Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos

Treatments of zebrafish embryos with retinoic acid (RA), a substance known to cause abnormal craniofacial cartilage development in other vertebrates, result in dose- and stage-dependent losses of dlx homeobox gene expression in several regions of the embryo, Dlx expression in neural crest cells migr...

Full description

Saved in:
Bibliographic Details
Published in:Mechanisms of development 1997-01, Vol.61 (1-2), p.23-36
Main Authors: Ellies, Debra L., Langille, Robert M., Martin, C. Cristofre, Akimenko, Marie-Andrée, Ekker, Marc
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cartilage
Cartilage - embryology
Cell Differentiation
Face - abnormalities
Gene Expression Regulation, Developmental - drug effects
Genes, Homeobox
Head skeleton
Homeobox genes
Homeodomain Proteins - physiology
In Situ Hybridization
Neural creast
Neural Crest - cytology
Retinoic acid
RNA, Messenger - genetics
Time Factors
Transcription Factors
Tretinoin - pharmacology
Zebrafish
Zebrafish - embryology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c459t-80a76efdfa20c4dbc3ffa885b98eaecf6541f818dc6d7231c559d8595864da9d3
cites cdi_FETCH-LOGICAL-c459t-80a76efdfa20c4dbc3ffa885b98eaecf6541f818dc6d7231c559d8595864da9d3
container_end_page 36
container_issue 1-2
container_start_page 23
container_title Mechanisms of development
container_volume 61
creator Ellies, Debra L.
Langille, Robert M.
Martin, C. Cristofre
Akimenko, Marie-Andrée
Ekker, Marc
description Treatments of zebrafish embryos with retinoic acid (RA), a substance known to cause abnormal craniofacial cartilage development in other vertebrates, result in dose- and stage-dependent losses of dlx homeobox gene expression in several regions of the embryo, Dlx expression in neural crest cells migrating from the hindbrain and in the visceral arch primordia is particularly sensitive to RA treatment. The strongest effects are observed when RA is administered prior to or during crest cell migration but effects can also be observed if RA is applied when the cells have entered the primordia of the arches. Losses of dlx expression correlated either with the loss of cartilage elements originating from hindbrain neural crest cells or with abnormal morphology of these elements. Cartilage elements that originate from midbrain neural crest cells, which do not express dlx genes, are less affected. Taken together with the observation that the normal patterns of visceral arch dlx expression just prior to cartilage condensation resemble the morphology of the cartilage elements that are about to differentiate, our results suggest that dlx genes are an important part of a multi-step process in the development of a subset of craniofacial cartilage elements.
doi_str_mv 10.1016/S0925-4773(96)00616-8
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78890253</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0925477396006168</els_id><sourcerecordid>78890253</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-80a76efdfa20c4dbc3ffa885b98eaecf6541f818dc6d7231c559d8595864da9d3</originalsourceid><addsrcrecordid>eNqFUU1v1DAQtRCobAs_oZJPCA4BO4kd-4RQBQWpEofC2XLG4-6gJA52Frr8An422e6qV05zeF-a9xi7lOKtFFK_uxW2VlXbdc1rq98IoaWuzBO2kaarK90o_ZRtHinP2XkpP4QQUmp5xs6s6LTu1Ib9vZ0RKBJwyH6iFD2QHzj4vNDg75CHfRlTnrfpDicsVDgkmoACFv6bli33fEil8BR5GO75gcTxfs5YCqWJ08QzLjSlNWB1DtWS0S8Y-B_ss49UthzHPu9TecGeRT8UfHm6F-z7p4_frj5XN1-vv1x9uKmgVXapjPCdxhiirwW0oYcmRm-M6q1BjxC1amU00gTQoasbCUrZYJRVRrfB29BcsFdH3zmnnzssixupAA6DnzDtiuuMsaJWzUpURyLk9cGM0c2ZRp_3Tgp3WMA9LOAO9Tqr3cMCzqy6y1PArh8xPKpOla_4-yOO65e_CLMrQDgBBsoIiwuJ_pPwD9hrmh4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78890253</pqid></control><display><type>article</type><title>Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Ellies, Debra L. ; Langille, Robert M. ; Martin, C. Cristofre ; Akimenko, Marie-Andrée ; Ekker, Marc</creator><creatorcontrib>Ellies, Debra L. ; Langille, Robert M. ; Martin, C. Cristofre ; Akimenko, Marie-Andrée ; Ekker, Marc</creatorcontrib><description>Treatments of zebrafish embryos with retinoic acid (RA), a substance known to cause abnormal craniofacial cartilage development in other vertebrates, result in dose- and stage-dependent losses of dlx homeobox gene expression in several regions of the embryo, Dlx expression in neural crest cells migrating from the hindbrain and in the visceral arch primordia is particularly sensitive to RA treatment. The strongest effects are observed when RA is administered prior to or during crest cell migration but effects can also be observed if RA is applied when the cells have entered the primordia of the arches. Losses of dlx expression correlated either with the loss of cartilage elements originating from hindbrain neural crest cells or with abnormal morphology of these elements. Cartilage elements that originate from midbrain neural crest cells, which do not express dlx genes, are less affected. Taken together with the observation that the normal patterns of visceral arch dlx expression just prior to cartilage condensation resemble the morphology of the cartilage elements that are about to differentiate, our results suggest that dlx genes are an important part of a multi-step process in the development of a subset of craniofacial cartilage elements.</description><identifier>ISSN: 0925-4773</identifier><identifier>EISSN: 1872-6356</identifier><identifier>DOI: 10.1016/S0925-4773(96)00616-8</identifier><identifier>PMID: 9076675</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Apoptosis ; Cartilage ; Cartilage - embryology ; Cell Differentiation ; Face - abnormalities ; Gene Expression Regulation, Developmental - drug effects ; Genes, Homeobox ; Head skeleton ; Homeobox genes ; Homeodomain Proteins - physiology ; In Situ Hybridization ; Neural creast ; Neural Crest - cytology ; Retinoic acid ; RNA, Messenger - genetics ; Time Factors ; Transcription Factors ; Tretinoin - pharmacology ; Zebrafish ; Zebrafish - embryology</subject><ispartof>Mechanisms of development, 1997-01, Vol.61 (1-2), p.23-36</ispartof><rights>1997</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-80a76efdfa20c4dbc3ffa885b98eaecf6541f818dc6d7231c559d8595864da9d3</citedby><cites>FETCH-LOGICAL-c459t-80a76efdfa20c4dbc3ffa885b98eaecf6541f818dc6d7231c559d8595864da9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9076675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellies, Debra L.</creatorcontrib><creatorcontrib>Langille, Robert M.</creatorcontrib><creatorcontrib>Martin, C. Cristofre</creatorcontrib><creatorcontrib>Akimenko, Marie-Andrée</creatorcontrib><creatorcontrib>Ekker, Marc</creatorcontrib><title>Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos</title><title>Mechanisms of development</title><addtitle>Mech Dev</addtitle><description>Treatments of zebrafish embryos with retinoic acid (RA), a substance known to cause abnormal craniofacial cartilage development in other vertebrates, result in dose- and stage-dependent losses of dlx homeobox gene expression in several regions of the embryo, Dlx expression in neural crest cells migrating from the hindbrain and in the visceral arch primordia is particularly sensitive to RA treatment. The strongest effects are observed when RA is administered prior to or during crest cell migration but effects can also be observed if RA is applied when the cells have entered the primordia of the arches. Losses of dlx expression correlated either with the loss of cartilage elements originating from hindbrain neural crest cells or with abnormal morphology of these elements. Cartilage elements that originate from midbrain neural crest cells, which do not express dlx genes, are less affected. Taken together with the observation that the normal patterns of visceral arch dlx expression just prior to cartilage condensation resemble the morphology of the cartilage elements that are about to differentiate, our results suggest that dlx genes are an important part of a multi-step process in the development of a subset of craniofacial cartilage elements.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Cartilage</subject><subject>Cartilage - embryology</subject><subject>Cell Differentiation</subject><subject>Face - abnormalities</subject><subject>Gene Expression Regulation, Developmental - drug effects</subject><subject>Genes, Homeobox</subject><subject>Head skeleton</subject><subject>Homeobox genes</subject><subject>Homeodomain Proteins - physiology</subject><subject>In Situ Hybridization</subject><subject>Neural creast</subject><subject>Neural Crest - cytology</subject><subject>Retinoic acid</subject><subject>RNA, Messenger - genetics</subject><subject>Time Factors</subject><subject>Transcription Factors</subject><subject>Tretinoin - pharmacology</subject><subject>Zebrafish</subject><subject>Zebrafish - embryology</subject><issn>0925-4773</issn><issn>1872-6356</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v1DAQtRCobAs_oZJPCA4BO4kd-4RQBQWpEofC2XLG4-6gJA52Frr8An422e6qV05zeF-a9xi7lOKtFFK_uxW2VlXbdc1rq98IoaWuzBO2kaarK90o_ZRtHinP2XkpP4QQUmp5xs6s6LTu1Ib9vZ0RKBJwyH6iFD2QHzj4vNDg75CHfRlTnrfpDicsVDgkmoACFv6bli33fEil8BR5GO75gcTxfs5YCqWJ08QzLjSlNWB1DtWS0S8Y-B_ss49UthzHPu9TecGeRT8UfHm6F-z7p4_frj5XN1-vv1x9uKmgVXapjPCdxhiirwW0oYcmRm-M6q1BjxC1amU00gTQoasbCUrZYJRVRrfB29BcsFdH3zmnnzssixupAA6DnzDtiuuMsaJWzUpURyLk9cGM0c2ZRp_3Tgp3WMA9LOAO9Tqr3cMCzqy6y1PArh8xPKpOla_4-yOO65e_CLMrQDgBBsoIiwuJ_pPwD9hrmh4</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Ellies, Debra L.</creator><creator>Langille, Robert M.</creator><creator>Martin, C. Cristofre</creator><creator>Akimenko, Marie-Andrée</creator><creator>Ekker, Marc</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos</title><author>Ellies, Debra L. ; Langille, Robert M. ; Martin, C. Cristofre ; Akimenko, Marie-Andrée ; Ekker, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-80a76efdfa20c4dbc3ffa885b98eaecf6541f818dc6d7231c559d8595864da9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Cartilage</topic><topic>Cartilage - embryology</topic><topic>Cell Differentiation</topic><topic>Face - abnormalities</topic><topic>Gene Expression Regulation, Developmental - drug effects</topic><topic>Genes, Homeobox</topic><topic>Head skeleton</topic><topic>Homeobox genes</topic><topic>Homeodomain Proteins - physiology</topic><topic>In Situ Hybridization</topic><topic>Neural creast</topic><topic>Neural Crest - cytology</topic><topic>Retinoic acid</topic><topic>RNA, Messenger - genetics</topic><topic>Time Factors</topic><topic>Transcription Factors</topic><topic>Tretinoin - pharmacology</topic><topic>Zebrafish</topic><topic>Zebrafish - embryology</topic><toplevel>online_resources</toplevel><creatorcontrib>Ellies, Debra L.</creatorcontrib><creatorcontrib>Langille, Robert M.</creatorcontrib><creatorcontrib>Martin, C. Cristofre</creatorcontrib><creatorcontrib>Akimenko, Marie-Andrée</creatorcontrib><creatorcontrib>Ekker, Marc</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellies, Debra L.</au><au>Langille, Robert M.</au><au>Martin, C. Cristofre</au><au>Akimenko, Marie-Andrée</au><au>Ekker, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos</atitle><jtitle>Mechanisms of development</jtitle><addtitle>Mech Dev</addtitle><date>1997-01</date><risdate>1997</risdate><volume>61</volume><issue>1-2</issue><spage>23</spage><epage>36</epage><pages>23-36</pages><issn>0925-4773</issn><eissn>1872-6356</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Treatments of zebrafish embryos with retinoic acid (RA), a substance known to cause abnormal craniofacial cartilage development in other vertebrates, result in dose- and stage-dependent losses of dlx homeobox gene expression in several regions of the embryo, Dlx expression in neural crest cells migrating from the hindbrain and in the visceral arch primordia is particularly sensitive to RA treatment. The strongest effects are observed when RA is administered prior to or during crest cell migration but effects can also be observed if RA is applied when the cells have entered the primordia of the arches. Losses of dlx expression correlated either with the loss of cartilage elements originating from hindbrain neural crest cells or with abnormal morphology of these elements. Cartilage elements that originate from midbrain neural crest cells, which do not express dlx genes, are less affected. Taken together with the observation that the normal patterns of visceral arch dlx expression just prior to cartilage condensation resemble the morphology of the cartilage elements that are about to differentiate, our results suggest that dlx genes are an important part of a multi-step process in the development of a subset of craniofacial cartilage elements.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>9076675</pmid><doi>10.1016/S0925-4773(96)00616-8</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0925-4773
ispartof Mechanisms of development, 1997-01, Vol.61 (1-2), p.23-36
issn 0925-4773
1872-6356
language eng
recordid cdi_proquest_miscellaneous_78890253
source BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS; ScienceDirect Freedom Collection 2022-2024
subjects Animals
Apoptosis
Cartilage
Cartilage - embryology
Cell Differentiation
Face - abnormalities
Gene Expression Regulation, Developmental - drug effects
Genes, Homeobox
Head skeleton
Homeobox genes
Homeodomain Proteins - physiology
In Situ Hybridization
Neural creast
Neural Crest - cytology
Retinoic acid
RNA, Messenger - genetics
Time Factors
Transcription Factors
Tretinoin - pharmacology
Zebrafish
Zebrafish - embryology
title Specific craniofacial cartilage dysmorphogenesis coincides with a loss of dlx gene expression in retinoic acid-treated zebrafish embryos
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-23T04%3A36%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Specific%20craniofacial%20cartilage%20dysmorphogenesis%20coincides%20with%20a%20loss%20of%20dlx%20gene%20expression%20in%20retinoic%20acid-treated%20zebrafish%20embryos&rft.jtitle=Mechanisms%20of%20development&rft.au=Ellies,%20Debra%20L.&rft.date=1997-01&rft.volume=61&rft.issue=1-2&rft.spage=23&rft.epage=36&rft.pages=23-36&rft.issn=0925-4773&rft.eissn=1872-6356&rft_id=info:doi/10.1016/S0925-4773(96)00616-8&rft_dat=%3Cproquest_cross%3E78890253%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c459t-80a76efdfa20c4dbc3ffa885b98eaecf6541f818dc6d7231c559d8595864da9d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=78890253&rft_id=info:pmid/9076675&rfr_iscdi=true