Changes in Locomotor Activity, Core Temperature, and Heart Rate in Response to Repeated Cocaine Administration

The effects of daily single injections of 20 mg/kg cocaine on locomotor activity, core temperature, and heart rate were determined by radiotelemetry. There was a progressive increase in locomotor activity over the 30-day treatment period. Cocaine-induced activity was 9–12-fold greater than that of s...

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Bibliographic Details
Published in:Physiology & behavior 1996-11, Vol.60 (5), p.1261-1267
Main Authors: Ansah, Twum-Ampofo, Wade, Littleton H, Shockley, Dolores C
Format: Article
Language:English
Subjects:
Animals
Behavioral psychophysiology
Biological and medical sciences
Body temperature
Body Temperature - drug effects
Cardiovascular
Cocaine
Cocaine - administration & dosage
Cocaine - pharmacology
Fundamental and applied biological sciences. Psychology
Heart rate
Heart Rate - drug effects
Hyperthermia
Injections, Intraperitoneal
Locomotor activity
Male
Motor Activity - drug effects
Narcotics - administration & dosage
Narcotics - pharmacology
Neurotransmission and behavior
Peripheral Nerves - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat
Rats
Rats, Wistar
Telemetry
Weight Gain - drug effects
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Summary:The effects of daily single injections of 20 mg/kg cocaine on locomotor activity, core temperature, and heart rate were determined by radiotelemetry. There was a progressive increase in locomotor activity over the 30-day treatment period. Cocaine-induced activity was 9–12-fold greater than that of saline-treated animals. Cocaine also caused increases in core temperature and heart rate. Tolerance did not develop to the locomotor, hyperthermic, and tachycardic responses resulting from repeated cocaine administration. Comparison of the time-course of the cocaine-induced responses revealed that, on Day 1 and 3, the peak locomotor activity was observed 15 min after cocaine administration, whereas the hyperthermic response peaked at 95 min on those days. The fact that the peak locomotor activity and the hyperthermic response occurred at different times suggests that different processes acting independently or interacting may be involved in these actions of cocaine.
ISSN:0031-9384
1873-507X
DOI:10.1016/S0031-9384(96)00250-8