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Divergence of insulin-like growth factors I and II in the elasmobranch, Squalus acanthias
Recent studies have shown that vertebrates, including teleostean fishes, amphibians, birds and mammals, contain two distinct insulin-like growth factor (IGF) genes. In contrast agnathans, represented by hagfish, apparently have only one IGF that has features characteristic of both IGF-I and IGF-II....
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| Published in: | FEBS letters 1995-08, Vol.371 (1), p.69-72 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c478E-d75c9c13ac836b5803588e63f941a277f3a77255b19aa83211246ace77e282083 |
| container_end_page | 72 |
| container_issue | 1 |
| container_start_page | 69 |
| container_title | FEBS letters |
| container_volume | 371 |
| creator | Duguay, Stephen J. Shu Jin Chan Mommsen, Thomas P. Steiner, Donald F. |
| description | Recent studies have shown that vertebrates, including teleostean fishes, amphibians, birds and mammals, contain two distinct insulin-like growth factor (IGF) genes. In contrast agnathans, represented by hagfish, apparently have only one IGF that has features characteristic of both IGF-I and IGF-II. Between these groups the elasmobranchs occupy a critical position in terms of the phylogeny of IGFs. We sought to determine if gene duplication and divergence of IGF-I and IGF-II occurred before or after divergence of elasmobranchs from other vertebrates by cloning IGF-like molecules from
Squalus acanthias. Our analysis shows that
Squalus liver produces two distinct IGF-like molecules. One has greater sequence identity to, and conserved features characteristic of, known IGF-I molecules, while the other is more IGF-II like. These results suggest that the prototypical IGF molecule duplicated and diverged in an ancestor of the extant gnathostomes. |
| doi_str_mv | 10.1016/0014-5793(95)00879-E |
| format | article |
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Squalus acanthias. Our analysis shows that
Squalus liver produces two distinct IGF-like molecules. One has greater sequence identity to, and conserved features characteristic of, known IGF-I molecules, while the other is more IGF-II like. These results suggest that the prototypical IGF molecule duplicated and diverged in an ancestor of the extant gnathostomes.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(95)00879-E</identifier><identifier>PMID: 7545136</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; bp, basepair ; Cloning, Molecular ; Conserved Sequence - genetics ; Dogfish - genetics ; Genes - genetics ; IGF, insulin-like growth factor ; ILP, insulin-like peptide ; Insulin-like growth factor ; Insulin-Like Growth Factor I - genetics ; Insulin-Like Growth Factor II - genetics ; Liver - chemistry ; Marine ; Molecular Sequence Data ; Multigene Family ; PCR, polymerase chain reaction ; Phylogeny ; RACE, rapid amplification of cDNA ends ; RNA - analysis ; RT-PCR, reverse transcriptase PCR ; Sequence Alignment ; Sequence Homology, Amino Acid ; Squalus acanthias ; Squalus acanthias (spiny dogfish shark)</subject><ispartof>FEBS letters, 1995-08, Vol.371 (1), p.69-72</ispartof><rights>1995</rights><rights>FEBS Letters 371 (1995) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478E-d75c9c13ac836b5803588e63f941a277f3a77255b19aa83211246ace77e282083</citedby><cites>FETCH-LOGICAL-c478E-d75c9c13ac836b5803588e63f941a277f3a77255b19aa83211246ace77e282083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2F0014-5793%2895%2900879-E$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2F0014-5793%2895%2900879-E$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,1424,27957,27958,45609,45610</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7545136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duguay, Stephen J.</creatorcontrib><creatorcontrib>Shu Jin Chan</creatorcontrib><creatorcontrib>Mommsen, Thomas P.</creatorcontrib><creatorcontrib>Steiner, Donald F.</creatorcontrib><title>Divergence of insulin-like growth factors I and II in the elasmobranch, Squalus acanthias</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Recent studies have shown that vertebrates, including teleostean fishes, amphibians, birds and mammals, contain two distinct insulin-like growth factor (IGF) genes. In contrast agnathans, represented by hagfish, apparently have only one IGF that has features characteristic of both IGF-I and IGF-II. Between these groups the elasmobranchs occupy a critical position in terms of the phylogeny of IGFs. We sought to determine if gene duplication and divergence of IGF-I and IGF-II occurred before or after divergence of elasmobranchs from other vertebrates by cloning IGF-like molecules from
Squalus acanthias. Our analysis shows that
Squalus liver produces two distinct IGF-like molecules. One has greater sequence identity to, and conserved features characteristic of, known IGF-I molecules, while the other is more IGF-II like. These results suggest that the prototypical IGF molecule duplicated and diverged in an ancestor of the extant gnathostomes.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>bp, basepair</subject><subject>Cloning, Molecular</subject><subject>Conserved Sequence - genetics</subject><subject>Dogfish - genetics</subject><subject>Genes - genetics</subject><subject>IGF, insulin-like growth factor</subject><subject>ILP, insulin-like peptide</subject><subject>Insulin-like growth factor</subject><subject>Insulin-Like Growth Factor I - genetics</subject><subject>Insulin-Like Growth Factor II - genetics</subject><subject>Liver - chemistry</subject><subject>Marine</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>PCR, polymerase chain reaction</subject><subject>Phylogeny</subject><subject>RACE, rapid amplification of cDNA ends</subject><subject>RNA - analysis</subject><subject>RT-PCR, reverse transcriptase PCR</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><subject>Squalus acanthias</subject><subject>Squalus acanthias (spiny dogfish shark)</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqNkc9P2zAUxy0Ego7xH4DkE9okstlxHNsXJFZSVglph20HTtar80I90qS1kyL--yW04jh2svy-P571MSHnnH3hjOdfGeNZIpURn4z8zJhWJikOyIRrJRKR5fqQTN4sJ-RDjH_YcNfcHJNjJTPJRT4hD7d-i-ERG4e0rahvYl_7Jqn9E9LH0D53S1qB69oQ6ZxCU9L5fDDRbokUa4irdhGgccsr-nPTQ91HCg6abukhfiRHFdQRz_bnKfk9K35Nvyf3P-7m05v7xGVKF0mppDOOC3Ba5AupmZBaYy4qk3FIlaoEKJVKueAGQIuU8zTLwaFSmOqUaXFKLne969BueoydXfnosK6hwbaPVqnMyCH2rpHLPGfasMGY7YwutDEGrOw6-BWEF8uZHdHbkasduVoj7St6Wwyxi31_v1hh-Rbasx702U5_9jW-_FennRXf0lEY50a-TsdF17siHLBuPQYbnR9_sPQBXWfL1v_7pX8BURWkhw</recordid><startdate>19950828</startdate><enddate>19950828</enddate><creator>Duguay, Stephen J.</creator><creator>Shu Jin Chan</creator><creator>Mommsen, Thomas P.</creator><creator>Steiner, Donald F.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19950828</creationdate><title>Divergence of insulin-like growth factors I and II in the elasmobranch, Squalus acanthias</title><author>Duguay, Stephen J. ; Shu Jin Chan ; Mommsen, Thomas P. ; Steiner, Donald F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478E-d75c9c13ac836b5803588e63f941a277f3a77255b19aa83211246ace77e282083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>bp, basepair</topic><topic>Cloning, Molecular</topic><topic>Conserved Sequence - genetics</topic><topic>Dogfish - genetics</topic><topic>Genes - genetics</topic><topic>IGF, insulin-like growth factor</topic><topic>ILP, insulin-like peptide</topic><topic>Insulin-like growth factor</topic><topic>Insulin-Like Growth Factor I - genetics</topic><topic>Insulin-Like Growth Factor II - genetics</topic><topic>Liver - chemistry</topic><topic>Marine</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>PCR, polymerase chain reaction</topic><topic>Phylogeny</topic><topic>RACE, rapid amplification of cDNA ends</topic><topic>RNA - analysis</topic><topic>RT-PCR, reverse transcriptase PCR</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><topic>Squalus acanthias</topic><topic>Squalus acanthias (spiny dogfish shark)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duguay, Stephen J.</creatorcontrib><creatorcontrib>Shu Jin Chan</creatorcontrib><creatorcontrib>Mommsen, Thomas P.</creatorcontrib><creatorcontrib>Steiner, Donald F.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duguay, Stephen J.</au><au>Shu Jin Chan</au><au>Mommsen, Thomas P.</au><au>Steiner, Donald F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Divergence of insulin-like growth factors I and II in the elasmobranch, Squalus acanthias</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1995-08-28</date><risdate>1995</risdate><volume>371</volume><issue>1</issue><spage>69</spage><epage>72</epage><pages>69-72</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Recent studies have shown that vertebrates, including teleostean fishes, amphibians, birds and mammals, contain two distinct insulin-like growth factor (IGF) genes. In contrast agnathans, represented by hagfish, apparently have only one IGF that has features characteristic of both IGF-I and IGF-II. Between these groups the elasmobranchs occupy a critical position in terms of the phylogeny of IGFs. We sought to determine if gene duplication and divergence of IGF-I and IGF-II occurred before or after divergence of elasmobranchs from other vertebrates by cloning IGF-like molecules from
Squalus acanthias. Our analysis shows that
Squalus liver produces two distinct IGF-like molecules. One has greater sequence identity to, and conserved features characteristic of, known IGF-I molecules, while the other is more IGF-II like. These results suggest that the prototypical IGF molecule duplicated and diverged in an ancestor of the extant gnathostomes.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>7545136</pmid><doi>10.1016/0014-5793(95)00879-E</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1995-08, Vol.371 (1), p.69-72 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77495211 |
| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS; Wiley Online Library |
| subjects | Amino Acid Sequence Animals Base Sequence bp, basepair Cloning, Molecular Conserved Sequence - genetics Dogfish - genetics Genes - genetics IGF, insulin-like growth factor ILP, insulin-like peptide Insulin-like growth factor Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor II - genetics Liver - chemistry Marine Molecular Sequence Data Multigene Family PCR, polymerase chain reaction Phylogeny RACE, rapid amplification of cDNA ends RNA - analysis RT-PCR, reverse transcriptase PCR Sequence Alignment Sequence Homology, Amino Acid Squalus acanthias Squalus acanthias (spiny dogfish shark) |
| title | Divergence of insulin-like growth factors I and II in the elasmobranch, Squalus acanthias |
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