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Binding of the c-myb proto-oncogene product to the simian virus 40 enhancer stimulates transcription
The proto-oncogene c-myb encodes a nuclear protein which binds to DNA. Here we find that bacterially synthesized c-myb protein binds to one site of the simian virus 40 enhancer. The c-myb protein purified from the human T-cell line, Molt4, was also shown to recognize the same sequence. In co-transfe...
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Published in: | The Journal of biological chemistry 1990-02, Vol.265 (6), p.3479-3483 |
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container_title | The Journal of biological chemistry |
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creator | Nakagoshi, H Nagase, T Kanei-Ishii, C Ueno, Y Ishii, S |
description | The proto-oncogene c-myb encodes a nuclear protein which binds to DNA. Here we find that bacterially synthesized c-myb protein binds to one site of the simian virus 40 enhancer. The c-myb protein purified from the human T-cell line, Molt4, was also shown to recognize the same sequence. In co-transfection experiments with a c-myb expression plasmid, tandem repeats of a c-myb-binding sequence were shown to function as a c-myb-dependent enhancer. These results indicate the c-myb protein is a simian virus 40 enhancer-binding protein that can positively regulate transcription. |
doi_str_mv | 10.1016/S0021-9258(19)39793-5 |
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Psychology ; Humans ; Mice ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Nuclear Proteins - metabolism ; Plasmids ; Protein-Tyrosine Kinases - metabolism ; Proto-Oncogene Proteins - isolation & purification ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-myb ; Proto-Oncogenes ; Recombinant Proteins - isolation & purification ; Recombinant Proteins - metabolism ; Simian virus 40 - genetics ; Transcription, Genetic ; Transcription. Transcription factor. Splicing. Rna processing ; Transfection</subject><ispartof>The Journal of biological chemistry, 1990-02, Vol.265 (6), p.3479-3483</ispartof><rights>1990 © 1990 ASBMB. 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Here we find that bacterially synthesized c-myb protein binds to one site of the simian virus 40 enhancer. The c-myb protein purified from the human T-cell line, Molt4, was also shown to recognize the same sequence. In co-transfection experiments with a c-myb expression plasmid, tandem repeats of a c-myb-binding sequence were shown to function as a c-myb-dependent enhancer. These results indicate the c-myb protein is a simian virus 40 enhancer-binding protein that can positively regulate transcription.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Enhancer Elements, Genetic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nuclear Proteins - metabolism</subject><subject>Plasmids</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - isolation & purification</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-myb</subject><subject>Proto-Oncogenes</subject><subject>Recombinant Proteins - isolation & purification</subject><subject>Recombinant Proteins - metabolism</subject><subject>Simian virus 40 - genetics</subject><subject>Transcription, Genetic</subject><subject>Transcription. Transcription factor. Splicing. 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Psychology</topic><topic>Humans</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nuclear Proteins - metabolism</topic><topic>Plasmids</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Proto-Oncogene Proteins - isolation & purification</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-myb</topic><topic>Proto-Oncogenes</topic><topic>Recombinant Proteins - isolation & purification</topic><topic>Recombinant Proteins - metabolism</topic><topic>Simian virus 40 - genetics</topic><topic>Transcription, Genetic</topic><topic>Transcription. Transcription factor. Splicing. Rna processing</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakagoshi, H</creatorcontrib><creatorcontrib>Nagase, T</creatorcontrib><creatorcontrib>Kanei-Ishii, C</creatorcontrib><creatorcontrib>Ueno, Y</creatorcontrib><creatorcontrib>Ishii, S</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakagoshi, H</au><au>Nagase, T</au><au>Kanei-Ishii, C</au><au>Ueno, Y</au><au>Ishii, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binding of the c-myb proto-oncogene product to the simian virus 40 enhancer stimulates transcription</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1990-02-25</date><risdate>1990</risdate><volume>265</volume><issue>6</issue><spage>3479</spage><epage>3483</epage><pages>3479-3483</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>The proto-oncogene c-myb encodes a nuclear protein which binds to DNA. Here we find that bacterially synthesized c-myb protein binds to one site of the simian virus 40 enhancer. The c-myb protein purified from the human T-cell line, Molt4, was also shown to recognize the same sequence. In co-transfection experiments with a c-myb expression plasmid, tandem repeats of a c-myb-binding sequence were shown to function as a c-myb-dependent enhancer. These results indicate the c-myb protein is a simian virus 40 enhancer-binding protein that can positively regulate transcription.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>2154480</pmid><doi>10.1016/S0021-9258(19)39793-5</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
subjects | Animals Base Sequence Biological and medical sciences Cell Line Enhancer Elements, Genetic Fundamental and applied biological sciences. Psychology Humans Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Nuclear Proteins - metabolism Plasmids Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - isolation & purification Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myb Proto-Oncogenes Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Simian virus 40 - genetics Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing Transfection |
title | Binding of the c-myb proto-oncogene product to the simian virus 40 enhancer stimulates transcription |
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