Effects of thymectomy and tolerance induction on tumor immunity in adult Xenopus laevis

Major‐histocompatibility‐complex homozygous partially inbred adults of the ff strain of Xenopus reject transplants of tumor cells of ff strain origin; ff tadpoles do not. Thymectomy, performed 5 days after fertilization, abrogated the adult tumor‐rejection response suggesting that in this system tum...

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Published in:International journal of cancer 1997-01, Vol.70 (3), p.330-334
Main Authors: Robert, Jacques, Guiet, Chantal, Cohen, Nicholas, Du Pasquier, Louis
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Freshwater
Histocompatibility Antigens - immunology
Host-tumor relations. Immunology. Biological markers
Immune Tolerance
Larva - immunology
Medical sciences
Neoplasm Transplantation - immunology
Neoplasms, Experimental - immunology
Thymectomy
Transplantation Immunology - immunology
Tumors
Xenopus laevis
Xenopus laevis - immunology
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container_title International journal of cancer
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creator Robert, Jacques
Guiet, Chantal
Cohen, Nicholas
Du Pasquier, Louis
description Major‐histocompatibility‐complex homozygous partially inbred adults of the ff strain of Xenopus reject transplants of tumor cells of ff strain origin; ff tadpoles do not. Thymectomy, performed 5 days after fertilization, abrogated the adult tumor‐rejection response suggesting that in this system tumor rejection is immunologically mediated by T cells. Thymectomy later in larval life did not alter tumor rejection, but it did reduce T‐cell numbers. Tolerance to minor‐histocompatibility(H) antigens segregating within the ff family, which was induced by grafting adult skin to metamorphosing larvae, did not affect the tumor‐rejection capacity of the tolerant adult hosts. This suggests that the ff‐2 tumor expresses (a) tumor‐specific antigen(s). Immunization of larvae with tumor cells did not induce tolerance to skin grafts transplanted during adult life. Indeed, such grafts were rejected in accelerated fashion, suggesting that memory cells generated in the larvae persist through metamorphosis. Int. J. Cancer, 70:330–334, 1997. © 1997 Wiley‐Liss, Inc.
doi_str_mv 10.1002/(SICI)1097-0215(19970127)70:3<330::AID-IJC14>3.0.CO;2-J
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Thymectomy, performed 5 days after fertilization, abrogated the adult tumor‐rejection response suggesting that in this system tumor rejection is immunologically mediated by T cells. Thymectomy later in larval life did not alter tumor rejection, but it did reduce T‐cell numbers. Tolerance to minor‐histocompatibility(H) antigens segregating within the ff family, which was induced by grafting adult skin to metamorphosing larvae, did not affect the tumor‐rejection capacity of the tolerant adult hosts. This suggests that the ff‐2 tumor expresses (a) tumor‐specific antigen(s). Immunization of larvae with tumor cells did not induce tolerance to skin grafts transplanted during adult life. Indeed, such grafts were rejected in accelerated fashion, suggesting that memory cells generated in the larvae persist through metamorphosis. Int. J. 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Thymectomy, performed 5 days after fertilization, abrogated the adult tumor‐rejection response suggesting that in this system tumor rejection is immunologically mediated by T cells. Thymectomy later in larval life did not alter tumor rejection, but it did reduce T‐cell numbers. Tolerance to minor‐histocompatibility(H) antigens segregating within the ff family, which was induced by grafting adult skin to metamorphosing larvae, did not affect the tumor‐rejection capacity of the tolerant adult hosts. This suggests that the ff‐2 tumor expresses (a) tumor‐specific antigen(s). Immunization of larvae with tumor cells did not induce tolerance to skin grafts transplanted during adult life. Indeed, such grafts were rejected in accelerated fashion, suggesting that memory cells generated in the larvae persist through metamorphosis. Int. J. 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subjects Animals
Biological and medical sciences
Freshwater
Histocompatibility Antigens - immunology
Host-tumor relations. Immunology. Biological markers
Immune Tolerance
Larva - immunology
Medical sciences
Neoplasm Transplantation - immunology
Neoplasms, Experimental - immunology
Thymectomy
Transplantation Immunology - immunology
Tumors
Xenopus laevis
Xenopus laevis - immunology
title Effects of thymectomy and tolerance induction on tumor immunity in adult Xenopus laevis
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