphine-induced rotation behavior, locomotor activity and anxiety-like behavior was not reconstituted in transplanted rats. However, we provided evidence for an interaction of locomotor activity/anxiety-like behavior with graft localization in the host striatum. These results emphasize the crucial role of graft localization for benefit of restorative cell therapy for PD. |
| doi_str_mv | 10.1016/j.bbr.2010.07.023 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_853475398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166432810005243</els_id><sourcerecordid>853475398</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-eafcf951ce3fabbe211c3d7cb64bdbf9c1699ce3854c107d81f69180a5d96c943</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhq0K1G4_fgAXlAvilMWO7SQWJ1RBQarEpZwtZzxeeZXYi-0g-u_r1S5w4zSamWdejR5C3jC6ZZT1H_bbaUrbjtaeDlva8QuyYePQtYMU6hXZVKZvBe_GK3Kd855SKqhkl-Sqo72UnIsNWZ_iIc5x99xE1_hQkskleVPM3Nh4MIsPmHYeml0yruTGYsF0HObGrQGKj6GSJtgGl3ju4logLljTmoBriiX-9qGdMdc12iaZkm_Ja2fmjHfnekN-fPn8dP-1ffz-8O3-02MLgonSonHglGSA3Jlpwo4x4HaAqReTnZwC1itVl6MUwOhgR-Z6xUZqpFU9KMFvyPtT7iHFnyvmohefAefZBIxr1qPkYpBcjZVkJxJSzDmh04fkF5OeNaP6KFvvdZWtj7I1HXSVXW_entPXaUH79-KP3Qq8OwMmg5ldMgF8_sdVpB_pkft44rC6-OUx6QweA6D1CaFoG_1_3ngB6HWgWg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>853475398</pqid></control><display><type>article</type><title>Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats</title><source>ScienceDirect Freedom Collection</source><creator>Jungnickel, Julia ; Kalve, Ieva ; Reimers, Linda ; Nobre, André ; Wesemann, Maike ; Ratzka, Andreas ; Halfer, Nina ; Lindemann, Christoph ; Schwabe, Kerstin ; Töllner, Kathrin ; Gernert, Manuela ; Grothe, Claudia</creator><creatorcontrib>Jungnickel, Julia ; Kalve, Ieva ; Reimers, Linda ; Nobre, André ; Wesemann, Maike ; Ratzka, Andreas ; Halfer, Nina ; Lindemann, Christoph ; Schwabe, Kerstin ; Töllner, Kathrin ; Gernert, Manuela ; Grothe, Claudia</creatorcontrib><description>▶ Locomotor activity measured in the EPM was decreased in 6-OHDA lesioned rats and could not be reversed by transplantation of differentiated progenitor cells. ▶ Anxiety-like behavior analyzed in the OF was increased after 6-OHDA lesions. ▶ Level of anxiety-like behavior and locomotor activity in transplanted animals correlated with the topology of the grafts.
Many Parkinson's disease (PD) patients suffer from anxiety disorders, which often precede the onset of classical motor symptoms. So far, there is no evidence from randomized, placebo-controlled trials for successful treatment of anxiety in patients with PD. Grafts of fetal nigral neurons are currently explored as a restorative cell therapy for PD. In PD animal models, intrastriatal transplantations of embryonic dopaminergic neurons have been shown to ameliorate behavioral defects. In our previous study we showed that expanded and differentiated neural progenitors improved drug-induced rotation behavior and posture balance as a more complex motor task. However, it is not clear whether grafting of these cells affected spontaneous locomotor activity and anxiety-like behavior in 6-OHDA lesioned rats. Therefore, we analyzed behavior of control, lesioned, sham-transplanted, and transplanted rats using open field (OF) and elevated plus maze (EPM). After unilateral 6-OHDA lesion of the medial forebrain bundle, we observed reduced locomotor activity in the EPM (wall-rearing, entries in closed arms) in lesioned and sham-transplanted rats, which correlated with the loss of dopaminergic neurons and apomorphine-induced rotation behavior. Furthermore, anxiety-like behavior in the EPM (entries and time in open arms) was increased in lesioned and sham-transplanted rats. Although exogenous cell replacement improved apomorphine-induced rotation behavior, locomotor activity and anxiety-like behavior was not reconstituted in transplanted rats. However, we provided evidence for an interaction of locomotor activity/anxiety-like behavior with graft localization in the host striatum. These results emphasize the crucial role of graft localization for benefit of restorative cell therapy for PD.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2010.07.023</identifier><identifier>PMID: 20655334</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>6-OHDA lesioned rats ; Analysis of Variance ; Animals ; Anxiety - physiopathology ; Anxiety-like behavior ; Behavioral psychophysiology ; Biological and medical sciences ; Brain Tissue Transplantation ; Corpus Striatum - embryology ; Corpus Striatum - metabolism ; Corpus Striatum - transplantation ; Dopamine - metabolism ; Dopaminergic progenitors ; Female ; Fetal Tissue Transplantation ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Locomotor activity ; Medial Forebrain Bundle - physiopathology ; Motor Activity - physiology ; Neurons - metabolism ; Neurons - transplantation ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Substantia Nigra - embryology ; Substantia Nigra - metabolism ; Substantia Nigra - transplantation ; Transplantation ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>Behavioural brain research, 2011, Vol.216 (1), p.129-135</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-eafcf951ce3fabbe211c3d7cb64bdbf9c1699ce3854c107d81f69180a5d96c943</citedby><cites>FETCH-LOGICAL-c414t-eafcf951ce3fabbe211c3d7cb64bdbf9c1699ce3854c107d81f69180a5d96c943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,4043,27956,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23436804$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20655334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jungnickel, Julia</creatorcontrib><creatorcontrib>Kalve, Ieva</creatorcontrib><creatorcontrib>Reimers, Linda</creatorcontrib><creatorcontrib>Nobre, André</creatorcontrib><creatorcontrib>Wesemann, Maike</creatorcontrib><creatorcontrib>Ratzka, Andreas</creatorcontrib><creatorcontrib>Halfer, Nina</creatorcontrib><creatorcontrib>Lindemann, Christoph</creatorcontrib><creatorcontrib>Schwabe, Kerstin</creatorcontrib><creatorcontrib>Töllner, Kathrin</creatorcontrib><creatorcontrib>Gernert, Manuela</creatorcontrib><creatorcontrib>Grothe, Claudia</creatorcontrib><title>Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>▶ Locomotor activity measured in the EPM was decreased in 6-OHDA lesioned rats and could not be reversed by transplantation of differentiated progenitor cells. ▶ Anxiety-like behavior analyzed in the OF was increased after 6-OHDA lesions. ▶ Level of anxiety-like behavior and locomotor activity in transplanted animals correlated with the topology of the grafts.
Many Parkinson's disease (PD) patients suffer from anxiety disorders, which often precede the onset of classical motor symptoms. So far, there is no evidence from randomized, placebo-controlled trials for successful treatment of anxiety in patients with PD. Grafts of fetal nigral neurons are currently explored as a restorative cell therapy for PD. In PD animal models, intrastriatal transplantations of embryonic dopaminergic neurons have been shown to ameliorate behavioral defects. In our previous study we showed that expanded and differentiated neural progenitors improved drug-induced rotation behavior and posture balance as a more complex motor task. However, it is not clear whether grafting of these cells affected spontaneous locomotor activity and anxiety-like behavior in 6-OHDA lesioned rats. Therefore, we analyzed behavior of control, lesioned, sham-transplanted, and transplanted rats using open field (OF) and elevated plus maze (EPM). After unilateral 6-OHDA lesion of the medial forebrain bundle, we observed reduced locomotor activity in the EPM (wall-rearing, entries in closed arms) in lesioned and sham-transplanted rats, which correlated with the loss of dopaminergic neurons and apomorphine-induced rotation behavior. Furthermore, anxiety-like behavior in the EPM (entries and time in open arms) was increased in lesioned and sham-transplanted rats. Although exogenous cell replacement improved apomorphine-induced rotation behavior, locomotor activity and anxiety-like behavior was not reconstituted in transplanted rats. However, we provided evidence for an interaction of locomotor activity/anxiety-like behavior with graft localization in the host striatum. These results emphasize the crucial role of graft localization for benefit of restorative cell therapy for PD.</description><subject>6-OHDA lesioned rats</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anxiety - physiopathology</subject><subject>Anxiety-like behavior</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain Tissue Transplantation</subject><subject>Corpus Striatum - embryology</subject><subject>Corpus Striatum - metabolism</subject><subject>Corpus Striatum - transplantation</subject><subject>Dopamine - metabolism</subject><subject>Dopaminergic progenitors</subject><subject>Female</subject><subject>Fetal Tissue Transplantation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Locomotor activity</subject><subject>Medial Forebrain Bundle - physiopathology</subject><subject>Motor Activity - physiology</subject><subject>Neurons - metabolism</subject><subject>Neurons - transplantation</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Substantia Nigra - embryology</subject><subject>Substantia Nigra - metabolism</subject><subject>Substantia Nigra - transplantation</subject><subject>Transplantation</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhq0K1G4_fgAXlAvilMWO7SQWJ1RBQarEpZwtZzxeeZXYi-0g-u_r1S5w4zSamWdejR5C3jC6ZZT1H_bbaUrbjtaeDlva8QuyYePQtYMU6hXZVKZvBe_GK3Kd855SKqhkl-Sqo72UnIsNWZ_iIc5x99xE1_hQkskleVPM3Nh4MIsPmHYeml0yruTGYsF0HObGrQGKj6GSJtgGl3ju4logLljTmoBriiX-9qGdMdc12iaZkm_Ja2fmjHfnekN-fPn8dP-1ffz-8O3-02MLgonSonHglGSA3Jlpwo4x4HaAqReTnZwC1itVl6MUwOhgR-Z6xUZqpFU9KMFvyPtT7iHFnyvmohefAefZBIxr1qPkYpBcjZVkJxJSzDmh04fkF5OeNaP6KFvvdZWtj7I1HXSVXW_entPXaUH79-KP3Qq8OwMmg5ldMgF8_sdVpB_pkft44rC6-OUx6QweA6D1CaFoG_1_3ngB6HWgWg</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Jungnickel, Julia</creator><creator>Kalve, Ieva</creator><creator>Reimers, Linda</creator><creator>Nobre, André</creator><creator>Wesemann, Maike</creator><creator>Ratzka, Andreas</creator><creator>Halfer, Nina</creator><creator>Lindemann, Christoph</creator><creator>Schwabe, Kerstin</creator><creator>Töllner, Kathrin</creator><creator>Gernert, Manuela</creator><creator>Grothe, Claudia</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>2011</creationdate><title>Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats</title><author>Jungnickel, Julia ; Kalve, Ieva ; Reimers, Linda ; Nobre, André ; Wesemann, Maike ; Ratzka, Andreas ; Halfer, Nina ; Lindemann, Christoph ; Schwabe, Kerstin ; Töllner, Kathrin ; Gernert, Manuela ; Grothe, Claudia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-eafcf951ce3fabbe211c3d7cb64bdbf9c1699ce3854c107d81f69180a5d96c943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>6-OHDA lesioned rats</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Anxiety - physiopathology</topic><topic>Anxiety-like behavior</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain Tissue Transplantation</topic><topic>Corpus Striatum - embryology</topic><topic>Corpus Striatum - metabolism</topic><topic>Corpus Striatum - transplantation</topic><topic>Dopamine - metabolism</topic><topic>Dopaminergic progenitors</topic><topic>Female</topic><topic>Fetal Tissue Transplantation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry</topic><topic>Locomotor activity</topic><topic>Medial Forebrain Bundle - physiopathology</topic><topic>Motor Activity - physiology</topic><topic>Neurons - metabolism</topic><topic>Neurons - transplantation</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Substantia Nigra - embryology</topic><topic>Substantia Nigra - metabolism</topic><topic>Substantia Nigra - transplantation</topic><topic>Transplantation</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jungnickel, Julia</creatorcontrib><creatorcontrib>Kalve, Ieva</creatorcontrib><creatorcontrib>Reimers, Linda</creatorcontrib><creatorcontrib>Nobre, André</creatorcontrib><creatorcontrib>Wesemann, Maike</creatorcontrib><creatorcontrib>Ratzka, Andreas</creatorcontrib><creatorcontrib>Halfer, Nina</creatorcontrib><creatorcontrib>Lindemann, Christoph</creatorcontrib><creatorcontrib>Schwabe, Kerstin</creatorcontrib><creatorcontrib>Töllner, Kathrin</creatorcontrib><creatorcontrib>Gernert, Manuela</creatorcontrib><creatorcontrib>Grothe, Claudia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jungnickel, Julia</au><au>Kalve, Ieva</au><au>Reimers, Linda</au><au>Nobre, André</au><au>Wesemann, Maike</au><au>Ratzka, Andreas</au><au>Halfer, Nina</au><au>Lindemann, Christoph</au><au>Schwabe, Kerstin</au><au>Töllner, Kathrin</au><au>Gernert, Manuela</au><au>Grothe, Claudia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2011</date><risdate>2011</risdate><volume>216</volume><issue>1</issue><spage>129</spage><epage>135</epage><pages>129-135</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><abstract>▶ Locomotor activity measured in the EPM was decreased in 6-OHDA lesioned rats and could not be reversed by transplantation of differentiated progenitor cells. ▶ Anxiety-like behavior analyzed in the OF was increased after 6-OHDA lesions. ▶ Level of anxiety-like behavior and locomotor activity in transplanted animals correlated with the topology of the grafts.
Many Parkinson's disease (PD) patients suffer from anxiety disorders, which often precede the onset of classical motor symptoms. So far, there is no evidence from randomized, placebo-controlled trials for successful treatment of anxiety in patients with PD. Grafts of fetal nigral neurons are currently explored as a restorative cell therapy for PD. In PD animal models, intrastriatal transplantations of embryonic dopaminergic neurons have been shown to ameliorate behavioral defects. In our previous study we showed that expanded and differentiated neural progenitors improved drug-induced rotation behavior and posture balance as a more complex motor task. However, it is not clear whether grafting of these cells affected spontaneous locomotor activity and anxiety-like behavior in 6-OHDA lesioned rats. Therefore, we analyzed behavior of control, lesioned, sham-transplanted, and transplanted rats using open field (OF) and elevated plus maze (EPM). After unilateral 6-OHDA lesion of the medial forebrain bundle, we observed reduced locomotor activity in the EPM (wall-rearing, entries in closed arms) in lesioned and sham-transplanted rats, which correlated with the loss of dopaminergic neurons and apomorphine-induced rotation behavior. Furthermore, anxiety-like behavior in the EPM (entries and time in open arms) was increased in lesioned and sham-transplanted rats. Although exogenous cell replacement improved apomorphine-induced rotation behavior, locomotor activity and anxiety-like behavior was not reconstituted in transplanted rats. However, we provided evidence for an interaction of locomotor activity/anxiety-like behavior with graft localization in the host striatum. These results emphasize the crucial role of graft localization for benefit of restorative cell therapy for PD.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>20655334</pmid><doi>10.1016/j.bbr.2010.07.023</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-4328 |
| ispartof | Behavioural brain research, 2011, Vol.216 (1), p.129-135 |
| issn | 0166-4328 1872-7549 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_853475398 |
| source | ScienceDirect Freedom Collection |
| subjects | 6-OHDA lesioned rats Analysis of Variance Animals Anxiety - physiopathology Anxiety-like behavior Behavioral psychophysiology Biological and medical sciences Brain Tissue Transplantation Corpus Striatum - embryology Corpus Striatum - metabolism Corpus Striatum - transplantation Dopamine - metabolism Dopaminergic progenitors Female Fetal Tissue Transplantation Fundamental and applied biological sciences. Psychology Immunohistochemistry Locomotor activity Medial Forebrain Bundle - physiopathology Motor Activity - physiology Neurons - metabolism Neurons - transplantation Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Random Allocation Rats Rats, Sprague-Dawley Substantia Nigra - embryology Substantia Nigra - metabolism Substantia Nigra - transplantation Transplantation Tyrosine 3-Monooxygenase - metabolism |
| title | Topology of intrastriatal dopaminergic grafts determines functional and emotional outcome in neurotoxin-lesioned rats |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-23T03%3A22%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Topology%20of%20intrastriatal%20dopaminergic%20grafts%20determines%20functional%20and%20emotional%20outcome%20in%20neurotoxin-lesioned%20rats&rft.jtitle=Behavioural%20brain%20research&rft.au=Jungnickel,%20Julia&rft.date=2011&rft.volume=216&rft.issue=1&rft.spage=129&rft.epage=135&rft.pages=129-135&rft.issn=0166-4328&rft.eissn=1872-7549&rft.coden=BBREDI&rft_id=info:doi/10.1016/j.bbr.2010.07.023&rft_dat=%3Cproquest_cross%3E853475398%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c414t-eafcf951ce3fabbe211c3d7cb64bdbf9c1699ce3854c107d81f69180a5d96c943%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=853475398&rft_id=info:pmid/20655334&rfr_iscdi=true |