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Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye Study
Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin. A food-frequency questionnaire was administer...
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| Published in: | American journal of epidemiology 1998-07, Vol.148 (2), p.204-214 |
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| container_issue | 2 |
| container_start_page | 204 |
| container_title | American journal of epidemiology |
| container_volume | 148 |
| creator | VandenLangenberg, Gina M. Mares-Perlman, Julie A. Klein, Ronald Klein, Barbara E. K. Brady, William E. Palta, Mari |
| description | Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin. A food-frequency questionnaire was administered at baseline (1988–1990) to collect dietary information for that time period and a period of time 10 years earlier (1978–1980) from a 50 percent random sample of persons participating in this study. The incidence of the specific lesions of larger drusen (>125 μ) and pigmentary abnormalities and the incidence of any ARM were assessed by masked grading of stereoscopic color fundus photographs in 1,709 persons who participated in 5-year follow-up eye examinations. Significant, but modest, inverse associations (p < 0.05) were observed between intakes of pro-vitamin A carotenoids and dietary vitamin E and the incidence of large drusen and between zinc and the incidence of pigmentary abnormalities. No significant inverse associations were found between antioxidant or zinc intake and the incidence of overall early ARM. If ARM, which is characterized by a broad spectrum of lesions, involves a number of different underlying pathophysiologic processes, then associations between specific antioxidants and the incidence of distinct macular lesions may be biologically important. However, because there were too few incident late ARM cases in this cohort, the authors were unable to assess whether antioxidant intake is associated with the progression of early ARM to late-stage macular degeneration. Clinical trials and longer-term prospective studies are needed to elucidate further the impact of antioxidants and zinc on the development and progression of ARM. Am J Epidemiol 1998;148:204–14. |
| doi_str_mv | 10.1093/oxfordjournals.aje.a009625 |
| format | article |
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K. ; Brady, William E. ; Palta, Mari</creator><creatorcontrib>VandenLangenberg, Gina M. ; Mares-Perlman, Julie A. ; Klein, Ronald ; Klein, Barbara E. K. ; Brady, William E. ; Palta, Mari</creatorcontrib><description>Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin. A food-frequency questionnaire was administered at baseline (1988–1990) to collect dietary information for that time period and a period of time 10 years earlier (1978–1980) from a 50 percent random sample of persons participating in this study. The incidence of the specific lesions of larger drusen (>125 μ) and pigmentary abnormalities and the incidence of any ARM were assessed by masked grading of stereoscopic color fundus photographs in 1,709 persons who participated in 5-year follow-up eye examinations. Significant, but modest, inverse associations (p < 0.05) were observed between intakes of pro-vitamin A carotenoids and dietary vitamin E and the incidence of large drusen and between zinc and the incidence of pigmentary abnormalities. No significant inverse associations were found between antioxidant or zinc intake and the incidence of overall early ARM. If ARM, which is characterized by a broad spectrum of lesions, involves a number of different underlying pathophysiologic processes, then associations between specific antioxidants and the incidence of distinct macular lesions may be biologically important. However, because there were too few incident late ARM cases in this cohort, the authors were unable to assess whether antioxidant intake is associated with the progression of early ARM to late-stage macular degeneration. Clinical trials and longer-term prospective studies are needed to elucidate further the impact of antioxidants and zinc on the development and progression of ARM. Am J Epidemiol 1998;148:204–14.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/oxfordjournals.aje.a009625</identifier><identifier>PMID: 9676703</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; age-related ; Aged ; Aged, 80 and over ; Aging ; antioxidants ; Antioxidants - administration & dosage ; Antioxidants - therapeutic use ; Biological and medical sciences ; Confounding Factors (Epidemiology) ; Diet ; Female ; Humans ; Incidence ; Logistic Models ; Macular Degeneration - diagnosis ; Macular Degeneration - epidemiology ; Macular Degeneration - prevention & control ; maculopathy ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Ophthalmology ; Pigment Epithelium of Eye - abnormalities ; Prospective Studies ; retina ; retinal degeneration ; Wisconsin - epidemiology ; Zinc - administration & dosage ; Zinc - therapeutic use</subject><ispartof>American journal of epidemiology, 1998-07, Vol.148 (2), p.204-214</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-d3dfd2b51b9279e0dbe7a721c6f9c564cd0a7ca047245e054577ff301886a6f43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2367401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9676703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VandenLangenberg, Gina M.</creatorcontrib><creatorcontrib>Mares-Perlman, Julie A.</creatorcontrib><creatorcontrib>Klein, Ronald</creatorcontrib><creatorcontrib>Klein, Barbara E. K.</creatorcontrib><creatorcontrib>Brady, William E.</creatorcontrib><creatorcontrib>Palta, Mari</creatorcontrib><title>Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye Study</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin. A food-frequency questionnaire was administered at baseline (1988–1990) to collect dietary information for that time period and a period of time 10 years earlier (1978–1980) from a 50 percent random sample of persons participating in this study. The incidence of the specific lesions of larger drusen (>125 μ) and pigmentary abnormalities and the incidence of any ARM were assessed by masked grading of stereoscopic color fundus photographs in 1,709 persons who participated in 5-year follow-up eye examinations. Significant, but modest, inverse associations (p < 0.05) were observed between intakes of pro-vitamin A carotenoids and dietary vitamin E and the incidence of large drusen and between zinc and the incidence of pigmentary abnormalities. No significant inverse associations were found between antioxidant or zinc intake and the incidence of overall early ARM. If ARM, which is characterized by a broad spectrum of lesions, involves a number of different underlying pathophysiologic processes, then associations between specific antioxidants and the incidence of distinct macular lesions may be biologically important. However, because there were too few incident late ARM cases in this cohort, the authors were unable to assess whether antioxidant intake is associated with the progression of early ARM to late-stage macular degeneration. Clinical trials and longer-term prospective studies are needed to elucidate further the impact of antioxidants and zinc on the development and progression of ARM. Am J Epidemiol 1998;148:204–14.</description><subject>Adult</subject><subject>age-related</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Confounding Factors (Epidemiology)</subject><subject>Diet</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Logistic Models</subject><subject>Macular Degeneration - diagnosis</subject><subject>Macular Degeneration - epidemiology</subject><subject>Macular Degeneration - prevention & control</subject><subject>maculopathy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Pigment Epithelium of Eye - abnormalities</subject><subject>Prospective Studies</subject><subject>retina</subject><subject>retinal degeneration</subject><subject>Wisconsin - epidemiology</subject><subject>Zinc - administration & dosage</subject><subject>Zinc - therapeutic use</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpVkVFv0zAUhSMEGmXwE5AshHhLsePEbnjrRkcnbQKJIcFerBv7hqVL7c52oPkD_G7MGlXiyb4-37Hlc7LsDaNzRmv-3u1b583GDd5CH-awwTlQWouiepLNWClFnrbiaTajlBZ5XYjiefYihA2ljNUVPclOaiGFpHyW_VmG4HQHsXM2kAbjb0RLljbN-86AjQSsIbed1eTSRrjHxzneIanyHwg-nerOoNVIXEtW4PuRLH9i7rGHiIZcgx56t4N4N5LOPhrPEH6hJx9hS1Yjkq9xMOPL7FmbvoKvpvU0-3axujlf51efP12eL69yXXIec8NNa4qmYk1dyBqpaVCCLJgWba0rUWpDQWqgpSzKCmlVVlK2LadssRAg2pKfZu8O9-68exgwRLXtgsa-B4tuCGqRIqoZ5wn8cAC1dyF4bNXOd1vwo2JU_StB_V-CSiWoqYRkfj29MjRbNEfrlHrS3046BA196yGFGI5YwYUsKUtYfsC6EHF_lMHfKyG5rNT6-626Lr_w9QW7UWf8L8L-phs</recordid><startdate>19980715</startdate><enddate>19980715</enddate><creator>VandenLangenberg, Gina M.</creator><creator>Mares-Perlman, Julie A.</creator><creator>Klein, Ronald</creator><creator>Klein, Barbara E. K.</creator><creator>Brady, William E.</creator><creator>Palta, Mari</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980715</creationdate><title>Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye Study</title><author>VandenLangenberg, Gina M. ; Mares-Perlman, Julie A. ; Klein, Ronald ; Klein, Barbara E. K. ; Brady, William E. ; Palta, Mari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-d3dfd2b51b9279e0dbe7a721c6f9c564cd0a7ca047245e054577ff301886a6f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>age-related</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Confounding Factors (Epidemiology)</topic><topic>Diet</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Logistic Models</topic><topic>Macular Degeneration - diagnosis</topic><topic>Macular Degeneration - epidemiology</topic><topic>Macular Degeneration - prevention & control</topic><topic>maculopathy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Pigment Epithelium of Eye - abnormalities</topic><topic>Prospective Studies</topic><topic>retina</topic><topic>retinal degeneration</topic><topic>Wisconsin - epidemiology</topic><topic>Zinc - administration & dosage</topic><topic>Zinc - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VandenLangenberg, Gina M.</creatorcontrib><creatorcontrib>Mares-Perlman, Julie A.</creatorcontrib><creatorcontrib>Klein, Ronald</creatorcontrib><creatorcontrib>Klein, Barbara E. K.</creatorcontrib><creatorcontrib>Brady, William E.</creatorcontrib><creatorcontrib>Palta, Mari</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VandenLangenberg, Gina M.</au><au>Mares-Perlman, Julie A.</au><au>Klein, Ronald</au><au>Klein, Barbara E. K.</au><au>Brady, William E.</au><au>Palta, Mari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye Study</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>1998-07-15</date><risdate>1998</risdate><volume>148</volume><issue>2</issue><spage>204</spage><epage>214</epage><pages>204-214</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><notes>2Current address: Department of Health and Sports Science, University of Richmond, Richmond, VA.</notes><notes>istex:85EA8EC8438DC17E4A4377C9B563917925522DF4</notes><notes>ArticleID:148.2.204</notes><notes>Reprint requests to Dr. Julie Mares-Perlman, Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, 405 WARF, Madison, WI 53705-2397</notes><notes>ark:/67375/HXZ-M4P3HF1T-B</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin. A food-frequency questionnaire was administered at baseline (1988–1990) to collect dietary information for that time period and a period of time 10 years earlier (1978–1980) from a 50 percent random sample of persons participating in this study. The incidence of the specific lesions of larger drusen (>125 μ) and pigmentary abnormalities and the incidence of any ARM were assessed by masked grading of stereoscopic color fundus photographs in 1,709 persons who participated in 5-year follow-up eye examinations. Significant, but modest, inverse associations (p < 0.05) were observed between intakes of pro-vitamin A carotenoids and dietary vitamin E and the incidence of large drusen and between zinc and the incidence of pigmentary abnormalities. No significant inverse associations were found between antioxidant or zinc intake and the incidence of overall early ARM. If ARM, which is characterized by a broad spectrum of lesions, involves a number of different underlying pathophysiologic processes, then associations between specific antioxidants and the incidence of distinct macular lesions may be biologically important. However, because there were too few incident late ARM cases in this cohort, the authors were unable to assess whether antioxidant intake is associated with the progression of early ARM to late-stage macular degeneration. Clinical trials and longer-term prospective studies are needed to elucidate further the impact of antioxidants and zinc on the development and progression of ARM. Am J Epidemiol 1998;148:204–14.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>9676703</pmid><doi>10.1093/oxfordjournals.aje.a009625</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of epidemiology, 1998-07, Vol.148 (2), p.204-214 |
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| subjects | Adult age-related Aged Aged, 80 and over Aging antioxidants Antioxidants - administration & dosage Antioxidants - therapeutic use Biological and medical sciences Confounding Factors (Epidemiology) Diet Female Humans Incidence Logistic Models Macular Degeneration - diagnosis Macular Degeneration - epidemiology Macular Degeneration - prevention & control maculopathy Male Medical sciences Middle Aged Miscellaneous Ophthalmology Pigment Epithelium of Eye - abnormalities Prospective Studies retina retinal degeneration Wisconsin - epidemiology Zinc - administration & dosage Zinc - therapeutic use |
| title | Associations between Antioxidant and Zinc Intake and the 5-Year Incidence of Early Age-related Maculopathy in the Beaver Dam Eye Study |
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