CD22 regulates thymus-independent responses and the lifespan of B cells

The B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells, and is capable of binding to ligands on T and B cells. CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling molecules, including the protein tyrosine phosphatase SHP1 (PTP1C, SHP),...

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Bibliographic Details
Published in:Nature (London) 1996-12, Vol.384 (6610), p.634-637
Main Authors: Otipoby, K L, Andersson, K B, Draves, K E, Klaus, S J, Farr, A G, Kerner, J D, Perlmutter, R M, Law, C L, Clark, E A
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - genetics
Antigens, CD - physiology
Antigens, Differentiation, B-Lymphocyte - genetics
Antigens, Differentiation, B-Lymphocyte - physiology
Apoptosis
B-Lymphocytes - immunology
B-Lymphocytes - physiology
Calcium - metabolism
Cell Adhesion Molecules
Cellular Senescence - genetics
Cellular Senescence - physiology
Gene Deletion
Lectins
Lymphocyte Activation
Mice
Sialic Acid Binding Ig-like Lectin 2
Spleen - cytology
Thymus Gland - cytology
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Summary:The B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells, and is capable of binding to ligands on T and B cells. CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling molecules, including the protein tyrosine phosphatase SHP1 (PTP1C, SHP), a putative negative regulator of BCR signalling. Thus CD22 may facilitate interactions with lymphocytes and regulate the threshold of BCR signalling. To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells.
ISSN:0028-0836
1476-4687
DOI:10.1038/384634a0