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Light-induced resetting of a circadian clock is mediated by a rapid increase in frequency transcript
To understand how light entrains circadian clocks, weexamined the effects of light on a gene known to encode a state variable of a circadian oscillator, the frequency ( frq) gene. frq is rapidly induced by short pulses of visible light; clock resetting is correlated with frq induction and is blocked...
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| Published in: | Cell 1995-06, Vol.81 (7), p.1003-1012 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c556t-36a12e7894f35da95778b9b499a2a1811a10bf203b97ad0d23332e7915306d403 |
| container_end_page | 1012 |
| container_issue | 7 |
| container_start_page | 1003 |
| container_title | Cell |
| container_volume | 81 |
| creator | Crosthwaite, Susan K. Loros, Jennifer J. Dunlap, Jay C. |
| description | To understand how light entrains circadian clocks, weexamined the effects of light on a gene known to encode a state variable of a circadian oscillator, the
frequency (
frq) gene.
frq is rapidly induced by short pulses of visible light; clock resetting is correlated with
frq induction and is blocked by drugs that block the synthesis of protein or translatable RNA. The speed and magnitude of
frq induction suggest that this may be the initial clock-specific event in light resetting. Light induction overcomes
frq negative autoregulation so that
frq expression can remain high in constant light. These data explain how a simple unidirectional signal (light and the induction of
frq) may be turned into a bidirectional clock response (time of day-specific advances and delays). This light entrainment model is easily generalized and may be the common mechanism by which the intracellular feedback cycles that comprise circadian clocks are brought into synchrony with external cycles in the real world. |
| doi_str_mv | 10.1016/S0092-8674(05)80005-4 |
| format | article |
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frequency (
frq) gene.
frq is rapidly induced by short pulses of visible light; clock resetting is correlated with
frq induction and is blocked by drugs that block the synthesis of protein or translatable RNA. The speed and magnitude of
frq induction suggest that this may be the initial clock-specific event in light resetting. Light induction overcomes
frq negative autoregulation so that
frq expression can remain high in constant light. These data explain how a simple unidirectional signal (light and the induction of
frq) may be turned into a bidirectional clock response (time of day-specific advances and delays). This light entrainment model is easily generalized and may be the common mechanism by which the intracellular feedback cycles that comprise circadian clocks are brought into synchrony with external cycles in the real world.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(05)80005-4</identifier><identifier>PMID: 7600569</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Analysis of Variance ; Calcium-Binding Proteins - biosynthesis ; Calcium-Binding Proteins - genetics ; Cell Nucleus - metabolism ; Circadian Rhythm - genetics ; Darkness ; Gene Expression Regulation, Fungal - radiation effects ; Light ; Nerve Tissue Proteins - biosynthesis ; Nerve Tissue Proteins - genetics ; Neurospora ; Neurospora - genetics ; Neurospora - physiology ; Open Reading Frames ; Oscillometry ; Protein Biosynthesis ; RNA, Messenger - biosynthesis ; Signal Transduction ; Transcription, Genetic</subject><ispartof>Cell, 1995-06, Vol.81 (7), p.1003-1012</ispartof><rights>1995 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-36a12e7894f35da95778b9b499a2a1811a10bf203b97ad0d23332e7915306d403</citedby><cites>FETCH-LOGICAL-c556t-36a12e7894f35da95778b9b499a2a1811a10bf203b97ad0d23332e7915306d403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7600569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crosthwaite, Susan K.</creatorcontrib><creatorcontrib>Loros, Jennifer J.</creatorcontrib><creatorcontrib>Dunlap, Jay C.</creatorcontrib><title>Light-induced resetting of a circadian clock is mediated by a rapid increase in frequency transcript</title><title>Cell</title><addtitle>Cell</addtitle><description>To understand how light entrains circadian clocks, weexamined the effects of light on a gene known to encode a state variable of a circadian oscillator, the
frequency (
frq) gene.
frq is rapidly induced by short pulses of visible light; clock resetting is correlated with
frq induction and is blocked by drugs that block the synthesis of protein or translatable RNA. The speed and magnitude of
frq induction suggest that this may be the initial clock-specific event in light resetting. Light induction overcomes
frq negative autoregulation so that
frq expression can remain high in constant light. These data explain how a simple unidirectional signal (light and the induction of
frq) may be turned into a bidirectional clock response (time of day-specific advances and delays). 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frequency (
frq) gene.
frq is rapidly induced by short pulses of visible light; clock resetting is correlated with
frq induction and is blocked by drugs that block the synthesis of protein or translatable RNA. The speed and magnitude of
frq induction suggest that this may be the initial clock-specific event in light resetting. Light induction overcomes
frq negative autoregulation so that
frq expression can remain high in constant light. These data explain how a simple unidirectional signal (light and the induction of
frq) may be turned into a bidirectional clock response (time of day-specific advances and delays). This light entrainment model is easily generalized and may be the common mechanism by which the intracellular feedback cycles that comprise circadian clocks are brought into synchrony with external cycles in the real world.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7600569</pmid><doi>10.1016/S0092-8674(05)80005-4</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cell, 1995-06, Vol.81 (7), p.1003-1012 |
| issn | 0092-8674 1097-4172 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77372845 |
| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Analysis of Variance Calcium-Binding Proteins - biosynthesis Calcium-Binding Proteins - genetics Cell Nucleus - metabolism Circadian Rhythm - genetics Darkness Gene Expression Regulation, Fungal - radiation effects Light Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Neurospora Neurospora - genetics Neurospora - physiology Open Reading Frames Oscillometry Protein Biosynthesis RNA, Messenger - biosynthesis Signal Transduction Transcription, Genetic |
| title | Light-induced resetting of a circadian clock is mediated by a rapid increase in frequency transcript |
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