Cerebrovascular Reactivity in Migraine During Headache-Free Intervals

Alterations of intracranial vessel tone have been implicated in the pathophysiology of migraine. The cerebrovascular reactivity was measured by means of transcranial Doppler in 60 migraine patients with (n = 30) or without aura (n = 30) during the headache-free interval and in 30 healthy controls. T...

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Bibliographic Details
Published in:Cephalalgia 1997-05, Vol.17 (3), p.191-194
Main Authors: Totaro, R, Marini, C, De Matteis, G, Di Napoil, M, Carolei, A
Format: Article
Language:English
Subjects:
Adult
Cerebrovascular Circulation - physiology
Cerebrovascular reactivity
Female
headache‐free interval
Humans
Hypercapnia - physiopathology
Male
Middle Aged
Migraine Disorders - physiopathology
migraine with aura
migraine without aura
Ultrasonography, Doppler, Transcranial
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Summary:Alterations of intracranial vessel tone have been implicated in the pathophysiology of migraine. The cerebrovascular reactivity was measured by means of transcranial Doppler in 60 migraine patients with (n = 30) or without aura (n = 30) during the headache-free interval and in 30 healthy controls. The vasomotor response was evaluated during hypercapnia induced by inhalation of a mixture of CO2 5% and O2 95% and during hypocapnia obtained after voluntary hyperventilation. To improve the power of the study in detecting possible abnormalities of cerebrovascular reactivity, two different measures were performed at 1 week intervals in migraine patients and controls. Reactivity index values during CO2 inhalation were significantly different (p=0.01) among the three groups during the first and second measurements; in particular, lower values were found in patients suffering from migraine without aura with respect to controls (p
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.1997.1703191.x