Neurokinin A-like immunoreactivity in feline dental pulp: its distribution, origin and coexistence with substance P-like immunoreactivity

The distribution and origin of neurokinin A (NKA)-like immunoreactivity were investigated in feline dental pulp by an indirect immunofluorescence method. NKA-containing nerve fibres with varicosities, which entered the dental pulp via apical foramen, were distributed throughout this tissue. Many NKA...

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Bibliographic Details
Published in:Cell and tissue research 1988-03, Vol.251 (3), p.565-569
Main Authors: Wakisaka, S, Ichikawa, H, Nishikawa, S, Matsuo, S, Takano, Y, Akai, M
Format: Article
Language:English
Subjects:
Animals
Cats
Dental Pulp - cytology
Dental Pulp - innervation
Female
Fluorescent Antibody Technique
Immune Sera
Male
Nerve Fibers - cytology
Neurokinin A
Neuropeptides - analysis
Neuropeptides - immunology
Substance P - analysis
Substance P - immunology
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Summary:The distribution and origin of neurokinin A (NKA)-like immunoreactivity were investigated in feline dental pulp by an indirect immunofluorescence method. NKA-containing nerve fibres with varicosities, which entered the dental pulp via apical foramen, were distributed throughout this tissue. Many NKA-containing nerve fibres were localized around blood vessels, but some were observed apart therefrom. At the odontoblastic layer, thin NKA-containing nerve fibres were observed running straight toward the pulp-predentinal border between odontoblasts. After inferior alveolar nerve section, all NKA-containing nerve fibres disappeared in the dental pulp, while the removal of the superior cervical ganglion resulted in no change in the distribution of these fibres. The correlation of NKA-like immunoreactivity and substance P (SP)-like immunoreactivity was also investigated by double-immunofluorescence technique. The distribution of NKA-containing nerve fibres was very similar to that of SP-containing nerve fibres; it appeared that all NKA-containing nerve fibres contained SP.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00214004