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Brain Transplants Enhance Rather Than Reduce the Impairment of Spatial Memory and Olfaction in Bulbectomized Rats
The possibility to compensate the loss of olfactory and non-olfactory functions due to removal of the olfactory bulb by embryonal brain grafts was investigated in adult rats. Spatial working memory was examined in an 8-arm radial water maze task 6 weeks after bulbectomy. During 15 daily trials, perf...
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| Published in: | Behavioral neuroscience 1989-02, Vol.103 (1), p.61-70 |
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| Main Authors: | , , , , , |
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| container_end_page | 70 |
| container_issue | 1 |
| container_start_page | 61 |
| container_title | Behavioral neuroscience |
| container_volume | 103 |
| creator | Amemori, Takashi Ermakova, Irina V Bures˘sová, Olga Z˘igová, Tatiana Rac˘ekova, Enikö Bures˘, Jan |
| description | The possibility to compensate the loss of olfactory and non-olfactory functions due to removal of the olfactory bulb by embryonal brain grafts was investigated in adult rats. Spatial working memory was examined in an 8-arm radial water maze task 6 weeks after bulbectomy. During 15 daily trials, performance gradually improved in bulbectomized controls (
n
= 10) and in rats with olfactory bulb transplants (
n
= 9), but did not attain that of intact controls (
n
= 10). No improvement was observed in the rats with substantia nigra grafts (
n
= 8). Eleven weeks after bulbectomy, the same rats were tested in the water tank navigation task. The performance improved during ten 12-trial sessions in bulbectomized rats less than in intact controls, but more than in the transplanted rats. The olfactory food retrieval test performed 14 weeks after bulbectomy revealed almost full recovery of smell in bulbectomized rats, but not in the transplanted animals. It is concluded that the spatial memory deficit is probably due to bulbectomy-induced interference with septohippocampal function which is not alleviated, but rather enhanced by transplantation. The results suggest that the effect of brain grafting is not always beneficial. |
| doi_str_mv | 10.1037/0735-7044.103.1.61 |
| format | article |
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n
= 10) and in rats with olfactory bulb transplants (
n
= 9), but did not attain that of intact controls (
n
= 10). No improvement was observed in the rats with substantia nigra grafts (
n
= 8). Eleven weeks after bulbectomy, the same rats were tested in the water tank navigation task. The performance improved during ten 12-trial sessions in bulbectomized rats less than in intact controls, but more than in the transplanted rats. The olfactory food retrieval test performed 14 weeks after bulbectomy revealed almost full recovery of smell in bulbectomized rats, but not in the transplanted animals. It is concluded that the spatial memory deficit is probably due to bulbectomy-induced interference with septohippocampal function which is not alleviated, but rather enhanced by transplantation. The results suggest that the effect of brain grafting is not always beneficial.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.103.1.61</identifier><identifier>PMID: 2923677</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Animal ; Animal behavior ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Central Nervous System - physiology ; Embryo, Mammalian ; Fundamental and applied biological sciences. Psychology ; Male ; Memory - physiology ; Mesencephalon ; Neural Transplantation ; Olfactory Bulb ; Olfactory Bulb - physiology ; Olfactory Bulb - transplantation ; Olfactory Pathways - physiology ; Olfactory Perception ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Short Term Memory ; Smell ; Spatial Behavior - physiology ; Spatial Memory ; Substantia Nigra - transplantation ; Transplants & implants</subject><ispartof>Behavioral neuroscience, 1989-02, Vol.103 (1), p.61-70</ispartof><rights>1989 American Psychological Association</rights><rights>1990 INIST-CNRS</rights><rights>Copyright American Psychological Association Feb 1989</rights><rights>1989, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a477t-15be72fe73e5936024e9c33c28287e85c010fa404753c41840b67c95381fda1e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6965311$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2923677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Thompson, Richard F</contributor><creatorcontrib>Amemori, Takashi</creatorcontrib><creatorcontrib>Ermakova, Irina V</creatorcontrib><creatorcontrib>Bures˘sová, Olga</creatorcontrib><creatorcontrib>Z˘igová, Tatiana</creatorcontrib><creatorcontrib>Rac˘ekova, Enikö</creatorcontrib><creatorcontrib>Bures˘, Jan</creatorcontrib><title>Brain Transplants Enhance Rather Than Reduce the Impairment of Spatial Memory and Olfaction in Bulbectomized Rats</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>The possibility to compensate the loss of olfactory and non-olfactory functions due to removal of the olfactory bulb by embryonal brain grafts was investigated in adult rats. Spatial working memory was examined in an 8-arm radial water maze task 6 weeks after bulbectomy. During 15 daily trials, performance gradually improved in bulbectomized controls (
n
= 10) and in rats with olfactory bulb transplants (
n
= 9), but did not attain that of intact controls (
n
= 10). No improvement was observed in the rats with substantia nigra grafts (
n
= 8). Eleven weeks after bulbectomy, the same rats were tested in the water tank navigation task. The performance improved during ten 12-trial sessions in bulbectomized rats less than in intact controls, but more than in the transplanted rats. The olfactory food retrieval test performed 14 weeks after bulbectomy revealed almost full recovery of smell in bulbectomized rats, but not in the transplanted animals. It is concluded that the spatial memory deficit is probably due to bulbectomy-induced interference with septohippocampal function which is not alleviated, but rather enhanced by transplantation. The results suggest that the effect of brain grafting is not always beneficial.</description><subject>Animal</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Central Nervous System - physiology</subject><subject>Embryo, Mammalian</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Mesencephalon</subject><subject>Neural Transplantation</subject><subject>Olfactory Bulb</subject><subject>Olfactory Bulb - physiology</subject><subject>Olfactory Bulb - transplantation</subject><subject>Olfactory Pathways - physiology</subject><subject>Olfactory Perception</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Short Term Memory</subject><subject>Smell</subject><subject>Spatial Behavior - physiology</subject><subject>Spatial Memory</subject><subject>Substantia Nigra - transplantation</subject><subject>Transplants & implants</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNqFkdFrFDEQxoMo9Vr9BwQhSPFF9kw2ySZ5tKXVQqVQz-cwm5ulW3az22T34fzrzXLHoSL6NHwzv_mG4SPkDWdrzoT-yLRQhWZSLnLN1xV_RlbcClswZuRzsjoCL8lpSo-MMcmkOiEnpS1FpfWKPF1EaAPdRAhp7CBMiV6FBwge6T1MDxjpJit6j9s5t3KD3vQjtLHHMNGhod9GmFro6Ffsh7ijELb0rmvAT-0QaDa-mLsa_TT07Q_cLpbpFXnRQJfw9aGeke_XV5vLL8Xt3eeby0-3BUitp4KrGnXZoBaorKhYKdF6IXxpSqPRKM84ayC_o5XwkhvJ6kp7q4ThzRY4ijPyfu87xuFpxjS5vk0eu_wkDnNy2hhrmeH_BbniSitTZfDdH-DjMMeQn3AVl4JxWel_QSUTxmqpWIbKPeTjkFLExo2x7SHuHGduidYtybkluUU6ng_kpbcH57nucXtcOWSZ5-eHOSQPXZMj9W06YpWtlOCLzYc9BiO4Me08xKn1HSY_x5hTdXXAX4-e_53-HfsJsqXE7w</recordid><startdate>19890201</startdate><enddate>19890201</enddate><creator>Amemori, Takashi</creator><creator>Ermakova, Irina V</creator><creator>Bures˘sová, Olga</creator><creator>Z˘igová, Tatiana</creator><creator>Rac˘ekova, Enikö</creator><creator>Bures˘, Jan</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>19890201</creationdate><title>Brain Transplants Enhance Rather Than Reduce the Impairment of Spatial Memory and Olfaction in Bulbectomized Rats</title><author>Amemori, Takashi ; Ermakova, Irina V ; Bures˘sová, Olga ; Z˘igová, Tatiana ; Rac˘ekova, Enikö ; Bures˘, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a477t-15be72fe73e5936024e9c33c28287e85c010fa404753c41840b67c95381fda1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animal</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Central Nervous System - physiology</topic><topic>Embryo, Mammalian</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Mesencephalon</topic><topic>Neural Transplantation</topic><topic>Olfactory Bulb</topic><topic>Olfactory Bulb - physiology</topic><topic>Olfactory Bulb - transplantation</topic><topic>Olfactory Pathways - physiology</topic><topic>Olfactory Perception</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Short Term Memory</topic><topic>Smell</topic><topic>Spatial Behavior - physiology</topic><topic>Spatial Memory</topic><topic>Substantia Nigra - transplantation</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amemori, Takashi</creatorcontrib><creatorcontrib>Ermakova, Irina V</creatorcontrib><creatorcontrib>Bures˘sová, Olga</creatorcontrib><creatorcontrib>Z˘igová, Tatiana</creatorcontrib><creatorcontrib>Rac˘ekova, Enikö</creatorcontrib><creatorcontrib>Bures˘, Jan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PsycArticles (via ProQuest)</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amemori, Takashi</au><au>Ermakova, Irina V</au><au>Bures˘sová, Olga</au><au>Z˘igová, Tatiana</au><au>Rac˘ekova, Enikö</au><au>Bures˘, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain Transplants Enhance Rather Than Reduce the Impairment of Spatial Memory and Olfaction in Bulbectomized Rats</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1989-02-01</date><risdate>1989</risdate><volume>103</volume><issue>1</issue><spage>61</spage><epage>70</epage><pages>61-70</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>The possibility to compensate the loss of olfactory and non-olfactory functions due to removal of the olfactory bulb by embryonal brain grafts was investigated in adult rats. Spatial working memory was examined in an 8-arm radial water maze task 6 weeks after bulbectomy. During 15 daily trials, performance gradually improved in bulbectomized controls (
n
= 10) and in rats with olfactory bulb transplants (
n
= 9), but did not attain that of intact controls (
n
= 10). No improvement was observed in the rats with substantia nigra grafts (
n
= 8). Eleven weeks after bulbectomy, the same rats were tested in the water tank navigation task. The performance improved during ten 12-trial sessions in bulbectomized rats less than in intact controls, but more than in the transplanted rats. The olfactory food retrieval test performed 14 weeks after bulbectomy revealed almost full recovery of smell in bulbectomized rats, but not in the transplanted animals. It is concluded that the spatial memory deficit is probably due to bulbectomy-induced interference with septohippocampal function which is not alleviated, but rather enhanced by transplantation. The results suggest that the effect of brain grafting is not always beneficial.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>2923677</pmid><doi>10.1037/0735-7044.103.1.61</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-7044 |
| ispartof | Behavioral neuroscience, 1989-02, Vol.103 (1), p.61-70 |
| issn | 0735-7044 1939-0084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78899081 |
| source | PsycArticles (EBSCO) |
| subjects | Animal Animal behavior Animals Behavioral psychophysiology Biological and medical sciences Brain Central Nervous System - physiology Embryo, Mammalian Fundamental and applied biological sciences. Psychology Male Memory - physiology Mesencephalon Neural Transplantation Olfactory Bulb Olfactory Bulb - physiology Olfactory Bulb - transplantation Olfactory Pathways - physiology Olfactory Perception Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Short Term Memory Smell Spatial Behavior - physiology Spatial Memory Substantia Nigra - transplantation Transplants & implants |
| title | Brain Transplants Enhance Rather Than Reduce the Impairment of Spatial Memory and Olfaction in Bulbectomized Rats |
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