Loading…
Cytokine Regulation of Human Immune Response to Schistosoma mansoni: Analysis of the Role of IL‐4, IL‐5 and IL‐10 on Peripheral Blood Mononuclear Cell Responses
The role of cytokines on the in vitro proliferative response of peripheral blood mononuclear cells (PBMC) from Schistosoma mansoni infected patients to soluble egg (SEA) and adult worm antigens (SWAP) were evaluated. The results obtained demonstrated that the proliferative response of PBMC from chro...
Saved in:
| Published in: | Scandinavian journal of immunology 1997-10, Vol.46 (4), p.393-398 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c5214-acf15ca633fb8d39ad0e5212ff1c6433ab4baf642a5a92d3c1c94ef5db94f0d23 |
|---|---|
| cites | |
| container_end_page | 398 |
| container_issue | 4 |
| container_start_page | 393 |
| container_title | Scandinavian journal of immunology |
| container_volume | 46 |
| creator | MALAQUIAS, L. C. C. FALCÃO, P. L. SILVEIRA, A. M. S. GAZZINELLI, G. PRATA, A. COFFMAN, R. L. PIZZIOLO, V. SOUZA, C. P. COLLEY, D. G. CORREA‐OLIVEIRA, R. |
| description | The role of cytokines on the in vitro proliferative response of peripheral blood mononuclear cells (PBMC) from Schistosoma mansoni infected patients to soluble egg (SEA) and adult worm antigens (SWAP) were evaluated. The results obtained demonstrated that the proliferative response of PBMC from chronic intestinal (INT) patients to SEA and SWAP is increased by the blockage of IL‐10 with specific monoclonal antibodies (MAb). The effects of these antibodies were readily reversed by the addition of recombinant IL‐10. In contrast, no effect was observed on the PBMC response of acute and hepatosplenic patients (HS) in the presence of anti‐IL‐10. Anti‐IL‐4 antibodies decreased the PBMC response of the intestinal (INT) and HS individuals to SEA and SWAP, and the PBMC response of acute patients to SEA but not to SWAP. Addition of anti‐IL‐5 MAb did not decrease the PBMC response of acute patients to SEA or SWAP. These results suggested that IL‐10 has an important role in the modulation of the immune response in chronic asymptomatic patients and that this cytokine may be an important factor in controlling morbidity. |
| doi_str_mv | 10.1046/j.1365-3083.1997.d01-136.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79366883</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79366883</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5214-acf15ca633fb8d39ad0e5212ff1c6433ab4baf642a5a92d3c1c94ef5db94f0d23</originalsourceid><addsrcrecordid>eNqVkcFu1DAQhi0EKtvCIyBZHDg1wc442XUPSGVV6FZbgSicLcexWS-OvcSJ2r3xCDwFD8aT4JDVXhGnGc3__zMjfQi9pCSnhFWvtzmFqsyALCCnnM_zhtAsjfKHR2h2lB6jGQFCMs7m5VN0GuOWEArFHE7QCYeSFJzO0K_lvg_frNf4k_46ONnb4HEw-Hpopcerth3-SnEXfNS4D_hObWzsQwytxMkSg7cX-NJLt482jsl-kwLB6bFfrX__-MnOp1pi6ZuppQSnMx91Z3cb3UmH37oQGnwbfPCDclp2eKmdOx6Oz9ATI13Uzw_1DH15d_V5eZ2tP7xfLS_XmSoLyjKpDC2VrABMvWiAy4boJBTGUFUxAFmzWpqKFbKUvGhAUcWZNmVTc2ZIU8AZejXt3XXh-6BjL1obVXpFeh2GKOYcqmqxgH8aaUVpBYwm48VkVF2IsdNG7Drbym4vKBEjTbEVIzIxIhMjTZFojiPxkMIvDleGutXNMXrAl_Q3k35vnd7_x2Zxd7OCksEfOkWzGw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16116341</pqid></control><display><type>article</type><title>Cytokine Regulation of Human Immune Response to Schistosoma mansoni: Analysis of the Role of IL‐4, IL‐5 and IL‐10 on Peripheral Blood Mononuclear Cell Responses</title><source>Wiley-Blackwell Journals</source><creator>MALAQUIAS, L. C. C. ; FALCÃO, P. L. ; SILVEIRA, A. M. S. ; GAZZINELLI, G. ; PRATA, A. ; COFFMAN, R. L. ; PIZZIOLO, V. ; SOUZA, C. P. ; COLLEY, D. G. ; CORREA‐OLIVEIRA, R.</creator><creatorcontrib>MALAQUIAS, L. C. C. ; FALCÃO, P. L. ; SILVEIRA, A. M. S. ; GAZZINELLI, G. ; PRATA, A. ; COFFMAN, R. L. ; PIZZIOLO, V. ; SOUZA, C. P. ; COLLEY, D. G. ; CORREA‐OLIVEIRA, R.</creatorcontrib><description>The role of cytokines on the in vitro proliferative response of peripheral blood mononuclear cells (PBMC) from Schistosoma mansoni infected patients to soluble egg (SEA) and adult worm antigens (SWAP) were evaluated. The results obtained demonstrated that the proliferative response of PBMC from chronic intestinal (INT) patients to SEA and SWAP is increased by the blockage of IL‐10 with specific monoclonal antibodies (MAb). The effects of these antibodies were readily reversed by the addition of recombinant IL‐10. In contrast, no effect was observed on the PBMC response of acute and hepatosplenic patients (HS) in the presence of anti‐IL‐10. Anti‐IL‐4 antibodies decreased the PBMC response of the intestinal (INT) and HS individuals to SEA and SWAP, and the PBMC response of acute patients to SEA but not to SWAP. Addition of anti‐IL‐5 MAb did not decrease the PBMC response of acute patients to SEA or SWAP. These results suggested that IL‐10 has an important role in the modulation of the immune response in chronic asymptomatic patients and that this cytokine may be an important factor in controlling morbidity.</description><identifier>ISSN: 0300-9475</identifier><identifier>EISSN: 1365-3083</identifier><identifier>DOI: 10.1046/j.1365-3083.1997.d01-136.x</identifier><identifier>PMID: 9350291</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Acute Disease ; Animals ; Antibodies, Monoclonal - pharmacology ; Antigens, Helminth - pharmacology ; Cells, Cultured ; Chronic Disease ; Cytokines - physiology ; Female ; Humans ; Interleukin-10 - physiology ; Interleukin-4 - immunology ; Interleukin-4 - physiology ; Interleukin-5 - immunology ; Interleukin-5 - physiology ; Intestinal Diseases, Parasitic - immunology ; Leukocytes, Mononuclear - immunology ; Liver Diseases, Parasitic - immunology ; Lymphocyte Activation ; Male ; Mice ; Schistosoma mansoni ; Schistosoma mansoni - growth & development ; Schistosoma mansoni - immunology ; Schistosomiasis mansoni - immunology ; Splenic Diseases - immunology</subject><ispartof>Scandinavian journal of immunology, 1997-10, Vol.46 (4), p.393-398</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5214-acf15ca633fb8d39ad0e5212ff1c6433ab4baf642a5a92d3c1c94ef5db94f0d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-3083.1997.d01-136.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-3083.1997.d01-136.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9350291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MALAQUIAS, L. C. C.</creatorcontrib><creatorcontrib>FALCÃO, P. L.</creatorcontrib><creatorcontrib>SILVEIRA, A. M. S.</creatorcontrib><creatorcontrib>GAZZINELLI, G.</creatorcontrib><creatorcontrib>PRATA, A.</creatorcontrib><creatorcontrib>COFFMAN, R. L.</creatorcontrib><creatorcontrib>PIZZIOLO, V.</creatorcontrib><creatorcontrib>SOUZA, C. P.</creatorcontrib><creatorcontrib>COLLEY, D. G.</creatorcontrib><creatorcontrib>CORREA‐OLIVEIRA, R.</creatorcontrib><title>Cytokine Regulation of Human Immune Response to Schistosoma mansoni: Analysis of the Role of IL‐4, IL‐5 and IL‐10 on Peripheral Blood Mononuclear Cell Responses</title><title>Scandinavian journal of immunology</title><addtitle>Scand J Immunol</addtitle><description>The role of cytokines on the in vitro proliferative response of peripheral blood mononuclear cells (PBMC) from Schistosoma mansoni infected patients to soluble egg (SEA) and adult worm antigens (SWAP) were evaluated. The results obtained demonstrated that the proliferative response of PBMC from chronic intestinal (INT) patients to SEA and SWAP is increased by the blockage of IL‐10 with specific monoclonal antibodies (MAb). The effects of these antibodies were readily reversed by the addition of recombinant IL‐10. In contrast, no effect was observed on the PBMC response of acute and hepatosplenic patients (HS) in the presence of anti‐IL‐10. Anti‐IL‐4 antibodies decreased the PBMC response of the intestinal (INT) and HS individuals to SEA and SWAP, and the PBMC response of acute patients to SEA but not to SWAP. Addition of anti‐IL‐5 MAb did not decrease the PBMC response of acute patients to SEA or SWAP. These results suggested that IL‐10 has an important role in the modulation of the immune response in chronic asymptomatic patients and that this cytokine may be an important factor in controlling morbidity.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Antigens, Helminth - pharmacology</subject><subject>Cells, Cultured</subject><subject>Chronic Disease</subject><subject>Cytokines - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-10 - physiology</subject><subject>Interleukin-4 - immunology</subject><subject>Interleukin-4 - physiology</subject><subject>Interleukin-5 - immunology</subject><subject>Interleukin-5 - physiology</subject><subject>Intestinal Diseases, Parasitic - immunology</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Liver Diseases, Parasitic - immunology</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Mice</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - growth & development</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosomiasis mansoni - immunology</subject><subject>Splenic Diseases - immunology</subject><issn>0300-9475</issn><issn>1365-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqVkcFu1DAQhi0EKtvCIyBZHDg1wc442XUPSGVV6FZbgSicLcexWS-OvcSJ2r3xCDwFD8aT4JDVXhGnGc3__zMjfQi9pCSnhFWvtzmFqsyALCCnnM_zhtAsjfKHR2h2lB6jGQFCMs7m5VN0GuOWEArFHE7QCYeSFJzO0K_lvg_frNf4k_46ONnb4HEw-Hpopcerth3-SnEXfNS4D_hObWzsQwytxMkSg7cX-NJLt482jsl-kwLB6bFfrX__-MnOp1pi6ZuppQSnMx91Z3cb3UmH37oQGnwbfPCDclp2eKmdOx6Oz9ATI13Uzw_1DH15d_V5eZ2tP7xfLS_XmSoLyjKpDC2VrABMvWiAy4boJBTGUFUxAFmzWpqKFbKUvGhAUcWZNmVTc2ZIU8AZejXt3XXh-6BjL1obVXpFeh2GKOYcqmqxgH8aaUVpBYwm48VkVF2IsdNG7Drbym4vKBEjTbEVIzIxIhMjTZFojiPxkMIvDleGutXNMXrAl_Q3k35vnd7_x2Zxd7OCksEfOkWzGw</recordid><startdate>199710</startdate><enddate>199710</enddate><creator>MALAQUIAS, L. C. C.</creator><creator>FALCÃO, P. L.</creator><creator>SILVEIRA, A. M. S.</creator><creator>GAZZINELLI, G.</creator><creator>PRATA, A.</creator><creator>COFFMAN, R. L.</creator><creator>PIZZIOLO, V.</creator><creator>SOUZA, C. P.</creator><creator>COLLEY, D. G.</creator><creator>CORREA‐OLIVEIRA, R.</creator><general>Blackwell Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199710</creationdate><title>Cytokine Regulation of Human Immune Response to Schistosoma mansoni: Analysis of the Role of IL‐4, IL‐5 and IL‐10 on Peripheral Blood Mononuclear Cell Responses</title><author>MALAQUIAS, L. C. C. ; FALCÃO, P. L. ; SILVEIRA, A. M. S. ; GAZZINELLI, G. ; PRATA, A. ; COFFMAN, R. L. ; PIZZIOLO, V. ; SOUZA, C. P. ; COLLEY, D. G. ; CORREA‐OLIVEIRA, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5214-acf15ca633fb8d39ad0e5212ff1c6433ab4baf642a5a92d3c1c94ef5db94f0d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Antigens, Helminth - pharmacology</topic><topic>Cells, Cultured</topic><topic>Chronic Disease</topic><topic>Cytokines - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-10 - physiology</topic><topic>Interleukin-4 - immunology</topic><topic>Interleukin-4 - physiology</topic><topic>Interleukin-5 - immunology</topic><topic>Interleukin-5 - physiology</topic><topic>Intestinal Diseases, Parasitic - immunology</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Liver Diseases, Parasitic - immunology</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Mice</topic><topic>Schistosoma mansoni</topic><topic>Schistosoma mansoni - growth & development</topic><topic>Schistosoma mansoni - immunology</topic><topic>Schistosomiasis mansoni - immunology</topic><topic>Splenic Diseases - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MALAQUIAS, L. C. C.</creatorcontrib><creatorcontrib>FALCÃO, P. L.</creatorcontrib><creatorcontrib>SILVEIRA, A. M. S.</creatorcontrib><creatorcontrib>GAZZINELLI, G.</creatorcontrib><creatorcontrib>PRATA, A.</creatorcontrib><creatorcontrib>COFFMAN, R. L.</creatorcontrib><creatorcontrib>PIZZIOLO, V.</creatorcontrib><creatorcontrib>SOUZA, C. P.</creatorcontrib><creatorcontrib>COLLEY, D. G.</creatorcontrib><creatorcontrib>CORREA‐OLIVEIRA, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MALAQUIAS, L. C. C.</au><au>FALCÃO, P. L.</au><au>SILVEIRA, A. M. S.</au><au>GAZZINELLI, G.</au><au>PRATA, A.</au><au>COFFMAN, R. L.</au><au>PIZZIOLO, V.</au><au>SOUZA, C. P.</au><au>COLLEY, D. G.</au><au>CORREA‐OLIVEIRA, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine Regulation of Human Immune Response to Schistosoma mansoni: Analysis of the Role of IL‐4, IL‐5 and IL‐10 on Peripheral Blood Mononuclear Cell Responses</atitle><jtitle>Scandinavian journal of immunology</jtitle><addtitle>Scand J Immunol</addtitle><date>1997-10</date><risdate>1997</risdate><volume>46</volume><issue>4</issue><spage>393</spage><epage>398</epage><pages>393-398</pages><issn>0300-9475</issn><eissn>1365-3083</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>The role of cytokines on the in vitro proliferative response of peripheral blood mononuclear cells (PBMC) from Schistosoma mansoni infected patients to soluble egg (SEA) and adult worm antigens (SWAP) were evaluated. The results obtained demonstrated that the proliferative response of PBMC from chronic intestinal (INT) patients to SEA and SWAP is increased by the blockage of IL‐10 with specific monoclonal antibodies (MAb). The effects of these antibodies were readily reversed by the addition of recombinant IL‐10. In contrast, no effect was observed on the PBMC response of acute and hepatosplenic patients (HS) in the presence of anti‐IL‐10. Anti‐IL‐4 antibodies decreased the PBMC response of the intestinal (INT) and HS individuals to SEA and SWAP, and the PBMC response of acute patients to SEA but not to SWAP. Addition of anti‐IL‐5 MAb did not decrease the PBMC response of acute patients to SEA or SWAP. These results suggested that IL‐10 has an important role in the modulation of the immune response in chronic asymptomatic patients and that this cytokine may be an important factor in controlling morbidity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9350291</pmid><doi>10.1046/j.1365-3083.1997.d01-136.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-9475 |
| ispartof | Scandinavian journal of immunology, 1997-10, Vol.46 (4), p.393-398 |
| issn | 0300-9475 1365-3083 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79366883 |
| source | Wiley-Blackwell Journals |
| subjects | Acute Disease Animals Antibodies, Monoclonal - pharmacology Antigens, Helminth - pharmacology Cells, Cultured Chronic Disease Cytokines - physiology Female Humans Interleukin-10 - physiology Interleukin-4 - immunology Interleukin-4 - physiology Interleukin-5 - immunology Interleukin-5 - physiology Intestinal Diseases, Parasitic - immunology Leukocytes, Mononuclear - immunology Liver Diseases, Parasitic - immunology Lymphocyte Activation Male Mice Schistosoma mansoni Schistosoma mansoni - growth & development Schistosoma mansoni - immunology Schistosomiasis mansoni - immunology Splenic Diseases - immunology |
| title | Cytokine Regulation of Human Immune Response to Schistosoma mansoni: Analysis of the Role of IL‐4, IL‐5 and IL‐10 on Peripheral Blood Mononuclear Cell Responses |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T16%3A31%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytokine%20Regulation%20of%20Human%20Immune%20Response%20to%20Schistosoma%20mansoni:%20Analysis%20of%20the%20Role%20of%20IL%E2%80%904,%20IL%E2%80%905%20and%20IL%E2%80%9010%20on%20Peripheral%20Blood%20Mononuclear%20Cell%20Responses&rft.jtitle=Scandinavian%20journal%20of%20immunology&rft.au=MALAQUIAS,%20L.%20C.%20C.&rft.date=1997-10&rft.volume=46&rft.issue=4&rft.spage=393&rft.epage=398&rft.pages=393-398&rft.issn=0300-9475&rft.eissn=1365-3083&rft_id=info:doi/10.1046/j.1365-3083.1997.d01-136.x&rft_dat=%3Cproquest_cross%3E79366883%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5214-acf15ca633fb8d39ad0e5212ff1c6433ab4baf642a5a92d3c1c94ef5db94f0d23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16116341&rft_id=info:pmid/9350291&rfr_iscdi=true |