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Effects of afterload on regional left ventricular torsion
To determine if left ventricular torsion, as measured by magnetic resonance tissue tagging, is afterload dependent in a canine isolated heart model in which neurohumoral responses are absent, and preload is constant. In ten isolated, blood perfused, ejecting, canine hearts, three afterloads were stu...
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| Published in: | Cardiovascular research 1996-06, Vol.31 (6), p.917-925 |
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| container_title | Cardiovascular research |
| container_volume | 31 |
| creator | MACGOWAN, G. A BURKHOFF, D WEISS, J. L SHAPIRO, E. P ROGERS, W. J SALVADOR, D AZHARI, H HEES, P. S ZWEIER, J. L HALPERIN, H. R SIU, C. O LIMA, J. A. C |
| description | To determine if left ventricular torsion, as measured by magnetic resonance tissue tagging, is afterload dependent in a canine isolated heart model in which neurohumoral responses are absent, and preload is constant.
In ten isolated, blood perfused, ejecting, canine hearts, three afterloads were studied, while keeping preload constant: low afterload, high afterload (stroke volume reduced by approx. 50% of low afterload), and isovolumic loading (infinite afterload).
There were significant effects of afterload on both torsion (P < 0.05) and circumferential shortening (P < 0.0005). Between low and high afterloads, at the anterior region of the endocardium only, where torsion was maximal, there was a significant reduction in torsion (15.1 +/- 2.2 degrees to 7.8 +/- 1.8 degrees, P < 0.05). Between high afterload and isovolumic loading there was no significant change in torsion (7.8 +/- 1.8 degrees to 6.2 +/- 1.5 degrees, P = NS). Circumferential shortening at the anterior endocardium was significantly reduced both between low and high afterload (-0.19 +/- 0.02 to -0.11 +/- 0.02, P < 0.0005), and also between high afterload and isovolumic loading (-0.11 +/- 0.02 to 0.00 +/- 0.02, P < 0.05). Plots of strains with respect to end-systolic volume demonstrated a reduction in both torsion and shortening with afterload-induced increases in end-systolic volume. Torsion, but not circumferential shortening, persisted at isovolumic loading.
Maximal regional torsion of the left ventricle is afterload dependent. The afterload response of torsion appears related to the effects of afterload on end-systolic volume. |
| doi_str_mv | 10.1016/0008-6363(96)00042-9 |
| format | article |
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In ten isolated, blood perfused, ejecting, canine hearts, three afterloads were studied, while keeping preload constant: low afterload, high afterload (stroke volume reduced by approx. 50% of low afterload), and isovolumic loading (infinite afterload).
There were significant effects of afterload on both torsion (P < 0.05) and circumferential shortening (P < 0.0005). Between low and high afterloads, at the anterior region of the endocardium only, where torsion was maximal, there was a significant reduction in torsion (15.1 +/- 2.2 degrees to 7.8 +/- 1.8 degrees, P < 0.05). Between high afterload and isovolumic loading there was no significant change in torsion (7.8 +/- 1.8 degrees to 6.2 +/- 1.5 degrees, P = NS). Circumferential shortening at the anterior endocardium was significantly reduced both between low and high afterload (-0.19 +/- 0.02 to -0.11 +/- 0.02, P < 0.0005), and also between high afterload and isovolumic loading (-0.11 +/- 0.02 to 0.00 +/- 0.02, P < 0.05). Plots of strains with respect to end-systolic volume demonstrated a reduction in both torsion and shortening with afterload-induced increases in end-systolic volume. Torsion, but not circumferential shortening, persisted at isovolumic loading.
Maximal regional torsion of the left ventricle is afterload dependent. The afterload response of torsion appears related to the effects of afterload on end-systolic volume.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1016/0008-6363(96)00042-9</identifier><identifier>PMID: 8759247</identifier><identifier>CODEN: CVREAU</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Computers ; Dogs ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart - anatomy & histology ; Heart - physiology ; Heart Ventricles ; Magnetic Resonance Imaging ; Models, Cardiovascular ; Perfusion ; Stroke Volume - physiology ; Torsion Abnormality ; Vertebrates: cardiovascular system</subject><ispartof>Cardiovascular research, 1996-06, Vol.31 (6), p.917-925</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-e919e403a48d37e6b2f06ea874227c9a9442ca06bb885d5345f6ae8d3458a61a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3123958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8759247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MACGOWAN, G. A</creatorcontrib><creatorcontrib>BURKHOFF, D</creatorcontrib><creatorcontrib>WEISS, J. L</creatorcontrib><creatorcontrib>SHAPIRO, E. P</creatorcontrib><creatorcontrib>ROGERS, W. J</creatorcontrib><creatorcontrib>SALVADOR, D</creatorcontrib><creatorcontrib>AZHARI, H</creatorcontrib><creatorcontrib>HEES, P. S</creatorcontrib><creatorcontrib>ZWEIER, J. L</creatorcontrib><creatorcontrib>HALPERIN, H. R</creatorcontrib><creatorcontrib>SIU, C. O</creatorcontrib><creatorcontrib>LIMA, J. A. C</creatorcontrib><title>Effects of afterload on regional left ventricular torsion</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>To determine if left ventricular torsion, as measured by magnetic resonance tissue tagging, is afterload dependent in a canine isolated heart model in which neurohumoral responses are absent, and preload is constant.
In ten isolated, blood perfused, ejecting, canine hearts, three afterloads were studied, while keeping preload constant: low afterload, high afterload (stroke volume reduced by approx. 50% of low afterload), and isovolumic loading (infinite afterload).
There were significant effects of afterload on both torsion (P < 0.05) and circumferential shortening (P < 0.0005). Between low and high afterloads, at the anterior region of the endocardium only, where torsion was maximal, there was a significant reduction in torsion (15.1 +/- 2.2 degrees to 7.8 +/- 1.8 degrees, P < 0.05). Between high afterload and isovolumic loading there was no significant change in torsion (7.8 +/- 1.8 degrees to 6.2 +/- 1.5 degrees, P = NS). Circumferential shortening at the anterior endocardium was significantly reduced both between low and high afterload (-0.19 +/- 0.02 to -0.11 +/- 0.02, P < 0.0005), and also between high afterload and isovolumic loading (-0.11 +/- 0.02 to 0.00 +/- 0.02, P < 0.05). Plots of strains with respect to end-systolic volume demonstrated a reduction in both torsion and shortening with afterload-induced increases in end-systolic volume. Torsion, but not circumferential shortening, persisted at isovolumic loading.
Maximal regional torsion of the left ventricle is afterload dependent. The afterload response of torsion appears related to the effects of afterload on end-systolic volume.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Computers</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart - anatomy & histology</subject><subject>Heart - physiology</subject><subject>Heart Ventricles</subject><subject>Magnetic Resonance Imaging</subject><subject>Models, Cardiovascular</subject><subject>Perfusion</subject><subject>Stroke Volume - physiology</subject><subject>Torsion Abnormality</subject><subject>Vertebrates: cardiovascular system</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNo9kEtLxDAUhYMo4zj6DxS6ENFFNe8mSxnGBwy40XW4TROpZNoxaQX_vRmnzOpyON85cA9ClwTfE0zkA8ZYlZJJdqvlXRaclvoIzUklRMkoF8dofkBO0VlKX1kKUfEZmqlKaMqrOdIr750dUtH7AvzgYuihKfquiO6z7TsIRXB-KH5cN8TWjgFiMfQxZescnXgIyV1Md4E-nlbvy5dy_fb8unxcl5YxMpROE-04ZsBVwyona-qxdKAqTmllNWjOqQUs61op0QjGhZfgMsuFAkmALdDNvncb--_RpcFs2mRdCNC5fkymUpSJ_G4G-R60sU8pOm-2sd1A_DUEm91iZjeH2c1h9L_g1Ogcu5r6x3rjmkNomij715MPyULwETrbpgPGCGVaKPYHfXxyJw</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>MACGOWAN, G. A</creator><creator>BURKHOFF, D</creator><creator>WEISS, J. L</creator><creator>SHAPIRO, E. P</creator><creator>ROGERS, W. J</creator><creator>SALVADOR, D</creator><creator>AZHARI, H</creator><creator>HEES, P. S</creator><creator>ZWEIER, J. L</creator><creator>HALPERIN, H. R</creator><creator>SIU, C. O</creator><creator>LIMA, J. A. C</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>Effects of afterload on regional left ventricular torsion</title><author>MACGOWAN, G. A ; BURKHOFF, D ; WEISS, J. L ; SHAPIRO, E. P ; ROGERS, W. J ; SALVADOR, D ; AZHARI, H ; HEES, P. S ; ZWEIER, J. L ; HALPERIN, H. R ; SIU, C. O ; LIMA, J. A. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-e919e403a48d37e6b2f06ea874227c9a9442ca06bb885d5345f6ae8d3458a61a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Computers</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Heart - anatomy & histology</topic><topic>Heart - physiology</topic><topic>Heart Ventricles</topic><topic>Magnetic Resonance Imaging</topic><topic>Models, Cardiovascular</topic><topic>Perfusion</topic><topic>Stroke Volume - physiology</topic><topic>Torsion Abnormality</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MACGOWAN, G. A</creatorcontrib><creatorcontrib>BURKHOFF, D</creatorcontrib><creatorcontrib>WEISS, J. L</creatorcontrib><creatorcontrib>SHAPIRO, E. P</creatorcontrib><creatorcontrib>ROGERS, W. J</creatorcontrib><creatorcontrib>SALVADOR, D</creatorcontrib><creatorcontrib>AZHARI, H</creatorcontrib><creatorcontrib>HEES, P. S</creatorcontrib><creatorcontrib>ZWEIER, J. L</creatorcontrib><creatorcontrib>HALPERIN, H. R</creatorcontrib><creatorcontrib>SIU, C. O</creatorcontrib><creatorcontrib>LIMA, J. A. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MACGOWAN, G. A</au><au>BURKHOFF, D</au><au>WEISS, J. L</au><au>SHAPIRO, E. P</au><au>ROGERS, W. J</au><au>SALVADOR, D</au><au>AZHARI, H</au><au>HEES, P. S</au><au>ZWEIER, J. L</au><au>HALPERIN, H. R</au><au>SIU, C. O</au><au>LIMA, J. A. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of afterload on regional left ventricular torsion</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>31</volume><issue>6</issue><spage>917</spage><epage>925</epage><pages>917-925</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><coden>CVREAU</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>To determine if left ventricular torsion, as measured by magnetic resonance tissue tagging, is afterload dependent in a canine isolated heart model in which neurohumoral responses are absent, and preload is constant.
In ten isolated, blood perfused, ejecting, canine hearts, three afterloads were studied, while keeping preload constant: low afterload, high afterload (stroke volume reduced by approx. 50% of low afterload), and isovolumic loading (infinite afterload).
There were significant effects of afterload on both torsion (P < 0.05) and circumferential shortening (P < 0.0005). Between low and high afterloads, at the anterior region of the endocardium only, where torsion was maximal, there was a significant reduction in torsion (15.1 +/- 2.2 degrees to 7.8 +/- 1.8 degrees, P < 0.05). Between high afterload and isovolumic loading there was no significant change in torsion (7.8 +/- 1.8 degrees to 6.2 +/- 1.5 degrees, P = NS). Circumferential shortening at the anterior endocardium was significantly reduced both between low and high afterload (-0.19 +/- 0.02 to -0.11 +/- 0.02, P < 0.0005), and also between high afterload and isovolumic loading (-0.11 +/- 0.02 to 0.00 +/- 0.02, P < 0.05). Plots of strains with respect to end-systolic volume demonstrated a reduction in both torsion and shortening with afterload-induced increases in end-systolic volume. Torsion, but not circumferential shortening, persisted at isovolumic loading.
Maximal regional torsion of the left ventricle is afterload dependent. The afterload response of torsion appears related to the effects of afterload on end-systolic volume.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>8759247</pmid><doi>10.1016/0008-6363(96)00042-9</doi><tpages>9</tpages></addata></record> |
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| ispartof | Cardiovascular research, 1996-06, Vol.31 (6), p.917-925 |
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| language | eng |
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| source | AUTh Library subscriptions: Oxford University Press |
| subjects | Animals Biological and medical sciences Computers Dogs Fundamental and applied biological sciences. Psychology Heart Heart - anatomy & histology Heart - physiology Heart Ventricles Magnetic Resonance Imaging Models, Cardiovascular Perfusion Stroke Volume - physiology Torsion Abnormality Vertebrates: cardiovascular system |
| title | Effects of afterload on regional left ventricular torsion |
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