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31P Magnetic resonance spectroscopy of human liver in elderly patients: Changes according to nutritional status and inflammatory state
Magnetic resonance spectroscopy (MRS) was used to determine the phosphorylated metabolite content in the liver of elderly patients in various nutritional states: normal, with protein deprivation, and with acute inflammatory syndrome. 31P-MRS investigations were performed at 1.5 T, and localized live...
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| Published in: | Metabolism, clinical and experimental clinical and experimental, 1996-09, Vol.45 (9), p.1059-1061 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c2360-cde9ef6bfe913dd1a2e093383898506d1233a9ef1b09842d85ba77d6742212373 |
| container_end_page | 1061 |
| container_issue | 9 |
| container_start_page | 1059 |
| container_title | Metabolism, clinical and experimental |
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| creator | Bourdel-Marchasson, Isabelle Biran, Marc Thiaudière, Eric Delalande, Christophe Decamps, Arnaud Manciet, Gérard Canioni, Paul |
| description | Magnetic resonance spectroscopy (MRS) was used to determine the phosphorylated metabolite content in the liver of elderly patients in various nutritional states: normal, with protein deprivation, and with acute inflammatory syndrome.
31P-MRS investigations were performed at 1.5 T, and localized liver spectra were recorded using a two-dimensional chemical shift imaging sequence. Comparison to control spectra recorded on 10 healthy volunteers (age, 30.5 ± 2.1 years) showed that the aging process does not significantly modify
31P-MRS liver spectra. Patients with protein deprivation exhibited a higher value than controls for the phosphomonoesters/nucleoside triphosphates (
PME
NTP
) ratio (
P < .05). This increase was not due to the decrease of NTP, since the ratio of inorganic phosphate to NTP (
P
i
NTP
) remained constant. A decrease in the phosphodiesters to NTP (
PDE
NTP
) ratio (
P < .04) contributed to the observed increase in the
PME
PDE
ratio (
P < .01). In contrast, no significant difference in
31P-MRS spectra was found between elderly patients with hypoalbuminemia associated with inflammatory syndrome and the control group. We conclude that elderly patients with protein deprivation displayed changes in the level of phosphorylated metabolites in the liver that were not observed in the case of inflammatory syndrome despite lower serum albumin (Alb) concentrations. |
| doi_str_mv | 10.1016/S0026-0495(96)90002-5 |
| format | article |
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31P-MRS investigations were performed at 1.5 T, and localized liver spectra were recorded using a two-dimensional chemical shift imaging sequence. Comparison to control spectra recorded on 10 healthy volunteers (age, 30.5 ± 2.1 years) showed that the aging process does not significantly modify
31P-MRS liver spectra. Patients with protein deprivation exhibited a higher value than controls for the phosphomonoesters/nucleoside triphosphates (
PME
NTP
) ratio (
P < .05). This increase was not due to the decrease of NTP, since the ratio of inorganic phosphate to NTP (
P
i
NTP
) remained constant. A decrease in the phosphodiesters to NTP (
PDE
NTP
) ratio (
P < .04) contributed to the observed increase in the
PME
PDE
ratio (
P < .01). In contrast, no significant difference in
31P-MRS spectra was found between elderly patients with hypoalbuminemia associated with inflammatory syndrome and the control group. We conclude that elderly patients with protein deprivation displayed changes in the level of phosphorylated metabolites in the liver that were not observed in the case of inflammatory syndrome despite lower serum albumin (Alb) concentrations.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/S0026-0495(96)90002-5</identifier><identifier>PMID: 8781290</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Aging - metabolism ; Aging - physiology ; Biological and medical sciences ; Body Mass Index ; Hepatitis - metabolism ; Hepatitis - physiopathology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Liver - metabolism ; Liver - physiology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Miscellaneous. Technology ; Nutritional Status ; Phosphorus Isotopes ; Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><ispartof>Metabolism, clinical and experimental, 1996-09, Vol.45 (9), p.1059-1061</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2360-cde9ef6bfe913dd1a2e093383898506d1233a9ef1b09842d85ba77d6742212373</citedby><cites>FETCH-LOGICAL-c2360-cde9ef6bfe913dd1a2e093383898506d1233a9ef1b09842d85ba77d6742212373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3205959$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8781290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bourdel-Marchasson, Isabelle</creatorcontrib><creatorcontrib>Biran, Marc</creatorcontrib><creatorcontrib>Thiaudière, Eric</creatorcontrib><creatorcontrib>Delalande, Christophe</creatorcontrib><creatorcontrib>Decamps, Arnaud</creatorcontrib><creatorcontrib>Manciet, Gérard</creatorcontrib><creatorcontrib>Canioni, Paul</creatorcontrib><title>31P Magnetic resonance spectroscopy of human liver in elderly patients: Changes according to nutritional status and inflammatory state</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Magnetic resonance spectroscopy (MRS) was used to determine the phosphorylated metabolite content in the liver of elderly patients in various nutritional states: normal, with protein deprivation, and with acute inflammatory syndrome.
31P-MRS investigations were performed at 1.5 T, and localized liver spectra were recorded using a two-dimensional chemical shift imaging sequence. Comparison to control spectra recorded on 10 healthy volunteers (age, 30.5 ± 2.1 years) showed that the aging process does not significantly modify
31P-MRS liver spectra. Patients with protein deprivation exhibited a higher value than controls for the phosphomonoesters/nucleoside triphosphates (
PME
NTP
) ratio (
P < .05). This increase was not due to the decrease of NTP, since the ratio of inorganic phosphate to NTP (
P
i
NTP
) remained constant. A decrease in the phosphodiesters to NTP (
PDE
NTP
) ratio (
P < .04) contributed to the observed increase in the
PME
PDE
ratio (
P < .01). In contrast, no significant difference in
31P-MRS spectra was found between elderly patients with hypoalbuminemia associated with inflammatory syndrome and the control group. We conclude that elderly patients with protein deprivation displayed changes in the level of phosphorylated metabolites in the liver that were not observed in the case of inflammatory syndrome despite lower serum albumin (Alb) concentrations.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - metabolism</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Hepatitis - metabolism</subject><subject>Hepatitis - physiopathology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver - metabolism</subject><subject>Liver - physiology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Miscellaneous. Technology</subject><subject>Nutritional Status</subject><subject>Phosphorus Isotopes</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkcuKFDEUhoMoYzv6CANZiOiiNJdOKnEj0jijMKKgrkM6OdUTqUrKJDXQL-Bzm-lueusqJP93LnxB6IqSt5RQ-e4HIUx2ZK3Fay3faNKunXiEVlRw1ilJyGO0OiNP0bNSfjem75W8QBeqV5RpskJ_Of2Ov9pdhBoczlBStNEBLjO4mlNxad7jNOC7ZbIRj-EeMg4Rw-ghj3s82xog1vIeb-5s3EHB1rmUfYg7XBOOS82hhtZzxKXaurQ8-tZgGO002Zry_vAOz9GTwY4FXpzOS_Tr-tPPzefu9tvNl83H284xLknnPGgY5HYATbn31DIgmnPFlVaCSE8Z57YRdEu0WjOvxNb2vZf9mrGW9fwSvTr2nXP6s0CpZgrFwTjaCGkpplfNitCkgeIIuiahZBjMnMNk895QYh78m4N_8yDXaGkO_o1odVenAct2An-uOglv-ctTbouz45Cb7VDOGGdtutAN-3DEoMm4D5BNcU20Ax9y-xjjU_jPIv8A0W-jZw</recordid><startdate>199609</startdate><enddate>199609</enddate><creator>Bourdel-Marchasson, Isabelle</creator><creator>Biran, Marc</creator><creator>Thiaudière, Eric</creator><creator>Delalande, Christophe</creator><creator>Decamps, Arnaud</creator><creator>Manciet, Gérard</creator><creator>Canioni, Paul</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199609</creationdate><title>31P Magnetic resonance spectroscopy of human liver in elderly patients: Changes according to nutritional status and inflammatory state</title><author>Bourdel-Marchasson, Isabelle ; Biran, Marc ; Thiaudière, Eric ; Delalande, Christophe ; Decamps, Arnaud ; Manciet, Gérard ; Canioni, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2360-cde9ef6bfe913dd1a2e093383898506d1233a9ef1b09842d85ba77d6742212373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - metabolism</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Hepatitis - metabolism</topic><topic>Hepatitis - physiopathology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver - metabolism</topic><topic>Liver - physiology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Miscellaneous. Technology</topic><topic>Nutritional Status</topic><topic>Phosphorus Isotopes</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bourdel-Marchasson, Isabelle</creatorcontrib><creatorcontrib>Biran, Marc</creatorcontrib><creatorcontrib>Thiaudière, Eric</creatorcontrib><creatorcontrib>Delalande, Christophe</creatorcontrib><creatorcontrib>Decamps, Arnaud</creatorcontrib><creatorcontrib>Manciet, Gérard</creatorcontrib><creatorcontrib>Canioni, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bourdel-Marchasson, Isabelle</au><au>Biran, Marc</au><au>Thiaudière, Eric</au><au>Delalande, Christophe</au><au>Decamps, Arnaud</au><au>Manciet, Gérard</au><au>Canioni, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>31P Magnetic resonance spectroscopy of human liver in elderly patients: Changes according to nutritional status and inflammatory state</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1996-09</date><risdate>1996</risdate><volume>45</volume><issue>9</issue><spage>1059</spage><epage>1061</epage><pages>1059-1061</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><abstract>Magnetic resonance spectroscopy (MRS) was used to determine the phosphorylated metabolite content in the liver of elderly patients in various nutritional states: normal, with protein deprivation, and with acute inflammatory syndrome.
31P-MRS investigations were performed at 1.5 T, and localized liver spectra were recorded using a two-dimensional chemical shift imaging sequence. Comparison to control spectra recorded on 10 healthy volunteers (age, 30.5 ± 2.1 years) showed that the aging process does not significantly modify
31P-MRS liver spectra. Patients with protein deprivation exhibited a higher value than controls for the phosphomonoesters/nucleoside triphosphates (
PME
NTP
) ratio (
P < .05). This increase was not due to the decrease of NTP, since the ratio of inorganic phosphate to NTP (
P
i
NTP
) remained constant. A decrease in the phosphodiesters to NTP (
PDE
NTP
) ratio (
P < .04) contributed to the observed increase in the
PME
PDE
ratio (
P < .01). In contrast, no significant difference in
31P-MRS spectra was found between elderly patients with hypoalbuminemia associated with inflammatory syndrome and the control group. We conclude that elderly patients with protein deprivation displayed changes in the level of phosphorylated metabolites in the liver that were not observed in the case of inflammatory syndrome despite lower serum albumin (Alb) concentrations.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8781290</pmid><doi>10.1016/S0026-0495(96)90002-5</doi><tpages>3</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 1996-09, Vol.45 (9), p.1059-1061 |
| issn | 0026-0495 1532-8600 |
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| subjects | Aged Aged, 80 and over Aging - metabolism Aging - physiology Biological and medical sciences Body Mass Index Hepatitis - metabolism Hepatitis - physiopathology Humans Investigative techniques, diagnostic techniques (general aspects) Liver - metabolism Liver - physiology Magnetic Resonance Spectroscopy Medical sciences Miscellaneous. Technology Nutritional Status Phosphorus Isotopes Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | 31P Magnetic resonance spectroscopy of human liver in elderly patients: Changes according to nutritional status and inflammatory state |
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